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See detailMes premiers pas en Bourse
Bodson, Laurent ULg

Conference given outside the academic context (2008)

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See detailMesencephalic and third ventricle cysts: diagnosis and management in four cases.
RAMAEKERS, Vincent ULg; Reul, J.; Siller, V. et al

in Journal of neurology, neurosurgery, and psychiatry (1994), 57(10), 1216-20

Four infants with obstructive hydrocephalus caused by space occupying third ventricle and mesencephalic cysts are reported. Despite immediate shunt insertion in all patients, there was either lack of ... [more ▼]

Four infants with obstructive hydrocephalus caused by space occupying third ventricle and mesencephalic cysts are reported. Despite immediate shunt insertion in all patients, there was either lack of clinical improvement or late onset of clinical deterioration. Neuroimaging (CT, MRI, and ventriculography) diagnosed the presence of non-communicating midline outpouchings of the CSF pathways causing obstruction of aqueductal CSF flow and brainstem signs. The cysts were of different origin. In one patient it was caused by a previous thalamic haemorrhage, in another patient by neonatal Escherichia coli meningoventriculitis. In two cases with obstructive hydrocephalus at birth, the aetiology is unclear. Direct puncture and drainage of the cysts led to clinical improvement. The cysts were poorly visualised on CT and could be misinterpreted as an enlarged third ventricle, simulating congenital aqueduct stenosis. Careful neuroradiological investigation is necessary to establish an accurate diagnosis and neurosurgical management. In such cases with hydrocephalus and persisting ventricular enlargement despite shunting, CT ventriculography is a useful tool. [less ▲]

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See detailMesenchymal Stem Cell Graft Improves Recovery after Spinal Cord Injury in Adult Rats through Neurotrophic and Pro-Angiogenic Actions.
Quertainmont, Renaud; Cantinieaux, Dorothée ULg; Botman, Olivier et al

in PLoS ONE (2012), 7(6), 39500

Numerous strategies have been managed to improve functional recovery after spinal cord injury (SCI) but an optimal strategy doesn't exist yet. Actually, it is the complexity of the injured spinal cord ... [more ▼]

Numerous strategies have been managed to improve functional recovery after spinal cord injury (SCI) but an optimal strategy doesn't exist yet. Actually, it is the complexity of the injured spinal cord pathophysiology that begets the multifactorial approaches assessed to favour tissue protection, axonal regrowth and functional recovery. In this context, it appears that mesenchymal stem cells (MSCs) could take an interesting part. The aim of this study is to graft MSCs after a spinal cord compression injury in adult rat to assess their effect on functional recovery and to highlight their mechanisms of action. We found that in intravenously grafted animals, MSCs induce, as early as 1 week after the graft, an improvement of their open field and grid navigation scores compared to control animals. At the histological analysis of their dissected spinal cord, no MSCs were found within the host despite their BrdU labelling performed before the graft, whatever the delay observed: 7, 14 or 21 days. However, a cytokine array performed on spinal cord extracts 3 days after MSC graft reveals a significant increase of NGF expression in the injured tissue. Also, a significant tissue sparing effect of MSC graft was observed. Finally, we also show that MSCs promote vascularisation, as the density of blood vessels within the lesioned area was higher in grafted rats. In conclusion, we bring here some new evidences that MSCs most likely act throughout their secretions and not via their own integration/differentiation within the host tissue. [less ▲]

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See detailMesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences.
Wislet, Sabine ULg; Laudet, Emerence ULg; Neirinckx, Virginie ULg et al

in Cellular and Molecular Life Sciences : CMLS (2012), 69(15), 2593-2608

The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The ... [more ▼]

The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crest stem cells (NCSC) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSC), including their similarities and differences. In this paper, using transcriptomic as well as proteomic technologies, we compared NCSC to MSC and stromal nestin-positive cells, all of them isolated from adult bone marrow. We demonstrated that the nestin-positive cell population, which was the first to be described as able to differentiate into functional neurons, was a mixed population of NCSC and MSC. More interestingly, we demonstrated that MSC shared with NCSC the same ability to truly differentiate into Tuj1-positive cells when co-cultivated with paraformaldehyde-fixed cerebellar granule neurons. Altogether, those results suggest that both NCSC and MSC can be considered as important tools for cellular therapies in order to replace neurons in various neurological diseases. [less ▲]

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See detailMesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials.
Franquesa, Marcella; Hoogduijn, Martin J.; Reinders, Marlies E. et al

in Transplantation (2013), 96(3), 234-238

The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of ... [more ▼]

The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies. [less ▲]

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014), 29

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailMesenchymal stromal cells : a new tool against graft-versus-host disease ?
Baron, Frédéric ULg; Storb, Rainer

in Biology of Blood & Marrow Transplantation (2012), 18(6), 822-840

Mesenchymal stromal cells (MSCs) represent a heterogeneous subset of multipotent cells that can be isolated from several tissues including bone marrow and fat. MSCs exhibit immunomodulatory and anti ... [more ▼]

Mesenchymal stromal cells (MSCs) represent a heterogeneous subset of multipotent cells that can be isolated from several tissues including bone marrow and fat. MSCs exhibit immunomodulatory and anti-inflammatory properties that prompted their clinical use as prevention and/or treatment for severe graft-versus-host disease (GVHD). Although a number of phase I-II studies have suggested that MSCs infusion was safe and might be effective for preventing or treating acute GVHD, definitive proof for their efficacy remains lacking thus far. Multicenter randomized studies are ongoing to more precisely assess the impact of MSCs infusion on GVHD prevention/treatment, whereas further research is performed in vitro and in animal models with the aims of determining the best way to expand MSCs ex vivo as well as the most efficient dose and schedule of MSCs administration. After introducing GVHD, MSC biology, and results of MSCs infusion in animal models of allogeneic hematopoietic cell transplantation, this article reviews the results of the first clinical trials investigating the use of MSCs infusion as prevention or treatment of GVHD. [less ▲]

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See detailMesenteric Doppler Blood Flow Velocities in Pre-Operative Infants with Transposition of the Great Arteries
Campbell, Morag; Rigo, Vincent ULg; Robertson, Murray

in Pediatric Research (2003, April), 53(4 Part 2/2), 386

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See detailMesh Enrichment with Spectral Band and Interface Finite Elements for the Modelling of the Shear Band Localisation
Charlier, Robert ULg; Wang, XiaoChuan; Pierry, Joelle

in Proc. of the 8th Int. Conf. of the Int. Ass. for Computer Methods and Advances in Geomechanics (1994, May)

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See detailMesh influence on cardiovascular simulations
Sauvage, E.; Marchandise, E.; Remacle, J.-F. et al

in Proceedings of the 5th international conference on Advanced COmputational Methods in ENgineering (ACOMEN 2011) (2011, November)

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See detailMesh Updating in Eulerian-Lagrangian FEM for Large Deformation Analysis
Ponthot, Jean-Philippe ULg; MINCKE, J. C.

in Actes du 2° Colloque Belge de Mécanique Théorique et Appliquée (1990)

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See detailA mesh-shape sensitivity synthesis for boundary-formulated shape optimal design
Hwang, Yearn-Tzuo; Fleury, Claude ULg

in The 34th AIAA/ASME/ASCE/AHS/ASC structures, structural dynamics, and materials conference AIAA/ASME, adaptive structures forum : April 19-22, 1993/La Jolla, CA (1993)

This paper presents a sequential mesh-shape sensitivity synthesis with which only the structural boundary information is required during the shape optimization process. Large structural shape reformation ... [more ▼]

This paper presents a sequential mesh-shape sensitivity synthesis with which only the structural boundary information is required during the shape optimization process. Large structural shape reformation as well as the minimum mesh distortion can be obtained. This method avoids the repetitive remeshing procedure by employing an optimization driven mesh smoothing algorithm proposed by Hwang and Fleury. It eliminates the need to explicitly define the grid point peturbations for the shape sensitivity by extracting the mesh sensitivity from the optimized mesh. Since only the structural boundary is involved in the shape optimization scheme, the method used to create the finite element mesh is not important as long as the element topology for the model is valid. Examples are provided to show the effectiveness of this approach. [less ▲]

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See detailThe Mesolithic of the Belgian Ardennes
Otte, Marcel ULg; Noiret, Pierre ULg

in Kind, Claus-Joachim (Ed.) After the Ice Age. Settlements, subsistence and social development in the Mesolithic of Central Europe (2006)

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See detailThe Mesolithic of Trou Al'Wesse Cave (Belgium) in Regional Context
Miller, Rebecca ULg; Stewart, John; Zwyns, Nicolas et al

in Oosterbeek, Luis; Fidalgo, Claudia (Eds.) Miscellania, Volume 47 of the Proceedings of the 15th UISPP Congress (2011)

Recent excavations at the cave site of Trou al'Wesse (Modave, Belgium) have yielded significant new data concerning the Mesolithic occupations at the site that contribute to the understanding of the ... [more ▼]

Recent excavations at the cave site of Trou al'Wesse (Modave, Belgium) have yielded significant new data concerning the Mesolithic occupations at the site that contribute to the understanding of the chronology and environmental context of the Belgian Mesolithic. We present the results of the analyses of lithic and faunal assemblages, site taphonomy and spatial distribution, and discuss the relationship of the site with other Mesolithic sites in Belgium. [less ▲]

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See detailLe Mésolithique du Bassin pannonien et la formation du Rubané
Otte, Marcel ULg; Noiret, Pierre ULg

in Anthropologie (L') (2001), 105(3, JUL-SEP), 409-419

The LBK appears as the result of acculturation of local Mesolithic Populations, beginning in the Pannonian Basin following a trans-Balkan colonisation. Economy, architecture and ceramic proceed from an ... [more ▼]

The LBK appears as the result of acculturation of local Mesolithic Populations, beginning in the Pannonian Basin following a trans-Balkan colonisation. Economy, architecture and ceramic proceed from an adaptation to local means, which explains the chronological disjunction between acculturation and geographic expansion. The whole is placed within a context already Indo-European, since the Late Palaeolithic. (C) 2001 Editions scientifiques et medicales Elsevier SAS. [less ▲]

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See detailLe Mésolithique récent du Trou Al’Wesse (comm. de Modave, Prov. de Liège) Découverte de tessons de type non rubanés ou «Bereitkeramiek»
Miller, Rebecca ULg; Otte, Marcel ULg; Stewart, John

in Notae Praehistoricae (2009), 29

On the terrace of the site of Trou Al'Wesse, commun of Modave (province of Liège, Belgium), stratum 4b-δ, excavated in 2008, has been attributed to the Late Mesolithic. Ceramic sherds of La Hoguette type ... [more ▼]

On the terrace of the site of Trou Al'Wesse, commun of Modave (province of Liège, Belgium), stratum 4b-δ, excavated in 2008, has been attributed to the Late Mesolithic. Ceramic sherds of La Hoguette type have been recovered from near the top of this Mesolithic context, which contains lithic artifacts, a charcoal lens, wild fauna including an aurochs astragalus with cutmarks, and a sawn red deer crown antler. LBK sherds of the type found in overlying stratum 4a, are absent in facies 4b-δ. This is the first time that La Hoguette sherds have been found instratified context associated with material that can be radiometrically dated, and also the first time that such sherds have been discovered south of the Meuse and Sambre in Belgium. New dates from this stratum contribute to placing these sherds and the other elements in chronological context. [less ▲]

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See detailMeson modes in Nuclear Matter in the Nambu – Jona-Lasinio Model
Jaminon, Martine ULg; Mendez Galain, Ramon; Stassart, Pierre

Conference (2001)

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See detailMesopelagic C mineralization at the Southern Ocean’s scale
Jacquet, S.; Dehairs; Elskens, M. et al

Conference (2007, April)

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See detailMesophilic biohydrogen production by Clostridium butyricum CWBI1009 in trickling biofilter reactor
Puhulwella, Rathnasiri G.; Beckers, Laurent; Delvigne, Frank ULg et al

in International Journal of Hydrogen Energy (2014), 39

This study investigates the mesophilic biohydrogen production from glucose using a strictly anaerobic strain, Clostridium butyricum CWBI1009, immobilized in a trickling bed sequenced batch reactor (TBSBR ... [more ▼]

This study investigates the mesophilic biohydrogen production from glucose using a strictly anaerobic strain, Clostridium butyricum CWBI1009, immobilized in a trickling bed sequenced batch reactor (TBSBR) packed with a Lantec HD Q-PAC® packing material (132 ft2/ft3 specific surface). The reactor was operated for 62 days. The main parameters measured here were hydrogen composition, hydrogen production rate and soluble metabolic products. pH, temperature, recirculation flow rate and inlet glucose concentration at 10 g/L were the controlled parameters. The maximum specific hydrogen production rate and the hydrogen yield found from this study were 146 mmol H2/L.d and 1.67 mol H2/mol glucose. The maximum hydrogen composition was 83%. Following a thermal treatment, the culture was active without adding fresh inoculum in the subsequent feeding and both the hydrogen yield and the hydrogen production rate were improved. For all sequences, the soluble metabolites were dominated by the presence of butyric and acetic acids compared to other volatile fatty acids. The results from the standard biohydrogen production (BHP) test which was conducted using samples from TBSBR as inoculum confirmed that the culture generated more biogas and hydrogen compared to the pure strain of C. butyricum CWBI1009. The effect of biofilm activity was studied by completely removing (100%) the mixed liquid and by adding fresh medium with glucose. For three subsequent sequences, similar results were recorded as in the previous sequences with 40% removal of spent medium. The TBSBR biofilm density varied from top to bottom in the packing bed and the highest biofilm density was found at the bottom plates. Moreover, no clogging was evidenced in this packing material, which is characterized by a relatively high specific surface area. Following a PCA test, contaminants of the Bacillus genus were isolated and a standard BHP test was conducted, resulting in no hydrogen production. [less ▲]

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