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Peer Reviewed
See detailAntagonistic Effects of Laminin and Fibronectin in Cell-to-Cell and Cell-to-Matrix Interactions in Mcf-7 Cultures
Noël, Agnès ULiege; Calle, A.; Emonard, H. et al

in In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association (1988), 24(5), 373-80

During morphogenesis, tumor progression and metastasis, cell adhesion, dissociation, and migration result from a complex balance between cell-to-cell and cell-to-matrix interactions. Two different ... [more ▼]

During morphogenesis, tumor progression and metastasis, cell adhesion, dissociation, and migration result from a complex balance between cell-to-cell and cell-to-matrix interactions. Two different organization patterns of MCF-7 cells were induced by different extracellular matrix proteins. When plated on plastic or polymeric type I collagen gel used as a model of interstitial matrix, MCF-7 cells spread and grew in monolayer. When cultured on a solid gel of basement membrane (BM) proteins (85% laminin) used as a model of BM, cells formed clusters attached to the matrix. Matrix proteins regulated these two types of cell organization by preferentially promoting cell-to-cell or cell-support interactions. On plastic in the presence of soluble laminin or on laminin-coated dishes, cells also formed clusters. Addition of soluble fibronectin induced spreading of the cells, suggesting that laminin and fibronectin have competitive antagonistic effects on MCF-7 cell morphology. Antilaminin antibodies inhibited cluster formation and attachment, emphasizing the important role of this glycoprotein not only in promoting cluster attachment but also in cell-to-cell contact formation. Such effects of extracellular matrix proteins could play significant roles in tumor progression and metastasis. [less ▲]

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See detailAntagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay
Goffin, Vincent; Kinet, Sandrina; Ferrag, Fatima et al

in Journal of Biological Chemistry (1996), 271(28), 16573-9

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding ... [more ▼]

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding site 2. We previously reported the unexpected agonistic properties of these hPRL analogs in the rat Nb2 bioassay (Goffin, V., Struman, I., Mainfroid, V., Kinet, S., and Martial, J. A. (1994) J. Biol. Chem. 269, 32598-32606). In order to investigate whether such paradoxical agonistic behavior might result from characteristic features of the Nb2 assay (e.g. species specificity), we transfected in the same cell system the cDNA encoding the PRLR from rat or human species along with reporter genes containing PRL-responsive DNA sequences. We characterized the agonistic, self-antagonistic and/or antagonistic effects of wild type rat PRL, wild type hPRL, and three hPRL analogs, mutated either at binding site 1 or at binding site 2. Our results clearly show that the agonistic/antagonistic properties of PRLs are species-specific. We thus propose different models of receptor activation, depending on the relative affinities of each hormonal binding site, which is directed by species specificity. Finally, this is the first report of hPRL binding site 2 analogs showing antagonistic properties on human and, to a lesser extent, rat receptors. [less ▲]

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See detailAntarctic cyanobacteria: from diversity to genomics
Wilmotte, Annick ULiege

Conference (2017, June 30)

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See detailAntarctic cyanobacterial diversity: how important are the geographical and ecological factors?
De Carvalho Maalouf, Pedro ULiege; Lambion, Alexandre ULiege; Gillard, Benjamin et al

Conference (2011, February)

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See detailAntarctic cyanobacterial diversity: how important are the geographical and ecological factors?
De Carvalho Maalouf, Pedro ULiege; Lambion, Alexandre ULiege; Gillard, Benjamin et al

Conference (2012, October 31)

On the Antarctic continent, cyanobacteria produce conspicuous benthic microbial mats in lakes, from the coastal regions to the mountains (till 84°S). However, little is known about theirl biodiversity in ... [more ▼]

On the Antarctic continent, cyanobacteria produce conspicuous benthic microbial mats in lakes, from the coastal regions to the mountains (till 84°S). However, little is known about theirl biodiversity in comparison with other regions of the world. The BelSPO project AMBIO aimed to test whether (i) microbial communities are structured by the same factors as those shaping communities of macroorganisms, and (ii) endemism among cyanobacteria does exist. We have analyzed the cyanobacterial biodiversity in a variety of aquatic habitats from the three main biogeographical regions (Continental, Maritime Antarctica and the Sub-Antarctic) and determined the ‘baseline’ data needed to understand the contribution of various processes that are responsible for the distribution patterns. [less ▲]

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See detailAn "Antarctic Marine Biodiversity Reference Centre" devoted to amphipod crustaceans
De Broyer, Claude; Van Roozendael, Françoise; Jazdzewski, Krzysztof et al

Poster (2000, April)

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See detailAntarctic Microbial BIOdiversity : the importance of geographical versus ecological factors
Obbels, Dagmar; De Carvalho Maalouf, Pedro ULiege; De Wever, Aaike et al

Poster (2012, July)

Antarctica is a prime region to test whether microbes have a biogeography and to study their metacommunity dynamics, because (i) it is isolated from the other continents, (ii) its extreme environmental ... [more ▼]

Antarctica is a prime region to test whether microbes have a biogeography and to study their metacommunity dynamics, because (i) it is isolated from the other continents, (ii) its extreme environmental conditions allow microorganisms to dominate its ecosystems, and (iii) lacustrine and terrestrial habitats occur isolated in a matrix of ice and ocean. We compiled a large set of samples from benthic microbial mats from Antarctic lakes in different ice-free regions and used a polyphasic approach to study their microbial biodiversity by combining morphological characterization of diatoms with molecular techniques such as Denaturing Gradient Gel Electrophoresis (green algae and cyanobacteria), 454 pyrosequencing and cultivation (prokaryotes). [less ▲]

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See detailAntarctic sea ice trophic status
Van der Linden, Fanny ULiege; Moreau, Sébastien; Champenois, Willy ULiege et al

Poster (2017, July)

The sea ice ecosystem is characterized by steep gradients in temperature, salinity, light and nutrient availability. Despite these challenging environmental conditions, sea ice provides a dynamic habitat ... [more ▼]

The sea ice ecosystem is characterized by steep gradients in temperature, salinity, light and nutrient availability. Despite these challenging environmental conditions, sea ice provides a dynamic habitat for diverse communities of microorganisms. These communities include a wide variety of organisms from different taxonomic groups such as algae, bacteria, heterotrophic protists, fungi as well as viruses [Horner et al., 1992; Deming, 2010; Thomas and Dieckmann, 2010; Poulin et al., 2011]. In the frame of the YROSIAE project (Year-Round survey of Ocean-Sea-Ice-Atmosphere Exchanges), carried out at Cape Evans in McMurdo Sound (Antarctica) from Nov. 2011 to Dec. 2012, ice cores, seawater, and brine material were collected at regular time intervals. Physical properties (salinity, temperature, texture) and biogeochemical parameters (pCO2, dissolved inorganic carbon, total alkalinity, chlorophyll-a, macro-nutrients) were analysed. We will here particularly consider changes inused dissolved inorganic carbon (DIC) and chlorophyll-a (chl-a) , used as a proxiesy of net community production and autotrophic biomass, respectively. A high spatial and temporal variability in ice algal biomass and DIC evolution were observed. From spring, very high chl-a concentrations (>2400μg.L^(-1)) were observed at the bottom of the ice, a common feature of land fast ice in the McMurdo Sound. This suggests high primary production. However Strikingly, , at the same time, nutrients at the bottom of the ice increased significantly suggesting high heterotrophyremineralisation. In the middle of the ice column, evolution of DIC is was marked by a succession of autotrophic and heterotrophic phases. The overall increase of DIC suggests that the ice interior was rather heterotroph. Such sea ice system should expel CO2. Yet, strong under-saturation in CO2 and DIC depletion appeared at the ice surface, suggesting that sea ice was taking up CO2 from the atmosphere. On the whole, land fast sea ice in McMurdo Sound appears as a puzzling ecosystem. It is able to support elevated growth of autotrophic organisms at the bottom, but still appears to be heterotrophicin parallel to high remineralization, while the top of the ice appears to be rather heterotrophic but stilland able to pump CO2 from the atmosphere. [less ▲]

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See detailAntarctic urchin ctenocidaris speciosa spines: Lessons from the deep
Catarino, A. I.; av FD Roosevelt 50, Brussels; Guibourt, V. et al

in Cahiers de Biologie Marine (2013), 54(4), 649-655

Ocean acidification is leading to changes in the oceanic carbonate system. As a result, calcium carbonate saturation horizon is shallowing, especially at high latitudes. Biogenic high magnesium-calcites ... [more ▼]

Ocean acidification is leading to changes in the oceanic carbonate system. As a result, calcium carbonate saturation horizon is shallowing, especially at high latitudes. Biogenic high magnesium-calcites could be particularly vulnerable, since their solubility is either similar or greater than that of aragonite. Cidaroid urchins have magnesium-calcite spines covered by a polycrystalline cortex which becomes exposed to seawater when mature (not covered by an epidermis). However, deep species live at low calcium carbonate saturation states, especially at high latitudes. We describe here the morphology and the magnesium content of Ctenocidaris speciosa spines collected at different depths from the Weddell Sea (Antarctica) and relate the features with seawater calcium carbonate saturation. We observed that the spines cortex of C. speciosa presented a thicker inner cortex layer and a lower [Mg2] below the aragonite saturation horizon. We suggest that the cortex of cidaroid spines is able to resist to low calcium carbonate saturation state. [less ▲]

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See detailAntarctica-Regional Climate and Surface Mass Budget
Favier; Krinner; Amory, Charles ULiege et al

in Current Climate Change Repports (2017)

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See detailAntecedents of Team Learning in New Product Development Teams
Ennabih, Abdessamad ULiege; Van Riel, Allard ULiege; Sasovova, Z.

Poster (2008, August 08)

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See detailAntegrade palliation for diminutive pulmonary arteries in Tetralogy of Fallot.
Seipelt, Ralf G; Vazquez-Jimenez, Jaime F; Sachweh, Jorg S et al

in European Journal of Cardio - Thoracic Surgery (2002), 21(4), 721-4724

OBJECTIVES: The purpose of this study was to evaluate the outcome following palliative reconstruction of right ventricular outflow tract in Tetralogy of Fallot (TOF) with diminutive pulmonary arteries ... [more ▼]

OBJECTIVES: The purpose of this study was to evaluate the outcome following palliative reconstruction of right ventricular outflow tract in Tetralogy of Fallot (TOF) with diminutive pulmonary arteries with central and peripheral stenosis. METHODS: Between 1986 and 1999 in 15 children with the diagnosis of TOF palliative reconstruction of the right ventricular outflow tract without closure of the ventricular septal defect (VSD) was performed. All patients were not suitable for an AP-Shunt because of a diminutive pulmonary vascular bed. Six patients were younger than 1 year at operation. RESULTS: There was one hospital death (6.7%) in a child with additional aortic valve insufficiency in multi-organ failure. Although the postoperative course was prolonged (median duration on ICU: 8 days) and complicated by congestive heart failure, clinically the 14 patients discharged improved significantly. The arterial oxygen saturation increased from 67 to 93% (P<0.001), the hemoglobin decreased from 16.1 to 13.3g/l (P=0.02) and hematocrit from 0.52 to 0.40 (P=0.06). In control angiography, the McGoon Index increased in the average from 1.01 to 1.95 (P<0.001). VSD closure was performed in 12 patients (median: 2.5 years after initial operation) with one perioperative death. A homograft had to be implanted in seven patients and a mechanical prosthesis in the right ventricular outflow tract in one. One late death occurred due to ventricular arrhythmia 12 years after antegrade palliation (11 years after corrective operation). CONCLUSIONS: The antegrade palliation seems to be an adequate strategy for the treatment of selected children with diminutive pulmonary arteries in TOF, who were not candidates for primary correction or an AP-Shunt. [less ▲]

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See detailAntemortem Diagnosis of Multicentric Lymphoblastic Lymphoma, Lymphoid Leukemia, and Inclusion Body Disease in a Boa Constrictor (Boa constrictor imperator)
Schilliger, Lionel; Rossfelder, Aurore; Bonwitt, Jesse et al

in Journal of Herpetological Medicine and Surgery (2014), 24(1-2), 11-19

A 1.85-kg, 6-yr-old, captive-bred, male boa constrictor (Boa constrictor imperator) was presented for lethargy, anorexia, postural abnormalities, and had an elongated mass on its ventrum, 20 cm distal to ... [more ▼]

A 1.85-kg, 6-yr-old, captive-bred, male boa constrictor (Boa constrictor imperator) was presented for lethargy, anorexia, postural abnormalities, and had an elongated mass on its ventrum, 20 cm distal to the snout. Clinical examination revealed a firm, nonmobile coelomic mass (4 cm × 2 cm) and loss of the righting reflex. Hematology showed a significant increase in white blood cells, lymphocytosis, and anemia. Cytologic examination of the blood smears showed the presence of lymphoid leukemia and eosinophilic intracytoplasmic inclusions consistent with inclusion body disease (IBD). Hyperphosphatemia was suggestive of renal failure. Radiography and ultrasound revealed a soft tissue mass at the level of the thymus proximal to, and distinct from, the heart. Cytology and postmortem histopathology confirmed the presence of a multicentric lymphoblastic lymphoma, lymphoid leukemia, and IBD. It remains unclear whether the neoplasms began their proliferation within the bone marrow or whether leukemia was a feature of disseminated, end-stage lymphoma. [less ▲]

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See detailAnterior cingulate activity and the self in disorders of consciousness.
Qin, Pengmin; Di, Haibo; Liu, Yijun et al

in Human Brain Mapping (2010), 31(12), 1993-2002

OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state ... [more ▼]

OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic resonance imaging (fMRI). EXPERIMENT DESIGN: We first conducted two fMRI experiments in healthy subjects to identify brain regions specifically associated with self-perception through the use of different auditory stimuli that had different grades of self-relatedness. We then applied these regions as functional localizers to examine the relationship between neural activity changes during self-relatedness and consciousness level in the patients with disorders of consciousness (DOC). PRINCIPAL OBSERVATIONS: We demonstrated recruitment of various anterior medial cortical regions including the anterior cingulate cortex (ACC) in healthy subjects during auditory perception of self-related stimuli. We further showed that patients with DOC showed signal changes in the ACC during auditory perception of self-related stimuli. Finally, it was shown that these signal changes correlate with the level of consciousness in the patients with DOC. CONCLUSION: The degree of consciousness in patients with DOC was correlated with neural activity in the ACC induced by self-related stimuli. Our results not only shed light on the pathophysiology of DOC, but may also suggest a useful neural, and thus diagnostic, marker of the dysfunction of consciousness in vegetative patients. [less ▲]

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See detailAnterior cingulate and motor network metabolic impairment in progressive supranuclear palsy
Salmon, Eric ULiege; Van der Linden, Martial ULiege; Franck, Georges ULiege

in Neuroimage (1997), 5(3), 173-178

Progressive supranuclear palsy is the prototype of subcortical dementia. Using positron emission tomography and statistical parametric mapping, we compared the glucose metabolic pattern obtained in this ... [more ▼]

Progressive supranuclear palsy is the prototype of subcortical dementia. Using positron emission tomography and statistical parametric mapping, we compared the glucose metabolic pattern obtained in this subcortical dementia to that observed in elderly healthy controls and in Alzheimer's disease, the prototype of cortical dementia. Progressive supranuclear palsy was characterized by a relative decrease of metabolism in anterior cingulate, adjacent supplementary motor area, precentral cortex, middle prefrontal cortex, midbrain tegmentum, globus pallidus, and ventrolateral and dorsomedial nuclei of thalamus. The data in progressive supranuclear palsy highlight predominant metabolic impairment in brain structures engaged in response selection, in attention for action, and in motor networks. [less ▲]

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See detailAnterior cingulate dysfunction in presenile dementia due to progressive supranuclear palsy
Salmon, Eric ULiege; Meulemans, Thierry ULiege; Van der Linden, Martial ULiege et al

in Acta Neurologica Belgica (1996), 96(3), 247-253

We report neuropsychological and neuroimaging investigations performed in a patient suffering from presenile onset degenerative dementia and subsequent mild extrapyramidal and pyramidal signs. Early ... [more ▼]

We report neuropsychological and neuroimaging investigations performed in a patient suffering from presenile onset degenerative dementia and subsequent mild extrapyramidal and pyramidal signs. Early neuropsychological testing revealed frontal lobe dysfunction. Neuroanatomical pictures were not contributive. After four years of evolution, the clinical pattern was consistent with progressive supranuclear palsy. Statistical parametric mapping analysis of functional imaging revealed a highly significant metabolic impairment in the anterior cingulate gyrus, that might be a key feature of subcortico-frontal dementia in progressive supranuclear palsy. [less ▲]

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See detailAnterior cingulate, insula and parietal operculum commonly activated during motor and vocal ties in patients with Tourette syndrome: An event-related functional MRI study
Bohlhalter, Stephan; Goldfine, Andrew; Matteson, Sarah et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2004), 19(Suppl. 9), 1109

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