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See detailThe human-macaque interface: the impact of anthropogenic factors on the behavioural ecology of Macaca fascicularis in Bangkok (Thailand) and Bali (Indonesia)
Brotcorne, Fany ULiege; Huynen, Marie-Claude ULiege; Wandia, I Nengah

Conference (2010, October 11)

The human-macaque interface is increasingly the focus of many researches in East and South-east Asia. The efforts target the understanding of human impacts on macaques and the risks of pathogen ... [more ▼]

The human-macaque interface is increasingly the focus of many researches in East and South-east Asia. The efforts target the understanding of human impacts on macaques and the risks of pathogen transmission, the mitigation of conflicts as well as the establishment of suitable management programs. Commensal relationships between humans and several species of macaques exist for centuries in some Asian locations, like in Bali (Indonesia), Japan or India. However, the frequency and the intensity of these interactions are strongly increasing over the recent decades, due to the extensive urbanization and recruitment of forestlands for cropping. We conducted a comparative study on two commensal long-tailed macaque (Macaca fascicularis) populations, one in Bangkok (Thailand) and the other in Bali (Indonesia), in order to assess the impact of anthropogenic factors (human presence and food provisioning frequency) on some eco-behavioural aspects of this macaque species living in urban landscapes. We found a consistent impact on the activity budget and the diet composition in both populations, suggesting an important role played by these anthropogenic factors for this species. Additionally, we did not find any impact of food provisioning on agonistic interactions in the two populations, contrary to previous studies in other macaque species. We suggest this surprising result could be explained by the high abundance and constant availability of human food in both sites, decreasing foraging pressures and the associated social competition. Further field studies are in progress in other populations of Macaca fascicularis in Bali in order to confirm this consistency of human impact on the behavioural ecology [less ▲]

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See detailHuman-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.
Cherrier, Thomas ULiege; Elias, Mikael; Jeudy, Alicia et al

in Virology Journal (2011), 8

The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological ... [more ▼]

The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in naive and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection. [less ▲]

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See detailHuman-visual-system-based fusion of multimodality 3D neuroimagery using brain-shift-compensating finite-element-based deformable models
Verly, Jacques ULiege; Vigneron, Lara M.; Martin, Christophe et al

Conference (2003)

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See detailHuman-Visual-System-Based Fusion of Multimodality 3D Neuroimagery using Brain-Shift-Compensating Finite-Element-Based Deformable Models
Verly, Jacques ULiege; Vigneron, Lara; Petitjean, Nicolas et al

in Proceedings of SPIE (2003, February), 5029

Our goal is to fuse multimodality imagery to enhance image-guided neurosurgery. Images that need to be fused must be registered. Registration becomes a challenge when the imaged object deforms between the ... [more ▼]

Our goal is to fuse multimodality imagery to enhance image-guided neurosurgery. Images that need to be fused must be registered. Registration becomes a challenge when the imaged object deforms between the times the images to be fused are taken. This is the case when “brain-shift” occurs. We begin by describing our strategy for nonrigid registration via finite-element methods. Then, we independently discuss an image fusion strategy based on a model of the human visual system. We illustrate the operation of many components of the registration system and the operation of the fusion system. [less ▲]

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See detailHuman/bovine chimeric MxA-like GTPases reveal a contribution of N-terminal domains to the magnitude of anti-influenza A activity
Garigliany, Mutien-Marie ULiege; Cornet, Anne ULiege; Desmecht, Daniel ULiege

in Journal of Interferon & Cytokine Research (2012), 32(7), 326-331

Type I interferons (IFN-) provide powerful and universal innate intracellular defence mechanisms against viruses. Among the antiviral effectors induced by IFN-, Mx proteins of some species appear as ... [more ▼]

Type I interferons (IFN-) provide powerful and universal innate intracellular defence mechanisms against viruses. Among the antiviral effectors induced by IFN-, Mx proteins of some species appear as key components of defence against influenza A viruses. The body of work published to date suggests that to exert anti-influenza activity, an Mx protein must possess a GTP-binding site, structural bases allowing multimerisation, and a specific C-terminal GTPase effector domain (GED). The human MxA and bovine Mx1 proteins both meet these minimal requirements, but the bovine protein is more active against influenza viruses. Here we measured the anti-influenza activity exerted by two human/bovine chimeric Mx proteins. We show that substituting the bovine GED for the human one in human MxA does not affect the magnitude of anti-influenza activity. Strikingly, however, substituting the human GED for the bovine one in bovine Mx1 yields a chimeric protein with much higher anti-influenza activity than the human protein. We conclude, in contradiction to the hypothesis currently in vogue in the literature, that the GED is not the sole determinant controlling the magnitude of the anti-influenza activity exercised by an Mx protein that can bind GTP and multimerise. Our results suggest that one or several motifs that remain to be discovered, located N-terminally with respect to the GED, may interact with a viral component or a cellular factor so as to alter the viral cycle. Identifying, in the N-terminal portion of bovine Mx1, the motif(s) responsible for its higher anti-influenza activity could contribute to the development of new anti-influenza molecules. [less ▲]

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See detailHumanisation de la marque et web 2.0
Brandt, Céline ULiege

Article for general public (2012)

La personnification est l’action de représenter sous les traits d’une personne une chose abstraite ou inanimée. Au sein des réseaux sociaux, les consommateurs souhaitent s’adresser directement au porte ... [more ▼]

La personnification est l’action de représenter sous les traits d’une personne une chose abstraite ou inanimée. Au sein des réseaux sociaux, les consommateurs souhaitent s’adresser directement au porte-parole de la marque, en général le dirigeant de la société. Les conséquences de ce type de communication personnelle sur le comportement du consommateur sont l’amélioration de la confiance, la satisfaction et l’engagement du consommateur. [less ▲]

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See detailL'humanisation de la mort
Lamy, Maurice ULiege

in Annales de l'Anesthésiologie Française (1980), 21(3), 313-314

Detailed reference viewed: 21 (1 ULiège)
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See detailHumanisme de conviction ou humanisme instrumental ? Une comparaison des directeurs de prison belges et français
Dubois, Christophe ULiege; Mouhanna, Christian

Conference (2014, May 20)

Bien que peu étudiés, les directeurs de prison se situent au centre de l’institution pénitentiaire et font office de véritables interfaces entre les politiques étatiques et les pratiques locales. L’étude ... [more ▼]

Bien que peu étudiés, les directeurs de prison se situent au centre de l’institution pénitentiaire et font office de véritables interfaces entre les politiques étatiques et les pratiques locales. L’étude empiriquement ancrée des pratiques de ce groupe professionnel révèle divers modes de prise en compte de la question humaniste par les acteurs d’un « système pénitentiaire » souvent considéré comme dominé par « l’impératif sécuritaire ». Quant à l’analyse de leurs discours, elle permet de rendre compte du positionnement particulier de nombreux directeurs de prison vis-à-vis de leur administration (collectivement, via les syndicats et associations de directeurs, ou individuellement, via les médias et autres publications) et vis-à-vis de l’institution judiciaire (juges d’instruction, tribunaux de l’application des peines, Conseil d’Etat). Notre contribution repose sur deux enquêtes réalisées au cours des trois dernières années auprès de directeurs belges (n = 32) et français (n = 20). Les degrés de hiérarchisation et de judiciarisation des contextes de travail des directeurs varient au sein des ces deux pays et déterminent, en partie, les modalités d’interaction quotidienne des directeurs en détention (avec les détenus, les services psychosociaux, les surveillants, etc.) et autour de la détention (avec l’administration centrale, le TAP, la justice, les associations diverses, etc.). Il s’agira de saisir et de rendre visible la dimension humaniste du travail des directeurs, tant au niveau de leurs pratiques (cultures professionnelle et organisationnelle) que de leurs discours professionnels (logiques de justification). En effet, ce qu’ils qualifient, par exemple, d’ « empathie », d’ « intensité des relations », de « recherche du sens de leur travail » et de « sens de la peine », semblent orienter leur travail dans des marges qu’il conviendra de préciser. [less ▲]

Detailed reference viewed: 75 (6 ULiège)
See detailL'humanisme face au terrorisme
Seron, Vincent ULiege

in Cahiers de défense sociale (2000)

Detailed reference viewed: 122 (9 ULiège)
See detailHumanisme pratique et antihumanisme théorique
Delruelle, Edouard ULiege

Article for general public (2012)

Detailed reference viewed: 28 (1 ULiège)
See detailHumanisme, classicisme et tradition dans la vie et l’œuvre d’Arsène Soreil
Delhalle, Nancy ULiege

in La Vie Wallonne (1989), 405-406

Detailed reference viewed: 27 (3 ULiège)
See detailL'humanisme, inutile et incertain? Une critique des droits de l'homme
Delruelle, Edouard ULiege

Book published by Labor (1999)

Detailed reference viewed: 96 (1 ULiège)
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See detailHumanitarian aid and health services in Eastern Kivu, Zaïre: collaboration or competition
Goyens, Philippe; Porignon, Denis ULiege; Mugisho Soron'Gane, Etienne et al

in Journal of Refugee Studies (1996), 9(3), 268-280

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean ... [more ▼]

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean health services in the health districts of Rutshuru, Kirotshe and Masisi, in spite of the political and socioeconomic disintegration of the country, were still functioning, and the local hospitals and health centres, although overwhelmed, contributed to a large extent to the disaster response. Prominent among the major problems facing the local health services were their limited adaptability, the inadequate coordination and collaboration offered to them by the humanitarian aid agencies, and the discrimination between the direct and secondary victims of the emergency. The public health consequences of the Rwandan refugee crisis for the Zairean population constitute an integral part of the disaster. [less ▲]

Detailed reference viewed: 12 (1 ULiège)
See detailHumanité / animalité : quelles frontières
Servais, Véronique ULiege

Conference given outside the academic context (2015)

Detailed reference viewed: 22 (2 ULiège)
See detailLes humanités chrétiennes
Kurth, Godefroid ULiege

Speech/Talk (1901)

Detailed reference viewed: 44 (3 ULiège)
See detailLes humanités de demain
Kurth, Godefroid ULiege

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (1902)

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See detailHumanities 2.0. Document, interpretation and intersubjectivity in the digital age
Bénel, Aurélien; Lejeune, Christophe ULiege

in International Journal of Web-Based Communities (2009), 5(4), 562-576

With their focus on documents, interpretation and intersubjectivity, Web 2.0 technologies have surprising analogies with philosophical hermeneutics, the theory of texts interpretation. Philosophical ... [more ▼]

With their focus on documents, interpretation and intersubjectivity, Web 2.0 technologies have surprising analogies with philosophical hermeneutics, the theory of texts interpretation. Philosophical hermeneutics was generalised from biblical hermeneutics by Dilthey in the 19th century, and chosen as an alternative to positivism as a foundation for the epistemology and methodology of the humanities and social sciences. This article explores how Web 2.0 technologies might better meet the needs of social and human sciences than traditional information technologies that are historically bound with logical positivism. Illustrations are provided from archaeology and sociology, two social and human sciences which were early adopters of punched cards and computers. [less ▲]

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See detailHumanized mice as a useful model to study HIV-1 induced immune activation, its mechanisms and potential therapeutic approaches
Singh, Maneesh; Singh, Pratibha; VAIRA, Dolorès ULiege et al

in Retrovirology (2011, October 03), 8

Recent understanding of HIV-1 pathogenesis mechanism has changed our views about possible mechanisms of CD4T-cell depletion during infection. Apart from HIV-1-mediated killing a more comprehensive ... [more ▼]

Recent understanding of HIV-1 pathogenesis mechanism has changed our views about possible mechanisms of CD4T-cell depletion during infection. Apart from HIV-1-mediated killing a more comprehensive explanation has appeared that includes T cell exhaustion and chronic immune activation as a central feature in HIV-1 pathogenesis. While highly active antiretroviral therapy (HAART) markedly reduces viral load, T cell activation levels and soluble markers of inflammation remain abnormally high. Markers of chronic activation, such as CD38, PD-1 or HLA-DR on T cells, appear to be better predictors for clinical progression during HIV infection than HIV RNA levels and CD4Tcell counts alone. Therefore, a better understanding of HIV-índuced immune activation and the design of new immunomodulatory approches in combination with HAART are needed. We have generated an efficient model of human stem cells (HSCs) engraftment in NOD/LtsZ-scidlL-2Rnull (NSG) mice that supports chronic HIV infection with high plasma viral loads. HIV-1 infection in these humanized mice is characterized by widespread immune activation with increased expression of PD-1, HLA-DR, CD38, CD69, CD25 and other immune activation markers. These humanized mice provide an effective in vivo system for the assessing novel approaches for their potential in suppressing chronic immune activation during HIV-1 infection, in absence of interference of antiretroviral therapy. In this study, we evaluated in vivo the benefits of two novel approaches aimed at reducing HIV-induced immune activation. Minocycline is an antibiotic of the tetracycline family with anti-inflammatory and immunomodulatory properties affecting CD4 T cells activation by a mechanism involving the inhibition of the NF-AT1 transcription factor activity. We hypothesized that this antibiotic could suppress the HIV-1-induced chronic immune activation and thus, limit the HIV pathogenesis when combined to HAART. Therefore, we treated HIV-1 (JRCSF) infected-humanized NSG mice with minocycline (100mg/kg/day) for 60 days. We next evaluated the expression, by flow cytometry, of several T cells activation markers together with CD4+T cells counts. Our data suggest that minocycline is effective in suppressing HIV-1 induced immune activation in peripheral blood and lymphoid organs (spleen, lymph nodes and bone marrow). Levels of cellular immune activation markers such as PD-1, HLA-DR, CD38, CD69, CD25, CD28 and CTLA-4 were significantly lower in minocycline treated group. These immunological benefits of minocycline were correlated with higher CD4+T cell counts in the treated group. The immune activation which is associated with retroviral infection is also associated with increased levels of intracytoplasmic cyclic AMP which could act as a positive feedback loop in the infection since several reports have suggested that cAMP and downstream signaling pathways play an important role in the permissivity of susceptible cells to HIV infection and replication. We have used a peptide which prevents the binding of the catalytic subunit of PKA type I to its anchoring protein and therefore blocks most effects of cyclic AMP within lymphocytes and monocytes (RIAD peptide). Mice were treated with 3.5 mg/kg of RIAD peptide weekly. Treatment of humanized mice with RIAD peptide limited viral replication after high dose of HIV intraperitoneal challenge and reduced the intracytoplasmic levels of cyclic AMP. Further experiments are needed to better appreciate the therapeutic potential of these novel therapies in the suppression of HIV-induced chronic immune activation. [less ▲]

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See detailHumanizing the Clinical Gaze: Movies and the Empathic Understanding of Psychosis
Raballo, A.; Laroi, Frank ULiege; Bell, V.

in Family Medicine (2009), 41(6), 387-388

Detailed reference viewed: 27 (1 ULiège)