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See detailAntimicrobial, antitumor and brine shrimp lethality assay of Ranunculus arvensis L. extracts
Muhammad Zeeshan Bhatti; Ali, Amjad ULg; Asma Saeed et al

in Pakistan Journal of Pharmaceutical Sciences (2015)

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE ... [more ▼]

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE), Methanol-Water Extract (MWE), Methanol-Acetone Extract (MAE), Methanol-Chloroform Extract (MCE) of Ranunculus arvensis (L.). Antitumor activity was evaluated with Agrobacterium tumefaciens (At10) induced potato disc assay. Cytotoxicity was evaluated with brine shrimp lethality assay. Antibacterial activity was evaluated with six bacterial strains including Escherichia coli, Enterobacter aerogenes, Bordetella bronchiseptica, Klebsiella pneumoniae, Micrococcus luteus and Streptococcus anginosus and antifungal screening was done against five fungal strains including Aspergillus niger, A. flavus, A. fumigates, Fusarium solani and Mucor species by using disc diffusion method. Best antitumor activity was obtained with ME and WE, having highest IC50 values 20.27±1.62 and 93.01±1.33μg/disc. Brine shrimp lethality assay showed LC50 values of AE, MAE and ME were obtained as 384.66±9.42μg/ml, 724.11±8.01μg/ml and 978.7±8.01μg/ml respectively. WE of R. arvensis revealed weak antimicrobial result against the tested microorganisms. On the other hand, the antifungal activity of the plant extracts was found to be insignificant. These findings demonstrate that extracts of R. arvensis possesses significant antitumor activity. Further extensive study is necessary to assess the therapeutic potential of the plant [less ▲]

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See detailAntimitotic activity of strychnopentamine, a bisindolic alkaloid
Tits, Monique ULg; Desaive, Claude ULg; Marnette, J. M. et al

in Journal of Ethnopharmacology (1984), 12

Strychnopentamine has been tested for its cytotoxicity and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine ... [more ▼]

Strychnopentamine has been tested for its cytotoxicity and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids. [less ▲]

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See detailAntimitotic and cytotoxic Activities of Guattegaumerine, a Bisbenzylisoquinoline Alkaloid
Quetin-Leclercq, Joëlle; De Pauw-Gillet, Marie-Claire ULg; Bassleer, Roger et al

in Planta Medica (1987), 53

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine ... [more ▼]

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells. [less ▲]

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See detailAntimony vibrations in skutterudites probed by Sb-121 nuclear inelastic scattering
Wille, H *-C; Hermann, Raphaël ULg; Sergueev, I. et al

in Physical Review. B, Condensed Matter and Materials Physics (2007), 76(14),

The specific lattice dynamic properties of antimony in the unfilled CoSb3 and filled EuFe4Sb12 skutterudites have been determined by nuclear inelastic scattering at the Sb-121 nuclear resonance energy of ... [more ▼]

The specific lattice dynamic properties of antimony in the unfilled CoSb3 and filled EuFe4Sb12 skutterudites have been determined by nuclear inelastic scattering at the Sb-121 nuclear resonance energy of 37.1298(2) keV with a 4.5 meV high-resolution backscattering sapphire monochromator. The Sb partial vibrational density of states (DOS) shows a maximum centered at 17 and 16 meV in CoSb3 and EuFe4Sb12, respectively. The difference between the Sb DOSs of CoSb3 and EuFe4Sb12 reveals that upon filling there is a transfer of 10% of the vibrational states toward lower energy. Further, a likely indication of the coupling between the guest and the host lattice in rattler systems is observed, a coupling that is required to reduce the lattice thermal conductivity. [less ▲]

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See detailAntimony-121 Mossbauer spectral study of alpha-Zn4Sb3
Hermann, Raphaël ULg; Grandjean, Fernande ULg; Chen, Tsi*-Chi et al

in Inorganic Chemistry (2007), 46(3), 767-770

The Mossbauer spectra of alpha-Zn4Sb3, a compound that is best formulated as alpha-Zn13Sb10 or (Zn2+)(13)(Sb3-)(6)(Sb-2(4-))(2), have been measured between 5 and 120 K. The resulting six spectra have been ... [more ▼]

The Mossbauer spectra of alpha-Zn4Sb3, a compound that is best formulated as alpha-Zn13Sb10 or (Zn2+)(13)(Sb3-)(6)(Sb-2(4-))(2), have been measured between 5 and 120 K. The resulting six spectra have been simultaneously fit with two components in the ratio of 3:2 corresponding to the Sb3- and Sb2- ions identified in this valence semiconductor. The fits yield temperature independent isomer shifts of -8.17(2) and -9.73(2) mm/s and quadrupole interactions of -4.9(2) and 0 mm/s for the Sb3- and Sb2- ions, respectively; the corresponding Mossbauer temperatures are 197(5) and 207(5) K, temperatures that are lower than the Debye temperature of beta-Zn4Sb3. The isomer shifts correspond to electronic configurations between 5s(2)5p(6) and 5s(1.75)5p(4.01) for the Sb3- ions and between 5s(2)5p(5) and 5s(1.80)5p(3.38) for the Sb2- ions, configurations that are in good agreement with the expected configurations for this valence semiconductor and with the results of band structure calculations. [less ▲]

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See detailAntimony-121 Mossbauer spectral study of the Eu14MnSb11 and Yb14MnSb11 Zintl compounds
Hermann, Raphaël ULg; Grandjean, Fernande ULg; Kafle, D. et al

in Inorganic Chemistry (2007), 46(25), 10736-10740

The antimony-121 Mossbauer spectra of the Yb14MnSb11 and Eu14MnSb11 Zintl compounds have been measured between 2 or 5 and 300 K. The resulting three-dimensional arrays of the spectral counts, velocity ... [more ▼]

The antimony-121 Mossbauer spectra of the Yb14MnSb11 and Eu14MnSb11 Zintl compounds have been measured between 2 or 5 and 300 K. The resulting three-dimensional arrays of the spectral counts, velocity, and temperature have been simultaneously fit with a minimum number of free parameters. These fits yield a 0 Kelvin transferred hyperfine field of 2.9(2) T, a Curie temperature of 57(3) K, and a Mossbauer temperature of 182(2) K for Yb14MnSb11; in this case the transferred field arises solely from the ordering of Mn2+. Because Eu14MnSb11 has both Eu2+ and Mn2+ ions that are magnetically ordered, its antimony-121 Mossbauer spectra are more complex and reveal two magnetic transitions, the first at 92(1) K resulting from the ordering of the Mn 2+ ions and the second at 9.5(1.0) K resulting from the ordering of the Eu2+ ions; the corresponding 0 Kelvin transferred hyperfine fields are 1.3(1) and 3.7(1) T. The antimony-121 isomer shifts yield electronic configurations of 5s(1.74)5p(4.28) and 5s(1.74)5p(4.19) for the average antimony anion in Yb14MnSb11 and Eu14MnSb11, respectively. [less ▲]

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See detailAntinucleolar antibodies: ultrastructural localisation of the antigens
Humbel, René L; Thiry, Marc ULg; Goessens, Guy ULg et al

Poster (1985)

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See detailAntinucleolar autoantibodies: ultrastructural localization of antigens on HEp 2 cells
Thiry, Marc ULg; Vigneron, Alain; Humbel, René L et al

Poster (1986)

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See detailAntiobesity pharmacotherapy in the management of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes/Metabolism Research & Reviews (2000), 16(2), 114-24

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction ... [more ▼]

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction should be considered as a key objective. In this respect, several antiobesity drugs have demonstrated potential. However, while fenfluramine and dexfenfluramine have been shown to promote weight loss and to directly improve insulin sensitivity, being two mechanisms contributing to better blood glucose control in obese Type 2 diabetic patients, they were recently withdrawn due to safety problems. Sibutramine, a new selective norepinephrine and serotonin reuptake inhibitor, promotes weight loss by decreasing food intake, an effect which leads to a mild improvement (significant in patients losing > or =5% of initial body weight) of blood glucose control in obese diabetic patients. Similarly, orlistat, a selective gastrointestinal lipase inhibitor which increases faecal fat losses, enhances diet-induced weight reduction and improves both blood glucose control and vascular risk profile, especially dyslipidaemia, in obese Type 2 diabetic patients. Further studies are required to better identify good responders to pharmacotherapy and specify the role of antiobesity agents in the overall long-term management of obese subjects with Type 2 diabetes. Other novel pharmacological approaches deserve further consideration, for instance beta-3 agonists aiming to increase energy expenditure, drugs interfering with tumor necrosis factor-alpha (TNF-alpha) or free fatty acid release by the adipose tissue or agents that slow gastric emptying. However, until now, results regarding efficacy and/or safety have been disappointing or preliminary in humans. [less ▲]

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See detailAntioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana
Yaya, AJG; Feumba, RD; Emmanuel, T et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6(2), 160-163

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract ... [more ▼]

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron. [less ▲]

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See detailAntioxidant Activity of Flavonoids Isolated From the Fruits of Xylopia parviflora (A. Rich.) Benth
Tchinda Tiabou, Alembert ULg; Agbor, GA; Tsala, DE et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6

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See detailAntioxidant activity of Passiflora edulis and Passiflora alata fruits
Yariwake, J.; Zeraik, M.; Serteyn, Didier ULg et al

in Planta Medica (2010, September), 76(12), 1274-1275

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See detailAntioxidant and anti-inflammatory activities of Ribes nigrum extracts.
Tabart, Jessica ULg; Franck, Thierry ULg; Kevers, Claire ULg et al

in Food Chemistry (2012), 131(4), 1116-1122

Blackcurrant berries contain high amounts of flavonoids with various health benefits as anti-inflammatory properties attributed to their antioxidant potential. Leaves and buds actually used to produce ... [more ▼]

Blackcurrant berries contain high amounts of flavonoids with various health benefits as anti-inflammatory properties attributed to their antioxidant potential. Leaves and buds actually used to produce food supplement could also exhibit such interesting properties. <br />In the literature, various methods are often used and valid indicators of the antioxidant potential of dietary substances. However these assays do not provide evidence that antioxidants have in vivo or ex vivo activity when consumed. To obtain biologically relevant information, the antioxidant activities of the extracts were evaluated on cellular models implicating the measurement of blood haemolysis, the Cellular Antioxidant Activity on endothelial cells and the anti-inflammatory activities on isolated equine stimulated neutrophils and purified myeloperoxidase. <br />These tests generally showed that the blackcurrant leaf extract have the highest antioxidant and <br />anti-inflammatory (inhibition of MPO activity and ROS production on activated neutrophils) capacities correlated to the highest total phenolics content. [less ▲]

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See detailAntioxidant and anti-inflammatory like properties of benzoic acid analogs on the oxidant response of neutrophils: structure/redox potential relationship study.
Franck, Thierry ULg; Mouithys-Mickalad, Ange ULg; Robert, Thierry ULg et al

in Free Radical Biology & Medicine (2012), 53(supplement 1),

We investigated the antioxidant capacity of phenolic acid derivatives by measuring their capacity to prevent ABTS oxidation and evaluating their anti-inflammatory like-properties on the oxidant response ... [more ▼]

We investigated the antioxidant capacity of phenolic acid derivatives by measuring their capacity to prevent ABTS oxidation and evaluating their anti-inflammatory like-properties on the oxidant response of neutrophils, especially on superoxide anion production and the activity of myeloperoxidase (MPO), an oxidant enzyme present and released by the primary granules of neutrophils. The superoxide anion production by PMA-stimulated neutrophils was measured by lucigenin-enhanced chimiluminescence (CL) and the activity of MPO by SIEFED to study the potential interaction of a molecule with the enzyme without interferences due to medium. The antioxidant and anti-inflammatory activities of the phenolic compounds were correlated to their redox potentials measured by voltammetry method, and discussed in relation to their molecular structure. The ability of the phenolic molecules to decrease ABTS oxidation and CL production was inversely correlated to their redox potential increasing as follows: propyl gallate > gallic acid > caffeic acid > 3,4-dihydroxybenzoic acid > ferulic acid > syringic acid > 2,6-dihydroxybenzoic acid > salicylic acid > benzoic acid. The number of hydroxyl groups (3) and their position (catechol) were essential for the efficacy of the molecules as stoichiometric antioxidants or scavengers. On MPO activity, the inhibitory capacity of the molecules was not really correlated with their redox potential and increased as follows: gallic acid > caffeic acid > 2,6-dihydroxybenzoic acid > propyl gallate > ferulic acid = syringic acid > 3,4-dihydroxybenzoic acid = salicylic acid > benzoic acid. The number of OH groups and the elongation of the carboxyl group were essential for the inhibition of MPO activity, probably by facilitating the interaction with the MPO active site or structure. The redox potential measurement seems to be a good technique to select stoichiometric antioxidants, but not anti-catalytic ones. [less ▲]

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See detailAntioxidant and Antiradical Activities of Manihot esculenta Crantz (Euphorbiaceae) Leaves and Other Selected Tropical Green Vegetables Investigated on Lipoperoxidation and Phorbol-12-myristate-13-acetate (PMA) Activated Monocytes
Tsumbu, César Ndele ULg; Deby-Dupont, Ginette; Tits, Monique ULg et al

in Nutrients (2011), 3(9), 818-838

Abelmoschus esculentus (Malvaceae), Hibiscus acetosella (Malvaceae), Manihot esculenta Crantz (Euphorbiaceae) and Pteridium aquilinum (Dennstaedtiaceae) leaves are currently consumed as vegetables by ... [more ▼]

Abelmoschus esculentus (Malvaceae), Hibiscus acetosella (Malvaceae), Manihot esculenta Crantz (Euphorbiaceae) and Pteridium aquilinum (Dennstaedtiaceae) leaves are currently consumed as vegetables by migrants from sub-Saharan Africa living in Western Europe and by the people in the origin countries, where these plants are also used in the folk medicine. Manihot leaves are also eaten in Latin America and some Asian countries. This work investigated the capacity of aqueous extracts prepared from those vegetables to inhibit the peroxidation of a linoleic acid emulsion. Short chain, volatile C-compounds as markers of advanced lipid peroxidation were measured by gas chromatography by following the ethylene production. The generation of lipid hydroperoxides, was monitored by spectroscopy using N-N′-dimethyl-p-phenylene-diamine (DMPD). The formation of intermediate peroxyl, and other free radicals, at the initiation of the lipid peroxidation was investigated by electron spin resonance, using α-(4-pyridyl-1-oxide)-N-tert-butylnitrone as spin trap agent. The ability of the extracts to decrease the cellular production of reactive oxygen species (ROS) in “inflammation like” conditions was studied by fluorescence technique using 2′,7′-dichlorofluorescine-diacetate as fluorogenic probe, in a cell model of human monocytes (HL-60 cells) activated with phorbol ester. Overall the extracts displayed efficient concentration-dependent inhibitory effects. Their total polyphenol and flavonoid content was determined by classic colorimetric methods. An HPLC-UV/DAD analysis has clearly identified the presence of some polyphenolic compounds, which explains at least partially the inhibitions observed in our models. The role of these plants in the folk medicine by sub-Saharan peoples as well as in the prevention of oxidative stress and ROS related diseases requires further consideration. [less ▲]

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See detailAntioxidant and cytotoxicity activity of essential oil grown Lavandula dentata
Imelouane, B.; El Bachiri, A.; Wathelet, Jean-Paul ULg et al

Poster (2009)

The present study describes the phytochemical profile Antioxidant and cytotoxicity activity of Lavandula dentata essential oil, collected in eastern Morocco (Taforalt). The sample of essential oil was ... [more ▼]

The present study describes the phytochemical profile Antioxidant and cytotoxicity activity of Lavandula dentata essential oil, collected in eastern Morocco (Taforalt). The sample of essential oil was obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. The in vitro cytotoxicity of the oil on the cancer cell lines PC-3 (prostate), V79 (fibroblaste) and normal P388D1 (murine macrophage) was examined. We have shown that the oil had negligible cytotoxic effects against all cell lines tested. The oil was also found to possess antioxidant activity as demonstrated by the 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical method. Lavandula dentata essential oil has promising potentials for incorporation into various food, cosmetic and pharmaceutical products for which a natural aroma, colour, antioxidant and antimicrobial additive is desired. [less ▲]

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See detailAntioxidant capacity and phenolic composition of red wines from various grape varieties : specificity of pinot noir.
degives, Julien; Kevers, Claire ULg; DEFRAIGNE, Jean ULg et al

in Giuseppe Viali (Ed.) 3rd international conference on cellular environmental stressors in biology and medicine : focus on redox reactions (2014, June 25)

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See detailAntioxidant capacity and phenolic composition of red wines from various grape varieties: Specificity of Pinot Noir.
Van Leeuw, Robin; Kevers, Claire ULg; PINCEMAIL, Joël ULg et al

in Journal of Food Composition and Analysis (2014), 36

Wines produced from various grape varieties present different properties affecting taste and color. The hypothesis was that grape genotype could have a deep impact on wine antioxidant properties and ... [more ▼]

Wines produced from various grape varieties present different properties affecting taste and color. The hypothesis was that grape genotype could have a deep impact on wine antioxidant properties and phenolic composition. But in this study on 38 different wines of 4 main grape varieties, large variability in the levels of individual phenolic compounds as well as in antioxidant capacity was observed in each grape variety. Comparisons of the wine varieties based on their individual phenolic profile (flavonols, anthocyanidins, flavan-3-ols, phenolic acids, resveratrol…) and antioxidant capacities (ORAC, DPPH, hemolysis, ESR, total phenolics) showed limited differences. An exception was the group of wines made from the grape variety Pinot Noir, in which the range of phenolic compounds was different from the other wines: anthocyanidins (87 mg L-1, 119 to 206 mg L-1 in other grape varieties) and flavonols (17 mg L-1, 20 to 57 mg L-1in others except Primitivo) showed lower levels while flavanols (327 mg L-1, 152 to 244 mg L-1 in others) and phenolic acids (161 mg L-1, 103 to 152 mg L-1 in others) showed levels higher than in the other wines. This different profile was associated with a lower antioxidant capacity (i.e. mean ORAC value: 20988 for Pinot Noir, 27820 to 33651 for others). [less ▲]

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See detailAntioxidant capacity of black currant varies with organ, season, and cultivar
Tabart, Jessica; Kevers, Claire ULg; Pincemail, Joël ULg et al

in Journal of Agricultural and Food Chemistry (2006), 54(17), 6271-6276

Small berries such as black currant constitute one of the important sources of potential health-promoting phytochemicals because these fruits are rich sources of compounds with high antioxidant properties ... [more ▼]

Small berries such as black currant constitute one of the important sources of potential health-promoting phytochemicals because these fruits are rich sources of compounds with high antioxidant properties. In this work, antioxidant capacities of different parts (buds, leaves, fruits) of various black currant cultivars were compared throughout the growing season with the aim to prepare extracts with high antioxidant capacity. Buds (opened, at the end of March) and leaves (in June) had a higher content in phenolics and antioxidants than fully ripened berries (in July) and the best yield (per branch) was obtained with the leaves collected in June due to their higher biomass. The differences observed among the eight cultivars tested were small. Concerning flavonols, quercetin was dominant in all organs and cultivars, myricetin varied widely among the cultivars, and kampferol was very low. [less ▲]

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See detailAntioxidant capacity of hydrophilic food matrices: optimization and validation of ORAC assay.
Kevers, Claire ULg; Sipel, Arnaud; PINCEMAIL, Joël ULg et al

in Food Analytical Methods (2014), 7

It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified ... [more ▼]

It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified parameters that can interfere with the ORAC assay and we optimized it. Then, experiments were conducted to determine the limits of linearity and response function, to determine the accuracy profiles to circumvent some of the drawbacks of traditional validation procedures. Trueness, selectivity and limits of quantification of the method were also determined. Our objective of ORAC method validation is thus to give guarantees that most of the results generated during use of this method will be close enough to unknown true value of antioxidant capacity of food matrices. The validation results indicate that the described method will give accurate and reliable results for Trolox equivalent values ranging from 50 to 200 µmol/L. [less ▲]

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