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See detailNon-local Damage-Enhanced MFH for Multiscale Simulations of Composites
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

in Patterson, Eann; Backman, David; Cloud, Gary (Eds.) Composite Materials and Joining Technologies for Composites, Volume 7 (2013)

In this work, a gradient-enhanced mean-field homogenization (MFH) procedure is proposed for fiber reinforced materials. In this approach, the fibers are assumed to remain linear elastic while the matrix ... [more ▼]

In this work, a gradient-enhanced mean-field homogenization (MFH) procedure is proposed for fiber reinforced materials. In this approach, the fibers are assumed to remain linear elastic while the matrix material obeys an elasto-plastic behavior enhanced by a damage model. As classical finite element simulations face the problems of losing uniqueness and strain localization when strain softening of materials is involved, we develop the mean-field homogenization in a non-local way. Toward this end we use the so-called non-local implicit approach, reformulated in an anisotropic way to describe the damage in the matrix. As a result we have a multi-scale model that can be used to study the damage process at the meso-scale, and in particular the damaging of plies in a composite stack, in an efficient comput0ational way. As a demonstration a stack with a hole is studied and it is shown that the model predicts the damaging process in bands oriented with the fiber directions. [less ▲]

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See detailNon-local damage-enhanced MFH for multiscale simulations of composites
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

in Proceedings of the XII SEM International Conference & Exposition on Experimental and Applied Mechanics (2012)

In this work, a gradient-enhanced mean-field homogenization (MFH) procedure is proposed for fiber reinforced materials. In this approach, the fibers are assumed to remain linear elastic while the matrix ... [more ▼]

In this work, a gradient-enhanced mean-field homogenization (MFH) procedure is proposed for fiber reinforced materials. In this approach, the fibers are assumed to remain linear elastic while the matrix material obeys an elasto-plastic behavior enhanced by a damage model. As classical finite element simulations face the problems of losing uniqueness and strain localization when strain softening of materials is involved, we develop the mean-field homogenization in a non-local way. Toward this end we use the so-called non-local implicit approach, reformulated in an anisotropic way to describe the damage in the matrix. As a result we have a multi-scale model that can be used to study the damage process at the meso-scale, and in particular the damaging of plies in a composite stack, in an efficient computational way. As a demonstration a stack with a hole is studied and it is shown that the model predicts the damaging process in bands oriented with the fiber directions. [less ▲]

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See detailNon-Local Incremental-Secant Mean-Field-Homogenization of Damage-Enhanced Elasto-Plastic Composites
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

Conference (2013, December)

An anisotropic gradient–enhanced continuum damage model is herein embedded in a mean–field homogenization (MFH) process for elasto-plastic composites. The homogenization procedure is based on the newly ... [more ▼]

An anisotropic gradient–enhanced continuum damage model is herein embedded in a mean–field homogenization (MFH) process for elasto-plastic composites. The homogenization procedure is based on the newly developed incremental secant mean-field homogenization formulation, for which the residual stress and strain states reached in the phases upon a fictitious elastic unloading are considered as starting point to apply the secant method. The mean stress fields in the phases are then computed using isotropic secant tensors, which are naturally used to define the Linear Comparison–Composite The resulting multi– scale model is then applied to study the damage process at the meso–scale of laminates, and in particular the damaging of plies in a composite stack. By using the gradient–enhanced continuum damage model, the problem of losing uniqueness upon strain softening is avoided. [less ▲]

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See detailA non-local MLT treatment fitting 3D simulations
Dupret, Marc-Antoine ULg; Goupil, M*-J; Samadi, R. et al

in Proceedings of SOHO 18/GONG 2006/HELAS I, Beyond the spherical Sun (2006, October 01)

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See detailNon-local multiscale analyzes of composite laminates based on a damage-enhanced mean–field homogenization formulation
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

Conference (2013, June)

Properties of carbon fiber reinforced epoxy laminates are studied using an anisotropic gradient–enhanced continuum damage model embedded in a mean–field homogenization (MFH) procedure. The fibers are ... [more ▼]

Properties of carbon fiber reinforced epoxy laminates are studied using an anisotropic gradient–enhanced continuum damage model embedded in a mean–field homogenization (MFH) procedure. The fibers are assumed to remain elastic, and the matrix material obeys an elasto–plastic behavior enhanced by the proposed damage model. The resulting multi– scale model is then applied to study the damage process at the meso–scale of laminates, and in particular the damaging of plies in a composite stack. By using the gradient–enhanced continuum damage model, the problem of losing uniqueness and strain localization, which happens in classical finite element simulations when strain softening of materials is involved, is avoided. As a demonstration a stack with a hole is studied and it is shown that the model predicts the damaging process in bands oriented with the fiber directions, accordingly to the conducted experimental results. [less ▲]

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See detailNon-local time-dependent treatments of convection in A-G type stars
Dupret, Marc-Antoine ULg; Samadi, R.; Grigahcene, A. et al

in Communications in Asteroseismology (2006), 147

Time-Dependent Convection (TDC) models obtained by combining the local treatment of Gabriel (1996) and Grigahcene et al. (2005) and the non-local prescriptions of Spiegel (1963) are presented. We show ... [more ▼]

Time-Dependent Convection (TDC) models obtained by combining the local treatment of Gabriel (1996) and Grigahcene et al. (2005) and the non-local prescriptions of Spiegel (1963) are presented. We show that in the stationary unperturbed case, these non-local treatments can be constrained by the results of 3D hydrodynamic simulations (Stein & Nordlund 1998). We consider here the case of solar-type stars with a large convective envelope and A-F type stars with two very thin surface convection zones. [less ▲]

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See detailNon-Lte Effects and Abundance Analyses of Halo Stars
Magain, Pierre ULg

in Cayrel de Strobel, G.; Spite, M. (Eds.) The Impact of Very High S/N Spectroscopy on Stellar Physics (1988)

The possible existence of departures from LTE affecting the abundance analyses of halo dwarfs and subgiants is analysed from the observational point of view, and illustrated by the case of the ... [more ▼]

The possible existence of departures from LTE affecting the abundance analyses of halo dwarfs and subgiants is analysed from the observational point of view, and illustrated by the case of the intermediate halo subgiant HD 76932. [less ▲]

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See detailNon-LTE effects on H-3(+) emission in the jovian upper atmosphere
Melin, Henrik; Miller, Steve; Stallard, Tom et al

in Icarus: International Journal of Solar System Studies (2005), 178(1), 97-103

Calculations of column intensities are performed for a number of infrared transitions of the H-3(+) molecular ion, using a model atmosphere recently produced by Grodent et al. [2001. A self-consistent ... [more ▼]

Calculations of column intensities are performed for a number of infrared transitions of the H-3(+) molecular ion, using a model atmosphere recently produced by Grodent et al. [2001. A self-consistent model of the jovian auroral thermal structure. J. Geophys. Res. 106, 12933-12952]. The line intensities integrated along the line of sight through the model atmosphere are first computed assuming that all of the emitting energy levels are in local thermodynamic equilibrium (LTE). These results are compared with those derived from a detailed balance calculation using a method recently proposed by Oka and Epp [2004. Non-thermal rotational distribution of H-3(+). Astrophys. J. In press]. It is shown that the population of excited vibrational levels starts to depart from that derived from LTE at attitudes higher than 500 km (above the jovian cloud tops). This effect has been noted previously by Kim et it. [1992. Densities and vibrational distribution of H-3(+) in the jovian auroral atmosphere. J. Geophys. Res. 97, 6093-6101]. By 2000 km, all of the excited vibrational levels are Populated at less than 10% of the expected LTE value. This has important implications for the jovian upper atmosphere. In particular, the H-3(+) cooling effect will be greatly reduced high in the atmosphere. Modelled LTE line emission is greater than that derived from non-LTE modelling. Comparison of the non-LTE modelling with recent spectral measurements of the jovian auroral/polar regions in the L- and K-infrared windows shows that the Grodent et al. [2001. A self-consistent model of the jovian auroral thermal structure. J. Geophys. Res. 106, 12933-12952] profile overestimates the measured line intensity by similar to 3. Allowing for this, the non-LTE modelling shows that the column densities derived from (quasi-)LTE treatment of the measured line intensities may underestimate the real H-3(+) abundance by a factor of between 6 and 200. This means that attempts to derive important ionospheric properties, such as conductivity and related energy inputs due to magnetosphere-ionosphere coupling, front observed spectra will need to take this into account, if they are not to be seriously in error. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailLe non-marchand, frein ou moteur pour la croissance ?
Defourny, Jacques ULg; Mertens de Wilmars, Sybille ULg; Salamé, Marc

in Defourny, Jacques; Jacquemin, J.-Ch. (Eds.) Avec quelle croissance devons-nous apprendre à vivre ? (1996)

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See detailNon-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: a phase II randomized trial.
Willems, Evelyne ULg; Baron, Frédéric ULg; Baudoux, Etienne ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2009), 23(3), 608-10

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See detailNon-native prosody: production and perception of accent
Rasier, Laurent ULg; Caspers, Johanneke; Van Heuven, Vincent

Conference (2008)

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See detailNon-native variëteiten van het Nederlands: verwerving en didactiek
Rasier, Laurent ULg

Conference (2009)

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See detailA non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Hagan, Christine L; Johnson, Russell J K; Dhulesia, Anne et al

in Protein Engineering, Design & Selection (2010), 23(7), 499-506

We report here the detailed characterisation of a non-naturally occurring variant of human lysozyme, I59T, which possesses a destabilising point mutation at the interface of the alpha- and beta-domains ... [more ▼]

We report here the detailed characterisation of a non-naturally occurring variant of human lysozyme, I59T, which possesses a destabilising point mutation at the interface of the alpha- and beta-domains. Although more stable in its native structure than the naturally occurring variants that give rise to a familial form of systemic amyloidosis, I59T possesses many attributes that are similar to these disease-associated species. In particular, under physiologically relevant conditions, I59T populates transiently an intermediate in which a region of the structure unfolds cooperatively; this loss of global cooperativity has been suggested to be a critical feature underlying the amyloidogenic nature of the disease-associated lysozyme variants. In the present study, we have utilised this variant to provide direct evidence for the generic nature of the conformational transition that precedes the ready formation of the fibrils responsible for lysozyme-associated amyloid disease. This non-natural variant can be expressed at higher levels than the natural amyloidogenic variants, enabling, for example, singly isotopically labelled protein to be generated much more easily for detailed structural studies by multidimensional NMR spectroscopy. Moreover, we demonstrate that the I59T variant can readily form fibrils in vitro, similar in nature to those of the amyloidogenic I56T variant, under significantly milder conditions than are needed for the wild-type protein. [less ▲]

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See detailNon-neoplastic surgical diseases of the vagina and vulva
Hamaide, Annick ULg

in Proceedings du 1st Surgical Forum ECVS (2001, July)

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See detailNon-O157 Shiga toxin-producing Escherichia coli isolated from diarrhoeic calves in Argentina.
Mercado, E. C.; Gioffre, A.; Rodriguez, Sabrina ULg et al

in Journal of Veterinary Medicine. B, Infectious Diseases & Veterinary Public Health (2004), 51(2), 82-8

Faecal samples from 76 diarrhoeic calves belonging to 36 farms located in the Pampas plain, Argentina, were examined for Shiga toxin-producing Escherichia coli (STEC). A total of 15 STEC strains were ... [more ▼]

Faecal samples from 76 diarrhoeic calves belonging to 36 farms located in the Pampas plain, Argentina, were examined for Shiga toxin-producing Escherichia coli (STEC). A total of 15 STEC strains were isolated from 12 (15.8%) calves which came from six different farms. All stx positive strains assayed by PCR were also positives in the Vero cell cytotoxicity test. The majority (60.0%) of the STEC strains carried the stx(1) gene. Twelve (80.0%) of the STEC isolates which belonged to serotypes O5:H- (n = 4), O26:H11 (n = 4), O26:H- (n = 1), O111:H- (n = 2), and O123:H38 (n = 1) were also enterohaemolysin (EHly) positive and carried the gene encoding for intimin (eae). All the stx positive strains were negative for the bfpA gene. Localized adherence to HEp-2 cells were observed in 83.3% of the eae+ STEC strains. STEC belonging to serotype O5:H- showed atypical biochemical properties, including urease production. Urease was also produced by two strains belonging to serotypes O153:H? and non-typeable, respectively. Resistance to three or more antibiotics was observed in 12 (80.0%) of the STEC isolates. Most of the serotypes of STEC recovered in this survey carried virulence traits that are associated with increased human and bovine pathogenicity. The present study shows that highly virulent STEC strains are being shed by diarrhoeic calves from farms located in a high incidence area of human STEC infections. [less ▲]

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See detailNon-observance thérapeutique: causes, conséquences, solutions.
Scheen, André ULg; Giet, Didier ULg

in Revue Médicale de Liège (2010), 65(5-6), 239-45

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication adherence seems to be rather low as 30 to 60% of patients with chronic disease may be ... [more ▼]

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication adherence seems to be rather low as 30 to 60% of patients with chronic disease may be categorised as being poorly or not adherent to drug therapy. Numerous factors may influence compliance among which patient's characteristics, disease peculiarities, drug treatment modalities, physician's attitudes and health system organisation. The consequences of non-compliance to drug therapy may not only be harmful for patient's health, but could also negatively impact the financial cost of public health services. Thus, all efforts should be focused to improve drug compliance, if possible by targeting all causes responsible for poor adherence to medications. [less ▲]

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See detailLa non-observance therapeutique: probleme majeur pour la prevention des maladies cardio-vasculaires.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(12), 914-20

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias ... [more ▼]

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias, diabetes mellitus and arterial hypertension. Such an approach first requires the adherence to life-style habits (healthy diet, physical activity and no smoking) and, in case of failure, the use of lipid-lowering drugs, antidiabetic agents and/or antihypertensive medications. Sometimes, a monotherapy may be sufficient but, in most cases, a drug combination is mandatory because of the need to reach tight therapeutic targets and of the presence of a polypathology, especially within the frame of the metabolic syndrome. Unfortunately, all surveys indicate that therapeutic compliance to non-pharmacological advice and even to drug prescriptions is far from being excellent. Such a non-compliance limits the efficacy of the prevention strategies and contributes to markedly increase the cost of metabolic diseases and associated complications. [less ▲]

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