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See detailLes mirages gravitationnels
Surdej, Jean ULg; Surdej, Anna ULg

Article for general public (2000)

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See detailMircea Eliade et la pensée mythique au Paléolithique supérieur
Noiret, Pierre ULg

in Arheologia Moldovei (2013), XXXVI

Avec le Paléolithique supérieur, de nombreuses données éclairent les fonctions symboliques. Au-delà des seules activités techniques, il est possible de restituer certains éléments d’une pensée mythique ... [more ▼]

Avec le Paléolithique supérieur, de nombreuses données éclairent les fonctions symboliques. Au-delà des seules activités techniques, il est possible de restituer certains éléments d’une pensée mythique, analogue à celle décrite par les ethnologues ou les historiens des religions. Leur étude ne permet pas de retrouver les mythes racontés, mais bien d’envisager lucidement leur nature et leur rôle fondamental pour le fonctionnement des sociétés paléolithiques. Dans les années 1990, la découverte de la grotte Chauvet a remis en cause l’évolution linéaire de l’art pariétal établie par André Leroi-Gourhan. La découverte récente de peintures très similaires en Roumanie, dans la grotte de Coliboaia, permet de compléter l’approche des phases initiales de cet art. Les similitudes entretenues entre les images de ces deux grottes poussent à retourner vers la notion de mythe. [less ▲]

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See detailLe mirmillon et le rétiaire ou comment concilier la domanialité publique et l'urbanisme
Pâques, Michel ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006)

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See detailmiRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients
Zadran, Sohila; Remacle, Françoise ULg; Levine, R. D.

in Proceedings of the National Academy of Sciences (2013), 110(47), 19160-19165

Toward identifying a cancer-specific gene signature we applied surprisal analysis to the RNAs expression behavior for a large cohort of breast, lung, ovarian, and prostate carcinoma patients. We ... [more ▼]

Toward identifying a cancer-specific gene signature we applied surprisal analysis to the RNAs expression behavior for a large cohort of breast, lung, ovarian, and prostate carcinoma patients. We characterize the cancer phenotypic state as a shared response of a set of mRNA or microRNAs (miRNAs) in cancer patients versus noncancer controls. The resulting signature is robust with respect to individual patient variability and distinguishes with high fidelity between cancer and noncancer patients. The mRNAs and miRNAs that are implicated in the signature are correlated and are known to contribute to the regulation of cancer-signaling pathways. The miRNA and mRNA networks are common to the noncancer and cancer patients, but the disease modulates the strength of the connectivities. Furthermore, we experimentally assessed the cancer-specific signatures as possible therapeutic targets. Specifically we restructured a single dominant connectivity in the cancer-specific gene network in vitro. We find a deflection from the cancer phenotype, significantly reducing cancer cell proliferation and altering cancer cellular physiology. Our approach is grounded in thermodynamics augmented by information theory. The thermodynamic reasoning is demonstrated to ensure that the derived signature is bias-free and shows that the most significant redistribution of free energy occurs in programming a system between the noncancer and cancer states. This paper introduces a platform that can elucidate miRNA and mRNA behavior on a systems level and provides a comprehensive systematic view of both the energetics of the expression levels of RNAs and of their changes during tumorigenicity. [less ▲]

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See detailmiRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization.
Valencia, Karmele; Luis-Ravelo, Diego; Bovy, Nicolas ULg et al

in Molecular oncology (2014), 8(3), 689-703

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a ... [more ▼]

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a process which entails reciprocal exchange of soluble signals between tumor cells and their osseous microenvironment. Recent evidence indicates that tumor-intrinsic miRNAs are pleiotropic regulators of gene expression. But they are also frequently released in exosome-like vesicles (ELV). Yet the functional relevance of the transference of tumor-derived ELV and their miRNA cargo to the extracellular milieu during osseous colonization is unknown. Comparative transcriptomic profiling using an in vivo murine model of bone metastasis identified a repressed miRNA signature associated with high prometastatic activity. Forced expression of single miRNAs identified miR-192 that markedly appeased osseous metastasis in vivo, as shown by X-ray, bioluminescence imaging and microCT scans. Histological examination of metastatic lesions revealed impaired tumor-induced angiogenesis in vivo, an effect that was associated in vitro with decreased hallmarks of angiogenesis. Isolation and characterization of ELV by flow cytometry, Western blot analysis, transmission electron microscopy and nanoparticle tracking analysis revealed the ELV cargo enrichment in miR-192. Consistent with these findings, fluorescent labeled miR-192-enriched-ELV showed the in vitro transfer and release of miR-192 in target endothelial cells and abrogation of the angiogenic program by repression of proangiogenic IL-8, ICAM and CXCL1. Moreover, in vivo infusion of fluorescent labeled ELV efficiently targeted cells of the osseous compartment. Furthermore, treatment with miR-192 enriched ELV in a model of in vivo bone metastasis pre-conditioned osseous milieu and impaired tumor-induced angiogenesis, thereby reducing the metastatic burden and tumor colonization. Changes in the miRNA-cargo content within ELV represent a novel mechanism heavily influencing bone metastatic colonization, which is most likely relevant in other target organs. Mechanistic mimicry of this phenomenon by synthetic nanoparticles could eventually emerge as a novel therapeutic approach. [less ▲]

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See detailMiroir interne déformant de l'image de soi : élaboration conceptuelle intégrant la clinique et les découvertes récentes des neurosciences
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est ... [more ▼]

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est différent de celui qui permet au sujet de donner des attributs à d'autres individus. Le réseau référé au self permet d'être en contact immédiat avec l'image et la connaissance de soi. De plus, le rappel mnésique des attributs positifs et négatifs référés au self met en jeu des réseaux neuronaux différents. Les attributs positifs référés au self activent la région préfrontale antéromédiane droite, les attributs négatifs référés au self la région préfrontale dorsolatérale droite. Le sujet sain active les deux réseaux de façon simultanée pour restituer une image de soi intégrée. Définition conceptuelle: Le "miroir interne" – distingué de l'objet qui lui est présenté – correspond¬ au réseau neuronal référé spécifiquement au self. Ce réseau accède à l'image de soi. S'il y a un dysfonctionnement du réseau référé au self, il restitue une image déformée de soi, et le "miroir interne" devient déformant. Le sujet associera son identité à cette image déformée. Clinique du «miroir interne déformant de l'image de soi» : Le regard de l'enfant sur lui-même lui renvoie une image plus négative que ce que ses interlocuteurs ne perçoivent de lui. Dès le départ, l'enfant a une mauvaise perception de lui-même. Lorsqu'un interlocuteur lui fait une remarque, l'enfant bascule dans une image déformée et bien plus négative que celle que ne lui prête l'interlocuteur. Un dysfonctionnement de ces réseaux déséquilibre la balance et ne fait apparaître "qu'une seule couleur" dans le "miroir interne" par une restitution mnésique univoque : ou des attributs positifs, ou des attributs négatifs. Une prépondérance de l'image négative évoque un terrain dépressif, des personnalités évitante ou dépendante. Une prépondérance de l'image positive évoque des personnalités narcissiques, une image mégalomaniaque. Un dysfonctionnement neuronal peut induire une labilité et une instabilité de cette image (borderline), ou, une bascule rapide en "on-off" d'images positives et négatives de soi (rencontrée en pédopsychiatrie). Une psychoéducation permet la prise de conscience de ce miroir interne déformant. [less ▲]

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See detailLe miroir magique. Voyageurs français du 19e siècle face à face avec Rembrandt
Andringa, Kim ULg

in Revue de Littérature Comparée (2007)

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See detailLe miroitement des mots
Verbeeck, Muriel ULg; Buyle, Marjan

in Buyle, Marjan (Ed.) Lustre et brillance en conservation-restauration - Glans in de conservait-restauratie (2014)

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See detailMirum dictu : les appositions de phrase chez les historiens latins
Longrée, Dominique ULg

in Bodelot, Colette (Ed.) "Éléments « asyntaxiques » ou hors structure dans l'énoncé latin" (2007)

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See detail(Mis)communicatie en reclametaal
Vromans, Joseph ULg

in Van Riel, C. (Ed.) Vormen en oorzaken van miscommunicatie (1980)

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See detail(Mis)communicatie en reclametaal: mogelijkheden binnen de perken
Vromans, Joseph ULg

in Riel, C. van (Ed.) Vormen en oorzaken van miscommunicatie (1980, September 12)

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See detailThe misattribution model of hallucinations: Metacognitive beliefs and hallucinations
Varese, Fillipo; Laroi, Frank ULg

in Jardri, Renaud (Ed.) The Neuroscience of Hallucinations (2012)

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See detailMiscellanea palaeontologica
Gerrienne, Philippe ULg; Petus, Elodie ULg; Steemans, Philippe ULg

Book published by Paléogéobio. Paléobot. Paléopalyno. (2009)

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See detailMiscellanea palaeontologica 2010
Gerrienne, Philippe ULg; Steemans, Philippe ULg

Book published by Paléogéobio. Paléobot. Paléopalyno. (2010)

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See detailMiscellanea Palaeontologica 2011
Steemans, Philippe ULg; Gerrienne, Philippe ULg

Book published by Paléogéobio. Paléobot. Paléopalyno. (2011)

Résumés des communications de la journée MVP-PPMB du 30 novembre 2011.

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See detailLes miscellanées de Jacques Plowert ou le lexique comme style.
Saint-Amand, Denis ULg

in Revue d'Études Françaises (2011), 16

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See detailMiscellaneous and Experimental Agents
Reginster, Jean-Yves ULg

in American Journal of the Medical Sciences (The) (1997), 313(1), 33-40

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally ... [more ▼]

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally demonstrated full prevention of the appearance or the recurrence of axial or peripheral fractures so far, many investigational compounds are being developed. Anabolic steroids act mainly as inhibitors of bone resorption with very few, if any, effects on bone formation. Because of the high occurrence of signs of virilization and the weak effects on bone structure, the risk/benefit ratio in osteoporosis should be considered at least problematic. If ongoing large-scale trials confirm the expected benefits of estrogen antagonist/agonists on the skeleton and confirm no cardiovascular risk to postmenopausal women with optimal uterine safety, these substances are likely to become the most prominent alternative to hormonal replacement therapy after the menopause. Additional studies are requested to evaluate the potential benefit of growth hormone or insulin-like growth factors in treatment of osteoporosis. Ipriflavone acts predominantly as an inhibitor of bone resorption. To confirm the efficacy of ipriflavone on the prevention of vertebral fractures and its effects on bone mineral density in women with postmenopausal established osteoporosis, a large multicentric European study is being conducted. Treatment with parathyroid peptides induces a significant gain in bone mass, mainly in the axial skeleton. Long-term studies that compare peptides, doses, and regimes are needed to better understand the exact position of parathyroid peptides as treatment of osteoporosis. Prolonged administration of strontium to postmenopausal osteoporotic women resulted in a decoupling between bone resorption and formation that yielded a significant increase in the lumbar spine bone mineral density of treated subjects. In the view of these promising results and of the excellent tolerance of strontium during preliminary trials, additional investigations of this compound in prevention and treatment of osteoporosis should be promptly initiated. Several other compounds have been punctually suggested for treatment of osteoporosis or are at very early stages of development. Finally, besides pharmacologic approaches to the treatment of osteoporosis, hip fractures may also be reduced by the use of hip protectors. [less ▲]

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See detailMiscellaneous spectroscopic observations of quasars and quasar candidates
Veron, P.; Veron-Cetty, M.-P.; Djorgovski, S. et al

in Astronomy and Astrophysics. Supplement Series (1990), 86

Spectroscopic observations are presented for 11 quasar candidates, as well as 19 quasars with uncertain redshift, three BL Lac candidates, and 11 objects located within a few arcsec of a quasar. The ... [more ▼]

Spectroscopic observations are presented for 11 quasar candidates, as well as 19 quasars with uncertain redshift, three BL Lac candidates, and 11 objects located within a few arcsec of a quasar. The spectra indicate than nine of the 11 quasar candidates are stars, while the remaining two are low-redshift galaxies. The individual objects studied and commented on include KPNO 1, CFHT 2, Q 0010+023, UM 232, UM 473, WEE 124, UM 644, PKS 1514+197, MC3 1639+155, and WEE 185. [less ▲]

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See detailMiscibility of poly(vinylidene fluoride) and poly(methylmethacrylate-co-zinc polyacrylate) ionomers
Moussaif, Noureddin; Jérôme, Robert ULg

in Polymer (1999), 40(24), 6831-6839

A random copolymer of methyl methacrylate and 5.7 mol.% of acrylic acid has been neutralized by zinc cation to different extents in order to study the effect of zinc carboxylate pendant groups on the ... [more ▼]

A random copolymer of methyl methacrylate and 5.7 mol.% of acrylic acid has been neutralized by zinc cation to different extents in order to study the effect of zinc carboxylate pendant groups on the miscibility of poly(methyl methacrylate) (PMMA) and poly(vinylidene fluoride) (PVDF). The interaction parameter (χ) has been calculated from the experimental depression of the PVDF melting point. χ is minimum at zinc carboxylate content of 2.8 mol.%. The dynamic mechanical analysis of the PVDF-PMMA ionomer binary blends does not agree with the additivity rule of the properties, consistently with the phase morphology that changes with composition. Blends are indeed amorphous as long as the PVDF content does not exceed 40 wt.%, otherwise, semicrystalline PVDF coexists with an amorphous mixed PVDF/copolymer phase. [less ▲]

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