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See detailLocalization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2
Bellefroid, Eric J.; Ried, Thomas; Riviere, Michele et al

in Genomics (1992), 14(3), 780-1

A cluster of Kruppel type zinc finger genes of the KRAB subclass has recently been localized on human chromosome 19p12-p13.1. We now report that ZNF117 (HPF9), a closely related zinc finger gene of this ... [more ▼]

A cluster of Kruppel type zinc finger genes of the KRAB subclass has recently been localized on human chromosome 19p12-p13.1. We now report that ZNF117 (HPF9), a closely related zinc finger gene of this KRAB subfamily, has been assigned to a distinct locus in the human genome: chromosome band 7q11.2. [less ▲]

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See detailLocalization of type I, III, IV collagen and fibronectin in benign tumors and epitheliomas of the human breast
Pages, A.; Foidart, Jean-Michel ULg; Gordenne, W.

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1984), 13(1), 35-40

Fibronectin and types I, III and IV collagens were localized by an indirect immunofluorescence technique in 10 fibro-adenomas and 27 mammary adenocarcinomas. In the benign lesions, a densification of a ... [more ▼]

Fibronectin and types I, III and IV collagens were localized by an indirect immunofluorescence technique in 10 fibro-adenomas and 27 mammary adenocarcinomas. In the benign lesions, a densification of a type III collagen meshwork was noted around galactophoric channels. In carcinomas, various patterns of connective tissue proteins distributions were observed depending upon the histological types of lesions. Connective tissue proteins are restricted to the perivascular areas in mucinous carcinomas. Type III collagen is largely distributed in the stroma of poorly differentiated tumors. In differentiated carcinomas, discontinuous linear deposits of type IV collagen or fibronectin are localized at the border of epithelial proliferations. They probably represent the remmants of epithelial basement membrane. In intra- canalar adenocarcinomas, type IV collagen and fibronectin form irregular and discontinuous depositifs . These finding indicate that extensive connective tissue remodelling is observed during neoplastic infiltration. The type of stroma and connective tissue proteins distributed in these epithelial proliferations depends primarily upon the histological type of malignant infiltrating carcinomas. [less ▲]

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See detailLocalization of varicella-zoster virus nucleic acids and proteins in human skin.
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Neurology (1995), 45(12 Suppl 8), 47-9

The pathogenic mechanisms involved in varicella-zoster virus (VZV) infections remain elusive. The pattern of cutaneous distribution of the IE63 protein and of the gpI (gE) and gpII glycoproteins with ... [more ▼]

The pathogenic mechanisms involved in varicella-zoster virus (VZV) infections remain elusive. The pattern of cutaneous distribution of the IE63 protein and of the gpI (gE) and gpII glycoproteins with their corresponding genome sequences during VZV infections was studied by immunohistochemistry and in situ hybridization. Skin biopsy specimens were obtained from immunocompetent and immunocompromised patients with varicella, herpes zoster, or atypical VZV lesions. The first evidence for VZV infection consisted of the presence of IE63 in keratinocytes. In the vesicles and pustules, the viral transcripts gpI, gpII, and IE63 and the corresponding nucleic acids for gpI and gpII were identified in keratinocytes, sebocytes, Langerhans cells, dermal dendrocytes, monocytes/macrophages, and endothelial cells. The gpI and gpII glycorpoteins were essentially located on the cellular membranes while IE63 expression was generally restricted to the nuclei. In three biopsies of early herpes zoster, viral proteins were disclosed in dermal nerves and in perineurial type I dendrocytes. This was never encountered in varicella. Vasculitic changes and endothelial cell involvement were more prominent in varicella than in herpes zoster. It is concluded that the secondary viremia in varicella that affects the dermal endothelial cells is followed by a cell-to-cell spread to keratinocytes. In herpes zoster, the viral progression through cutaneous nerves primarily extends to the pilosebaceous units with a secondary involvement of epidermal keratinocytes, followed by a further spread to dermal cells. [less ▲]

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See detailLocalized electron dynamics in attosecond-pulse-excited molecular systems: Probing the time-dependent electron density by sudden photoionization
Mignolet, Benoît ULg; Levine, Raphael; Remacle, Françoise ULg

in Physical Review. A (2012)

Ultrafast UV excitation can prepare a nonstationary coherent superposition of molecular electronic states. The purely electronic dynamics before the onset of nuclear motion can be probed by a sudden XUV ... [more ▼]

Ultrafast UV excitation can prepare a nonstationary coherent superposition of molecular electronic states. The purely electronic dynamics before the onset of nuclear motion can be probed by a sudden XUV ionization of the electronic wave packet. Dynamical computations at the many-electron level on the LiH and 1-azabicyclo[3.3.3]undecane (C10H19N) molecules showthat molecular frame photoelectron angular distributions reflect the spatial localization and undulations of the electronic coherent superposition accessed by the initial ultrafast UV excitation. The sudden ionization is sensitive to interference effects. [less ▲]

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See detailLocalized failure in saturated porous media
Desrues, Jacques; Collin, Frédéric ULg

in Vermeer, Peter; Ehlers, W.; Herrmann, H. J. (Eds.) Modelling of Cohesive-Frictionl Materials (2004)

Strain localisation in soils and rocks has been studied extensively for the last 20 years. A part of these studies have been devoted to the response of specimens submitted to tests in undrained situation ... [more ▼]

Strain localisation in soils and rocks has been studied extensively for the last 20 years. A part of these studies have been devoted to the response of specimens submitted to tests in undrained situation. It was shown that shear banding can take place in both contractive and dilative specimens, with some special features due to the coupling between the granular skeleton and the pore fluid. In the paper, the relevance of the bifurcation criterion in shear band mode in the case of hydromechanical coupling is assessed by numerical study of the response of the constitutive model CLoE –the Hypoplastic model developed in L3S-Grenoble– in two kinds of numerical integration: local, i.e. at the material point level and global, i.e. in boundary value problems analyzed by finite elements. [less ▲]

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See detailLocalized iterative generalized multipole technique for large two-dimensional scattering problems
Obelleiro, Fernando; Landesa, Luis; Rodriguez, Jose Luis et al

in Ieee Transactions On Antennas And Propagation (2001), 49(6), 961-970

In this work, we propose a novel and efficient solution for the generalized multipole technique (GMT): the localized iterative generalized multipole technique (LIGMT). In LIGMT, an analytic constraint is ... [more ▼]

In this work, we propose a novel and efficient solution for the generalized multipole technique (GMT): the localized iterative generalized multipole technique (LIGMT). In LIGMT, an analytic constraint is imposed on the power radiated by the set of multipole sources sharing the same origin, rendering it minimum over a given angular sector. In this way, the power radiated by each set of multipoles is confined to a different section of the scatterer surface. It follows that each set of multipole coefficients can be solved step by step via an iterative process, which circumvents the need to solve the large and full matrix equation. This implies a significant reduction of the computational and storage cost, enhancing the scope of application of the GMT method to larger problems. [less ▲]

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See detaillocalized modulation of testosterone action: Function of steroid receptor coactivators in the brain
Charlier, Thierry ULg; Balthazart, Jacques ULg

in Ardis, L. I. (Ed.) New research on testosterone (2008)

Testosterone, through its activation of androgen and estrogen receptors, has been shown to play a critical role in brain development and physiology. Recent studies have shown that the activity of these ... [more ▼]

Testosterone, through its activation of androgen and estrogen receptors, has been shown to play a critical role in brain development and physiology. Recent studies have shown that the activity of these receptors can be modulated by the interaction with several proteins and, in particular, that coactivators are required to enhance their transcriptional activity. The steroid receptor coactivator-1, SRC-1 is the best-characterized coactivator and we review here the current knowledge on the distribution, regulation of expression and function of this protein in the brain, focusing mostly on our work in Japanese quail. As expected for a ubiquitous coactivator, SRC-1 is present throughout the brain in both mammalian and avian species but is found in particularly high concentrations in testosterone-sensitive areas such as the preoptic area in rat and Japanese quail and in the song control nuclei in songbirds. Further analysis demonstrates that the expression of SRC-1 is not constitutive but regulated in specific brain areas by the sex, acute stress and testosterone treatment. In addition, the protein concentration appears to fluctuate through the day in some brain regions. These modulations of SRC-1 expression by endogenous (sex) and exogenous (stress) factors could potentially exacerbate at specific times the competition or squelching between different nuclear receptors and therefore decrease the biological response induced by one or another hormonal system. Although the existence of such a phenomenon has not yet been demonstrated in a functionally intact biological system, the effects of SRC-1 antisense treatments clearly strengthen this hypothesis. Indeed, the decrease of SRC-1 expression in the hypothalamus induced by antisense oligonucleotide injections clearly inhibited both estrogen-dependent male sexual behavior and androgen-dependent pre- and post-copulatory displays (strut) in Japanese quail, therefore demonstrating a role of the coactivator in the transcriptional activation induced by both estrogen and androgen receptors. Interestingly, the inhibitory effect on sexual behavior of SRC-1 knock down was not systematically associated with modifications of several histological (definition of median preoptic nucleus [POM] using Nissl staining), immunohistochemical (aromatase and vasotocin cells and fibers in the POM) and biochemical (aromatase enzymatic activity) markers of testosterone action in the brain. This dissociation of the effects of SRC-1 on behavior on the one hand and on aromatase and POM neurochemistry on another hand suggests that other system(s) involved in the activation of male sexual behavior are likely more sensitive to a decrease of SRC-1 expression. In future research, it will be essential to determine the other cofactors involved in specific physiological responses and to define whether these coactivators act synergistically, in parallel or independently in the modulation of the activity of one or several nuclear receptors linked to a particular physiological event. In several biological models, the observed changes in concentration of the circulating hormone and /or its receptors are apparently not sufficient to explain the physiological and behavioral responses observed after testosterone treatment. The discovery of steroid receptor coactivators opens new perspectives in the study of the molecular basis of steroid action at the level of the organism and a complete understanding of the mechanisms of steroid action will not be achieved without a detailed characterization of nuclear receptor cofactors. [less ▲]

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See detailLocalizing and comparing weight maps generated from linear kernel machine learning models
Schrouff, Jessica ULg; CREMERS, Julien ULg; GARRAUX, Gaëtan ULg et al

in 2013 Third International Workshop on Pattern Recognition in NeuroImaging (PRNI 2013): proceedings (2013)

Recently, machine learning models have been applied to neuroimaging data, allowing to make predictions about a variable of interest based on the pattern of activation or anatomy over a set of voxels ... [more ▼]

Recently, machine learning models have been applied to neuroimaging data, allowing to make predictions about a variable of interest based on the pattern of activation or anatomy over a set of voxels. These pattern recognition based methods present undeniable assets over classical (univariate) techniques, by providing predictions for unseen data, as well as the weights of each voxel in the model. However, the obtained weight map cannot be thresholded to perform regionally specific inference, leading to a difficult localization of the variable of interest. In this work, we provide local averages of the weights according to regions defined by anatomical or functional atlases (e.g. Brodmann atlas). These averages can then be ranked, thereby providing a sorted list of regions that can be (to a certain extent) compared with univariate results. Furthermore, we defined a “ranking distance”, allowing for the quantitative comparison between localized patterns. These concepts are illustrated with two datasets. [less ▲]

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See detailLOCALLY BOUNDED NONCONTINUOUS LINEAR-FORMS ON STRONG DUALS OF NONDISTINGUISHED KOTHE ECHELON SPACES
Bastin, Françoise ULg; Bonet, Jose

in Proceedings of the American Mathematical Society (1990), 108(3), 769-774

In this note it is proved that if Al (A) is any nondistinguished Kothe echelon space of order one and K. ,0 (AI (A))' is its strong dual, then there is even a linear form : K - C which is locally bounded ... [more ▼]

In this note it is proved that if Al (A) is any nondistinguished Kothe echelon space of order one and K. ,0 (AI (A))' is its strong dual, then there is even a linear form : K - C which is locally bounded (i.e. bounded on the bounded sets) but not continuous. It is also shown that every nondistinguished Kothe echelon space contains a sectional subspace with a particular structure [less ▲]

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See detailLocating carbon nanotubes (CNTs) at the surface of polymer microspheres using poly(vinyl alcohol) grafted CNTs as dispersion co-stabilizers
Thomassin, Jean-Michel ULg; Molenberg, Isabel; Huynen, Isabelle et al

in Chemical Communications (2010), 46(3330), 3332

In this communication, we prepared carbon nanotubes (CNTs) modified by poly(vinyl alcohol) that are used as co-stabilizers for the dispersion polymerization of methyl methacrylate. Poly(methyl ... [more ▼]

In this communication, we prepared carbon nanotubes (CNTs) modified by poly(vinyl alcohol) that are used as co-stabilizers for the dispersion polymerization of methyl methacrylate. Poly(methyl methacrylate) microspheres with CNTs selectively located at their surface are formed. This specific localization is a way to enhance the electrical conductivity of the nanocomposite. [less ▲]

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See detailLocating Migration: Rescaling Cities and Migrants
Martiniello, Marco ULg

in Contemporary Sociology: A Journal of Reviews (2012), 41(3), 364-365

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See detailLocating Migration: Rescaling Cities and Migrants
Martiniello, Marco ULg

in Glick Schiller, Nina; Çagglar, Ayse (Eds.) Locating Migration: Rescaling Cities and Migrants (2011)

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See detailLocating transcribed and non-transcribed rDNA spacer sequences within the nucleolus by in situ hybridization and immunoelectron microscopy.
Thiry, Marc ULg; Thiry-Blaise, L.

in Nucleic Acids Research (1991), 19(1), 11-5

Immunoelectron microscopy and in situ hybridization have been used to investigate the precise location of transcribed and non-transcribed rDNA spacer sequences. Whereas a 5'-external transcribed spacer ... [more ▼]

Immunoelectron microscopy and in situ hybridization have been used to investigate the precise location of transcribed and non-transcribed rDNA spacer sequences. Whereas a 5'-external transcribed spacer sequence is predominantly visualized in the fibrillar centers of nucleoli, a non-transcribed spacer sequence is preferentially detected in the interstices, in close contact with the fibrillar centers and which interrupt the surrounding dense fibrillar component. Occasionally these two spacers are also observed in clumps of dense nucleolus-associated chromatin. These observations provide insights into the organization of ribosomal repeats within the nucleolus. [less ▲]

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See detailLocation adjustment for the minimum volume ellipsoid estimator
Croux, C.; Haesbroeck, Gentiane ULg; Rousseeuw, P. J.

in Statistics and Computing (2002), 12(3), 191-200

Estimating multivariate location and scatter with both affine equivariance and positive breakdown has always been difficult. A well-known estimator which satisfies both properties is the Minimum Volume ... [more ▼]

Estimating multivariate location and scatter with both affine equivariance and positive breakdown has always been difficult. A well-known estimator which satisfies both properties is the Minimum Volume Ellipsoid Estimator (MVE). Computing the exact MVE is often not feasible, so one usually resorts to an approximate algorithm. In the regression setup, algorithms for positive-breakdown estimators like Least Median of Squares typically recompute the intercept at each step, to improve the result. This approach is called intercept adjustment. In this paper we show that a similar technique, called location adjustment, can be applied to the MVE. For this purpose we use the Minimum Volume Ball (MVB), in order to lower the MVE objective function. An exact algorithm for calculating the MVB is presented. As an alternative to MVB location adjustment we propose L-1 location adjustment, which does not necessarily lower the MVE objective function but yields more efficient estimates for the location part. Simulations compare the two types of location adjustment. We also obtain the maxbias curves of both L-1 and the MVB in the multivariate setting, revealing the superiority of L-1. [less ▲]

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See detailLocation and Accessibility of Neighborhoods: Two Key Factors for the Sustainability of Built Environments
Marique, Anne-Françoise ULg

in Cohen Alexis (Ed.) Urban and Built Environments: Sustainable Development, Health Implications and Challenges (in press)

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See detailLocation and Characterization of the Bovine Herpesvirus Type 4 Thymidine Kinase Gene; Comparison with Thymidine Kinase Genes of Other Herpesviruses
Lomonte, P.; Bublot, M.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1992), 127(1-4), 327-37

The location and nucleotide sequence of the bovine herpesvirus type 4 (BHV-4) thymidine kinase (TK) gene was determined. The coding region of the TK gene is 1335 nucleotides long and corresponds to a ... [more ▼]

The location and nucleotide sequence of the bovine herpesvirus type 4 (BHV-4) thymidine kinase (TK) gene was determined. The coding region of the TK gene is 1335 nucleotides long and corresponds to a polypeptide of 445 amino acids. Comparison of TK amino acid sequences of BHV-4 and 16 herpesvirus TKs reveals a greater homology to those of the gammaherpesviruses EBV and specially HVS, than to those of alphaherpesviruses. The open reading frames detected in the vicinity of TK gene were homologous to the corresponding ones in other herpesviruses. [less ▲]

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See detailLocation and market area of rail-road terminals
Limbourg, Sabine ULg; Jourquin, Bart

Scientific conference (2010, January 28)

The European transport policy has focused on sustainable transport solutions. One of its objectives for freight transport is to restore the balance between modes and to develop intermodality. Among the ... [more ▼]

The European transport policy has focused on sustainable transport solutions. One of its objectives for freight transport is to restore the balance between modes and to develop intermodality. Among the various types of intermodal transports, this research is concerned with rail-road container terminals embedded in a hub-and–spoke network. These terminals will further be referred to as hubs. Hub-and-spoke networks have been implemented in a number of transportation systems when it is favourable to consolidate and disseminate flows at certain locations called hubs. The efficiency of such a network depends on the location of the hubs. The problem is to find the optimal hub locations and to allocate the remaining nodes to these hubs. This problem is known as the p-hub median problem (p-HMP) where p is the number of hubs to locate. This location-allocation problem is proved to be NP-hard. The time needed to solve it increases as the number of nodes exponent three. Thus, in order to model rail-road transport on the trans-European networks, a subset of nodes that can be considered as good potential locations is needed. We applied the p-HMP to a set of potential locations obtained by both spatial aggregation of demand nodes using hierarchical clustering methods and by a flow-based approach which takes the flows of commodities and their geographic spread into account. They showed that the latest method gives better results and that is why it is retained to determine a set of potential locations. The set of potential locations is used as input for an iterative procedure. One of the main contributions of this research is to propose this iterative procedure based on both the p-HMP and the multi-modal assignment problem. Moreover, the objective function of our p-hub median formulation includes the costs for pre- and post-haulages by road, trans-shipment (according to the number of handled containers into account) and rail haulage. Furthermore, in the p-hub median problem, the total demand is assigned to the hubs. In this research however, the demand can be assigned over all the transportation modes, with the possibility (but not the obligation) of using the trans-shipment facilities. Finally, we presents a methodology able to compare road and rail-road intermodal market areas that takes the network structures, the operation costs and the location of the rail-road terminals into account. This methodology is applied to the optimal configurations obtained by the resolution of the p-HMP and the p-hub centre problem (p-HCP) for the whole trans-European network. Indeed, p-HMP has an efficiency goal by minimizing the total transportation cost. The hub network design obtained by this method can sometimes lead to unsatisfactory results when worst-case origin-destination pairs are separated by a very large distance. Therefore, the p-HCM meets the equity objective by minimizing the maximum cost of a combined transport. [less ▲]

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See detailLocation and Morphology of Io's FUV Footprint Emissions on Jupiter
Grodent, Denis ULg; Gérard, Jean-Claude ULg; Saglam, A. et al

Conference (2005, August 07)

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