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See detailImpact of cooking and species on intestinal fermentation patterns of vegetables in a humanized in vitro model of the gastro-intestinal tract
Kalala Bolokango, Gaetan ULg; Kambashi Mutiaka, Bienvenu ULg; Njeumen Lemotio, Georges Patrick ULg et al

Poster (2016, June 21)

Obesity and associated pathologies have dramatic consequences on patients’lives as well as high societal costs. Because of the role of intestinal dysbiosis and microbiota make-up on the pathogenesis of ... [more ▼]

Obesity and associated pathologies have dramatic consequences on patients’lives as well as high societal costs. Because of the role of intestinal dysbiosis and microbiota make-up on the pathogenesis of obesity, several strategies such as eating prebiotics and dietary fibre supplements are being investigated to reshape the intestinal microbial communities of obese patients. Beyond supplement, dietary fibre is supplied through plant ingredients in the meals. In the framework of the multidisciplinary research project Food4Gut, the use of vegetables rich in specific targeted dietary fiber, namely fructans, is being scrutinized for its ability to induce positive changes in the intestinal ecophysiology. Because expected effect might differ according the content in dietary fibre and fructans, the soluble:insoluble ratio, as well as the cooking of the vegetables, the fermentation patterns of several vegetables are being investigated in an dual in vitro model combining enzymatic hydrolysis to an in vitro fermentation step using faecal inoculums from humans, to evaluate the performance of gut microbiota, modulation of metabolic functions. Six vegetables were sampled in triplicates (N=3) and steamed for 20 to 30 min.: Jerusalem artichoke, salsify, asparagus, pumpkin, fennel and swede. They were chosen because they display a variety of contents in fructans, soluble (SDF) and insoluble dietaryfibre (IDF). Steamed vegetable samplesand burgers from local fast food restaurants (negative control) were hydrolyzed in vitro why porcine pepsin and pancreatin to mimic digestion in the upper gut and indigested fiber residues were recover using a 6kDa dialysis membrane.Subsequently, in vitro fermentation is being run with independent fecal inoculums from obese and lean patients (N=4). Fermentation kinetics over 24h as well as short-chain fatty acid production and profiles will be compared according to the individual donor and the vegetable species and multivariate analysis will be used to explore the relationships between donor, vegetable species and composition and fermentation patterns. [less ▲]

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See detailImpact of cord blood banking technologies on clinical outcome: a Eurocord/Cord Blood Committee (CTIWP), European Society for Blood and Marrow Transplantation and NetCord retrospective analysis
Saccardi, Riccardo; Tucunduva, Luciana; Ruggeri, Annalisa et al

in Transfusion (2016), 56(8), 2021-2029

BACKGROUND Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without ... [more ▼]

BACKGROUND Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without altering the biologic properties of the graft. A large-scale, registry-based assessment of the impact of the banking variables on the clinical outcome is currently missing. STUDY DESIGN AND METHODS A total of 677 single cord blood transplants (CBTs) carried out for acute leukemia in complete remission in centers affiliated with the European Society for Blood and Marrow Transplantation were selected. An extensive set of data concerning CBU banking were collected and correlations with clinical outcome were assessed. Clinical endpoints were transplant-related mortality, engraftment, and graft-versus-host disease (GVHD). RESULTS The median time between collection and CBT was 4.1 years (range, 0.2-16.3 years). Volume reduction (VR) of CBUs before freezing was performed in 59.2% of available reports; in half of these the frozen volume was less than 30 mL. Cumulative incidences of neutrophil engraftment on Day 60, 100-day acute GVHD (II-IV), and 4-year chronic GVHD were 87, 29, and 21 ± 2%. The cumulative incidence of nonrelapse mortality (NRM) at 100 days and 4-year NRM were, respectively, 16 ± 2 and 30 ± 2%. Neither the variables related to banking procedures nor the interval between collection and CBT influenced the clinical outcome. CONCLUSION These findings indicate a satisfactory validation of the techniques associated with CBU VR across the banks. Cell viability assessment varied among the banks, suggesting that efforts to improve the standardization of CBU quality controls are needed. [less ▲]

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See detailThe impact of corporate disclosures on information asymmetry and stock-market liquidity in France
Sougné, Danielle ULg; Ajina, Aymen ULg

Conference (2011, May 30)

This paper aims at studying the effect of the extent of disclosure on information asymmetry and stock-market liquidity in France. Our sample includes196 French listed firms over a period ranging from 2004 ... [more ▼]

This paper aims at studying the effect of the extent of disclosure on information asymmetry and stock-market liquidity in France. Our sample includes196 French listed firms over a period ranging from 2004 to 2007, the results show that the extent of disclosure in annual reports positively influence the liquidity of the French market. This is explained by the negative effect of the disclosure on the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. This result should encourage French authorities to further improve their information environment as essential to reduce the costs of asymetric information and prevent the risk of illiquidity. [less ▲]

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See detailImpact of cotransplantation of mesenchymal stem cells on lung function after unrelated allogeneic hematopoietic stem cell transplantation following non-myeloablative conditioning
MOERMANS, Catherine ULg; LECHANTEUR, Chantal ULg; BAUDOUX, Etienne ULg et al

in Transplantation (2014), 98(3), 348-353

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal ... [more ▼]

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal models, MSC were shown to cause pulmonary alterations after systemic administration. The impact of MSC infusion on lung function has not been studied in humans. The objective of the study was to investigate the impact of MSC co-infusion on lung function and airway inflammation as well as on the incidence of pulmonary infections and cytomegalovirus (CMV) reactivation after HSCT. Methods: We have prospectively followed 30 patients who underwent unrelated HSCT with MSC co-infusion after non-myeloablative conditioning (NMA). Each patient underwent detailed lung function testing (FEV1, FVC, FEV1/FVC, RV, TLC, DLCO and KCO) and measurement of exhaled nitric oxide before HSCT and 3, 6 and 12 months posttransplant. The incidence of pulmonary infections and CMV reactivation were also monitored. This group was compared with another group of 28 patients who underwent the same type of transplantation but without MSC co-infusion. Results: Lung function tests did not show important modifications over time and did not differ between the MSC and control groups. There was a higher 1-year incidence of infection, particularly of fungal infections, in patients having received a MSC co-infusion. There was no difference between groups regarding the 1-year incidence of CMV reactivation. Conclusions: MSC co-infusion does not induce pulmonary deterioration 1 year after HSCT with NMA conditioning. MSC appear to be safe for the lung but close monitoring of pulmonary infections remains essential. [less ▲]

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See detailThe impact of countries of origin on civic participation in the host countries
Gsir, Sonia ULg

Scientific conference (2014)

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See detailThe impact of countries of origin on social interaction in the host countries
Gsir, Sonia ULg

Scientific conference (2014)

Detailed reference viewed: 13 (0 ULg)
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See detailIMPACT OF COVER CROP AND CROP RESIDUE MANAGEMENT ON CROP PRODUCTION
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2013, July 03)

The aim of this project is to study the crop development in relation to soil tillage and organic residue management and to understand its impact on crop production but also on the dynamics of weed ... [more ▼]

The aim of this project is to study the crop development in relation to soil tillage and organic residue management and to understand its impact on crop production but also on the dynamics of weed populations and intensity of fungal diseases occurring on the crops. Various cropping systems with different tillage methods dedicated to bury the residues from the previous crop and/or from the intercropping and to prepare the implantation of following crop are studied. [less ▲]

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See detailIMPACT OF COVER CROP MANAGEMENT ON CROP PRODUCTION: A FIELD EXPERIMENT IN WALLONIA CONTEXT
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2014, February)

Minimal soil tillage methods, crop rotation, cover crop and continuous plant residue cover are the main pillars of sustainable agriculture. Lower energy consumption, costs and time are some direct ... [more ▼]

Minimal soil tillage methods, crop rotation, cover crop and continuous plant residue cover are the main pillars of sustainable agriculture. Lower energy consumption, costs and time are some direct benefits in favor to the adaptation of this agriculture. This practices aims also directly at protecting the soil from wind and water erosion by covering the soil. Lower disruption of the soil aims at developping the micro- and macro-fauna activity that increases soil fertility and carbon and nitrogen sequestration in soils. Unfortunately, some of the great constraints to the adaptation of conservation agriculture remain weed management, fungal diseases and pest management, that has been shown to be a problem in non-ploughed fields. The aim of our study is to evaluate, on a same field (Wallonia context), contrasted tillage methods for managing the cover crop and the implantation of the main crop. The following measurements were taken: germination rate, root and shoot biomass development, root notation (size and shape), leaf area index and quality of harvested product. Preliminary results indicate that the different tillage methods did not have a significant impact on crop production or development. However changes in germination dynamics were observed, the reduced tillage inducing slower germination. Regarding weeds populations, some difference were observed in weed occurrences. Since a field exp [less ▲]

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See detailImpact of cristallinity index on the stability and physical properties of inulin during moisture uptake.
Ronkart, Sébastien; Paquot, Michel ULg; Fougnies, C. et al

Poster (2008, April)

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See detailImpact of crops on biomass and soil carbon: steady state simulations
Nemry, B.; François, Louis ULg; Gérard, Jean-Claude ULg et al

in Cramer, W.; Doherty, R.; Hulme, M. (Eds.) et al Climate Scenarios for Agricultural, Forest and Ecosystem Impacts (2000)

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See detailImpact of cultivation practices on soil respiration
Dufranne, Delphine ULg; Vancutsem, Françoise ULg; Bodson, Bernard ULg et al

Poster (2012, February 08)

In addition to its, evident, food supply function, agriculture is subjected to various pressures and has to respond to many challenges like reducing its CO2 emissions, maintaining or improving the soil ... [more ▼]

In addition to its, evident, food supply function, agriculture is subjected to various pressures and has to respond to many challenges like reducing its CO2 emissions, maintaining or improving the soil quality, maintaining productivity, sequestrating of the carbon stock in soil... Cultivation practices are known to induce a modification of soil organic matter quantity, quality and spatial distribution, which may impact dry matter decomposition kinetics. In order to bring answers to these questions, a multidisciplinary project (SOLRESIDUS) was set up by the University of Liege, Gembloux Agro-Bio Tech in collaboration with Walloon Agricultural Research Centre (CRA-W). The aim was to investigate the impact of cultivation practices (tillage and residue restitution) on crop growth, yield and environment, as well as on soil properties and on activities. In the present study, we focused on the impacts on soil CO2 fluxes. The experimental site is situated in Gembloux, in the Belgian loamy region. The plot is divided into 4 latin squares where two tillage modalities (plough after 2 stubble breaking vs only 2 stubble breaking) and two straw management practices (restitution vs. exportation) were compared. For 3 years, soil respiration was measured with automatic and manual dynamic soil chambers. Moreover, soil respiration was measured as well in cropping zone (total respiration) as in root exclusion zones created with root exclusion cylinders (heterotrophic respiration). As first results, we observed: -a significantly higher flux in plots with residue restitution, which is clearly explained by the larger amount of organic carbon prone to decomposition; -a decrease of standardized heterotrophic respiration (linked with residue decomposition) during growing seasons; -no significant differences in soil respiration between tillage modalities after 3 growing seasons. The experiment is still in progress, more years being necessary in order to evaluate the long-term impacts of cultivation practices on soil respiration. [less ▲]

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See detailImpact of cultivation practices on soil respiration
Dufranne, Delphine ULg; Vancutsem, Françoise ULg; Bodson, Bernard ULg et al

Poster (2012, February 10)

Cultivation practices are known to induce a modification of soil organic matter quantity, quality and spatial distribution, which may impact dry matter decomposition kinetics. In order to bring answers to ... [more ▼]

Cultivation practices are known to induce a modification of soil organic matter quantity, quality and spatial distribution, which may impact dry matter decomposition kinetics. In order to bring answers to these questions, a multidisciplinary project (SOLRESIDUS) was set up by the University of Liege, Gembloux Agro-Bio Tech in collaboration with Walloon Agricultural Research Centre (CRA-W). The aim was to investigate the impact of cultivation practices (tillage and residue restitution) on crop growth, yield and environment, as well as on soil properties and on activities. In the present study, we focused on the impacts on soil respiration soil for 3 years. We will present our first results. [less ▲]

Detailed reference viewed: 36 (10 ULg)
See detailThe Impact of Cultural Values on Customer Coping Responses After Service Failure
Van Vaerenbergh, Yves; De Keyser, Arne; Hazee, Simon ULg

Scientific conference (2015, March)

Detailed reference viewed: 19 (1 ULg)
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See detailThe impact of culture on cognitive performance in neuropsychological tests.
Schmitz, Xavier ULg; Mardaga, Julie; Meulemans, Thierry ULg

Poster (2009, September 17)

Detailed reference viewed: 33 (7 ULg)
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See detailImpact of cutting frequency on the vigour of Rumex obtusifolius
Stilmant, Didier ULg; Bodson, Bernard ULg; Vrancken, C. et al

in Grass & Forage Science (2010), 65(2), 147-153

The control of Rumex obtusifolius, even with the use of herbicides, is difficult in permanent grasslands where R. obtusifolius reduces both productivity and nutritive value of herbage. It is important to ... [more ▼]

The control of Rumex obtusifolius, even with the use of herbicides, is difficult in permanent grasslands where R. obtusifolius reduces both productivity and nutritive value of herbage. It is important to find alternative approaches to managing R. obtusifolius. Two greenhouse experiments were conducted to compare the impact of different cutting frequencies, which simulated grazing (three cuts), silage making (two cuts) and hay making (one cut) on shoot and root measurements of the vigour of R. obtusifolius. In both experiments the same cutting frequencies were imposed but in Experiment 1 the treatments were imposed for 2 years and in Experiment 2 for 1 year. Compared to the silage-making and hay-making treatments, there was a reduction in the vigour of the aerial parts of R. obtusifolius on the grazing treatment, associated with a reduction in the number of leaves (Experiment 1), in the size of the largest leaf (Experiment 1) and in the herbage mass of dry matter (Experiments 1 and 2). Roots had higher concentrations of total soluble sugar and lower concentrations of starch in the grazing treatment than in the other treatments. These results showed that a reduction in the vigour of R. obtusifolius in permanent grasslands is possible only if the plants are submitted to a high frequency of defoliation under cutting or grazing. [less ▲]

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See detailImpact of cyclic hypoxia on HIF-1a regulation in endothelial cells: new insights for anti-tumor treatments
Martinive, Philippe ULg

in FEBS Journal (2008)

Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells - new insights for anti-tumor treatments.Martinive P, Defresne F, Quaghebeur E, Daneau G, Crokart N, Grégoire V, Gallez B, Dessy C ... [more ▼]

Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells - new insights for anti-tumor treatments.Martinive P, Defresne F, Quaghebeur E, Daneau G, Crokart N, Grégoire V, Gallez B, Dessy C, Feron O. Unit of Pharmacology and Therapeutics, Université catholique de Louvain, Brussels, Belgium. Heterogeneities in tumor blood flow are associated with cyclic changes in pO(2) or cyclic hypoxia. A major difference from O(2) diffusion-limited or chronic hypoxia is that the tumor vasculature itself may be directly influenced by the fluctuating hypoxic environment, and the reoxygenation phases complicate the usual hypoxia-induced phenotypic pattern. Here, we determined the cyclic hypoxia-driven pathways that modulate hypoxia inducible factor (HIF)-1alpha abundance in endothelial cells to identify possible therapeutic targets. We found that exposure of endothelial cells to cycles of hypoxia/reoxygenation led to accumulation of HIF-1alpha during the hypoxic periods and the phosphorylation of protein kinase B (Akt), extracellular regulated kinase (ERK) and endothelial nitric oxide synthase (eNOS) during the reoxygenation phases. We identified stimulation of mitochondrial respiration and activation of the phosphoinositide-3 kinase (PI3K)/Akt pathway during intervening reoxygenation periods as major triggers of the stabilization of HIF-1alpha. We also found that the NOS inhibitor nitro-l-arginine methyl ester further stimulated the cyclic hypoxia-driven HIF-1alpha accumulation and the associated gain in endothelial cell survival, thereby mirroring the effects of a PI3K/Akt inhibitor. However, combination of both drugs resulted in a net reduction in HIF-1alpha and a dramatic in decrease in endothelial cell survival. In conclusion, this study identified cyclic hypoxia, as reported in many tumor types, as a unique biological challenge for endothelial cells that promotes their survival in a HIF-1alpha-dependent manner through phenotypic alterations occurring during the reoxygenation periods. These observations also indicate the potential of combining Akt-targeting drugs with anti-angiogenic drugs, in particular those interfering with the NO pathway. PMID: 19077164 [PubMed - as supplied by publisher [less ▲]

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See detailImpact of cyclonic and anticyclonic activity on Greenland ice sheet surface mass balance variation during 1980–2013
Chen, L.; Fettweis, Xavier ULg; Knudsen, E. et al

in International Journal of Climatology (2016)

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective ... [more ▼]

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective, extratropical cyclones and anticyclones are the major systems influencing Greenland weather conditions. Seasonal cyclonic and anticyclonic activities have been quantified for the area of 50°–90°N, 80°W–10°E during 1980–2013. Based on a singular value decomposition (SVD) analysis, we investigated the role of synoptic scale cyclonic and anticyclonic activities in determining snow accumulation (SA) and surface air temperature (SAT). Thus, the SA-driven and melt-driven SMB variability has been determined. SA-related synoptic patterns identified from the leading and the second SVD modes explain up to 80% of the inter-annual SMB variance, especially in southern and northwestern Greenland, where we found the largest and second largest amount of annual SA. SAT-related patterns account for up to 80% of the inter-annual SMB variation along the west and northwest coast of Greenland, where significant surface mass loss has been observed over the last decades. It should be noted that the negative phase of the SA-related pattern derived from the first SVD mode in June-July-August and the positive phase of the SAT-related (anti)cyclonic patterns have occurred more frequently since 2005, meaning that the phase change of these patterns has made a major contribution to the accelerated GrIS surface ice loss during recent years. [less ▲]

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See detailImpact of Data Structure on the Estimators R-Square and adjusted R-Square in Linear Regression
Akossou, A. Y. J.; Palm, Rodolphe ULg

in International Journal of Mathematics and Computation (2013), 20(3), 84-93

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See detailImpact of delays on a consensus-based primary frequency control scheme for AC systems connected by a multi-terminal HVDC grid
Dai, Jing; Phulpin, Yannick; Sarlette, Alain ULg et al

in Proceedings of the 2010 IREP Symposium - Bulk Power Systems Dynamics and Control - VIII (2010, August)

This paper addresses the problem of sharing primary frequency control reserves among nonsynchronous AC systems connected by a multi-terminal HVDC grid. We focus on a control scheme that modifies the power ... [more ▼]

This paper addresses the problem of sharing primary frequency control reserves among nonsynchronous AC systems connected by a multi-terminal HVDC grid. We focus on a control scheme that modifies the power injections from the different areas into the DC grid based on remote measurements of the other areas’ frequencies. This scheme is proposed and applied to a simplified system in a previous work by the authors. The current paper investigates the effects of delays on the control scheme’s effectiveness. The study shows that there generally exists a maximum acceptable delay, beyond which the areas’ frequency deviations fail to converge to an equilibrium point. This constraint should be taken into account when commissioning such a control scheme. [less ▲]

Detailed reference viewed: 73 (9 ULg)