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See detailLymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis.
Baert, F.; Wouters, K.; D'Haens, G. et al

in Gut (1999), 45(3), 375-81

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical ... [more ▼]

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS: Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS: Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis. [less ▲]

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See detailLymphoid cell apoptosis induced by trophoblastic cells: a model of active foeto-placental tolerance
Coumans, Bernard ULg; Thellin, Olivier ULg; Zorzi, Willy ULg et al

in Journal of Immunological Methods (1999), 224(1-2), 185-196

To test the hypothesis that CD95-L (Fas-L) present on trophoblastic cells plays a part in establishing foeto-placental tolerance by inducing apoptosis of immune defence cells, we cocultured trophoblasts ... [more ▼]

To test the hypothesis that CD95-L (Fas-L) present on trophoblastic cells plays a part in establishing foeto-placental tolerance by inducing apoptosis of immune defence cells, we cocultured trophoblasts with lymphoid cells and scored the frequency of cell death in these cultures. We prepared human trophoblastic cells from term placentas removed by C-section and placed them in culture for 48 h before introducing the lymphoid cells. We added Jurkat cells, a CD3 + lymphoid cell line, or purified T cells from human blood to the cultured trophoblasts and monitored apoptosis by electron microscopy and flow cytometry after TUNEL or annexin V labelling. The frequency of cell death in the CD3 + cell population was higher when the lymphoid cells were cocultured with trophoblastic cells than when they were cultured alone. This frequency increased with time but was reduced when anti-CD95-L antibodies were added to the culture medium. Cell death was less frequent in the lymphoid cell population when trophoblasts were replaced with human fibroblasts not expressing CD95-L. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe lymphomas. Nuclear Medicine
Jerusalem, Guy ULg; Hustinx, Roland ULg

in Canellos, George P.; Lister, Andrew T.; Young, Brian (Eds.) The lymphomas. (2006)

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See detailLymphome centrocytique-centroblastique ou est-il bon, est-il méchant ?
Fillet, Georges ULg; Desoignies, J.; Jardon-Jeghers, C. et al

in Revue Médicale de Liège (1982)

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See detailLymphome du manteau : prise en charge 2011
Bonnet, Christophe ULg; CAERS, Jo ULg; DE PRIJCK, Bernard ULg et al

in Revue Médicale Suisse (2011), 7

Le lymphome du manteau (LM) représente 6% des lymphomes non hodgkiniens (LNH). Le diagnostic repose sur l'immunophénotypage et la démonstration de la présence de la location entre les chromosomes 11 et 14 ... [more ▼]

Le lymphome du manteau (LM) représente 6% des lymphomes non hodgkiniens (LNH). Le diagnostic repose sur l'immunophénotypage et la démonstration de la présence de la location entre les chromosomes 11 et 14, avec surexpression de la cycline D1. Le traitement de première ligne du sujet jeune associe trois cures de R-CHOP21 alternées avec trois cures de R-DHAP21, suivies d'une autogreffe conditionnée par irradiation corporelle totale, cyclophosphamide et aracytine. Le sujet de plus de 65 ans peut bénéficier de huit cures de R-CHOP21. L'intérêt du traitement de maintenance est en cours d'évaluation. L'allogreffe de cellules souches hématopoïétiques offre une chance de guérison aux patients en rechute en bon état général. Les traitements ciblés permettront une amélioration du pronostic de cette maladie. [less ▲]

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See detailLe lymphome malin primitif du rachis: aspects cliniques et progrès thérapeutiques
Vanderick, JEAN ULg; Toussaint; Massager et al

in Acta Orthopaedica Belgica (1999), 65(1), 23-32

Malignant lymphomas are occasionally encountered in the spine, where they are usually secondary deposits. The authors report the case of a primary non-Hodgkin lymphoma of the L1 vertebra in whom surgical ... [more ▼]

Malignant lymphomas are occasionally encountered in the spine, where they are usually secondary deposits. The authors report the case of a primary non-Hodgkin lymphoma of the L1 vertebra in whom surgical treatment (two operations and double approach) was followed by radiotherapy and chemotherapy. The diagnosis is often made at a late stage, when neurological deficits produced by epidural compression become evident. The surgical treatment is only palliative but has several goals: obtaining a biopsy, improving the neurological symptoms through decompression, stabilizing and "rebuilding" the spinal column; it is performed using posterior, anterior or combined approaches which are discussed. The combined surgical, radiotherapeutic and polychemotherapeutic treatment is associated with a 5-year survival rate of 60-80%. Such a prognosis justifies the risk of surgery which will lead to a stable and lasting reconstruction. [less ▲]

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See detailLes lymphomes
Jerusalem, Guy ULg; Hustinx, Roland ULg; Beguin, Yves ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2003), 27(8), 401-410

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique ... [more ▼]

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique concernant le diagnostic, la classification de la maladie et la détermination des facteurs pronostiques permet de choisir la thérapeutique la plus appropriée. Les auteurs passent en revue les examens à réaliser au diagnostic et discutent de la place de la tomographie à émission de positons (TEP) dans cette indication. Ils évoquent ensuite le problème des masses résiduelles. La TEP est maintenant l'examen de choix pour établir le bilan de fin de traitement. Les auteurs discutent également du rôle potentiel de la TEP pour l'évaluation thérapeutique précoce et le suivi régulier des patients après traitement pour lymphome. Enfin, l'aspect particulier des lymphomes de l'enfant est abordé. [less ▲]

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See detailLymphotoxin alpha gene in Crohn's disease patients: absence of implication in the response to infliximab in a large cohort study
Dideberg, Vinciane ULg; Louis, Edouard ULg; Farnir, Frédéric ULg et al

in Pharmacogenetics and Genomics (2006), 16(5), 369-373

A haplotype in the lymphotoxin alpha (LTA) gene has been associated with a lack of response to infliximab in a small cohort of Crohn's disease (CD) patients. The present study aimed to confirm the ... [more ▼]

A haplotype in the lymphotoxin alpha (LTA) gene has been associated with a lack of response to infliximab in a small cohort of Crohn's disease (CD) patients. The present study aimed to confirm the implication of this haplotype in the response to infliximab in a larger cohort of Caucasian patients. The response to the first infusion with infliximab was evaluated in 214 Caucasian patients with either luminal (n = 150) or fistulising (n = 64) CD. Clinical response was based on the decrease in CID Activity Index (luminal) or on the evolution in the fistula discharge (fistulising). Biological response was assessed in 139 patients who had elevated C-reactive protein (CRP) before treatment and for whom CRP values were also available after treatment. A positive biological response was defined as a decrease in CRP of at least 25%. The patients were genotyped for six polymorphisms in the LTA gene. A positive clinical response was present in 65.4% of the patients and a positive biological response was observed in 80.6% of the patients. No association was found with any of the studied polymorphisms, nor with the previously published LTA haplotype and the response to infliximab. We could not confirm an association between the LTA locus and clinical or biological response to infliximab in a large cohort of CID patients. Pharmacogenetics and Genomics 16:369-373 (c) 2006 Lippincott Williams [less ▲]

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See detailThe lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

in Immunity (2002), 17

The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of ... [more ▼]

The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of this receptor induces the processing of the cytosolic NF-kappaB2/p100 precursor to yield the mature p52 subunit, followed by translocation of p52 to the nucleus. This activation of NF-kappaB2 requires NIK and IKKalpha, while NEMO/IKKgamma is dispensable for p100 processing. IKKbeta-dependent activation of canonical NF-kappaB is required for the expression but not processing of p100 and for the expression of proinflammatory molecules including VCAM-1, MIP-1beta, and MIP-2 in response to LTbetaR ligation. In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF. [less ▲]

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See detailLymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes
Huber, Christoph; Thielen, Caroline ULg; Seeger, Harald et al

in Journal of Immunology (2005), 174(9), 5526-5536

Affinity-maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular ... [more ▼]

Affinity-maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT beta receptor (LT beta R) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expression analysis of 3 of 12 genes both enriched in FDCs and down-regulated by LT beta R signaling suppression validated them as FDC markers. Functional analysis of one of these three, clusterin, suggests a role as an FDC-derived trophic factor for GC B cells. Hence, the set of genes presented in this study includes markers emanating from LT beta R signaling and transcripts relevant to GC and FDC function. [less ▲]

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See detailThe lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

Conference (2009, October 30)

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See detailThe lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

Conference (2002)

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See detailLyngbyapeptin A, a modified tetrapeptide from Lyngbya bouillonii (Cyanophyceae)
Didier Klein; Jean-Claude Braekman; Désiré Daloze et al

in Tetrahedron Letters (1999)

Lyngbyapeptin A 1, a novel tetrapeptide containing the rate 3-methoxy-2-butenoyl moiety was isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Its structure (without ... [more ▼]

Lyngbyapeptin A 1, a novel tetrapeptide containing the rate 3-methoxy-2-butenoyl moiety was isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Its structure (without stereochemistry) was established by mass spectral- and two-dimensional NMR studies. [less ▲]

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See detailLyophilisation and resuscitation of sporozoites of Theileria parva: preliminary experiments
Marcotty, T.; Berkvens, D.; Besa, R. K. et al

in Vaccine (2003), 22(2), 213-216

Lyophilisation of Theileria parva sporozoite stabilates used for immunisation of cattle against East Coast fever would greatly improve vaccine storage and delivery. We report three attempts to lyophilise ... [more ▼]

Lyophilisation of Theileria parva sporozoite stabilates used for immunisation of cattle against East Coast fever would greatly improve vaccine storage and delivery. We report three attempts to lyophilise and resuscitate the sporozoites of T parva. Sporozoites survived lyophilisation and were effective for immunisation. Lyophilised stabilate survived for 2 weeks at 5degreesC and for 12 weeks at -20degreesC. Although the viability of the stabilates was severely reduced during lyophilisation, this work suggests that this method has potential and should be considered for other Apicomplexan parasites such as Babesia sp. or Plasmodium sp. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailLyophilized Preparations Of Bacteriocinogenic Lactobacillus Curvatus And Lactococcus Lactis Subsp Lactis As Potential Protective Adjuncts To Control Listeria Monocytogenes In Dry-Fermented Sausages
Benkerroum, N.; Daoudi, A.; Hamraoui, T. et al

in Journal of Applied Microbiology (2005), 98(1),

Methyl oleate was used as a primary carbon source and as an alternative inducer for the production of an extracellular lipase, Lip2, in Y. lipol.vtica strain LgX64.81 grown in a 20-1 bioreactor. The ... [more ▼]

Methyl oleate was used as a primary carbon source and as an alternative inducer for the production of an extracellular lipase, Lip2, in Y. lipol.vtica strain LgX64.81 grown in a 20-1 bioreactor. The lipase-encoding gene, LIP2, was investigated during culture on methyl oleate using a pLIP2-LacZ reporter fusion and we provide evidence for the involvement of methyl oleate in its regulation. [less ▲]

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See detailLyotard : le déssaisissement de l'art
Steinmetz, Rudy ULg

in L'atelier d'esthétique (Ed.) Esthétique et philosophie de l'art (2002)

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See detailLYP inhibits T-cell activation when dissociated from CSK
Vang; Liu, Wallace H; Delacroix, Laurence ULg et al

in Nature Chemical Biology (2012)

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T-cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T-cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here we studied the spatiotemporal dynamics of the LYP–CSK complex in T cells. We demonstrate that dissociation of this complex is necessary for recruitment of LYP to the plasma membrane, where it downmodulates TCR signaling. Development of a potent and selective chemical probe of LYP confirmed that LYP inhibits T-cell activation when removed from CSK. Our findings may explain the reduced TCR-mediated signaling associated with a single-nucleotide polymorphism that confers increased risk for certain autoimmune diseases, including type 1 diabetes and rheumatoid arthritis, and results in expression of a mutant LYP that is unable to bind CSK. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

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See detailLyrical Cartographies: Re-Drawing the Boundaries of the Black Atlantic in Dionne Brand's A Map to the Door of No Return and At the Full and Change of the Moon
Mergeai, Mathilde ULg

in Durán Almarza, Liamar; Álvarez López, Esther (Eds.) Diasporic Women's Writing of the Black Atlantic: (En)Gendering Literature and Performance (2014)

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See detailLyrics, Music and Voice: a Comparative Semiotics of Emotions in Cole Porter's "Miss Otis Regrets"
Lindenberg Lemos, Carolina ULg

Conference (2012, June 27)

What makes for an engaging song? One may credit the lyrics, another the melody, but in fact the two components are indissociable (Tatit, 2007). In Cole Porter's “Miss Otis Regrets”, we are introduced to ... [more ▼]

What makes for an engaging song? One may credit the lyrics, another the melody, but in fact the two components are indissociable (Tatit, 2007). In Cole Porter's “Miss Otis Regrets”, we are introduced to the sad account of Miss Otis. The lyrics give us fragments of her story but not from her point of view. How, then, do we relate to her tragedy? In this paper, a comparative semiotic approach to lyrics, music, and voice will be used to demonstrate the narrator is key to this process. It is from the latter's point of view that we approach the story. First, an analysis of the linguistic component, based on Greimas (1983; 1987) and Zilberberg (1988; 2006), will show how the choice of vocabulary and repetitions subtly disagree with the values assumed by the community that condemns Miss Otis. However, non-linguistic components also play a central role. Following Tatit's (1997; 2007) proposals for the semiotic approach to songs, we will investigate how Porter's choices of accents, elongations and the exploration of pitch range emphasize the points that are most filled with emotions in the narrative. Melody and lyrics are shown to work together in the construction of the emotional connotations. Nonetheless, it is only when it is no longer in paper, but in the form of an actual execution, that the song may be said to move. We then explore the well-known rendition of Ella Fitzgerald. Despite the accompanying piano, we focus here on the voice as the place where linguistic and musical components meet. Our analysis compares the recording and the original score in order to assess the level of adequacy and change that the interpreter promoted. Variations in notes, stress, and rhythm may be shown to change the original direction dramatically, while others offer accentuated distinctions that were already in place. In all cases, the singer’s transformations take the song a step further in its emotional contents. Adopting this comparative semiotic approach, we reestablish the chain that extracts the emotions from the narrative, to the music, and to the voice, showing that the path that ensures the emotional attachment of the listener is in the integration of the three components: lyrics, music, and voice. References: Greimas, A. J. (1983). “De la colère: étude de sémantique lexicale” In: Du sens II. Paris: Seuil, p. 225-246. __________ (1987). De l'imperfection. Périgueux: Fanlac. Tatit, L. (1997). Musicando a Semiótica: Ensaios. São Paulo: Annablume. __________ (2007). Semiótica da Canção: Melodia e Letra. São Paulo: Escuta. Zilberberg, C. (1988). Raison et poétique du sens. Paris: PUF. __________ (2006). Eléments de grammaire tensive. Limoges: Pulim. [less ▲]

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