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See detailImaging Guided Proteomics Unveils Heterogeniety in Colorectal Carcinoma Liver Metastases – Implications for Targeted Therapies.
blomme, Arnaud; Turtoi, Andrei ULg; Delvaux, David ULg et al

in Proceedings Giga Day 2012 (2012, May 04)

Detailed reference viewed: 58 (23 ULg)
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See detailImaging in aortic aneurysms. Aortic Aneurysms. New insights into an old problem
NCHIMI LONGANG, Alain ULg; SAKALIHASAN, Natzi ULg; KUIVANIEMI, H. et al

in Imaging in aortic aneurysms. Aortic Aneurysms. New insights into an old problem (2008)

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See detailImaging in Disorder of Self-Consciousness
Martial, Charlotte ULg

Conference (2015, December)

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See detailImaging in vivo herpes simplex virus thymidine kinase gene transfer and expression in tumors using positron emission tomography.
HUSTINX, Roland ULg; SHIUE, CY.; ZHUANG, H. et al

in Journal of Nuclear Medicine (The) (2000), 41(SUPPL), 264

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See detailImaging in Vivo Herpes Simplex Virus Thymidine Kinase Gene Transfer to Tumour-Bearing Rodents Using Positron Emission Tomography And
Hustinx, Roland ULg; Shiue, C. Y.; Alavi, A. et al

in European Journal of Nuclear Medicine (2001), 28(1), 5-12

Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex virus thymidine kinase (HSVtk) expression. This study evaluated the use of positron emission tomography ... [more ▼]

Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex virus thymidine kinase (HSVtk) expression. This study evaluated the use of positron emission tomography (PET) imaging with 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) to assess gene transfer into tumours. HSVtk-positive and HSVtk-negative cell lines were first treated in vitro with [18F]FHPG. To assess the efficacy of PET in detecting HSVtk expression following in vivo gene transfer, mice were injected intravenously with an adenovirus encoding HSVtk (Ad.HSVtk), a control vector (Ad.Bgl2) or saline. Subcutaneous human glioma xenografts were grown in mice and treated by direct injection of Ad.HSVtk or Ad.Bgl2. Imaging was performed 48 h after transduction. Similar experiments were performed using Fischer rats implanted with syngeneic tumours. The presence of the HSVtk protein was confirmed by immunohistochemistry. Biodistribution studies were also obtained in 14 naive mice. In vitro studies showed high and specific uptake of [18F]FHPG in HSVtk-positive cell lines, with an uptake ratio of up to 27:1. PET imaging and direct counting of major organs demonstrated HSVtk-specific tracer retention. In mice, HSVtk-positive tumours retained 3.4% dose/gram as compared to 0.6% for control tumours (P=0.03). They were clearly seen on the PET images as early as 100 min post injection. Similar results were obtained with syngeneic rat tumours. Biodistribution studies demonstrated the rapid distribution and clearance of the tracer in all major organs. Our results demonstrate that PET imaging of HSVtk gene transfer to tumours is feasible and is highly specific for HSVtk expression. [less ▲]

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See detailImaging mass spectrometry and proteomics of 3D cell cultures
Longuespée, Rémi ULg; Piron, Céline; Fléron, Maximilien et al

Poster (2013, October)

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See detailImaging Mixed Lipid Monolayers By Dynamic Atomic Force Microscopy
Deleu, Magali ULg; Nott, Katherine ULg; Brasseur, Robert ULg et al

in Biochimica et Biophysica Acta-Biomembranes (2001), 1513(1),

Phase imaging with tapping mode atomic force microscopy (AFM) and force modulation microscopy were used to probe the mechanical properties of phase-separated lipid monolayers made of a mixture (0.25:0.75 ... [more ▼]

Phase imaging with tapping mode atomic force microscopy (AFM) and force modulation microscopy were used to probe the mechanical properties of phase-separated lipid monolayers made of a mixture (0.25:0.75) of the surface-active lipopeptide surfactin and of dipalmitoylphosphatidylcholine (DPPC). The π–A isotherms and the result of a molecular modeling study revealed a loose, 2-D liquid-like organization for the surfactin molecules and a closely packed, 2-D solid-like organization for DPPC molecules. This difference in molecular organization was responsible for a significant contrast in height, tapping mode phase and force modulation amplitude images. Phase imaging at light tapping, i.e., with a ratio of the set-point tapping amplitude with respect to the free amplitude Asp/A0≈0.9, showed larger phase shifts on the solid-like DPPC domains attributed to larger Young’s modulus. However, contrast inversion was observed for Asp/A0<0.7, suggesting that at moderate and hard tapping the image contrast was dominated by the probe–sample contact area. Surprisingly, force modulation amplitude images showed larger stiffness for the liquid-like surfactin domains, suggesting that the contrast was dominated by contact area effects rather than by Young’s modulus. These data emphasize the complex nature of the contrast mechanisms of dynamic AFM images recorded on mixed lipid monolayers. [less ▲]

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See detailImaging MS: strategies for the identification of analytes
Debois, Delphine ULg; Smargiasso, Nicolas ULg; Jourdan, Emmanuel et al

Scientific conference (2014, April 04)

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See detailImaging myeloma and related monoclonal plasma cell disorders using MRI, low dose whole-body CT and FDG PET/CT
WITHOFS, Nadia ULg; NANNI, C.; SIMONI, Paolo ULg et al

in Clinical and Translational Imaging (2015), 3

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial ... [more ▼]

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial assessment of the disease. <br />Although the radiological skeletal survey is the gold standard to detect bone osteolytic lesions, it may miss small bone lesions or lesions located in the spine or pelvis due to the superimposed images of soft tissues. These limitations propelled newer imaging techniques such as positron emission tomography combined with computed tomography (PET/CT) and magnetic resonance imaging (MRI) in the diagnosis of multiple myeloma. In addition, 18F-fluorodeoxyglucose PET/CT and MRI have prognostic value and can be used to monitor disease. <br />This review discusses the additional value of PET/CT and MRI in the management of MM. [less ▲]

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See detailImaging of large vessel vasculitis with (18)FDG PET: illusion or reality? A critical review of the literature data
Belhocine, Tarik; Blockmans, Daniel; Hustinx, Roland ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2003), 30(9), 1305-1313

Fluorine-18 fluorodeoxyglucose positron emission tomography ((18)FDG PET) plays a major role in the management of oncology patients. Owing to the singular properties of the glucose tracer, many patients ... [more ▼]

Fluorine-18 fluorodeoxyglucose positron emission tomography ((18)FDG PET) plays a major role in the management of oncology patients. Owing to the singular properties of the glucose tracer, many patients suffering from non-malignant diseases such as inflammatory or infectious diseases may also derive clinical benefit from the appropriate use of metabolic imaging. Large vessel vasculitides such as giant cell arteritis and Takayasu arteritis are other examples that may potentially extend the field of (18)FDG PET indications. The purpose of the present article is to assess the feasibility of metabolic imaging in vasculitis on the basis of the current literature data. In particular, the clinical context and the (18)FDG imaging patterns seen in patients with large vessel vasculitis are analysed in order to identify potential indications for metabolic imaging. [less ▲]

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See detailImaging of liquid distribution in reactive distillation packings with a new high-energy x-ray tomograph
Toye, Dominique ULg; Crine, Michel ULg; Marchot, Pierre ULg

in Measurement Science & Technology (2005), 16(11), 2213-2220

We describe a new, high-energy (420 kV), large-scale (0.45 m in diameter, 4 m in height) x-ray tomograph developed to investigate gas and liquid flow through fixed bed like absorption, distillation and ... [more ▼]

We describe a new, high-energy (420 kV), large-scale (0.45 m in diameter, 4 m in height) x-ray tomograph developed to investigate gas and liquid flow through fixed bed like absorption, distillation and reactive distillation columns. The first results obtained with this set-up on test objects (physical phantoms), such as a cylindrical container filled with water or a large diameter structured metallic packing, validate the technique as a quantitative tool for geometrical measurements. Very detailed two-dimensional (21)) and three-dimensional (3D) images of a 0.09 m diameter KATAPAK-SP 12, a reactive distillation packing, are presented. Quantitative information relative to liquid hold-up distribution may be obtained from tomographic imaging performed on an irrigated column packed with this element. [less ▲]

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See detailImaging Orbitals by Ionization or Electron Attachment: The Role of Dyson Orbitals
Mignolet, Benoît ULg; Kus, Tomasz ULg; Remacle, Françoise ULg

in Joachim, C.; Grill, L. (Eds.) Imaging and Manipulating Molecular Orbitals (2013)

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See detailImaging osteoarthritis using (18F)FPRGD2 PET/CT : observation and potential application.
WITHOFS, Nadia ULg; ALVAREZ MIEZENTSEVA, Victoria ULg; SIMONI, Paolo ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 250

Detailed reference viewed: 17 (3 ULg)
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See detailImaging polarimeters based on Liquid Crystal Variable Retarders: an emergent technology for space instrumentation
Alvarez-Herrero, A.; Uribe-Patarroyo, N.; Garcia Parejo, P. et al

in Show, J. A.; Scott Tyo, J. (Eds.) Proc. SPIE Vol 8160 on Polarization Science and Remote Sensing V (2011, September 09)

Detailed reference viewed: 67 (1 ULg)