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See detailMitochondrial Translation in Green Algae and Higher Plants
Salinas, Thalia; Remacle, Claire ULg; Maréchal-Drouard, Laurence

in Duchêne, A-M (Ed.) Translation in mitochondria and other organelles (2013)

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See detailMitochondrial UCPs: New insights into regulation and impact
Sluse, Francis ULg; Jarmuszkiewicz, Wieslawa; Navet, Rachel ULg et al

in Biochimica et Biophysica Acta-Bioenergetics (2006), 1757(5-6, Suppl 1), 101

Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins sustaining an inducible proton conductance. They weaken the proton electrochemical gradient built up by the mitochondrial respiratory ... [more ▼]

Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins sustaining an inducible proton conductance. They weaken the proton electrochemical gradient built up by the mitochondrial respiratory chain. Brown fat UCP1 sustains a free fatty acid (FA)-induced purine nucleotide (PN)-inhibited proton conductance. Inhibition of the proton conductance by PN has been considered as a diagnostic of UCP activity. However, conflicting results have been obtained in isolated mitochondria for UCP homologues (i.e., UCP2, UCP3, plant UCP, and protist UCP) where the FFA-activated proton conductance is poorly sensitive to PN under resting respiration conditions. Our recent work clearly indicates that the membranous coenzyme Q, through its redox state, represents a regulator of the inhibition by PN of FFA-activated UCP1 homologues under phosphorylating respiration conditions. Several physiological roles of UCPs have been suggested, including a control of the cellular energy balance as well as the preventive action against oxidative stress. In this paper, we discuss new information emerging from comparative proteomics about the impact of UCPs on mitochondrial physiology, when recombinant UCP1 is expressed in yeast and when UCP2 is over-expressed in hepatic mitochondria during steatosis [less ▲]

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See detailMitochondrial uncoupling proteins: new insights from functional and proteomic studies.
Douette, P.; Sluse, Francis ULg

in Free Radical Biology & Medicine (2006), 40

Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in ... [more ▼]

Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in inducible proton conductance. They dissipate the proton electrochemical gradient established by the respiratory chain at the expense of reducing substrates. Several physiological roles have been suggested for uncoupling proteins, including roles in the control of the cellular energy balance and in preventive action against oxidative stress. This review focuses on new leads emerging from comparative proteomics about the involvement of uncoupling protein in the mitochondrial physiology. A brief overview on uncoupling proteins and on proteomics applied to mitochondria is also presented herein. [less ▲]

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See detailMitochondrion plasticity evidenced by coupled comparisons of mitochondrial and cellular proteomes
Mathy, Grégory ULg

Poster (2007, May 16)

Mitochondria are key organelles in primary metabolism: they are the main source of energy production and the starting point of important biosynthetic pathways. Thus the control of the mitochondrial ... [more ▼]

Mitochondria are key organelles in primary metabolism: they are the main source of energy production and the starting point of important biosynthetic pathways. Thus the control of the mitochondrial function is a prerequisite for cellular survival in front of a wide spectrum of exogenous or endogenous stresses. By using the SILAC method, we have investigated the yeast mitochondrial and cellular proteome adaptation to the heterologous expression of a mitochondrial alternative oxidase (AOX). AOX is an energy dissipating enzyme that catalyses the re-oxidation of ubiquinol within the respiratory chain and compete with the Cytochrome pathway for electrons and thus, prevents proton pumping, and consequently leads to a decrease in ATP synthesis. [less ▲]

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See detailMitogen-Activated Lymphocytes: A Good Model for Characterising Lung Cyp1a1 Inducibility
Lambert, Vincent ULg; Todaro, Anna ULg; Kremers, Pierre ULg et al

in European Journal of Epidemiology (1997), 13(2), 177-83

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility ... [more ▼]

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility factor, generally evaluated on mitogen-activated lymphocytes after PAH induction, represents correctly the lung situation. Optimal experimental conditions were determined for evaluating, on both lymphocytes and lung tissue explants, the inducibility factor, defined as the ratio of EROD activity (CYP1A1-specific) to cytochrome c reductase activity (unaffected by PAH induction). Paired results for lymphocytes and lung tissue samples from 10 lung cancer patients were compared. A good correlation was observed between lymphocyte and lung tissue inducibilities (R = 0.809; p = 0.005). In conclusion, mitogen-activated lymphocyte inducibility is indicative of lung tissue inducibility and constitutes a good marker for evaluating individual PAH inducibilities. [less ▲]

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See detailMitoproteome plasticity of rat brown adipocytes in response to cold acclimation
Navet, Rachel ULg; Mathy, Grégory ULg; Douette, Pierre ULg et al

in Journal of Proteome Research (2007), 6(1), 25-33

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein ... [more ▼]

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling. [less ▲]

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See detailmitotic cycling of radial glial cells of the fetal murine cerebral wall: a combined autoradiographic and immunohistochemical study.
Misson, Jean-Paul ULg; Edwards, Michael; Yamamoto, M. et al

in Developmental Brain Research (1988), 38

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See detailMitotic spindle: focus on the function of huntingtin
Godin, Juliette ULg; Humbert, Sandrine

in International Journal of Biochemistry & Cell Biology (2011), 43(6), 852-856

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See detailMitral regurgitation after transcatheter aortic valve replacement: Does the prosthesis matter?
Unger, Philippe; Dedobbeleer, Chantal; Vanden Eynden, Frederic et al

in International Journal of Cardiology (2013)

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See detailMitral regurgitation in patients with aortic stenosis undergoing valve replacement.
Unger, P.; Dedobbeleer, C.; Van Camp, G. et al

in Heart (2009)

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See detailMitral regurgitation in patients with systolic heart failure: more than a bystander
Lancellotti, Patrizio ULg; Dulgheru, R.

in Revista Espanola de Cardiologia (2011)

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See detailMitral repair versus replacement for ischemic mitral regurgitation comparison of short-term and long-term survival
Magne, Julien ULg; Girerd, N.; Sénéchal, M. et al

in Circulation (2009), 120(SUPPL. 1), 104-111

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See detailMitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral regurgitation.
Fattouch, Khalil; Murana, Giacomo; Castrovinci, Sebastiano et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2012), 143(4 Suppl), 38-42

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To ... [more ▼]

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To plan mitral valve repair by annuloplasty and papillary muscle (PPM) relocation, we proposed a valve repair procedure oriented by the new main features obtained by real-time 3D TOE reconstruction of the mitral valve apparatus. METHODS: Since January 2008, 25 patients with severe FMR before mitral valve repair were examined. Mean coaptation depth and mean tenting area were 1.3 +/- 0.2 cm and 3.2 +/- 0.5 cm(2), respectively. Intraoperative 2D and 3D TOE were performed, followed by a 3D offline reconstruction of the mitral valve apparatus. A schematic mitral valve apparatus model was obtained. A geometric model like a truncated cone was traced in according to the preoperative measurements. The size of the prosthetic ring was selected preoperatively according to the anterior leaflet surface. The expected truncated cone after annuloplasty was retraced. A conventional normal coaptation depth about 0.6 cm was used to detect the new position of the PPM tips. RESULTS: Offline reconstruction of the mitral valve apparatus and respective truncated cone were feasible in all patients. The expected position of the PPM tips desirable to reach a normal tenting area with a coaptation depth 0.6 cm or less was obtained in all patients. After surgery, all parameters were calculated and no statistically significant difference was found compared with the expected data. CONCLUSIONS: PPM relocation plus ring annuloplasty reduce mitral valve tenting and may improve mitral valve repair results for patients with severe FMR. This technique may be easily and precisely guided by preoperative offline 3D echocardiographic mitral valve reconstruction. [less ▲]

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See detailMitral valve dynamics in a closed-loop model of the cardiovascular system
Paeme, Sabine ULg; Chase, J. Geoffrey; Hann, christopher et al

in Archives des Maladies du Coeur et des Vaisseaux. Pratique (2009, December), hors série 1

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This work describes a new coupled model of the cardiovascular system that accounts for progressive mitral valve aperture. Simulations show good correlation with physiologically expected results for healthy or diseased valves. The large number of valve model parameters indicates a need for emerging, lighter and minimal mitral valve models that are readily identifiable to achieve full benefit in real-time use. These results suggest a further use of this model to track, diagnose and control valves pathologies. [less ▲]

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See detailMitral valve dynamics in a closed-loop model of the cardiovascular system
Paeme, Sabine ULg; Chase, J. Geoffrey; Hann, Christopher et al

Poster (2009, December 17)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This research couples the CVS model with a model describing the progressive aperture of the mitral valve. [less ▲]

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See detailMitteldevonische Sporen Aus Der Bohrung Schwarzbachtal 1.
Streel, Maurice ULg; Paproth, E

in Senckenbergiana Lethaea (1982), 63(4), 175-181

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See detailDie mittelniederländischen Nachdichtungen Hoffmanns von Fallersleben
Vromans, Joseph ULg

in Hipp, H. (Ed.) Niederlandistik und Germanistik. Tangenten und Schnittpunkte. Festschrift für Gerhard Worgt zum 65. Geburtstag (1993)

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See detailMix stability as a criterion for optimizing the granular composition to improve concrete durability – an application
Willem, Xavier; Courard, Luc ULg; Darimont, Anne ULg et al

in Marchand, J.; Bissonnette, B.; Gagné, R. (Eds.) et al Advances in Concrete through Science and Engineering (2006, September)

Detailed reference viewed: 41 (13 ULg)