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See detailHipertension arterial renal en el anciano
Valdes, Eduardo Fernando; VALDES SOCIN, Hernan Gonzalo ULiege

in Romero Villanueva, Horacio; Farah, Ruben (Eds.) Hipertension en el anciano (1996)

The kidney is both a key regulator of arterial pressure and a target organ of hypertension in the elderly. The aging kidney presents several anatomical and functional changes. Main anatomical changes are ... [more ▼]

The kidney is both a key regulator of arterial pressure and a target organ of hypertension in the elderly. The aging kidney presents several anatomical and functional changes. Main anatomical changes are weight loss (250 g in the adult and 180g in the elderly) and cortical and glomerular atrophy. As a consequence, the glomerular filtration, (600 ml/min in the adult an 300 ml/min in the elderly) and the creatinine clearence usualy fall down in these patients. In considering pharmacological treatment, one needs to remember these important features. This chapter summarizes the different and most frequent causes of renal hypertension in the elderly and disscuss the main therapeutic implications. [less ▲]

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See detailHipogonadismo masculino
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2013, March)

Conferencia: Hipogonadismo masculino Aula Prof Niepominitzce. Hospital de Clinicas . Universidad de Buenos Aires. Argentina Marzo 2013 El hipogonadismo congénito es un síndrome clínico que se caracteriza ... [more ▼]

Conferencia: Hipogonadismo masculino Aula Prof Niepominitzce. Hospital de Clinicas . Universidad de Buenos Aires. Argentina Marzo 2013 El hipogonadismo congénito es un síndrome clínico que se caracteriza por un impuberismo parcial o completo. El hipogonadismo congénito puede resultar de una estimulación insuficiente del eje hipotalámico y de la liberación del GnRH, o bien de una secreción insuficiente de las gonadotropinas hipofisarias LH y FSH o bien manifestarse primariamente a nivel testicular. En el hombre, varios genes participan en la vía de la olfacción y de la migración de las neuronas de GnRH, pudiendo interactuar durante la vida embrionaria y postnatal. Se empieza a describir un creciente número de mutaciones en genes diferentes, responsables del hipogonadismo masculino congénito (1). Esta presentación incluye el reconocimiento de diferentes patologías que cursan con un hipogonadismo genético (síndromes de Klinefelter, Kallman, Noonan, Prader Willy, testículo feminizante). En la segunda parte de la presentación resumimos los datos clínicos, biológicos y estudios genéticos de un paciente que es visto en el hospital universitario de Lieja por hipogonadismo, presentando un eunucoidismo y un cierto grado de espermatogénesis. Casi 50 años después de la descripción los médicos argentinos Pasqualini y Bur pudimos reconocer, en colaboración con un equipo suizo, la causa genética de este síndrome, a saber un déficit de la LH debido a una mutación invalidante homocigota de la subunidad beta de dicha hormona(2). Un tratamiento en base a hCG permitió por primera vez restituir la fertilidad al paciente. Su esposa quedo embarazada gracias a un tratamiento de fertilidad asistida , y ambos tuvieron un niño, heterocigoto para la mutación de beta LH (3,4). La tercera parte de la conferencia está dedicada a los avances en la fisiología y endocrinología de las kispeptinas. Las mutationes del gen de kisspeptina y de su receptor son una nueva causa de hipogonadismo congénitos. Describimos nuestra experiencia en la determinación plasmática de kisspeptina en pacientes obesos e hipo gonádicos (5). Demostramos asimismo la diferente expresión espacio-temporal de kisspeptina en las placentas normales y patológicas (6). En la última parte de la conferencia incluimos todas estas nuevas causas de hipogonadismo en un modelo para mejorar la comprensión del funcionamiento del eje reproductor en el hombre. Referencias 1-H. Valdes-Socin , F.G. Debray, A.S. Parent, M.C. Lebrethon, J.P. Bourguignon, V. Bours A. Beckers. Comment je diagnostique un hypogonadisme hypogonadotrope congénital isolé? Rev Med Liège 2010 Nov;65(11):634-41. 2-H Valdes-Socin, R Salvi, A Daly, F Pralong, R Gaillard R and A Beckers. Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene.N Engl J Med. 2004 Dec 16;351(25):2619-25 3-H Valdes-Socin, R Salvi , A Thiry, AF. Daly, F P. Pralong, R Gaillard, A Beckers. Testicular effects of isolated luteinizing hormone deficiency and reversal by long-term human chorionic gonadotropin treatment. J Clin Endocrinol Metab. 2009 Jan;94(1):3-4. 4-Daly, A., Valdes-Socin, H., Beckers, A. “A tall man with hypogonadism”. In: Wartofsky L. editor. Diagnostic Dilemmas: Images in Endocrinology. The Endocrine Society Press. (2011). p.204-207. 5-Valdes Socin, H. G, Cavalier, E, Beckaert, A. C, Carlisi, A, Chavez, M, & Beckers, A. (2011). Elévation des kisspeptines plasmatiques chez les hommes obèses avec hypogonadisme acquis et chez les hommes avec hypogonadisme congénital : Etude pilote des modifications plasmatiques des kisspeptines avant et après administration de hCG et testostérone. Annales d'Endocrinologie - 28ème congrès de la société Française d'Endocrinologie. 6-H Valdes-Socin , C Munaut , M Chavez, F Chantrain, K Delbecque , P Delvenne, JM Foidart , A Beckers: expression et localisation spatio-temporelle de kiss1 et de son récepteur KissR dans le placenta humain normal et pathologique. Annales d'Endocrinologie 2012. Société Française d'Endocrinologie [less ▲]

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See detailHipóteses estatísticas : revendo idéias sobre ortogonalidade e balanceamento em análise de varîancia
Iemma, Antonio Francisco; Claustriaux, Jean-Jacques ULiege; Palm, Rodolphe ULiege

in Multiciência (2000), 4(1), 62-82

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See detailHipparcos Astrometric Binaries in the Ninth Catalogue of Spectroscopic Binary Orbits: A Testbench for the Detection of Astrometric Binaries with Gaia
Jancart, Sylvie ULiege; Jorissen, A.; Pourbaix, D.

in O'Flaherty, K.S.; Perryman, M.A.C (Eds.) The Three-Dimensional Universe with Gaia (2005, January 01)

The Ninth Catalogue of Spectroscopic Binary Orbits1 and the Hipparcos Intermediate Astrometric Data (IAD) are used to retrieve astrometric binaries from the Hipparcos data. It is found that basically all ... [more ▼]

The Ninth Catalogue of Spectroscopic Binary Orbits1 and the Hipparcos Intermediate Astrometric Data (IAD) are used to retrieve astrometric binaries from the Hipparcos data. It is found that basically all (non-SB2) systems with periods larger than about 100 d, and parallaxes larger than 5-10 mas exhibit an astrometric orbital motion which can be extracted from the IAD. The lessons learned from this kind of approach will be very valuable for the design of the Gaia reduction pipeline. [less ▲]

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See detailThe Hipparcos Input Catalogue. Volumes 1 - 7.
Turon, C.; Crézé; Egret, D. et al

in The Hipparcos Input Catalogue. Volumes 1 - 7., by Turon, C.; Crézé, M.; Egret, D.; Gomez, A.; Grenon, M.; Jahreià , H.; Réquième, Y.; Argue, A. N.; Bec-Borsenberger, A.; Dommanget, J.; Mennessier, M. O.; Arenou, F.; Chareton, M.; Crifo, F.; Mermilliod, J. C.; Morin, D.; Nicolet, B.; Nys, O.; Prévot, L.; Rousseau, M.; Perryman, M. A. C.; Arlot, J. E.; Baglin, A.; Barthès, D.; Baylac, M. O.; Brosche, P.; Burnet, M.; Delhaye, J.; Dettbarn, C.; Erbach, M.; Figueras, F.; Fricke, W.; Helmer, L.; Hemenway, P.; Jordi, C.; Lampens, P.; Lederle, T.; Lub, J.; Manfroid, J.; Mattei, J. A.; Mazurier, J. M.; Mermilliod, M.; Morisson, L. V.; Murray, C. A.; Oblak, E.; Périé, J. P.; Pernier, B.; Le Poole, R. S.; Quijano, L.; Rapaport, M.; Sellier, A.; Torra, J.; Tucholke, H.-J.; de Vegt, C.; Høg, E.; Kovalevsky, J.; van Leeuwen, F.; Lindegren, L.; Schütz, A.; Schrijver, H.. European Space Agency, Paris (France), Mar 1992, 3211 p., ISBN 92-9092-120, Price Dfl. 180.00. (1992)

Vol. 1 - 5: The Hipparcos Input Catalogue. Vol. 6: Annex 1. Double and multiple stars. Vol. 7: Annex 2. The atlas of identification charts for faint stars. Annex 3. Identification charts for stars in ... [more ▼]

Vol. 1 - 5: The Hipparcos Input Catalogue. Vol. 6: Annex 1. Double and multiple stars. Vol. 7: Annex 2. The atlas of identification charts for faint stars. Annex 3. Identification charts for stars in galactic open clusters. Annex 4. Identification charts for stars in the Magellanic Clouds. The Hipparcos Input Catalogue was constructed as the observing programme for the European Space Agency's Hipparcos astrometry mission. The requirements of the project in terms of completeness, sky coverage, astrometric and photometric accuracy, as well as the necessary optimisation of the scientific impact, resulted in an extended effort to compile and homogenize existing data, to clarify sources and identifications and, where needed, to collect new data matching the required accuracy. This has resulted in an unprecedented catalogue of stellar data including up-to-date information on positions, proper motions, magnitudes and colours, and (whenever available) spectral types, radial velocities, multiplicity and variability information. The catalogue is complete to well-defined magnitude limits, and includes a substantial sampling of the most important stellar categories present in the solar neighborhood beyond these limits. The magnitude limits vary from 7.3 to 9 mag as a function of galactic latitude and spectral type, and there are no stars fainter than about V = 13 mag. [less ▲]

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See detailHippocampal response at training promotes insight after sleep
Darsaud, Annabelle; Balteau, Evelyne ULiege; Desseilles, Martin ULiege et al

in NeuroImage (2006), 31(Suppl. 1),

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See detailHippocrate dans un monde de chrétiens : la réception des traités hippocratiques dans la chôra égyptienne à la période byzantine (284-641)
Marganne, Marie-Hélène ULiege

in Jouanna, Jacques; Zink, Michel (Eds.) Hippocrate et les hippocratismes : médecine, religion, société. Actes du XIVe Colloque International Hippocratique (2014)

Dans le cadre d'une recherche sur la réception des œuvres des auteurs de l’antiquité classique dans l’Égypte christianisée, on examine les témoignages papyrologiques de la période byzantine relatifs aux ... [more ▼]

Dans le cadre d'une recherche sur la réception des œuvres des auteurs de l’antiquité classique dans l’Égypte christianisée, on examine les témoignages papyrologiques de la période byzantine relatifs aux traités hippocratiques, leur texte, leur mise en texte et leur contexte, en vue, non seulement de définir leur spécificité par rapport aux autres papyrus grecs médicaux et aux papyrus iatro-magiques de la même époque, mais aussi d’y déceler des traces éventuelles de copie ou d’utilisation en contexte chrétien. [less ▲]

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See detailL'hippocratisme digital.
Salerno, D.; Delwaide, Jean ULiege; Detry, Olivier ULiege

in Revue Médicale de Liège (2010), 65(2), 88-92

Digital clubbing is a clinical sign known for centuries. Though, no theory could yet explain this entire phenomenon, neither in its primary nor its secondary form. This article reviews the actual ... [more ▼]

Digital clubbing is a clinical sign known for centuries. Though, no theory could yet explain this entire phenomenon, neither in its primary nor its secondary form. This article reviews the actual hypotheses bringing a plausible explanation, regarding the most current pathologies associated with digital clubbing. A focus is made on pulmonary and digestive pathologies, and particularly cirrhosis. The knowledge of the mechanisms underlying finger clubbing might lead, in the future, to an effective treatment. [less ▲]

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See detailHippokratész ikrei: jog és filozófia a kelseni jogértelmezéstanban
Paksy, Máté ULiege

in Vilagossag (2005), 11

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See detailHippopotamus of the W-Arli-Pendjari-Oti-Mandouri-Keran Ecosystem. West Africa. Status, distribution and conservation issues
Bouché, Philippe ULiege

in Suiform soundings PPHSG Newsletter (2004), 4(1), 14-19

For the first time in April 2003, an aerial total wildlife count of the entire W-Arli-Pendjari-Oti- Mandouri-Keran (WAPOK) Ecosystem, the largest savannah ecosystem of West Africa, has been conducted ... [more ▼]

For the first time in April 2003, an aerial total wildlife count of the entire W-Arli-Pendjari-Oti- Mandouri-Keran (WAPOK) Ecosystem, the largest savannah ecosystem of West Africa, has been conducted. During this survey, Hippopotamus have been observed 51 times, totaling 696 individuals. An average of 13.86 ± 16.73 individuals was noted. The group size varied between 1 and 65 individuals. In the WAPOK ecosystem, the future of hippopotamus is ensured by the tourism activity in the area and the redistribution of tourism revenue to human communities living around the ecosystem, thanks to several conservation project, but more certainly, to the conservation initiative of several private stakeholders. [less ▲]

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See detailHirsutisme et hyperthrycose
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2002, June 04)

L'hypertrycose est un ecause fréquente de consultation chez les femmes, et souvent invalidante sur le plan psychologique. L'objet de cette présentation est de différencier l'hirsutisme (de cause ... [more ▼]

L'hypertrycose est un ecause fréquente de consultation chez les femmes, et souvent invalidante sur le plan psychologique. L'objet de cette présentation est de différencier l'hirsutisme (de cause endocrinienne) de l'hypertycose (constitutionnelle). Nous rappelons la sémiologie, la mise au point biologique, la physiopathologie et les différentes explorations de l'hyperandrogénie, qui déterminent ube prise en charge appropriée. [less ▲]

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See detail'His Horses are like Falcons': War Imagery in Ramesside Texts
Gillen, Todd Jonathan ULiege

Scientific conference (2006)

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See detailHis Horses are like Falcons: War Imagery in Ramesside Texts
Gillen, Todd Jonathan ULiege

in Endreffy, Kata; Gulyas, Andras (Eds.) Proceedings of the Fourth Central European Conference of Young Egyptologists (2007)

Detailed reference viewed: 35 (1 ULiège)
See detailHiSea: High resolution merged satellite sea surface temperature fields
Alvera Azcarate, Aïda ULiege; Barth, Alexander ULiege; Toussaint, Marie-Eve ULiege et al

Conference (2011, May 25)

Several satellites measure Sea Surface Temperature (SST), each of these with different technical specificities and error sources. Together with in situ data, they form a highly complementary data set. The ... [more ▼]

Several satellites measure Sea Surface Temperature (SST), each of these with different technical specificities and error sources. Together with in situ data, they form a highly complementary data set. The creation of merged SST products, integrating the strengths of each of its components and minimising their weaknesses, is however not an easy task, but it is certainly a desirable goal that has generated a large amount of research over the last years. The main objectives of this project are, among others: 1.To develop a technology, based on DINEOF (Data Interpolating Empirical Orthogonal Functions), that allows to merge different data sets at very different sampling intervals (in space and time) and create an integrated product at the highest sampling frequency and with the highest quality possible. 2.To provide improved, merged analyses of variables such as SST and chlorophyll. 3.Obtain a better understanding of the diurnal cycle of the studied variables. 4.To better understand the relation between variables (and take advantage of these relationship to improve the analyses). 5.Using the above-mentioned developments, explore the capability of the developed technology to produce SST forecasts based on multi-variate EOFs and model forecasts. We will present the first preliminary results for merging different SST data sets, as well as our plans for future developments and applications. Website of the project: http://www.gher.ulg.ac.be/HiSea/ [less ▲]

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See detailHistamine et bronchospasme d'effort
Bury, Thierry ULiege

Master of advanced studies dissertation (1989)

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See detailHistamine H3 antagonist thioperamide dose-dependently enhances memory consolidation and reverses amnesia induced by dizocilpine or scopolamine in a one-trial inhibitory avoidance task in mice
Bernaerts, P.; Lamberty, Y.; Tirelli, Ezio ULiege

in Behavioural Brain Research (2004), 154(1), 211-219

In the literature, there is some evidence indicating that H3 histamine receptor antagonists, in particular thioperamide, can facilitate learning and memory retrieval in laboratory rodents. The present ... [more ▼]

In the literature, there is some evidence indicating that H3 histamine receptor antagonists, in particular thioperamide, can facilitate learning and memory retrieval in laboratory rodents. The present study aimed at verifying whether this also holds for memory consolidation, a phase of memory for which there is scarcity of convincing data on the effects of H3 receptor antagonists given systemically. To that end, memory consolidation was assessed in C57BL/6J mice using the one-trial step-through inhibitory avoidance task, the compounds being injected immediately after training (foot-shock) and performance measured 24 h later. More specifically, the following effects of thioperamide (1.25-20 mg/kg) were dose-dependently analysed: (1) its potential direct effects on memory consolidation; (2) its potential reversing effects on retrograde amnesia induced by the NMDA antagonist dizocilpine (MK-801, 0.5 mg/kg) and (3) its potential reversing effects on the well-known amnesia induced by the muscarinic antagonist scopolamine (0.25 mg/kg). We found that thioperamide exerted a dose-dependent facilitative effect on memory consolidation. Furthermore, the H3 receptor antagonist reversed scopolamine- and especially dizocilpine-induced amnesia. The results strongly support the view that the brain mechanisms of memory consolidation involve a functional interaction between the NMDA and the H3 sites. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe histamine H3-receptor inverse agonist Pitolisant improves fear memory in mice
Brabant, Christian ULiege; Charlier, Yana ULiege; Tirelli, Ezio ULiege

in Behavioural Brain Research (2013), 243

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive ... [more ▼]

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive disorders. Pitolisant (BF2.649, 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride) was the first H3R inverse agonist that has been tested in human trials and is well tolerated. The present study investigated whether Pitolisant (0.625–20 mg/kg, i.p.) improves consolidation and reconsolidation processes in the fear conditioning task in female C57BL/6J mice. We also tested whether Pitolisant reverses memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (MK-801). Our results indicate that post-training systemic injections of Pitolisant facilitated consolidation of contextual fear memory and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine. In addition, none of the doses of Pitolisant we have tested after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas dizocilpine disrupted it. However, Pitolisant was able to reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine. The present results are the first demonstration that Pitolisant is effective in improving consolidation processes in the fear condition task and add further evidence to its potential for treating cognitive disorders. [less ▲]

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See detailHistamine liberation related to cardiopulmonary bypass in children: Possible relation to transient postoperative arrhythmias
Seghaye, Marie-Christine ULiege; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(5), 971-981

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 ... [more ▼]

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 children undergoing cardiac operations. The relationship between inflammatory response to cardiopulmonary bypass and transient postoperative arrhythmias was analyzed. Cardiopulmonary bypass was conducted with circulatory arrest and deep hypothermia in 10 patients and with continuous low-flow and moderate hypothermia in 16 patients. Transient postoperative arrhythmias diagnosed on standard or atrial electrocardiograms (or both) were seen in eight of the 26 examined children: accelerated junctional rhythm (n = 3), junctional ectopic tachycardia (n = 3), second-degree atrioventricular block (n = 1), and third- degree atrioventricular block (n = 1). Children with transient postoperative arrhythmias were younger than those without (p < 0.05). Compared with baseline values, there was in all patients a significant release of histamine and eosinophil cationic protein (p < 0.05) related to cardiopulmonary bypass, reaching peak values 4 hours after the operation. In contrast, tumor necrosis factor-α production and prostaglandin D2 release were not significant. This suggests that activated basophils but not mast cells are the major sources of histamine liberated during and after cardiopulmonary bypass. Histamine release but not eosinophil cationic protein release correlated with circulatory arrest and deep hypothermia (p < 0.05), suggesting the participation of physicochemical alterations of circulating basophils leading to histamine liberation. Four hours after the operation, patients with transient postoperative arrhythmias had significantly higher blood concentrations of histamine (p < 0.02) and eosinophil cationic protein (p < 0.05) than did those without transient postoperative arrhythmias. On the first postoperative day, four of the eight patients with transient postoperative arrhythmias had persisting elevated histamine levels, whereas in patients without transient postoperative arrhythmias histamine reached baseline values. The multivariate analysis retained histamine release and eosinophil cationic protein variations related to cardiopulmonary bypass for the emerging model to predict transient postoperative arrhythmias. The results of this study show significant histamine release related to cardiopulmonary bypass. Furthermore, they document a possible relationship between circulating histamine and transient postoperative arrhythmias. The latter may therefore be suspected among the consequences of the inflammatory response to cardiopulmonary bypass. [less ▲]

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See detailHistamine modulation of neutrophil chemotaxis and T-lymphocyte proliferation in man
Bury, Thierry ULiege; Radermecker, Maurice ULiege

in Schweizerische Medizinische Wochenschrift (1991), 121(9), 35

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