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See detailApoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility.
Fouchecourt, S.; Livera, G.; Messiaen, S. et al

in Cell death and differentiation (2016)

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction ... [more ▼]

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction. We specifically tested this possibility by ablating Mdm2, an E3 ligase that regulates p53 protein stability and transactivation function, specifically in Sertoli cells (SCs) using the AMH-Cre line and created the new SC-Mdm2-/- line. Heterozygous SC-Mdm2-/+ adult males were fertile, but SC-Mdm2-/- males were infertile and exhibited: a shorter ano-genital distance, an extra duct along the vas deferens that presents a uterus-like morphology, degenerated testes with no organized seminiferous tubules and a complete loss of differentiated germ cells. In adults, testosterone levels as well as StAR, P450c17 (Cyp17a1) and P450scc (Cyp11a1) mRNA levels decreased significantly, and both plasma LH and FSH levels increased. A detailed investigation of testicular development indicated that the phenotype arose during fetal life, with SC-Mdm2-/- testes being much smaller at birth. Interestingly, Leydig cells remained present until adulthood and fetal germ cells abnormally initiated meiosis. Inactivation of Mdm2 in SCs triggered p53 activation and apoptosis as early as 15.5 days post conception with significant increase in apoptotic SCs. Importantly, testis development occurred normally in SC-Mdm2-/- lacking p53 mice (SC-Mdm2-/-p53-/-) and accordingly, these mice were fertile indicating that the aforementioned phenotypes are entirely p53-dependent. These data not only highlight the importance of keeping p53 in check for proper testicular development and male fertility but also certify the critical role of SCs in the maintenance of meiotic repression.Cell Death and Differentiation advance online publication, 16 October 2015; doi:10.1038/cdd.2015.120. [less ▲]

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See detailApoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.
Vidlickova, Ivana; Dequiedt, Franck ULg; Jelenska, Lenka et al

in BMC Cancer (2016), 16(1), 239

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion ... [more ▼]

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer prognosis. We previously showed that the CA IX ECD release is mediated by disintegrin and metalloproteinase ADAM17. Here we investigated the CA IX ECD shedding in tumor cells undergoing apoptosis in response to cytotoxic drugs, including cycloheximide and doxorubicin. METHODS: Presence of cell surface CA IX was correlated to the extent of apoptosis by flow cytometry in cell lines with natural or ectopic CA IX expression. CA IX ECD level was assessed by ELISA using CA IX-specific monoclonal antibodies. Effect of recombinant CA IX ECD on the activation of molecular pathways was evaluated using the cell-based dual-luciferase reporter assay. RESULTS: We found a significantly lower occurrence of apoptosis in the CA IX-positive cell subpopulation than in the CA IX-negative one. We also demonstrated that the cell-surface CA IX level dropped during the death progress due to an increased ECD shedding, which required a functional ADAM17. Inhibitors of metalloproteinases reduced CA IX ECD shedding, but not apoptosis. The CA IX ECD release induced by cytotoxic drugs was connected to elevated expression of CA IX in the surviving fraction of cells. Moreover, an externally added recombinant CA IX ECD activated a pathway driven by the Nanog transcription factor implicated in epithelial-mesenchymal transition and stemness. CONCLUSIONS: These findings imply that the increased level of the circulating CA IX ECD might be useful as an indicator of an effective antitumor chemotherapy. Conversely, elevated CA IX ECD might generate unwanted effects through autocrine/paracrine signaling potentially contributing to resistance and tumor progression. [less ▲]

Detailed reference viewed: 37 (3 ULg)
See detailL’aporie de la mathématisation de la physique en contexte aristotélicien
Dubouclez, Olivier ULg

Scientific conference (2014, February)

Detailed reference viewed: 27 (1 ULg)
See detailLes apories de l’engagement
Vrancken, Didier ULg

in Guillaume, Jean-François (Ed.) Aventuriers solitaires en quête d’utopie. Les formes contemporaines de l’engagement (2006)

Quel sens donner aujourd'hui aux notions de retrait et d'engagement sans une société de plus en plus traversée par les impératifs de participation, d'implication, de mobilisation des ressources et des ... [more ▼]

Quel sens donner aujourd'hui aux notions de retrait et d'engagement sans une société de plus en plus traversée par les impératifs de participation, d'implication, de mobilisation des ressources et des compétences ? [less ▲]

Detailed reference viewed: 27 (8 ULg)
See detailLes apories du matérialisme dialectique
Seba, Jean-Renaud ULg

Conference (2007, December 07)

Detailed reference viewed: 41 (3 ULg)
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See detailApparatuses as loci of bio-political emergence: development of genetic testing in Belgium
Fallon, Catherine ULg

Conference (2015, October)

In his vision of “biopolitics” Lemke (2011) proposes to conceptualize life and politics as entities intertwined within a dynamic relationship. These technologies change the production of norms and the ... [more ▼]

In his vision of “biopolitics” Lemke (2011) proposes to conceptualize life and politics as entities intertwined within a dynamic relationship. These technologies change the production of norms and the apparatuses (Foucault 2008) organizing the distribution of the living in the domain of utility: therefore biopolitics must be analyzed as center pieces in the transformation of politics. The developments in genomics and epigenetics support the vision of the individual body as an “information network” rather than a physical substrate. The experts (with the active support of the patients) construct models for the calculation of life in the development of policy regulation and contribute actively to frame the policy relevant issues – either at individual or at population level, on the basis of power strategies mobilizing and disseminating specific forms of knowledge which are disciplined and selective. The contribution will present the recent evolution of the apparatuses producing the technical regulation and financial norms for the use of genetic testing in the federal Belgian public health system, considering the two complementary level of the “dispositif” : - At the political level, transformation of the « Conseil supérieur de la Génétique humaine » (1973-2013) into a « Collège de médecins pour le centre de génétique humaine » and the development of new control relations between the subsidizing and control bodies and the hospitals, - At the individual level, transformation of the cooperation between medical doctors, biomedical experts and psycho-sociologists in the relationship with the patients, as they can be observed at the level of the hospital; Who has the resources (intellectual, technological or financial) to control the technology and its use ? what are the social, institutional and technological constrains? who defines and select the legitimate options ? The analysis is not so much normative than critical, giving due attention to the social context and contingent rationalities in the evolution of this peculiar political action, with the aim of opening new areas of discussions transgressing disciplinary and institutional borders which are too often considered as self evident. [less ▲]

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See detailL'appareil de saut des Taupins (Coléoptères Elatérides)
Jeuniaux, Charles ULg

Article for general public (1950)

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See detailL’appareil sexuel femelle de l’Ascaride mégalocéphale
Van Beneden, Édouard ULg

in Archives de Biologie (1883), 4

Detailed reference viewed: 16 (1 ULg)
See detailL'appareil vocal
FINCK, Camille ULg

in Rossius, Raymond (Ed.) Le monde de l'Opéra (1997)

Detailed reference viewed: 6 (1 ULg)
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See detailAppareillage informatique et logiciels d'analyse qualitative en sciences humaines et sociales : réflexions épistémologiques et méthodologiques
Lejeune, Christophe ULg

Scientific conference (2008, September 26)

L'histoire des logiciels d'analyse qualitative en sciences débute dans les années soixante. Il faut cependant attendre les années quatre-vingt et l'avènement de la micro-informatique pour voir se ... [more ▼]

L'histoire des logiciels d'analyse qualitative en sciences débute dans les années soixante. Il faut cependant attendre les années quatre-vingt et l'avènement de la micro-informatique pour voir se multiplier ces outils. On peut regrouper les dizaines d'outils existant à ce jour en quatre familles selon que les traitements soient (ou non) automatisés et que le logiciel prend en charge l'exploration ou l'annotation du matériau : les lexicomètres, les concordanciers, les automates et les CAQDAS. Bien entendu, les logiciels existant proposent chacun un grand nombre de fonctionnalités (susceptibles de relever de différentes familles); notre distinction porte donc sur les fonctionnalités plus que sur les outils. Chacune de ces familles relève d'une tradition que remonte à bien avant l'ère de l'informatique (les concordanciers, par exemple, datent du XIIIe siècle). Celle-ci a participé à forger une technique congruente avec ses fins et son matériau. En explicitant la configuration historico-technique des différents logiciels proposés aujourd'hui au qualitativiste, on se rend compte que - contrairement à ce qui est professé et pratiqué - les différentes fonctionnalités s'appuient sur des présupposés épistémologiques plus ou moins pertinents selon le matériaux et la question de recherche. En définitive, on voudrait inviter les chercheurs en sciences humaines et sociales à une réflexion méthodologique et épistémologique sur l'appareillage informatique constitutif de leur dispositif méthodologique. [less ▲]

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See detailL’appareillage orthétique distal du membre inférieur chez le patient neurologique
DOUCHAMPS, Frédéric ULg; Kaux, Jean-François ULg; WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2012), XVI(8), 268-274

La prescription d’une orthèse doit tenir compte: • de la spasticité des muscles tibial postérieur et triceps sural (échelle d’Ashworth) ; • de la force des releveurs (échelle de Lovett) ; • de la statique ... [more ▼]

La prescription d’une orthèse doit tenir compte: • de la spasticité des muscles tibial postérieur et triceps sural (échelle d’Ashworth) ; • de la force des releveurs (échelle de Lovett) ; • de la statique plantaire (pied varus et/ou talus en phase d’appui) ; • de l’âge et du niveau d’activité (sédentaire, sportif) ; • de l’attente des patients. [less ▲]

Detailed reference viewed: 87 (20 ULg)
See detailLes appareils idéologiques du Prince. Une lecture de “Machiavel et nous” (Althusser)
Mancuso, Eva ULg

Scientific conference (2015, April 25)

Detailed reference viewed: 24 (0 ULg)
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See detailApparent absence of a barrier to nuclear gene flow between mitochondrial lineages of the bank vole (Myodes glareolus) in Central Finland
Pisano, Julie ULg; Leblois, Raphael; Henttonen, Heikki et al

Poster (2013, August)

Detailed reference viewed: 10 (1 ULg)
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See detailApparent And True Ileal Digestibility Of Amino-Acids And Nitrogen-Balance Measured In Pigs With Ileorectal Anastomosis Or T-Cannulas, Given A Diet Containing Peas
Leterme, Pascal; Thewis, André ULg; Beckers, Yves ULg et al

in Journal of the Science of Food and Agriculture (1990), 52(4), 485-497

Detailed reference viewed: 19 (4 ULg)
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See detailApparent changes of the Ordovician-Mississippian plant diversity
Cascales-Miñana, Borja ULg

in Review of Palaeobotany and Palynology (2016)

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See detailApparent Coexistence of Multiple Regimes of Self-Excited Vibrations in Deep Drilling Systems
Depouhon, Alexandre ULg; Detournay, Emmanuel

in Proceedings of ICTAM 2008, Adelaide (2008)

Detailed reference viewed: 23 (6 ULg)
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See detailApparent Coexistence of Multiple Regimes of Self-Excited Vibrations in Drilling Systems
Depouhon, Alexandre ULg; Detournay, Emmanuel

in Proceedings of the 1st International Colloquium on Non-Linear Dynamics and Control of Deep Drilling Systems, Liège, March 2009 (2009, March)

Detailed reference viewed: 26 (5 ULg)