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See detailL'apocalisse incolore. Saggio su "Petrolio".
Fichera, Gabriele ULg

in Parol. Quaderni d'arte e d'epistemologia (2012), 22

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See detailApolipoprotein L-1 Promotes Trypanosome Lysis By Forming Pores In Lysosomal Membranes
Perez-Morga, David; Vanhollebeke, Benoit; Paturiaux-Hanocq, Françoise et al

in Science (2005), 309(5733), 469-72

Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a ... [more ▼]

Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing domain. In lipid bilayer membranes, apolipoprotein L-I formed anion channels. In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed. [less ▲]

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See detailApolipoprotein L-I is the trypanosome lytic factor of human serum.
Vanhamme, Luc; Paturiaux-Hanocq, Francoise; Poelvoorde, Philippe et al

in Nature (2003), 422(6927), 83-7

Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS ... [more ▼]

Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS). Resistance to NHS is conferred by a gene that encodes a truncated form of the variant surface glycoprotein termed serum resistance associated protein (SRA). We show that SRA is a lysosomal protein, and that the amino-terminal alpha-helix of SRA is responsible for resistance to NHS. This domain interacts strongly with a carboxy-terminal alpha-helix of the human-specific serum protein apolipoprotein L-I (apoL-I). Depleting NHS of apoL-I, by incubation with SRA or anti-apoL-I, led to the complete loss of trypanolytic activity. Addition of native or recombinant apoL-I either to apoL-I-depleted NHS or to fetal calf serum induced lysis of NHS-sensitive, but not NHS-resistant, trypanosomes. Confocal microscopy demonstrated that apoL-I is taken up through the endocytic pathway into the lysosome. We propose that apoL-I is the trypanosome lytic factor of NHS, and that SRA confers resistance to lysis by interaction with apoL-I in the lysosome. [less ▲]

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See detailApolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.
Helgadottir, Anna; Gretarsdottir, Solveig; Thorleifsson, Gudmar et al

in Journal of the American College of Cardiology (2012), 60(8), 722-9

OBJECTIVES: The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND ... [more ▼]

OBJECTIVES: The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND: It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. METHODS: The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (n(e) = 4,572); venous thromboembolism (n(e) = 4,607); intracranial aneurysm (n(e) = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). RESULTS: LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 x 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). CONCLUSIONS: LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. [less ▲]

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See detailApollinaire et la rime (deuxième partie)
Purnelle, Gérald ULg

in Apollinaire (2013), 13

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See detailApollinaire et la rime (première partie)
Purnelle, Gérald ULg

in Apollinaire (2012), 12

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See detailApollinaire poète en prose
Delbreil, Daniel; Purnelle, Gérald ULg

Book published by Calliopées (2014)

Au début du 20e siècle, la poésie éprouve la tentation de la prose : nombre de poètes, lassés par des formes qu'ils jugent épuisées ou obsolètes, cherchent des voies nouvelles hors des vers et se font ... [more ▼]

Au début du 20e siècle, la poésie éprouve la tentation de la prose : nombre de poètes, lassés par des formes qu'ils jugent épuisées ou obsolètes, cherchent des voies nouvelles hors des vers et se font prosateurs. Apollinaire est de ceux-là. Les études réunies ici s'attachent à montrer de quelle façon il nous invite à admettre que la poésie trouve aussi bien sa place entre vers et prose que dans des formes scripturales et graphiques nouvelles, d'une hybridité déroutante (ni pleinement prose, ni pleinement vers, ou mi-prose, mi-vers) ou encore s'inscrit, comme le calligramme, dans la dimension spatiale. Apollinaire, poète en prose et inventeur de formes, apparaît ainsi comme étant toujours en quête d'un langage et d'un lyrisme neufs jusqu'à perdre le vers : "Perdre Mais perdre vraiment Pour laisser place à la trouvaille". [less ▲]

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See detailApollo 13. Jos de Haes en het reële van zijn verlangen
Spinoy, Erik ULg

in De Haes, Jos (Ed.) Gedichten (2004)

This is a rereading of the poetry of the Flemish poet Jos de Haes, the author of a limited body of work which, notwithstanding, had great influence in postwar Flemish poetry.

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See detailApollo op vrijersvoeten. een onderzoek naar de thematische coherentie in de Verzamelde verhalen van Simon Vestdijk
Nachtergaele, Lutgarde ULg

Book published by Editions Peeters (1996)

study of the thematical coherence in the short stories written by Simon Vestdijk (1898-1971)

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See detailApologie et Comédie chez Platon: essai de reconstitution croisée (Nuées, Apologie de Socrate et Théétète)
Gavray, Marc-Antoine ULg

in Revue Philosophique de la France et de l'Etranger (2007), 132(2, APR-JUN), 131

In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes' Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology ... [more ▼]

In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes' Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology for him, as well in the Theaetetus, that answers the charges in the comedy against Protagoras, becoming in a certain way his << lawyer >>. But why and what for ? Analysing the concepts of geloion and comic mimesis, we show how Plato undertakes to give a philosophical reading of Protagoras' thought, which, in the same time, constitutes a critical thinking about the object of comedy. [less ▲]

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See detailApomorphine-induced conditioned sensitization and differential habituation to environmental novelty
Tirelli, Ezio ULg; Heidbreder, C.

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (1998), 23

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See detailL'Apophyse du massif stratiforme de Bjerkreim-Sokndal (Rogaland, Norvège) : une intrusion composite de la suite charnockitique
Bolle, Olivier ULg

in Demaiffe, Daniel (Ed.) Petrology and Geochemistry of magmatic suites of rocks in the continental and oceanic crusts (1996)

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See detailL'apoprotéine E et ses implications
Chapelle, Jean-Paul ULg; Férir, A. M.

Conference (1996, March 21)

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See detailL’apoptose mammaire dans le sein normal et en pathologie
DESREUX, Joëlle ULg; GOFFIN, Frédéric ULg; BELIARD, Aude ULg et al

in Références en Gynécologie Obstétrique (1999), 6

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See detailApoptosis and cytolysis induced by giganteosides and hederacolchisides in HL-60 cells
Gerkens, Pascal; Dobson, Rowan ULg; tabatadze, Nino et al

in Anticancer Research (2007), 27

The viability, cytolysis and apoptosis-mediated cellular death induced by giganteosides D and E (Gig-D and Gig-E) and hederacolchisides A and A1 (Hcol-A and Hcol- A1) were analysed in HL-60 cells ... [more ▼]

The viability, cytolysis and apoptosis-mediated cellular death induced by giganteosides D and E (Gig-D and Gig-E) and hederacolchisides A and A1 (Hcol-A and Hcol- A1) were analysed in HL-60 cells. Materials and Methods: the end-point metabolic (WST1) and lactate dehydrogenase (LDH) assays were used. Cell cycle analysis and apoptosis were measured by flow cytometry, DNA laddering and caspase 3 analyses. Results: the HL-60 cell line was more sensitive to Hcol-A1 and Gig-D (IC50 3-5 ÌM) than to Gig-E and Hcol-A (IC50 8-13 ÌM; WST1 assay). This was related to LDH release. The induction of apoptosis could be detected without caspase 3 activation after 24 h of treatment. DNA fragmentation could be detected only with Gig-D. With Hcol- A1 and Gig-D, an accumulation of cells in the S-phase and an increase of cells in sub-G1 peak were observed. By the annexinV-fluorescein isothiocyanate (FITC)/7-aminoactinomycin D (AAD) assay, the majority of cells were in late apoptosis with Gig-D, and in necrosis with Hcol-A1. Conclusion: Hcol-A1 is more cytotoxic than Gig-D, followed by Gig-E and finally Hcol-A. This is related to a membrane permeabilization effect, leading to cytolysis [less ▲]

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See detailApoptosis characterizes immunological failure of HIV infected patients
Mhawej, Marie-José; Brunet-Francois, Cécile; Fonteneau, Raphaël ULg et al

in Control Engineering Practice (2009), 17(7), 798-804

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are ... [more ▼]

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure. [less ▲]

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See detailApoptosis During the Development of Radiogenic Thymic Lymphomas: Effects of Treatments Inhibiting Lymphoma Development
Humblet, Chantal ULg; Denis, Ghislaine; Greimers, Roland ULg et al

in Anticancer Research (1998), 18(5A, Sep-Oct), 3469-74

INTRODUCTION: Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which preleukemic cells progressively transform into leukemic cells within an ... [more ▼]

INTRODUCTION: Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which preleukemic cells progressively transform into leukemic cells within an abnormal thymic microenvironment. A bone marrow graft or repeated cytokine injections prevent lymphoma development. We think that these treatments restore altered mechanisms controlling apoptosis. MATERIALS AND METHODS: Apoptosis was analyzed by flow cytometry in thymocytes from different groups of mice (control, preleukemic, prevented mice). RESULTS: The apoptotic rates did not change in freshly isolated thymocytes from different experimental groups. However, after culture, the level of apoptosis increased in preleukemic thymuses; and returned to normal value in cultured thymocytes from irradiated mice after lymphoma preventing treatments. Furthermore, thymic microenvironmental factors can control thymocyte apoptosis. CONCLUSION: We propose that after leukemogenic irradiation, there is an increase of cells with an activated suicide program, but that alterations of thymic environmental factors rescue them from apoptosis, allowing their further neoplastic transformation. [less ▲]

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