Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults

in Vaccine (2007), 25(24), 4697-4705

Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine ... [more ▼]

Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerated, with the incidence of solicited and unsolicited symptoms within a clinically acceptable range. One serious adverse event was reported in the phase I trial which was considered to be of suspected relationship to vaccination. The gp350 vaccine formulations were immunogenic and induced gp350-specific antibody responses (including neutralising antibodies). (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

Phase I/IIclinical trial of local GM-CSF application in patients with cervical HPV-associated low grade squamous intraepithelial lesions

Conference (2007)

Background: Quantitative and functional alterations of professional antigen-presenting cells (APC) in SIL suggest that these lesions may have a diminished capacity to capture viral antigens. Moreover, GM ... [more ▼]

Background: Quantitative and functional alterations of professional antigen-presenting cells (APC) in SIL suggest that these lesions may have a diminished capacity to capture viral antigens. Moreover, GM-CSF (whose production is decreased in HPV-transformed keratinocytes) is an essential factor for the migration of APC in cervical (pre)neoplastic lesions formed in vitro and transplanted in vivo on mouse. In this study we performed a phase I/II clinical trial in order to determine whether a local application of GM-CSF on cervical low-grade squamous intraepithelial lesions (LSIL) might increase the recruitment of APC into the epithelium and indirectly the viral antigen presentation to the immune system. Methods: Fifteen patients with LSIL (10 GM-CSF and 5 placebo) were enrolled in this study. Patients received 4 GM-CSF applications (or placebo gel) and were followed during 6-7 months. APC infiltration was quantified by immunostaining with anti-CD1a mAb. Cellular immune response was evaluated by using an IFN-gamma intracellular staining on PBMC stimulated in vitro with the E7 HPV16 protein and L1 HPV16 Virus-like particles (VLP). Hybrid capture was performed to semi-quantify the viral DNA in cervical brush specimens. Results: GM-CSF applications were well tolerated in all patients. No difference in the cytological/histological and viral parameters assessed at 2 and 6 months after the last application was observed between the GM-CSF and the placebo group. An increased number of CD1a+ APC was observed in 6/10 patients treated by GM-CSF compared to 1/5 patient in the placebo group. There was an increased immune response against HPV in the GM-CSF group showed by NK and T cells producing IFN-gamma. [less ▲]

Phase II study of docetaxel alternating with cisplatin in chemotherapy-naïve patients with advanced non-small cell lung cancer

in Anti-Cancer Drugs (2000), 11

Phase II trial exploring gemcitabine and cisplatin as treatment of patients with non-small cell lung cancer (NSCLC) and inoperable brain metastases

in Lung Cancer (2003), 41(supp2), 145

Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B).

in Annals of Oncology (2012)

Background The superiority of a chemotherapy with doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP) in comparaison with cyclophosphamide, doxorubicin, vincristin and prednisone ... [more ▼]

Background The superiority of a chemotherapy with doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP) in comparaison with cyclophosphamide, doxorubicin, vincristin and prednisone plus radiotherapy for Young patients with localized diffuse large B-cell lymphoma (DLBCL) was previously demonstrated. We report the results of a trial which évaluâtes the role of rituximab combined with ACVBP (R- ACVBP) in these patients. Patients and methods untreated patients younger than 66 years with stage I or II DLBCL and no adverse prognostic factors of the age-adjusted International Prognostic Index were randomly assigned to receive three cycles of ACVBP plus sequential consolidation with or without the addition of four infusions of rituximab. Results a total of 223 patients were randomly allocated to the study, 110 in the R-ACVBP group and 113 in the ACVBP group. After a median follow-up of 43 months, our 3-year estimate of event-free survival was 93% in the R-ACVBP group and 82% in the ACVBP group (P=0.0487). Three-year estimate of progression-free survival was increased in the R-ACVBP group (95% versus 83%, P=0.0205). Overall survival did not differ between the two groups with a 3-year estimâtes of 98% and 97%, respectively (P=0.686). Conclusion in Young patients with low-risk localized DLBCL, rituximab combined with three cycles of ACVBP plus consolidation is significantly Superior to ACVBP plus consolidation alone. [less ▲]

Phase ratio estimations from true color images

(1996)

Phase referencing in optical interferometry

in Schöller, Markus; Danchi, William; Delplancke, Françoise (Eds.) Optical and Infrared Interferometry (2008, July 01)

One of the aims of next generation optical interferometric instrumentation is to be able to make use of information contained in the visibility phase to construct high dynamic range images. Radio and ... [more ▼]

One of the aims of next generation optical interferometric instrumentation is to be able to make use of information contained in the visibility phase to construct high dynamic range images. Radio and optical interferometry are at the two extremes of phase corruption by the atmosphere. While in radio it is possible to obtain calibrated phases for the science objects, in the optical this is currently not possible. Instead, optical interferometry has relied on closure phase techniques to produce images. Such techniques allow only to achieve modest dynamic ranges. However, with high contrast objects, for faint targets or when structure detail is needed, phase referencing techniques as used in radio interferometry, should theoretically achieve higher dynamic ranges for the same number of telescopes. Our approach is not to provide evidence either for or against the hypothesis that phase referenced imaging gives better dynamic range than closure phase imaging. Instead we wish to explore the potential of this technique for future optical interferometry and also because image reconstruction in the optical using phase referencing techniques has only been performed with limited success. We have generated simulated, noisy, complex visibility data, analogous to the signal produced in radio interferometers, using the VLTI as a template. We proceeded with image reconstruction using the radio image reconstruction algorithms contained in aips imagr (clean algorithm). Our results show that image reconstruction is successful in most of our science cases, yielding images with a 4 milliarcsecond resolution in K band. We have also investigated the number of target candidates for optical phase referencing. Using the 2MASS point source catalog, we show that there are several hundred objects with phase reference sources less than 30 arcseconds away, allowing to apply this technique. [less ▲]

Phase retarders in liquid crystals polymers

Scientific conference (2012, March 12)

Liquid crystals polymers posses birefringent properties and they are locally orientable, they allow the realization of space variant optical retarders which creates non uniformly polarized beam. To ... [more ▼]

Liquid crystals polymers posses birefringent properties and they are locally orientable, they allow the realization of space variant optical retarders which creates non uniformly polarized beam. To realize a retarder, liquid crystals are exposed to a UV linearly polarized beam, the optical axis of the retarder will be parallel to the incident polarization. We shall present an innovative way to produce space-variant retarders without mechanical interaction polarization holography . Superposing several beams differently polarized, results in a non-uniformly polarized recording beam used to realize space variant retarders. We shall also present our research retarders for two applications based on this method polarization analysis and coronagraphy. [less ▲]

Phase segregation in binary sandpiles on fractal bases

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1999), 59(1), 631-635

We have built experimentally and have numerically studied sandpiles on a base having a prefractal perimeter. This type of perimeter induces the formation of quite complex pile shapes characterized by both ... [more ▼]

We have built experimentally and have numerically studied sandpiles on a base having a prefractal perimeter. This type of perimeter induces the formation of quite complex pile shapes characterized by both ridges and valleys. The effects of a fractal base on the phase segregation of a binary granular system have been investigated. Both demixing and self-stratification phenomena have been investigated. It is found that the demixing of binary granular piles is enhanced by the prefractal perimeter character. The concentration profiles are given. This is briefly discussed in terms of length scale selection. [less ▲]

Phase separation during silica gel formation followed by time-resolved SAXS

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2005), 238(1-4), 141-145

Time-resolved small angle X-ray scattering data are collected during the formation of silica gels from the base catalyzed polymerization of tetraethoxysilane in ethanol with 3-(2-aminoethylamino ... [more ▼]

Time-resolved small angle X-ray scattering data are collected during the formation of silica gels from the base catalyzed polymerization of tetraethoxysilane in ethanol with 3-(2-aminoethylamino)propyltrimethoxysilane and 3-aminopropyltriethoxysilane as additives. It is shown that a polymerization-induced spinodal demixing occurs during the gel formation. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]