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Peer Reviewed
See detailAntagonistes calciques et calcithérapie : incompatibilité ?
Mottard, L; Lecart, MP; Reginster, Jean-Yves ULg

in Actualité Médicale Belge (1992), 335

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See detailLes antagonistes calciques ont-ils une place de première ligne dans le traitement de l'hypertension artérielle?
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2002), 57(2), 79-84

During the nineties, a controversy was noted in the literature about the potential risk of using calcium antagonists in the treatment of hypertension. Several recent studies, such as the INSIGHT’s one ... [more ▼]

During the nineties, a controversy was noted in the literature about the potential risk of using calcium antagonists in the treatment of hypertension. Several recent studies, such as the INSIGHT’s one have not confirmed this provided that one uses long-acting molecule. But the real beneficial effect due to the different antihypertensive classes is mainly linked to the magnitude of the blood pressure lowering effect. [less ▲]

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See detailLes antagonistes des flux calciques dans le traitement de l'hypertension artérielle
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Revue Médicale de Liège (1984), 34(6), 232-237

Les antagonistes des flux calciques constituent un nouveau groupe, à part entière, de substances à action antihypertensive. Ils s'avèrent être particulièrement prometteurs dans ce domaine: ils agissent ... [more ▼]

Les antagonistes des flux calciques constituent un nouveau groupe, à part entière, de substances à action antihypertensive. Ils s'avèrent être particulièrement prometteurs dans ce domaine: ils agissent, en effet, en empêchant l'entrée de calcium à l'intérieur de la cellule musculaire lisse vasculaire et s'opposent ainsi à la contraction de celle-CI, donc à l'élévation des résistances vasculaires. Après un rappel rapide du site et du mode d'action biochimique de ces molécules, cet article tend à dégager leurs principales indications dans le traitement d'une hypertension artérielle, basées surtout sur le profil hémodynamique original engendré lors de leur administration. [less ▲]

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See detailLes antagonistes des récepteurs de l'angiotensine II
Krzesinski, Jean-Marie ULg

in Vaisseaux, Coeur, Poumons (1998), 3(4), 116-119

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See detailAntagonistic activity of yeast against post-harvest diseases of tropical fruits
Jijakli, Haissam ULg

Conference (2004, February)

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See detailAntagonistic activity of yeast against post-harvest diseases of tropical fruits.
Jijakli, Haissam ULg; Lassois, Ludivine ULg; Lahlali, R.

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2004), 50(2), 153-163

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See detailAntagonistic Effects of Laminin and Fibronectin in Cell-to-Cell and Cell-to-Matrix Interactions in Mcf-7 Cultures
Noël, Agnès ULg; Calle, A.; Emonard, H. et al

in In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association (1988), 24(5), 373-80

During morphogenesis, tumor progression and metastasis, cell adhesion, dissociation, and migration result from a complex balance between cell-to-cell and cell-to-matrix interactions. Two different ... [more ▼]

During morphogenesis, tumor progression and metastasis, cell adhesion, dissociation, and migration result from a complex balance between cell-to-cell and cell-to-matrix interactions. Two different organization patterns of MCF-7 cells were induced by different extracellular matrix proteins. When plated on plastic or polymeric type I collagen gel used as a model of interstitial matrix, MCF-7 cells spread and grew in monolayer. When cultured on a solid gel of basement membrane (BM) proteins (85% laminin) used as a model of BM, cells formed clusters attached to the matrix. Matrix proteins regulated these two types of cell organization by preferentially promoting cell-to-cell or cell-support interactions. On plastic in the presence of soluble laminin or on laminin-coated dishes, cells also formed clusters. Addition of soluble fibronectin induced spreading of the cells, suggesting that laminin and fibronectin have competitive antagonistic effects on MCF-7 cell morphology. Antilaminin antibodies inhibited cluster formation and attachment, emphasizing the important role of this glycoprotein not only in promoting cluster attachment but also in cell-to-cell contact formation. Such effects of extracellular matrix proteins could play significant roles in tumor progression and metastasis. [less ▲]

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See detailAntagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay
Goffin, Vincent; Kinet, Sandrina; Ferrag, Fatima et al

in Journal of Biological Chemistry (1996), 271(28), 16573-9

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding ... [more ▼]

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding site 2. We previously reported the unexpected agonistic properties of these hPRL analogs in the rat Nb2 bioassay (Goffin, V., Struman, I., Mainfroid, V., Kinet, S., and Martial, J. A. (1994) J. Biol. Chem. 269, 32598-32606). In order to investigate whether such paradoxical agonistic behavior might result from characteristic features of the Nb2 assay (e.g. species specificity), we transfected in the same cell system the cDNA encoding the PRLR from rat or human species along with reporter genes containing PRL-responsive DNA sequences. We characterized the agonistic, self-antagonistic and/or antagonistic effects of wild type rat PRL, wild type hPRL, and three hPRL analogs, mutated either at binding site 1 or at binding site 2. Our results clearly show that the agonistic/antagonistic properties of PRLs are species-specific. We thus propose different models of receptor activation, depending on the relative affinities of each hormonal binding site, which is directed by species specificity. Finally, this is the first report of hPRL binding site 2 analogs showing antagonistic properties on human and, to a lesser extent, rat receptors. [less ▲]

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See detailAntarctic cyanobacteria: from diversity to genomics
Wilmotte, Annick ULg

Conference (2017, June 30)

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See detailAntarctic cyanobacterial diversity: how important are the geographical and ecological factors?
De Carvalho Maalouf, Pedro ULg; Lambion, Alexandre ULg; Gillard, Benjamin et al

Conference (2011, February)

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See detailAntarctic cyanobacterial diversity: how important are the geographical and ecological factors?
De Carvalho Maalouf, Pedro ULg; Lambion, Alexandre ULg; Gillard, Benjamin et al

Conference (2012, October 31)

On the Antarctic continent, cyanobacteria produce conspicuous benthic microbial mats in lakes, from the coastal regions to the mountains (till 84°S). However, little is known about theirl biodiversity in ... [more ▼]

On the Antarctic continent, cyanobacteria produce conspicuous benthic microbial mats in lakes, from the coastal regions to the mountains (till 84°S). However, little is known about theirl biodiversity in comparison with other regions of the world. The BelSPO project AMBIO aimed to test whether (i) microbial communities are structured by the same factors as those shaping communities of macroorganisms, and (ii) endemism among cyanobacteria does exist. We have analyzed the cyanobacterial biodiversity in a variety of aquatic habitats from the three main biogeographical regions (Continental, Maritime Antarctica and the Sub-Antarctic) and determined the ‘baseline’ data needed to understand the contribution of various processes that are responsible for the distribution patterns. [less ▲]

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See detailAn "Antarctic Marine Biodiversity Reference Centre" devoted to amphipod crustaceans
De Broyer, Claude; Van Roozendael, Françoise; Jazdzewski, Krzysztof et al

Poster (2000, April)

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See detailAntarctic Microbial BIOdiversity : the importance of geographical versus ecological factors
Obbels, Dagmar; De Carvalho Maalouf, Pedro ULg; De Wever, Aaike et al

Poster (2012, July)

Antarctica is a prime region to test whether microbes have a biogeography and to study their metacommunity dynamics, because (i) it is isolated from the other continents, (ii) its extreme environmental ... [more ▼]

Antarctica is a prime region to test whether microbes have a biogeography and to study their metacommunity dynamics, because (i) it is isolated from the other continents, (ii) its extreme environmental conditions allow microorganisms to dominate its ecosystems, and (iii) lacustrine and terrestrial habitats occur isolated in a matrix of ice and ocean. We compiled a large set of samples from benthic microbial mats from Antarctic lakes in different ice-free regions and used a polyphasic approach to study their microbial biodiversity by combining morphological characterization of diatoms with molecular techniques such as Denaturing Gradient Gel Electrophoresis (green algae and cyanobacteria), 454 pyrosequencing and cultivation (prokaryotes). [less ▲]

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See detailAntarctic sea ice trophic status
Van der Linden, Fanny ULg; Moreau, Sébastien; Champenois, Willy ULg et al

Poster (2017, July)

The sea ice ecosystem is characterized by steep gradients in temperature, salinity, light and nutrient availability. Despite these challenging environmental conditions, sea ice provides a dynamic habitat ... [more ▼]

The sea ice ecosystem is characterized by steep gradients in temperature, salinity, light and nutrient availability. Despite these challenging environmental conditions, sea ice provides a dynamic habitat for diverse communities of microorganisms. These communities include a wide variety of organisms from different taxonomic groups such as algae, bacteria, heterotrophic protists, fungi as well as viruses [Horner et al., 1992; Deming, 2010; Thomas and Dieckmann, 2010; Poulin et al., 2011]. In the frame of the YROSIAE project (Year-Round survey of Ocean-Sea-Ice-Atmosphere Exchanges), carried out at Cape Evans in McMurdo Sound (Antarctica) from Nov. 2011 to Dec. 2012, ice cores, seawater, and brine material were collected at regular time intervals. Physical properties (salinity, temperature, texture) and biogeochemical parameters (pCO2, dissolved inorganic carbon, total alkalinity, chlorophyll-a, macro-nutrients) were analysed. We will here particularly consider changes inused dissolved inorganic carbon (DIC) and chlorophyll-a (chl-a) , used as a proxiesy of net community production and autotrophic biomass, respectively. A high spatial and temporal variability in ice algal biomass and DIC evolution were observed. From spring, very high chl-a concentrations (>2400μg.L^(-1)) were observed at the bottom of the ice, a common feature of land fast ice in the McMurdo Sound. This suggests high primary production. However Strikingly, , at the same time, nutrients at the bottom of the ice increased significantly suggesting high heterotrophyremineralisation. In the middle of the ice column, evolution of DIC is was marked by a succession of autotrophic and heterotrophic phases. The overall increase of DIC suggests that the ice interior was rather heterotroph. Such sea ice system should expel CO2. Yet, strong under-saturation in CO2 and DIC depletion appeared at the ice surface, suggesting that sea ice was taking up CO2 from the atmosphere. On the whole, land fast sea ice in McMurdo Sound appears as a puzzling ecosystem. It is able to support elevated growth of autotrophic organisms at the bottom, but still appears to be heterotrophicin parallel to high remineralization, while the top of the ice appears to be rather heterotrophic but stilland able to pump CO2 from the atmosphere. [less ▲]

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See detailAntarctic urchin ctenocidaris speciosa spines: Lessons from the deep
Catarino, A. I.; av FD Roosevelt 50, Brussels; Guibourt, V. et al

in Cahiers de Biologie Marine (2013), 54(4), 649-655

Ocean acidification is leading to changes in the oceanic carbonate system. As a result, calcium carbonate saturation horizon is shallowing, especially at high latitudes. Biogenic high magnesium-calcites ... [more ▼]

Ocean acidification is leading to changes in the oceanic carbonate system. As a result, calcium carbonate saturation horizon is shallowing, especially at high latitudes. Biogenic high magnesium-calcites could be particularly vulnerable, since their solubility is either similar or greater than that of aragonite. Cidaroid urchins have magnesium-calcite spines covered by a polycrystalline cortex which becomes exposed to seawater when mature (not covered by an epidermis). However, deep species live at low calcium carbonate saturation states, especially at high latitudes. We describe here the morphology and the magnesium content of Ctenocidaris speciosa spines collected at different depths from the Weddell Sea (Antarctica) and relate the features with seawater calcium carbonate saturation. We observed that the spines cortex of C. speciosa presented a thicker inner cortex layer and a lower [Mg2] below the aragonite saturation horizon. We suggest that the cortex of cidaroid spines is able to resist to low calcium carbonate saturation state. [less ▲]

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