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See detailMMP-2 and MMP-9 synergize in promoting choroidal neovascularization
Lambert, Vincent ULg; Wielockx, B.; Munaut, Carine ULg et al

in FASEB Journal (2003), 17(15), 2290-2292

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but ... [more ▼]

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but their precise role and potential interactions remain unclear. To address the question of MMP-2 and MMP-9 functions, mice deficient in the expression of MMP-2 (MMP-2 KO), MMP-9 (MMP-9 KO), and both MMP-2 and MMP-9 (MMP-2,9 KO) with their corresponding wild-type mice (WT) underwent CNV induction by laser-induced rupture of the Bruch's membrane. Both the incidence and the severity of CNV were strongly attenuated in double deficient compared with single gene deficient mice or corresponding WT controls. The reduced neovascularization was accompanied by fibrinogen/fibrin accumulation. Furthermore, overexpression of the endogenous MMP inhibitors TIMP-1 or TIMP-2 (delivered by adenoviral vectors) in WT mice or daily injection of a synthetic and gelatinase selective MMP inhibitor (Ro 26-2853) significantly decreased the pathological reaction. These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization. [less ▲]

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See detailMMP-2 and MMP-9-Linked Gelatinolytic Activity in the Sputum from Patients with Asthma and Chronic Obstructive Pulmonary Disease
Cataldo, Didier ULg; Munaut, Carine ULg; Noël, Agnès ULg et al

in International Archives of Allergy & Immunology (2000), 123(3), 259-67

BACKGROUND: The course of asthma and chronic obstructive pulmonary disease (COPD) is associated with bronchial morphological changes. Metalloproteinases are thought to play a role in these structural ... [more ▼]

BACKGROUND: The course of asthma and chronic obstructive pulmonary disease (COPD) is associated with bronchial morphological changes. Metalloproteinases are thought to play a role in these structural changes. METHODS: We studied the gelatinolytic activity present in the induced sputum from 20 patients with asthma, 20 with COPD and 19 healthy controls. The assessment of gelatinolytic activity was performed by quantitative zymography, and gelatinolytic species were identified by Western blot analysis. Tissue inhibitor of metalloproteinase-1 (TIMP-1) was detected by reverse zymography and ELISA. RESULTS: From zymography, we found significantly higher gelatinolytic activity linked to pro-matrix metalloproteinase-9 (pro-MMP-9) in the sputum from asthmatics (p < 0.0001) and COPD patients (p < 0.0001) compared to the control group. Furthermore, the activated form of MMP-9 (85 kD) was found in the sputum from 60% of asthmatics and 85% of COPD patients, but was absent in that of control subjects (p < 0.0001). Importantly, although less frequently detectable than pro-MMP-9, pro- MMP-2 (72 kD) was found more frequently in asthmatics (50%) than in control subjects (5%) (p < 0. 005). We also described two unusual gelatinolytic species of 45 and 120 kD and showed that they derived from MMP-9 according to their ability to bind gelatin and anti-MMP-9 antibody. Levels of TIMP-1 were higher in asthmatics (p < 0.05) and COPD patients (p < 0.05) than in controls. CONCLUSION: Asthmatics and COPD patients display an increased gelatinolytic activity linked to MMP-2 and MMP-9 and higher levels of TIMP-1 in their sputum. [less ▲]

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See detailMMP-9 activity and 8-ISO-PGF2alphaare increased in bronchoalveolar lavage fluid in a model of feline asthma
Kirschvink, Nathalie; Leemans, Jérôme ULg; Delvaux, F. et al

in Proceedings of the American College of Veterinary Internal Medicine, Baltimore, Maryland (2005)

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See detailMMP-9 regulates both positively and negatively collagen gel contraction - A nonproteolytic function of MMP-9
Defawe, Olivier D; Kenagy, Richard D; Choi, Chun et al

in Cardiovascular Research (2005), 66(2), 402-409

Objective: Constrictive remodeling accounts for lumen loss in postangioplasty restenosis. Matrix metalloproteinase-9 (MMP-9) has been shown to prevent constrictive remodeling in vivo. To investigate ... [more ▼]

Objective: Constrictive remodeling accounts for lumen loss in postangioplasty restenosis. Matrix metalloproteinase-9 (MMP-9) has been shown to prevent constrictive remodeling in vivo. To investigate potential mechanisms for this observation, we investigated the role of MMP-9 in smooth muscle cell (SMC)-mediated collagen gel contraction, an in vitro model of constrictive remodeling. Methods: Fischer rat SMCs were stably transfected with a construct-expressing rat-MMP-9 under the control of a tetracycline (Tet)-off promoter. SMCs were seeded in type 1 collagen gels (2.4 mg/ml) in the presence or not of tetracycline (1 mu g/ml), and gel contraction was defined as the percentage of retraction of the collagen gel. The depletion of MMP-9 was obtained by using siRNA targeting MMP-9 mRNA or a blocking antibody. Results: Gel contraction was significantly reduced at all times when MMP-9 was overexpressed (Tet-) as compared with the control condition (Tet+). However, MMP-9 depletion of control (Tet+) SMCS (using siRNA or antibody) also inhibited gel contraction. To resolve the apparent discrepancy and determine if MMP-9 exerts a dose-dependent biphasic effect on gel contraction, conditioned medium and purified rat-MMP-9 were prepared. Gel contraction was significantly increased by addition of 0.8 mg/ml of MMP-9, while high concentrations of MMP-9 (>= 100 mg/ml) inhibited contraction. The addition of BB94 and TIMP-1 did not alter the inhibitory or stimulatory effect of MMP-9. Conclusions: Our data Suggest that MMP-9, independent of its proteolytic function, has a biphasic effect on SMC-mediated collagen gel contraction. Understanding the different roles of MMP-9 Should allow the development of better therapeutic strategies for restenotic vascular disease. (c) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailMMP-Mediated Collagen Remodeling and Vessel Functions
Noël, Agnès ULg; Sounni, Nor Eddine ULg

in Brix, Klaudia; Stocker, Walter (Eds.) Proteases: Structure and Function (2013)

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See detailMMP-Mediated Collagen Remodeling and Vessel Functions
Noël, Agnès ULg; Sounni, Nor Eddine ULg

in BRIX, K.; STOCKER, W. (Eds.) Proteases: Structure and Function, (2014)

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See detailMMPs and their inhibitors in vascular remodeling and vascular disease
Sounni, Nor Eddine ULg

Conference (2010, March)

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See detailMMPs regulation of vascular permeability in cancer
Sounni, Nor Eddine ULg

Conference (2009, May 29)

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See detailMnasistratos, the hierophant at Andania (IG 5.1.1390 and Syll.³ 735)
Pirenne-Delforge, Vinciane ULg

in Kuiper, Yme B.; Dijkstra, Jitse H.F.; Kroesen, Justin E.A. (Eds.) Myths, Martyrs and Modernity – Studies in the History of Religion in Honor of Jan N. Bremmer (2010)

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See detailMnemopoetics. Memory and Slavery in African American Drama
Bada, Valérie ULg

Book published by Peter Lang (2008)

Through the close reading and socio-historical analysis of 8 African American plays from 1939 to 1996, Bada seeks to unravel the fluctuating patterns in the shaping of the theatrical memory of slavery ("a ... [more ▼]

Through the close reading and socio-historical analysis of 8 African American plays from 1939 to 1996, Bada seeks to unravel the fluctuating patterns in the shaping of the theatrical memory of slavery ("a mnemopoetics of slavery") long after its abolition. [less ▲]

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See detailMnemosyne et le Denkraum renaissant. Pratique du document visuel chez Aby Warburg
Hagelstein, Maud ULg

Scientific conference (2008, March 22)

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See detail"Mnemosyne" et le "Denkraum" renaissant. Pratique du document visuel chez Aby Warburg
Hagelstein, Maud ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2009), 2

L’historien de l’art juif allemand Aby Warburg (1866-1929) a marqué de manière décisive toute une génération de théoriciens de l’art du xxe siècle. Relativement discrète, son oeuvre prend toute son ... [more ▼]

L’historien de l’art juif allemand Aby Warburg (1866-1929) a marqué de manière décisive toute une génération de théoriciens de l’art du xxe siècle. Relativement discrète, son oeuvre prend toute son ampleur lorsqu’elle est envisagée du point de vue de l’épistémologie de l’histoire de l’art. En effet, Warburg s’est distingué par ses nombreuses audaces méthodologiques : son sens désarmant du détail, sa bibliothèque — dont le classement thématique défiait toute systématicité —, ses propositions inaugurales pour l’iconologie, sa désinvolture à l’égard des frontières disciplinaires. Son dernier projet (inachevé), l’atlas d’images Mnemosyne, rassemble tous ces points. L’Atlas témoigne, par ailleurs, d’une pratique du document visuel inédite pour l’époque, où le matériau iconographique, révélé par de subtils montages, fait surgir de nouveaux problèmes théoriques. Afin d’en dégager toute l’originalité, on aura ici recours aux principes exposés par Foucault dans L’archéologie du savoir (1969). [less ▲]

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See detailMnémotechnique des analogies de Neper
Folie, François ULg

in Annuaire de l'Observatoire Royal de Belgique (1889), 56

The author indicates a mnemonic process for writing the Napier’s formulae.

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See detailMô hình phân tích cầu tiêu dùng thịt gia cầm tại Hà Nội
Vu Dinh, Ton; Phan Dang, Thang; Do Duc, Luc et al

in Nghiên cứu Kinh tế" - Viện kinh tế Việt Nam (= Economic studies) (2012), (405 (2-2012)), 59-68

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See detailMOA 2010-BLG-477Lb: Constraining the Mass of a Microlensing Planet from Microlensing Parallax, Orbital Motion, and Detection of Blended Light
Bachelet, E.; Shin, I.-G.; Han, C. et al

in Astrophysical Journal (2012), 754

Microlensing detections of cool planets are important for the construction of an unbiased sample to estimate the frequency of planets beyond the snow line, which is where giant planets are thought to form ... [more ▼]

Microlensing detections of cool planets are important for the construction of an unbiased sample to estimate the frequency of planets beyond the snow line, which is where giant planets are thought to form according to the core accretion theory of planet formation. In this paper, we report the discovery of a giant planet detected from the analysis of the light curve of a high-magnification microlensing event MOA 2010-BLG-477. The measured planet-star mass ratio is q = (2.181 ± 0.004) × 10[SUP]-3[/SUP] and the projected separation is s = 1.1228 ± 0.0006 in units of the Einstein radius. The angular Einstein radius is unusually large θ[SUB]E[/SUB] = 1.38 ± 0.11 mas. Combining this measurement with constraints on the "microlens parallax" and the lens flux, we can only limit the host mass to the range 0.13 < M/M [SUB]&sun;[/SUB] < 1.0. In this particular case, the strong degeneracy between microlensing parallax and planet orbital motion prevents us from measuring more accurate host and planet masses. However, we find that adding Bayesian priors from two effects (Galactic model and Keplerian orbit) each independently favors the upper end of this mass range, yielding star and planet masses of M [SUB]*[/SUB] = 0.67[SUP]+0.33[/SUP] [SUB]- 0.13[/SUB] M [SUB]&sun;[/SUB] and m[SUB]p[/SUB] = 1.5[SUP]+0.8[/SUP] [SUB]- 0.3[/SUB] M [SUB]JUP[/SUB] at a distance of D = 2.3 ± 0.6 kpc, and with a semi-major axis of a = 2[SUP]+3[/SUP] [SUB]- 1[/SUB] AU. Finally, we show that the lens mass can be determined from future high-resolution near-IR adaptive optics observations independently from two effects, photometric and astrometric. [less ▲]

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See detailMOA-2009-BLG-387Lb: a massive planet orbiting an M dwarf
Batista, V.; Gould, A.; Dieters, S. et al

in Astronomy and Astrophysics (2011), 529

<BR /> Aims: We report the discovery of a planet with a high planet-to-star mass ratio in the microlensing event MOA-2009-BLG-387, which exhibited pronounced deviations over a 12-day interval, one of the ... [more ▼]

<BR /> Aims: We report the discovery of a planet with a high planet-to-star mass ratio in the microlensing event MOA-2009-BLG-387, which exhibited pronounced deviations over a 12-day interval, one of the longest for any planetary event. The host is an M dwarf, with a mass in the range 0.07 M[SUB]&sun;[/SUB] < M[SUB]host[/SUB] < 0.49 M[SUB]&sun;[/SUB] at 90% confidence. The planet-star mass ratio q = 0.0132 ± 0.003 has been measured extremely well, so at the best-estimated host mass, the planet mass is m[SUB]p[/SUB] = 2.6 Jupiter masses for the median host mass, M = 0.19 M[SUB]&sun;[/SUB]. <BR /> Methods: The host mass is determined from two "higher order" microlensing parameters. One of these, the angular Einstein radius θ[SUB]E[/SUB] = 0.31 ± 0.03 mas has been accurately measured, but the other (the microlens parallax π[SUB]E[/SUB], which is due to the Earth's orbital motion) is highly degenerate with the orbital motion of the planet. We statistically resolve the degeneracy between Earth and planet orbital effects by imposing priors from a Galactic model that specifies the positions and velocities of lenses and sources and a Kepler model of orbits. <BR /> Results: The 90% confidence intervals for the distance, semi-major axis, and period of the planet are 3.5 kpc < D[SUB]L[/SUB] < 7.9 kpc, 1.1 AU < a < 2.7 AU, and 3.8 yr < P < 7.6 yr, respectively. Photometric data is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/529/A102">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/529/A102</A> [less ▲]

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See detailMOA-2010-BLG-073L: An M-dwarf with a Substellar Companion at the Planet/Brown Dwarf Boundary
Street, R. A.; Choi, J.-Y.; Tsapras, Y. et al

in Astrophysical Journal (2013), 763

We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the ... [more ▼]

We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the source was previously known to be photometrically variable. Analyzing the pre-event source light curve, we demonstrate that it is an irregular variable over timescales >200 days. Its dereddened color, (V - I)[SUB] S, 0[/SUB], is 1.221 ± 0.051 mag, and from our lens model we derive a source radius of 14.7 ± 1.3 R [SUB]&sun;[/SUB], suggesting that it is a red giant star. We initially explored a number of purely microlensing models for the event but found a residual gradient in the data taken prior to and after the event. This is likely to be due to the variability of the source rather than part of the lensing event, so we incorporated a slope parameter in our model in order to derive the true parameters of the lensing system. We find that the lensing system has a mass ratio of q = 0.0654 ± 0.0006. The Einstein crossing time of the event, t [SUB]E[/SUB] = 44.3 ± 0.1 days, was sufficiently long that the light curve exhibited parallax effects. In addition, the source trajectory relative to the large caustic structure allowed the orbital motion of the lens system to be detected. Combining the parallax with the Einstein radius, we were able to derive the distance to the lens, D[SUB]L[/SUB] = 2.8 ± 0.4 kpc, and the masses of the lensing objects. The primary of the lens is an M-dwarf with M [SUB] L, 1[/SUB] = 0.16 ± 0.03 M [SUB]&sun;[/SUB], while the companion has M [SUB] L, 2[/SUB] = 11.0 ± 2.0 M [SUB]J[/SUB], putting it in the boundary zone between planets and brown dwarfs. [less ▲]

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See detailMOA-2010-BLG-311: A planetary candidate below the threshold of reliable detection
Yee, J. C.; Hung, L.-W.; Bond, I. A. et al

in Astrophysical Journal (2013), 769(1), 77

We analyze MOA-2010-BLG-311, a high magnification (A_max>600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals. We fit this event with both a ... [more ▼]

We analyze MOA-2010-BLG-311, a high magnification (A_max>600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals. We fit this event with both a point lens and a 2-body lens model and find that the 2-body lens model is a better fit but with only Delta chi^2~140. The preferred mass ratio between the lens star and its companion is $q=10^(-3.7+/-0.1), placing the candidate companion in the planetary regime. Despite the formal significance of the planet, we show that because of systematics in the data the evidence for a planetary companion to the lens is too tenuous to claim a secure detection. When combined with analyses of other high-magnification events, this event helps empirically define the threshold for reliable planet detection in high-magnification events, which remains an open question. [less ▲]

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See detailMOA-2010-BLG-328Lb: a sub-Neptune orbiting very late M dwarf ?
Furusawa, K.; Udalski, A.; Sumi, T. et al

in Astrophysical Journal (2013), 91

We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of Mh = 0.11+/-0.01 M_{sun} and Mp = 9.2+/-2.2M_Earth, corresponding to a very late M dwarf and ... [more ▼]

We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of Mh = 0.11+/-0.01 M_{sun} and Mp = 9.2+/-2.2M_Earth, corresponding to a very late M dwarf and sub-Neptune-mass planet, respectively. The system lies at DL = 0.81 +/- 0.10 kpc with projected separation r = 0.92 +/- 0.16 AU. Because of the host's a-priori-unlikely close distance, as well as the unusual nature of the system, we consider the possibility that the microlens parallax signal, which determines the host mass and distance, is actually due to xallarap (source orbital motion) that is being misinterpreted as parallax. We show a result that favors the parallax solution, even given its close host distance. We show that future high-resolution astrometric measurements could decisively resolve the remaining ambiguity of these solutions. [less ▲]

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See detailMOA-2010-BLG-523: "Failed Planet" = RS CVn Star
Gould, A.; Yee, J. C.; Bond, I. A. et al

in Astrophysical Journal (2013), 763

The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The ... [more ▼]

The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge. Based on observations made with the European Southern Observatory telescopes, Program ID 85.B-0399(I). [less ▲]

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