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See detailImplication of HDAC-5 in heterochromatin replication
Peixoto, P; Castronovo, V; Matheus, N et al

Poster (2012)

Detailed reference viewed: 23 (5 ULg)
Peer Reviewed
See detailImplication of honeydew microflora in ant-aphid mutualism
Fischer, Christophe ULg; Lognay, Georges ULg; Haubruge, Eric ULg et al

Poster (2012, February 10)

Some ant and aphid species can present a mutualistic relationship, ants using aphid honeydew as sugar source and in exchange providing the aphid colony cleaning and protection. From a behavioral point of ... [more ▼]

Some ant and aphid species can present a mutualistic relationship, ants using aphid honeydew as sugar source and in exchange providing the aphid colony cleaning and protection. From a behavioral point of view, this phe-nomenon has been well studied from decades. However, its chemistry and semiochemical mechanisms are still largely unknown. This study aims to identify semiochemicals involved in the establishment of this relation, using both chemical and behavioral approaches. Bioassays revealed that the great-est part of ant attraction toward aphid colonies is due to honeydew volatile compounds; enabling ant scouts to find more quickly aphid colonies and distantly recognize myrmecophilous species. Many of those VOCs seeming to have microbial origins, the main honeydew microorganisms have been isolated and their roles in VOCs production and ant attraction have been investigated. It appeared that honeydew microflora holds a key role in the establishment of ant-aphids mutualistic relationship. [less ▲]

Detailed reference viewed: 117 (14 ULg)
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See detailImplication of Importin-8 in mouse brain development
Nganou, Gerry ULg; Denijs, Laurence; Lakaye, Bernard ULg et al

Poster (2016, October 08)

Regulation of nucleocytoplasmic transport of proteins by the karyopherin superfamily is critical for cell physiology as it controls mainy fundamental processes such as division, differenciation, migration ... [more ▼]

Regulation of nucleocytoplasmic transport of proteins by the karyopherin superfamily is critical for cell physiology as it controls mainy fundamental processes such as division, differenciation, migration, adaptation to external environment etc. Beside this fundamental role, ß1 and ß2 members of this superfamily are also implicated in mitosis and ciliary entry respectively. Importin-8 (IPO8), a member of the β-karyopherin family, is reported to control the transport Ago-2, c-Jun and Smad-4 for example, three proteins important for brain development. First, we have verify the subcellular localisation of IPO8 in HEK and hTert cells. No colocalisation with either the mitotic spindle or the primary cilia could be observed. So it seems IPO8 only plays a role in nuclear transport of proteins. Then we have assessed the expression of IPO8 in mouse brain by In Situ Hybridization at various embryonic (E12, E14, E18) and post natal age (P5, P60). A strong expression was observed during embryonic stages, and especially in the ventricular zone and the cortical plate of the cerebral cortex and the ganglionic eminences both at E14. Therefore, the implication of IPO8 in the radial migration has been assessed by in utero electroporation of shRNA at E14. Three days after IUE, we observed that neuroblast accumulates in the Intermediate zone (IZ) and do not reach the cortical plate (CP) in constrast to the control condition. This effect can be corrected by coexpressing a form of IPO8 that is not targeted by the shRNA, demonstrating the specificity of the effect. In conclusion, regarding its role in transport, IPO8 could modulate neurons migration in the developing brain and could be also at the origin of some diseases associated with neurons migration defects. [less ▲]

Detailed reference viewed: 19 (3 ULg)
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See detailImplication of Importin-8 in mouse brain development
Nganou, Gerry ULg; Coumans, Bernard ULg; De Nijs, Laurence et al

Poster (2016, December 06)

Importin-8 (IPO8) is a protein that regulates the nucleocytoplasmic transport of some proteins important for cerebral development (Ago2, c-Jun, Smad4). In HEK cells, IPO8 seems to not plays others roles ... [more ▼]

Importin-8 (IPO8) is a protein that regulates the nucleocytoplasmic transport of some proteins important for cerebral development (Ago2, c-Jun, Smad4). In HEK cells, IPO8 seems to not plays others roles (like mitotic spindle formation, primary cilium transport). In situ hybridization performed in mouse brains slices shows that IPO8 is already expressed at E14. Moreover, inhibition of its action (IPO8) in embryonic mouse brain leads to impairment of neuroblast migration to upper cortical layers. IPO8 could then be at the origin of some pathologies with neuronal migration deficit. [less ▲]

Detailed reference viewed: 26 (5 ULg)
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See detailImplication of microRNAs in the response of Brachypodium distachyon (L.) Beauv. root system architecture to rhizobacterial volatiles
Baudson, Caroline ULg; Bouché, Frédéric ULg; Saunier de Cazenave, Magdalena ULg et al

Scientific conference (2013, February)

The metabolic roles of volatile organic compounds (VOCs) emitted by plant growth-promoting rhizobacteria (PGPR) and the identity of the molecules responsible for the growth promotion are still poorly ... [more ▼]

The metabolic roles of volatile organic compounds (VOCs) emitted by plant growth-promoting rhizobacteria (PGPR) and the identity of the molecules responsible for the growth promotion are still poorly documented. As well, the implication of microRNAs in root development is a recent discovery that deserves to be explored. In this study, the implication of microRNAs in the response of Brachypodium distachyon (L.) Beauv. Bd21 root architecture to rhizobacterial VOCs was investigated. Nineteen PGPR strains were screened to select those showing the strongest phenotypic effects. The strain Bacillus subtilis AP305-GB03 induced the most important promotion of biomass production and root development. Total RNA extraction and RT-qPCR analysis of microRNAs were performed on Bd21 root samples. The expression of miR160 a-d, miR164 f, miR167 c-d, miR397 b and miR399 a-b was measured in roots every 2 days during the first 10 days of Bd21 development, in the presence or absence of the bacterial VOCs. Differences in the expression profile of miR164 f and miR167 c-d were observed in the roots exposed to GB03 VOCs, as compared to the control. These differences could be correlated to the root system architecture modifications observed after 10 days of growth with GB03. miR397 b and miR399 a-b also showed differences in the expression profile of roots exposed to the bacterial VOCs. These microRNAs have been respectively involved in cold stress tolerance and in the response to phosphate starvation. [less ▲]

Detailed reference viewed: 133 (19 ULg)
Peer Reviewed
See detailImplication of Peyer’s patches dendritic cells in prion diseases.
Dorban, G.; Defaweux, Valérie ULg; Demonceau, C. et al

Poster (2005, June)

Detailed reference viewed: 9 (1 ULg)
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Peer Reviewed
See detailImplication of plant-soil relationships for conservation and restoration of copper-cobalt ecosystems
Faucon, M.-P.; Le Stradic, Soizig ULg; Boisson, Sylvain ULg et al

in Plant and Soil (2015)

Background: Chemical soil factors play an important role in generating and maintaining plant diversity. Naturally metal-enriched habitats support highly distinctive plant communities consisting of many ... [more ▼]

Background: Chemical soil factors play an important role in generating and maintaining plant diversity. Naturally metal-enriched habitats support highly distinctive plant communities consisting of many rare and endemic species. Species of these plant communities possess remarkable physiological adaptations and are now being considered key elements in the implementation of green technologies aimed at phytoremediation of contaminated soils and post-mined soils. Several studies have emphasised that industrial mineral extraction results in serious damage to ecosystems and serious threats to human health and leads to the extinction of metallophyte species. In the southeastern Democratic Republic of the Congo (DRC), mining activities represent a threat to the long-term persistence of communities located on metalliferous copper and cobalt outcrops and their associated endemic metallophytes, which are currently considered some of the most critically endangered plants in the world. Scope: Plant diversity conservation of metal-rich soils must assess soil-plant relationships at different scales (ecosystems, communities, and populations) to define in-situ and ex-situ conservation and restoration projects. This paper proposes a review of soil-plant relationships involved in plant diversity and endemism and their implications for biodiversity conservation and restoration. © 2015 Springer International Publishing Switzerland [less ▲]

Detailed reference viewed: 32 (4 ULg)
See detailImplication of plasmacytoid dendritic cells in the malignant transformation of cervical epithelial metaplasia
Demoulin, Stéphanie ULg; Herfs, Michael ULg; Somja, Joan ULg et al

Poster (2010, September)

The cervical transformation zone is a dynamic area of a few millimeters in which a glandular epithelium has been replaced by a squamous epithelium through a metaplastic process. Interestingly, a ... [more ▼]

The cervical transformation zone is a dynamic area of a few millimeters in which a glandular epithelium has been replaced by a squamous epithelium through a metaplastic process. Interestingly, a substantial majority (87%) of cervical (pre)cancerous lesions develops within this peculiar microenvironment. Our previous studies reported that intrinsic immune features altered in the metaplastic epithelium could contribute to cancer development by preventing efficient antitumor/antiviral immune response. Plasmacytoid dendritic cells (pDC) are key effectors in host innate immunity and orchestrate adaptive immune responses. Recently, infiltration by these subtypes of dendritic cells has been shown in different cancers. However their implication in antitumor response is largely debated. The present study was performed to determine the implication of pDC in the cervical “metaplasia-dysplasia-cancer” sequence. We demonstrated that the density of pDC increases in the epithelium of metaplastic and (pre)cancerous cervical tissues as well as in underlying stroma as compared with normal exocervical epithelium. This could be partially explained by the increased expression of chemerin, their chemotactic peptide, observed in those areas. We developed a method to efficiently generate pDC cells exhibiting morphological and immunohistochemical features of blood pDC from a limited number of CD34+ cord blood progenitors. Using these in vitro generated pDC, we demonstrated that medium conditioned by transformed keratinocytes modified the activation status of pDC, by inducing a decreased expression of costimulatory molecules such as CD86 and HLA-DR. Moreover, malignant keratinocytes diminished the ability of pDC to produce IFNα in response to an oligonucleotide containing CpG motifs, a defined microbial stimulus for pDC. These results suggest that pDC could be educated within the metaplastic and/or (pre)cancerous microenvironment to acquire a tolerogenic phenotype that could promote carcinogenesis. In agreement with those results, we observed that both metaplastic areas and (pre)cancerous lesions of the cervix are infiltrated by T regulatory cells. [less ▲]

Detailed reference viewed: 50 (7 ULg)
See detailThe implication of short-term memory in numerical magnitude processing: evidence from Turner syndrome
Attout, Lucie ULg; Noël, Marie-Pascale; Rousselle, Laurence ULg

Conference (2016, April 21)

Most studies on early magnitude representation focused on the visual modality with no possibility to disentangle the influence of visuo-spatial skills and short-term memory (STM) abilities on visual ... [more ▼]

Most studies on early magnitude representation focused on the visual modality with no possibility to disentangle the influence of visuo-spatial skills and short-term memory (STM) abilities on visual quantification processes. In order to specify the influence of visuo-spatial and STM processing on numerical abilities, a series of magnitudes comparison tasks differing on visuo-spatial processing requirement (no/high), on the nature of the magnitude to be processed (continuous/discrete/symbolic magnitude) and on WM demands (simultaneous/sequential presentation) were administred to twenty patients with Turner syndrome (TS), a genetic condition characterized by poor mathematical achievement, low spatial skills and reduced STM abilities. Our results showed a lower acuity than a control group matched on verbal IQ when participants with TS compared the numerical magnitudes of stimuli presented sequentially (low visuo-spatial processing and high STM load: Dot sequence and Sound sequence). No difference was observed in the numerical comparison of sets presented simultaneously or when comparing continuous and symbolic magnitude stimuli. Besides, the group difference in sequential tasks disappeared when controlling for STM abilities. These results highlight the importance of STM abilities to extract numerosity through a sequential presentation and underline the importance of considering the impact of format presentation on magnitude judgments. [less ▲]

Detailed reference viewed: 37 (3 ULg)
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Peer Reviewed
See detailThe implication of short-term memory in numerical magnitude processing: evidence from Turner syndrome
Attout, Lucie ULg; Noël, Marie-Pascale; Rousselle, Laurence ULg

Poster (2016, June 24)

Most studies on early magnitude representation focused on the visual modality with no possibility to disentangle the influence of visuo-spatial skills and short-term memory (STM) abilities on visual ... [more ▼]

Most studies on early magnitude representation focused on the visual modality with no possibility to disentangle the influence of visuo-spatial skills and short-term memory (STM) abilities on visual quantification processes. In order to specify the influence of visuo-spatial and STM processing on numerical abilities, a series of magnitudes comparison tasks differing on visuo-spatial processing requirement (no/high), on the nature of the magnitude to be processed (continuous/discrete/symbolic magnitude) and on WM demands (simultaneous/sequential presentation) were administred to twenty patients with Turner syndrome (TS), a genetic condition characterized by poor mathematical achievement, low spatial skills and reduced STM abilities. Our results showed a lower acuity than a control group matched on verbal IQ when participants with TS compared the numerical magnitudes of stimuli presented sequentially (low visuo-spatial processing and high STM load: Dot sequence and Sound sequence). No difference was observed in the numerical comparison of sets presented simultaneously or when comparing continuous and symbolic magnitude stimuli. Besides, the group difference in sequential tasks disappeared when controlling for STM abilities. These results highlight the importance of STM abilities to extract numerosity through a sequential presentation and underline the importance of considering the impact of format presentation on magnitude judgments. [less ▲]

Detailed reference viewed: 66 (1 ULg)