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Peer Reviewed
See detailMixed Phenotype Murine Leukemias
Defresne, Marie-Paule ULg; Borremans, B.; Verhofstede, C. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(8), 1253-60

Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed ... [more ▼]

Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed phenotype with myeloid cytochemical markers, pre-B surface antigens and molecular markers of pro-B lymphocytes. They represent murine models for mixed phenotype (pro-pre-B-myeloid) leukemias. [less ▲]

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See detailMixed Reality Prototypes to Support Early Creative Design
Safin, Stéphane ULg; Delfosse, Vincent ULg; Leclercq, Pierre ULg

in Dubois, E.; Gray, P.; Nigay, L. (Eds.) The Engineering of Mixed Reality Systems (2010)

Many complex IT projects are still primarily focusing on today's technological challenges. The adaptation of the core technologies to potential applications often occurs in a second stage where the end ... [more ▼]

Many complex IT projects are still primarily focusing on today's technological challenges. The adaptation of the core technologies to potential applications often occurs in a second stage where the end-users are involved. We describe a different approach, involving the users at the very beginning of the development. The domain we address is the creative design, mainly architecture. Rooted in a multidisciplinary approach as well as a deep understanding of architecture and design, our method aims at proposing adapted mixed reality solution to support two crucial activities : sketch-based preliminary design and distant synchronous collaboration in design. This chapter provides a summary of our work on a mixed-reality device based on a drawing table (the Virtual Desktop) designed specifically to address real-life/trade-focused issues. We explain our methodology, describe the two supported activities and the related users’s needs, we detail the technological solution we have developed and we present the main results of the multiple evaluation sessions. We then conclude on the usefulness of the profession-centered methodology and on the pertinence of the mixed reality to support creative design activities. [less ▲]

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See detailMixed self-assembly of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers and sodium dodecyl sulfate in aqueous solution
Vangeyte, Patrick; Leyh, Bernard ULg; Auvray, L. et al

in Langmuir (2004), 20(21), 9019-9028

Interaction of amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers with anionic sodium dodecyl sulfate (SDS) has been investigated in aqueous solution. Formation of mixed micelles has ... [more ▼]

Interaction of amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers with anionic sodium dodecyl sulfate (SDS) has been investigated in aqueous solution. Formation of mixed micelles has been confirmed by surface tension measurements, whereas the influence of the surfactant on the copolymer self-assembling has been studied by measurement of the 1H NMR self-diffusion coefficients and by small-angle neutron scattering. As a rule, the surfactant decreases the heterogeneity of the micellar structures formed by the copolymer in water. Moreover, increasing the content of SDS results in the increasingly more important extension of the poly(ethylene oxide) (PEO) corona chains and the copolymer micelle deaggregation. The stability of the micelles against SDS increases with the length of the hydrophobic block. Preliminary two-dimensional NMR measurements with nuclear Overhauser enhancement have confirmed the spatial vicinity between SDS and the constitutive blocks of the copolymer. [less ▲]

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See detailA mixed solid-shell element for the analysis of laminated composites
Rah, Kamran; Paepegem, Wim; Habraken, Anne ULg et al

in International Journal for numerical methods in engineering (2012), 89(7), 805-828

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See detailMixed symmetric baryon multiplets in large $N_c$ QCD: two and three flavours
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2010), 11(1), 37-43

We propose a new method to study mixed symmetric multiplets of baryons in the context of the $1/N_c$ expansion approach. The simplicity of the method allows to better understand the role of various ... [more ▼]

We propose a new method to study mixed symmetric multiplets of baryons in the context of the $1/N_c$ expansion approach. The simplicity of the method allows to better understand the role of various operators acting on spin and flavour degrees of freedom. The method is tested on two and three flavours. It is shown that the spin and flavour operators proportional to the quadratic invariants of SU$_S$(2) and SU$_F$(3) respectively are dominant in the mass formula. [less ▲]

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See detailMixed Zone 3: "What is Africa to me now? The continent and its literary diasporas"
Ledent, Bénédicte ULg; Tunca, Daria ULg

Article for general public (2013)

Présentation bilingue des écrivains Jackie Kay, Caryl Phillips et Chika Unigwe, ainsi que du photographe Johny Pitts, suivie d'extraits vidéo de leurs interventions dans le cadre du colloque "What is ... [more ▼]

Présentation bilingue des écrivains Jackie Kay, Caryl Phillips et Chika Unigwe, ainsi que du photographe Johny Pitts, suivie d'extraits vidéo de leurs interventions dans le cadre du colloque "What is Africa to me now? The continent and its literature diasporas". [less ▲]

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See detailA mixed-integer heuristic for the structural optimization of a cruise ship
Bay, Maud ULg; Crama, Yves ULg; Richir, Thomas et al

in COMPIT 2007 , Cortona, Italy (2007, April 23)

A heuristic approach is proposed to solve the structural optimization problem of a cruise ship. The challenge of optimization is to define the scantling of the structure of a ship in order to minimize the ... [more ▼]

A heuristic approach is proposed to solve the structural optimization problem of a cruise ship. The challenge of optimization is to define the scantling of the structure of a ship in order to minimize the weight or the production cost. The variables are the dimensions and positions of the constitutive elements of the structure: they are discrete by nature. The objective functions are nonlinear functions. The structure is submitted to geometric constraints and to structural constraints. The geometric constraints are linear functions and the structural constraints are implicit functions requiring a high computation cost. The problem belongs to the class of mixed-integer nonlinear problems (MINLP). A local heuristic of the type “dive and fix” is combined with a solver based on approximation methods. The solver is used as a black-box tool to perform the structural analysis and solve the nonlinear optimization problems (NLP) defined by the heuristic. The heuristic is designed to always provide a discrete feasible solution. Experiments on a real-size structure demonstrate that the optimal value of the mixed-integer problem is of the same magnitude as the optimal value of the optimization problem for which all the variables can take continuous values. [less ▲]

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See detailMixed-integer sets from two rows of two adjacent simplex bases
Andersen, Kent; Louveaux, Quentin ULg; Weismantel, Robert

in Mathematical Programming (2010), 124(1-2), 455-480

In 2007 we studied a mixed-integer set arising from two rows of a simplex tableau. We showed that facets of such a set can be obtained from lattice point free triangles and quadrilaterals associated with ... [more ▼]

In 2007 we studied a mixed-integer set arising from two rows of a simplex tableau. We showed that facets of such a set can be obtained from lattice point free triangles and quadrilaterals associated with either three or four variables. In this paper we generalize our findings and show that, when upper bounds on the non-basic variables are also considered, further classes of facets arise that cannot be obtained from triangles and quadrilaterals. Specifically, when exactly one upper bound on a non-basic variable is intro- duced, stronger inequalities that can be derived from pentagons involving up to six variables also appear. [less ▲]

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See detailMixing in magnetic OB stars
Morel, Thierry ULg

in Bulletin de la Société Royale des Sciences de Liège (2011), 80

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See detailMixing in two magnetic OB stars discovered by the MiMeS collaboration
Morel, Thierry ULg

in IAU Symposium 272: Active OB Stars: Structure, Evolution, Mass Loss and Critical Limits (2011)

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See detailMixing proximal regularization, penalization and parallel decomposition in convex programming
Tossings, Patricia ULg

in Oettli, W.; Pallaschke, D. (Eds.) Advances in Optimization (W. Oettli - D. Pallaschke Editors), Proceedings FRG, Lambrecht (1991)

Let A and B be two mutually complementary subspaces of a real Hilbert space H, T being a maximal monotone operator on H. The method of partial inverses has been introduced by J. Spingarn in 1983 for ... [more ▼]

Let A and B be two mutually complementary subspaces of a real Hilbert space H, T being a maximal monotone operator on H. The method of partial inverses has been introduced by J. Spingarn in 1983 for solving problems in which the object is to find x in A and y in B such that y in Tx. We present a perturbed version of this method and its most important application: a perturbed method of parallel decomposition in convex programming. [less ▲]

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Peer Reviewed
See detailMixmaster universe in fourth-order gravity theories
Cotsakis, S.; Demaret, Jacques; De Rop, Yves ULg et al

in Physical Review. D : Particles and Fields (1993), 48

We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically ... [more ▼]

We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically. By directly analyzing the full fourth-order field equations we prove explicitly that the Belinski-Khalatnikov-Lifshitz (BKL) analytic solution (and the accompanying bounce law) is also a solution to the more general case that we consider. But it appears to be nongeneric, because a perturbation analysis shows that power-law Kasner asymptotes are unstable on approach to the singularity. On the other hand, we find that the model possesses a stable isotropic monotonic power-law asymptotic solution and accordingly we show that there is a general solution which is nonchaotic near the space-time singularity. Numerical experiments confirm the existence of such a behavior. The inclusion of matter fields does not alter the evolution in the neighborhood of the singularity. The role of space-time dimensionality on the chaotic evolution of the mixmaster universe in these theories is also spelled out. In particular, we show that it is impossible to build a mixmaster universe in space-time dimensions higher than four in the full fourth-order gravity theory based on the BKL approximation scheme. [less ▲]

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See detailMixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference
Gianola, D.; Odegard, J.; Heringstad, B. et al

in Genetics, Selection, Evolution (2004), 36(1, JAN-FEB), 3-27

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop ... [more ▼]

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an important udder disease. Parameter estimation is by maximum likelihood or by an extension of restricted maximum likelihood. A Monte Carlo expectation- maximization algorithm is used for this purpose. The expectation step is carried out using Gibbs sampling, whereas the maximization step is deterministic. Ranking rules based on the conditional probability of membership in a putative group of uninfected animals, given the somatic cell information, are discussed. Several extensions of the model are suggested. [less ▲]

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See detailA mixture model to assess the effect of a hormonal stimulation on the development of follicles in prepubertal heifers
Lambert, Philippe ULg

in Journal of the Royal Statistical Society : Series C (Applied Statistics) (2002), 4

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as ... [more ▼]

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as in post-pubertal heifers: after a few days, a dominant follicle arises on one of the two ovaries whereas the other subordinate follicles regress.The dominant follicle remains detectable when the next wave occurs. The number and the diameters of these follicles have been measured for 14 days.The same experiment was repeated after a 3-day FSH stimulation. Several large follicles now arise simultaneously on both ovaries together with small follicles which cannot be detected any more when the next wave occurs. Unfortunately, follicles were not individually tracked. Therefore a three-component mixture model was used to describe the potential simultaneous observation of dominant, decaying dominant and subordinate follicles before the FSH stimulation; the same type of model was considered for large, decaying large and small follicles after the hormonal stimulation. Moreover, for technical reasons, only follicles larger than 2 mm are observable. Measurements were thus left truncated.The models fitted are used to quantify the effects of the stimulation and to determine the ideal time point at which follicles should be punctured under ultrasonography to harvest ovocytes that will be fertilized and cultured in vitro. [less ▲]

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See detailMixtures of Bagged Markov Tree Ensembles
Schnitzler, François ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

in Cano Utrera, Andrès; Gómez-Olmedo, Manuel; Nielsen, Thomas (Eds.) Proceedings of the 6th European Workshop on Probabilistic Graphical Models (2012, September)

Markov trees, a probabilistic graphical model for density estimation, can be expanded in the form of a weighted average of Markov Trees. Learning these mixtures or ensembles from observations can be ... [more ▼]

Markov trees, a probabilistic graphical model for density estimation, can be expanded in the form of a weighted average of Markov Trees. Learning these mixtures or ensembles from observations can be performed to reduce the bias or the variance of the estimated model. We propose a new combination of both, where the upper level seeks to reduce bias while the lower level seeks to reduce variance. This algorithm is evaluated empirically on datasets generated from a mixture of Markov trees and from other synthetic densities. [less ▲]

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See detailA MLPA-oligochromatographic multiplex assay for identification of the toxin genotype and the hypervirulent ribotype O27 of Clostridium difficile
Durenne, Bastien ULg; Laurent, Thierry; Leclipteux, Thierry et al

in Clinical Microbiology & Infection (2009, May), 15(s4),

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See detailMMP-19 Deficiency Promotes Tenascin-C Accumulation and Allergen-induced Airway Inflammation.
Guéders, Maud ULg; Hirst, S.; Quesada Calvo, Florence ULg et al

in American Journal of Respiratory Cell and Molecular Biology (2010), 43(3), 286-95

Matrix metalloproteinases (MMPs) recently appeared as key regulators of inflammation, allowing recruitment and clearance of inflammatory cells and modifying the biological activity of many peptidic ... [more ▼]

Matrix metalloproteinases (MMPs) recently appeared as key regulators of inflammation, allowing recruitment and clearance of inflammatory cells and modifying the biological activity of many peptidic mediators by cleavage. MMP-19 is a newly described MMP and preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date. The purpose of the present study was to assess MMP-19 expression in a murine asthma model and to address biological effects of MMP-19 deficiency in mice. Allergenexposed wild-type (WT) mice displayed an increased expression of MMP-19 mRNA and an increased number of MMP-19-positive cells in the lungs detected by immunohistochemistry. After allergen challenge of MMP-19 knockout (MMP-19-/-) mice, an exacerbated eosinophilic inflammation was detected in bronchoalveolar lavage fluid and bronchial tissue along with an increased airway responsiveness to methacholine. A shift towards increased Th2-driven inflammation in MMP-19-/- mice was demonstrated by 1) increased numbers of cells expressing the IL-33 receptor T1/ST2 in lung parenchyma, 2) increased IgG1 levels in serum and 3) higher levels of IL-13 and CCL11 in lung extracts. Tenascin-C was found accumulated in peribronchial areas of MMP-19-/- after allergen challenges as assessed by Western blot and immunohistochemistry analysis. We conclude that MMP-19 is a new mediator in asthma, preventing tenascin-C accumulation and directly or indirectly controlling Th2-driven airway eosinophilia and airway hyperreactivity. Our data suggest that MMP-19 might act on Th2 inflammation homeostasis through preventing tenascin protein accumulation. [less ▲]

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See detailMMP-2 and MMP-9 activity is increased in bronchoalveolar lavage fluid of asthmatic cats
Kirschvink, N.; Delvaux, François ULg; Leemans, J. et al

in Autumn Meeting, Belgian Society of Fundamental and Clinical physiology and Pharmacology - Liège - Belgique - novembre 2003 (2003, November)

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See detailMMP-2 and MMP-9 synergize in promoting choroidal neovascularization
Lambert, Vincent ULg; Wielockx, B.; Munaut, Carine ULg et al

in FASEB Journal (2003), 17(15), 2290-2292

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but ... [more ▼]

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but their precise role and potential interactions remain unclear. To address the question of MMP-2 and MMP-9 functions, mice deficient in the expression of MMP-2 (MMP-2 KO), MMP-9 (MMP-9 KO), and both MMP-2 and MMP-9 (MMP-2,9 KO) with their corresponding wild-type mice (WT) underwent CNV induction by laser-induced rupture of the Bruch's membrane. Both the incidence and the severity of CNV were strongly attenuated in double deficient compared with single gene deficient mice or corresponding WT controls. The reduced neovascularization was accompanied by fibrinogen/fibrin accumulation. Furthermore, overexpression of the endogenous MMP inhibitors TIMP-1 or TIMP-2 (delivered by adenoviral vectors) in WT mice or daily injection of a synthetic and gelatinase selective MMP inhibitor (Ro 26-2853) significantly decreased the pathological reaction. These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization. [less ▲]

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