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See detailLoading and skeletal development and maintenance.
Bergmann, P.; Body, J. J.; BOONEN, S. et al

in Journal of Osteoporosis (2010), 2011

Mechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the ... [more ▼]

Mechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the lacuno-canalicular system. Intracellular transduction implies several kinases and phosphorylation of the estrogen receptor. Several extra-cellular mediators, among which NO and prostaglandins are transducing the signal to the effector cells. Disuse results in osteocytes apoptosis and rapid imbalanced bone resorption, leading to severe osteoporosis. Exercising during growth increases peak bone mass, and could be beneficial with regards to osteoporosis later in life, but the gain could be lost if training is abandoned. Exercise programs in adults and seniors have barely significant effects on bone mass and geometry at least at short term. There are few data on a possible additive effect of exercise and drugs in osteoporosis treatment, but disuse could decrease drugs action. Exercise programs proposed for bone health are tedious and compliance is usually low. The most practical advice for patients is to walk a minimum of 30 to 60 minutes per day. Other exercises like swimming or cycling have less effect on bone, but could reduce fracture risk indirectly by maintaining muscle mass and force. [less ▲]

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See detailloads hungry and masses too big: measure nouns on the move?
Declerck, Bernard; Brems, Lieselotte ULg

Conference (2010)

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See detailLobe frontal, mémoire de travail et mémoire épisodique
Van der Linden, Martial ULg; Collette, Fabienne ULg; Andrès, Pilar

in Azouvi, Philippe; Bussel, B. (Eds.) Syndrome frontal : évaluation et rééducation : actes des 11e Entretiens de l'Institut Garches (1998)

Detailed reference viewed: 32 (11 ULg)
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See detailLobeline-Induced Hyperpnea in Equids. Comparison with Rebreathing Bag and Exercise
Art, Tatiana ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1991), 38(2), 148-152

In order to facilitate lung auscultation, a transitory hyperpnea may be obtained by lobeline administration, use of a rebreathing bag or exercise. The effect of these three methods on the pulmonary ... [more ▼]

In order to facilitate lung auscultation, a transitory hyperpnea may be obtained by lobeline administration, use of a rebreathing bag or exercise. The effect of these three methods on the pulmonary function were studied and compared in 5 healthy ponies. Respiratory airflow and tidal volume were measured with a pneumotachograph Nr. 5 and pleural pressure with the esophageal balloon catheter technique. Pulmonary function values were measured before, during and after the hyperpnea induced by (i) lobeline, (ii) rebreathing and (iii) exercise. Lobeline administration induced an hyperpnea due to both an increase in tidal volume and respiratory rate; this increase in ventilation lasted for about 90 s and was accompanied by a sharp rise in the respiratory peak airflows, especially the expiratory ones. The rebreathing method induced a less hyperpnea which lasted only 30 s. Lastly the hyperpnea after a light treadmill exercise was the longer in duration and intermediate between the preceding methods in intensity [less ▲]

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See detailLocal acceptance of windmills and lessons learned for nuclear projects
Rossignol, Nicolas ULg; Schröder, Jantinne

Conference (2013, May 31)

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See detailLocal administration of nicotinamide enhances neutrophil apoptosis and decreases mice endotoxin-induced airway inflammation
Fernandes, C. A.; Fievez, Laurence ULg; Ucakar, B. et al

in Société Belge de Sciences Pharmaceutiques (2009)

Detailed reference viewed: 20 (5 ULg)
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See detailLocal administration of nuclear factor-kB decoy oligodeoxinucleotides prevents allergic airway inflammation
Bureau, Fabrice ULg; Gosset, P.; Desmet, Christophe ULg et al

in 12th European Respiratory Society Annual Congress (2002)

Detailed reference viewed: 31 (6 ULg)
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See detailLocal and global ship vibrations
Constantinescu, A.; Rigo, Philippe ULg; Chirica, I. et al

in IMPROVE Workshop (EU Project FP6 n°031382), DUBROVNIK 17-18 Sept. 2009, Croatia, Editor V. Zanic – Univ. of Zagreb, pp41-45 (Vol I) + Powerpoint (Vol II) (2009, September)

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See detailLocal and interactive post-buckling of RHS thin-walled members - Comparing a new special beam finite element with shell FE models
Degée, Hervé ULg; Boissonnade, Nicolas; Rossi, Barbara ULg

in International Journal of Structural Stability & Dynamics (2007), 7(2), 213-241

This paper presents a special thin-walled plane beam. nite element that accounts for the in-plane cross-section local deformation. The element is based on the superposition of a classical beam ... [more ▼]

This paper presents a special thin-walled plane beam. nite element that accounts for the in-plane cross-section local deformation. The element is based on the superposition of a classical beam displacement field and of an additional field describing local e. ects, with an approximation on the local second-order membrane stress. eld. The theoretical formulation is summarized and an application of the resulting numerical tool to the post-buckling analysis of RHS thin-walled members with moderate local and global slenderness susceptible to both global and local buckling is then performed. Different types of analyses are presented (computation of critical bifurcation loads, geometrically non-linear analysis, geometrically and materially non-linear analysis). The results obtained with the proposed beam. nite element are compared to values provided by shell FE models. [less ▲]

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See detailLocal and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.
Moermans, Catherine ULg; HEINEN, Vincent ULg; NGUYEN DANG, Delphine ULg et al

in Cytokine (2011), 56(2), 298-304

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also ... [more ▼]

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also features systemic inflammation. The purpose of our study was to compare airway and systemic inflammation in COPD to that seen in healthy subjects and to relate the inflammation with the disease severity. METHODS: Ninety-five COPD patients, encompassing the whole severity spectrum of the disease, were recruited from our outpatient clinic and rehabilitation center and compared to 33 healthy subjects. Induced sputum and blood samples were obtained for measurement of inflammatory cell count. Interleukin (IL)-4, IL-6, IL-10, TNF-alpha and IFN-gamma produced by 24h sputum and blood cell cultures were measured. RESULTS: Compared to healthy subjects, COPD exhibited a prominent airway neutrophilic inflammation associated with a marked IL-10, IL-6 and TNF-alpha release deficiency that contrasted with a raised IFN-gamma production. Neutrophilic inflammation was also prominent at blood level together with raised production of IFN-gamma, IL-10 and TNF-alpha. Furthermore, sputum neutrophilia correlated with disease severity assessed by GOLD stages. Likewise the extent of TNF-alpha release from blood cells also positively correlated with the disease severity but negatively with that of sputum cell culture. Blood release of TNF-alpha and IL-6 negatively correlated with body mass index. Altogether, our results showed a significant relationship between cellular marker in blood and sputum but poor relationship between local and systemic release of cytokines. CONCLUSIONS: COPD is characterized by prominent neutrophilic inflammation and raised IFN-gamma production at both bronchial and systemic level. Overproduction of TNF-alpha at systemic level correlates with disease severity and inversely with body mass index. [less ▲]

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See detailLocal Anesthetics
Chavarria Bolanos, Daniel ULg

Scientific conference (2014, March 29)

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See detailLocal applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions.
Hubert, Pascale ULg; Doyen, Jean ULg; Capelle, Xavier ULg et al

in American Journal of Reproductive Immunology (2010), 64(2), 126-136

Abstract Problem Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished ... [more ▼]

Abstract Problem Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished capacity to capture viral antigens and to induce a protective immune response. Method of study To test if a cervical application of GM-CSF could restore an immune response against HPV in women with cervical low-grade squamous intraepithelial lesions (LSIL). We performed two clinical trials with11 healthy women and 15 patients with LSIL. Results GM-CSF applications were well tolerated in all enrolled women and no difference in toxicity between the treated and placebo groups was observed during the follow up (until 30 months). Interestingly, in the GM-CSF treated group, a significant increased APC and cytotoxic T lymphocyte infiltration was observed in the cervical biopsies with no change in regulatory T cell numbers. All the HPV16+ patients exhibited an immune response against HPV16 after GM-CSF applications, as shown by NK and/or T cells producing IFN-γ whereas no cellular immune response was observed before the treatment. Moreover, the anti-VLP antibody titers also increased after the treatment. Conclusion These encouraging results obtained from a limited number of subjects justify further study on the therapeutic effect of APC in cervical (pre)neoplastic lesions. [less ▲]

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See detailLocal assimilation of sea surface temperature and elevation in a two-way nested model of the Gulf of Lions, using a single multigrid state vector
Vandenbulcke, Luc ULg; Barth, Alexander ULg; Ben Bouallegue, Z. et al

Conference (2005, April)

A three fold nested model is built, covering (a) the Mediterranean Sea (resolution 1/4 degree) (b) its North-Western part (resolution 1/20 degree), and (c) the Gulf of Lions (resolution 1/100 degree). The ... [more ▼]

A three fold nested model is built, covering (a) the Mediterranean Sea (resolution 1/4 degree) (b) its North-Western part (resolution 1/20 degree), and (c) the Gulf of Lions (resolution 1/100 degree). The GHER hydrodynamic model (see e.g. [1]) is used for a simulation of the springs of 1997 and 1998. As the model allows mode splitting, the timestep in each grid is 3 seconds for the barotropic modes, and 3 minutes for the baroclinic modes. ECMWF atmospheric forcings and MODB4/MEDAR climatic data are used. This simulation is run with one-directionnal and bi-directionnal nesting (i.e. without and with statevector feedback), and results are compared. The output of the 1997 and 1998 simulations (3D temperature and salinity fields, and sea surface elevation field) are then used to build 3D multivariate EOFs over the 3 grids alltogether. This guarantees perfect correlations between points from different grids, that are physically at the same location. The following twin experiment is then set up. The simulation from 1998 serves as a control run. A delayed state of this run, serves as initial conditions for the perturbed run. The first 40 EOFs are used to build a reduced-rank model errorspace. Sea surface temperature and sea surface elevation from the reference run, physically located in the Gulf of Lions, are then assimilated in the perturbed run, using a reduced-rank optimal interpolation assimilation scheme. A previous experiment showed non-physical long-range corrections (far outside the Gulf of Lions); these corrections are removed by multiplying the corrections with a radial Gaussian function centered on the corresponding observations. The multivariate statevector ensures corrections are made to temperature, salinity and sea surface elevation fields. Using the corrected fields, the geostrophic equilibrium is used to calculate corrections to the velocity field. In this above twin experiment, observations are assimilated all at once in the 3 grids since a single statevector is used. The results are compared to classic approaches where each grid has a corresponding statevector, and observations are assimilated in a single grid (or in different grids separately). Finally, ongoing research about statistical predictors is presented. Indeed, primitive equation models are too costly to evolve the errorspace in time, even when reducedrank assimilation schemes are used. Statistical methods aim to replace the hydrodynamic model by a much faster method, that would then be used to evolve in time each of the directions of the errorspace, or alternately, the members of an ensemble method. Statistical methods need to be trained on real results; they are thus first tested on the model itself rather than on the errorspace. Preliminary results are presented. [less ▲]

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See detailLocal Buckling Check According to Eurocode-3 for Plastic-hinge Analysis of 3D Steel Frames
Hoang, Van Long ULg; Nguyen, Dang Hung

in Engineering Structures (2008), 30

Detailed reference viewed: 86 (8 ULg)
See detailLocal buckling in case of fire
Franssen, Jean-Marc ULg; Talamona, Didier

Conference (2000, October 13)

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See detailLocal buckling of structures in case of fire
Talamona, D.; Franssen, Jean-Marc ULg

in Proceedings of the 4th annual workshop Targeted Research Action - Environmentally Friendly Construction Technologies, ECCREDI (2000)

Detailed reference viewed: 12 (0 ULg)