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Peer Reviewed
See detailMinimal brain damage: L'invention d'une maladie
Gauthier, Jean-Marie ULg; Van der Linden, Martial ULg

in Perspectives (1986), 7

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See detailMinimal cardiovascular system model including a physiological description of progressive mitral valve orifice dynamics for studying valve dysfunction
Paeme, Sabine ULg; Moorhead, Katerine; Chase, J. Geoffrey et al

in XXIIIrd congress of the International Society of Biomechanics, July 3-7, 2011 (2011, July)

This research presents a new closed-loop cardiovascular system model including a description of the progressive opening and closing dynamic of the mitral valve. Furthermore, this model includes a ... [more ▼]

This research presents a new closed-loop cardiovascular system model including a description of the progressive opening and closing dynamic of the mitral valve. Furthermore, this model includes a mathematical description of the left atrium. This new CVS model enables the study of valve dysfunction in the appropriate clinical context of the overall cardiac and circulatory hemodynamics. [less ▲]

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See detailminimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; chase, J. Geoffrey et al

in 9th Belgian National Day on Biomedical Engineering, Bruxelles, 26th november (2010, November 26)

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the ... [more ▼]

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the “open on pressure, close on flow” law. However, this model does not describe the progressive valve opening and therefore, it is not suitable for studying valve dysfunctions. [less ▲]

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See detailMinimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; Chase, J. Geoffrey et al

Poster (2010, November 26)

This research describes a new closed-loop cardiovascular system (CVS) model including a model of the left atrium and a model describing the progressive aperture of the mitral valve

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See detailMinimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats
Liégeois, Jean-François ULg; Bruhwyler, J.; Hendrick, J. C. et al

in Neuroscience Letters (2002), 319(1), 49-52

Antipsychotic therapy is frequently associated with several side effects such as hyperprolactinemia. The influence of a putative antipsychotic JL 13 on prolactin release was assessed after intraperitoneal ... [more ▼]

Antipsychotic therapy is frequently associated with several side effects such as hyperprolactinemia. The influence of a putative antipsychotic JL 13 on prolactin release was assessed after intraperitoneal injection in gentled male rats in comparison with clozapine and haloperidol. A total of 30 or 150 min after administration, whole blood was collected for preparing serum samples. Prolactin was quantified by radioimmunoassay method. At 30 min, JL 13 like clozapine, increased prolactin concentration only at the higher dose (30 mg/kg) while haloperidol at both tested doses induced a dramatic increase of prolactin concentration. At 150 min after injection, only haloperidol (0.3 mg/kg) significantly increased serum prolactin level. This minimal effect on prolactinemia reinforces the similarity of clozapine and JL 13 regarding the atypical antipsychotic profile. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailMinimal error rate of linear, quadratic and logistic rules in discriminant analysis
Glele Kakaï, R.; Palm, Rodolphe ULg

in Global Journal of Mathematical Sciences (2005), 4(1 & 2), 89-93

A simulation study has been used to evaluate the minimal error rate of three affectation rules and to compare five estimators of this error rate for two groups of observations, in 480 situations ... [more ▼]

A simulation study has been used to evaluate the minimal error rate of three affectation rules and to compare five estimators of this error rate for two groups of observations, in 480 situations characterized by the distribution and to the overlap of the populations, the number of variables, the sample size and the heteroscedasticity degree of the population under study. The results of this study suggest that the quadratic rule might be the best for heteroscedastic normal models. The linear rule showed better performance for homoscedastic normal or moderate non-normal models. The logistic rule is the best for severe non-normal models except when homoscedasticity occurs. As far as the comparison of five estimators is concerned, the results of the study indicate that eDS and eB are the best estimators of the minimal error rate for the linear rule, e5 for the quadratic rule and eD for the logistic rule. [less ▲]

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See detailThe Minimal Fusion Peptide Of Simian Immunodeficiency Virus Corresponds To The 11 First Residues Of Gp32
Lorin, A.; Lins, Laurence ULg; Stroobant, V. et al

in Journal of Peptide Science (2008), 14(4), 423-8

We had previously predicted successfully the minimal fusion peptides (FPs) of the human immunodeficiency virus 1 (HIV-1) gp41 and the bovine leukemia virus (BLV) gp30 using an original approach based on ... [more ▼]

We had previously predicted successfully the minimal fusion peptides (FPs) of the human immunodeficiency virus 1 (HIV-1) gp41 and the bovine leukemia virus (BLV) gp30 using an original approach based on the obliquity/fusogenicity relationship of tilted peptides. In this paper, we have used the same method to predict the shortest FP capable of inducing optimal fusion in vitro of the simian immunodeficiency virus (SIV) mac isolate and of other SIVs and human immunodeficiency virus (HIV-2) isolates. In each case, the 11-residue-long peptide was predicted as the minimal FP. For the SIV mac isolate, liposome lipid-mixing and leakage assays confirmed that this peptide is the shortest peptide inducing optimal fusion in vitro, being therefore the minimal FP. These results are another piece of evidence that the tilted properties of FPs are important for the fusion process and that our method can be used to predict the minimal FPs of other viruses. [less ▲]

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See detailMinimal influence of the time interval between injection of regular insulin and food intake on blood glucose control of type 1 diabetic patients on a basal-bolus insulin scheme.
Scheen, André ULg; Letiexhe, Michel ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1999), 25(2), 157-62

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in ... [more ▼]

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in patients with type 1 diabetes on intensive insulin therapy. Fifteen C-peptide negative subjects were submitted, in a randomized order, to two 6-week treatment periods in which regular insulin was injected either 5 minutes or 30 minutes before each of the three main meals, in combination with a bedtime NPH insulin injection. The changes in plasma glucose excursions following a breakfast test (Cmax, Tmax, Cmin, Tmin, AUC0-240 min) were similar in the two experimental protocols. Furthermore, no significant changes were observed in daily insulin dosages nor in glucose profiles obtained using home blood glucose monitoring. Only a tendency to a greater 90-minutes postprandial increase in blood glucose levels was observed when regular insulin was injected 5 minutes rather than 30 minutes before meal. Glycated haemoglobin levels were similar after each treatment period (7.6 +/- 0.2% versus 7.5 +/- 0.2%; NS) and no differences in the incidence or severity of hypoglycaemic episodes were noticed between the two insulin schemes. In conclusion, in type 1 diabetic patients who are rather well controlled with a basal-bolus insulin scheme, the injection of regular insulin 30 minutes before each main meal provides no significant advantage as compared to the injection of regular insulin 5 minutes before meal. [less ▲]

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See detailMinimal Lepton Flavor Violating Realizations of Minimal Seesaw Models.
Aristizabal Sierra, Diego ULg; Degée, Audrey ULg; Kamenik, Jernej F.

in Journal of High Energy Physics [=JHEP] (2012), JHEP 1207 (2012) 135(2012), 135-156

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. In the context of minimal type I seesaw ... [more ▼]

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. In the context of minimal type I seesaw scenarios with a slightly broken U(1)R, we show that, depending on the R-charge assignments, two classes of generic models can be identi fied. Models where the right-handed neutrino masses and the lepton number breaking scale are decoupled, and models where the parameters that slightly break the U(1)R induce a suppression in the light neutrino mass matrix. We show that within the fi rst class of models, contributions of right-handed neutrinos to charged lepton flavor violating processes are severely suppressed. Within the second class of models we study the charged lepton flavor violating phenomenology in detail, focusing on \ mu->e \gamma , \mu->3e and \mu- e conversion in nuclei. We show that sizable contributions to these processes are naturally obtained for right-handed neutrino masses at the TeV scale. We then discuss the interplay with the eff ects of the right- handed neutrino interactions on primordial B- L asymmetries,fi nding that sizable right-handed neutrino contributions to charged lepton flavor violating processes are incompatible with the requirement of generating (or even preserving preexisting) B-L asymmetries consistent with the observed baryon asymmetry of the Universe. [less ▲]

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See detailMinimal Levels of Serum Estradiol Prevent Postmenopausal Bone Loss
Reginster, Jean-Yves ULg; Sarlet, Nathalie ULg; Deroisy, Rita ULg et al

in Calcified Tissue International (1992), 51

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 ... [more ▼]

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 healthy women including 158 patients receiving estrogen replacement therapy (ERT) for at least 6 months, 49 eugonadal women, and 55 untreated postmenopausal women. A significant (P < 0.001) correlation exists between serum E2 and Ca/Cr: Ca/Cr (mg/dl) = -0.00044 E2 (pg/ml) + 0.129 (n = 262; r = -0.37), serum E2 and OH/Cr: (OH/Cr (mg/g) = -0.049 E2 (pg/ml) + 18.76 (n = 262; r = -0.36), serum E1 and Ca/Cr: Ca/Cr (mg/dl) = -0.0003 E1 (pg/ml) + 0.127 (n = 261; r = -0.28) but not between serum E1 and OH/Cr. Women with circulating levels of E2 between 60 and 90 pg/ml have a significant (P < 0.01) reduction of Ca/Cr and OH/Cr when compared with those with lower levels of E2. Higher values of E2 do not provide additional benefit. We conclude that in postmenopausal women receiving an estrogen replacement therapy (ERT), a significant reduction of bone resorption is achieved when circulating levels of estradiol reach a value (60 pg/ml) corresponding to the one measured, in eugonadal women, during the last days of the early follicular phase of the menstrual cycle. We suggest that oral or percutaneous ERT should induce a minimal value of 60 pg/ml to prevent postmenopausal bone loss. [less ▲]

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See detailMinimal Reduction of Unscheduled Flows for Security Restoration: Application to Phase Shifter Control
Marinakis, Adamantios ULg; Glavic, Mevludin; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (2010), 25(1), 506-515

More and more transmission system operators, noticeably in Europe, equip their systems with phase shifting transformers to counteract transit flows that take place in a large meshed interconnection. This ... [more ▼]

More and more transmission system operators, noticeably in Europe, equip their systems with phase shifting transformers to counteract transit flows that take place in a large meshed interconnection. This paper proposes algorithms for the coordinated control of several phase shifters by one operator with the objective of reducing the unscheduled flow through its system. Minimum reduction of unscheduled flow and minimum deviation with respect to present operating point are sought in order to minimize the trouble caused, while ensuring secure operation. Attention is paid to combining pre and post-contingency controls. The resulting algorithms, simple and compatible with real-time applications, are illustrated on a realistic test system. [less ▲]

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See detailMinimal seesaw models and minimal lepton flavor violation.
Degée, Audrey ULg

in Frascati Physics Series Vol. LIV (2012), Frascati Phys.Ser. 55(2012), 31-36

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. Our discussion is done in the context of ... [more ▼]

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. Our discussion is done in the context of explicit minimal type-I seesaw scenarios, where depending on the R-charge assignment different models can be constructed. We study the charged lepton flavor violating phenomenology of a concrete realization paying special attention to μ → eγ and μ → 3e [less ▲]

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See detailA minimalistic approach to identify substrate binding features in B1 Metallo-beta-lactamases
Poeylaut-Palena, Andres A; Tomatis, Pablo E; Karsisiotis, Andreas I et al

in Bioorganic & Medicinal Chemistry Letters (2007), 17(18), 5171-5174

The 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal P-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-p-lactamase Bell. None of ... [more ▼]

The 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal P-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-p-lactamase Bell. None of them was hydrolyzed by the enzyme. While the azetidinone was not able to bind Bell, aztreonam was shown to bind in a nonproductive mode. These results provide an explanation for the unability of Metallo-beta-lactamases to inactive monobactams and give some clues for inhibitor design. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMinimally-invasive spinal surgery to remove a broken epidural catheter fragment
Eap, C; Frappart, M; Litré, Claude Fabien ULg et al

in International Journal of Obstetric Anesthesia (2011)

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See detailMinimally-supervised extraction of domain-specific part–whole relations using Wikipedia as knowledge-base
Ittoo, Ashwin ULg; Bouma, Gosse

in Data & Knowledge Engineering (2013), 85

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See detailMinimally-supervised learning of domain-specific causal relations using an open-domain corpus as knowledge base
Ittoo, Ashwin ULg; Bouma, Gosse

in Data & Knowledge Engineering (2013)

Detailed reference viewed: 25 (4 ULg)