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See detailInvestigation of the evolutionary development of the genus bifidobacterium by comparative genomics
Lugli, Gabriele; Milani, Christian; Turroni, Francesca et al

in Applied and Environmental Microbiology (2014)

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See detailInvestigation of the fine structure of European populations with applications to disease association studies
heath, sc; gut, ivo; brennan, p et al

in European Journal of Human Genetics (2008), 16

An investigation into fine-scale European population structure was carried out using high-density genetic variation on nearly 6000 individuals originating from across Europe. The individuals were ... [more ▼]

An investigation into fine-scale European population structure was carried out using high-density genetic variation on nearly 6000 individuals originating from across Europe. The individuals were collected as control samples and were genotyped with more than 300 000 SNPs in genome-wide association studies using the Illumina Infinium platform. A major East-West gradient from Russian (Moscow) samples to Spanish samples was identified as the first principal component (PC) of the genetic diversity. The second PC identified a North-South gradient from Norway and Sweden to Romania and Spain. Variation of frequencies at markers in three separate genomic regions, surrounding LCT, HLA and HERC2, were strongly associated with this gradient. The next 18 PCs also accounted for a significant proportion of genetic diversity observed in the sample. We present a method to predict the ethnic origin of samples by comparing the sample genotypes with those from a reference set of samples of known origin. These predictions can be performed using just summary information on the known samples, and individual genotype data are not required. We discuss issues raised by these data and analyses for association studies including the matching of case-only cohorts to appropriate pre-collected control samples for genome-wide association studies. [less ▲]

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See detailInvestigation of the geomechanical aspects of a large landslide by means of a finite-element method: a case study
François, Bertrand ULg; Bonnard, Christophe; Laloui, Lyesse

in 12th IACMAG Conference (2008)

Using advanced geomechanical finite element modelling, it has been possible to simulate the mechanical behaviour of a large slope movement, namely the Triesenberg landslide. This slope is located along ... [more ▼]

Using advanced geomechanical finite element modelling, it has been possible to simulate the mechanical behaviour of a large slope movement, namely the Triesenberg landslide. This slope is located along the Rhine valley in the Principality of Liechtenstein, covering an area of around 5 km2 which includes two villages. Pore water pressure fields calculated by a separated hydrogeological model were used as an input for the geomechanical model. The results obtained through 2- and 3-dimension numerical simulations agree fairly well with field measurements of peak velocity, spatial and temporal distribution of velocity and total displacements. Such results were obtained using a Modified Cam-Clay elasto-plastic constitutive model. In addition, a parametric study has been carried out to evaluate the effect of the selected friction angle and of the range of water pressure variation on the movements during a crisis period. [less ▲]

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See detailInvestigation of the glucose metabolism of the chicken by embryonic injection of tolbutamide
Franssens, Lies; Wang, Yufeng; Willems, Els et al

in Proceedings of the XXIV World's Poultry Congress (2012)

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See detailInvestigation of the glucose metabolism of the embryonic and neonatal broiler chicks by injection of insulin
Franssens, L.; Lesuisse, J.; Koppenol, A. et al

in EAAP series (2013)

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See detailInvestigation of the glucose metabolisme of the chicken embryo by injection of insulin
Franssens, Lies; Koppenol, Astrid; Wang, Yufeng et al

Poster (2012)

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See detailInvestigation of the influence of packing geometry and of liquid viscosity on the liquid flow morphology by using X-ray tomography
Janzen, Anna; Steube, Julia; Kenig, Evgeny et al

in Proceedings of the 7th World Congress on Industrial Process Tomography (2014)

X-ray tomography is used to investigate the influence of packing geometry and of liquid viscosity on hydrodynamic quantities, as well as on the liquid flow morphology inside a packed column successively ... [more ▼]

X-ray tomography is used to investigate the influence of packing geometry and of liquid viscosity on hydrodynamic quantities, as well as on the liquid flow morphology inside a packed column successively filled with two structured metallic packing, M752Y and M500X. As expected, liquid holdup and gas-liquid interfacial area increase with liquid flow rate and viscosity. In both packings, the film flow pattern predominates, while flooded regions remain minority. The influence of liquid flow rate and viscosity on flow morphology depends on the packing geometry. In M752Y, film and flooded region flows are clearly influenced, whereas in M500X, they are not. [less ▲]

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See detailInvestigation of the influence of surface roughness modification of bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Pyka, Grzegorz; Van Bael, Simon et al

in Abstract book SkyScan User Meeting 2010 (2010)

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailInvestigation of the innate immunity in the lower respiratory tract in exercising horses
Frellstedt, Linda ULg; Gosset, Philippe; Desmet, Christophe ULg et al

in Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (2011)

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See detailInvestigation of the interaction between a β-cyclodextrin and DMPC liposomes: a small angle neutron scattering study
Joset, Arnaud ULg; Grammenos, Angeliki; Hoebeke, Maryse ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2015), 83(3), 227-238

The Small Angle Neutron Scattering technique (SANS) has been applied to investigate the interaction between a cyclodextrin (CD) and liposomes. From the modelling of the experimental neutron scattering ... [more ▼]

The Small Angle Neutron Scattering technique (SANS) has been applied to investigate the interaction between a cyclodextrin (CD) and liposomes. From the modelling of the experimental neutron scattering cross sections, the detailed structure of dimyristoylphosphatidylcholine (DMPC) liposomes is assessed upon addition of increasing amounts of randomly methylated β-CD (RAMEB). This study has been performed at two temperatures bracketing the phase transition of the DMPC bilayers. The fraction of DMPC molecules incorporated into the vesicles is inferred. The dose-dependent phospholipidic extraction by RAMEB is quantified as well as the concomitant evolution of the liposome radius and of the thickness of the hydrophobic and hydrophilic parts of the membrane. The possible formation of CD-DMPC inclusion complexes is also assessed. The data suggest the dose-dependent coverage by RAMEB of the outer liposome interface. Our analysis highlights the important role of temperature on the mechanism of action of RAMEB. These results are discussed in the framework of the Area-Difference-Elasticity model. [less ▲]

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See detailInvestigation of the interactions of polyvinylpyrrolidone with mixtures of anionic and nonionic surfactants or anionic and zwitterionic surfactants by pulsed field gradient NMR
Misselyn-Bauduin, Anne-Marie; Thibaut, André ULg; Grandjean, Jean ULg et al

in Journal of Colloid & Interface Science (2001), 238(1), 1-7

The interaction of polyvinylpyrrolidone (PVP) with an anionic surfactant (sodium dodecyl sulfate, SDS), a nonionic surfactant (pentaethylene glycol monodecyl ether, C(10)E(5)), and a zwitterionic ... [more ▼]

The interaction of polyvinylpyrrolidone (PVP) with an anionic surfactant (sodium dodecyl sulfate, SDS), a nonionic surfactant (pentaethylene glycol monodecyl ether, C(10)E(5)), and a zwitterionic surfactant (lauryl amido propyl betaine, LAPB) has been investigated by means of pulsed gradient spin-echo NMR (FT-PGSE NMR), allowing self-diffusion coefficients to be determined. The results confirm the strong interaction prevailing in the PVP/SDS system, whereas no association has been observed in the PVP/C(10)E(5) and PVP/LAPB systems. Mixing PVP with two surfactants, namely SDS and C(10)E(5) or SDS and LAPB, results in the formation of ternary aggregates between the polymer and the mixed micelles. [less ▲]

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See detailAn investigation of the large-scale variability of the apparently single Wolf-Rayet star WR 1
Morel, Thierry ULg; Georgiev, L. N.; Grosdidier, Y. et al

in Astronomy and Astrophysics (1999), 349

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with ... [more ▼]

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with the existence of an unseen (collapsed?) companion or of spatially extended wind structures as potential candidates. We present observations of <ASTROBJ>WR 1</ASTROBJ> which highlight the unusual character of the variations in this object. Our narrowband photometric observations reveal a gradual increase of the stellar continuum flux amounting to Delta v ~ 0.09 mag followed by a decline on about the same timescale (3-4 days). Only marginal evidence for variability is found during the 11 following nights. Strong, daily line-profile variations are also observed but they cannot be easily linked to the photometric variations. Similarly to the continuum flux variations, coherent time-dependent changes are observed in 1996 in the centroid, equivalent width, and skewness of He Ii lambda 4686. Despite the generally coherent nature of the variations, we do not find evidence in our data for the periods claimed in previous studies. While the issue of a cyclical pattern of variability in <ASTROBJ>WR 1</ASTROBJ> is still controversial, it is clear that this object might constitute in the future a cornerstone for our understanding of the mechanisms leading to the formation of largely anisotropic outflows in Wolf-Rayet stars. [less ▲]

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See detailAn Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease.
Balla, christina; PEPIN, Jean-Louis ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Dementia & Geriatric Cognitive Disorders (2014), 4

BACKGROUND: Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). PATIENTS AND METHODS: We measured the ... [more ▼]

BACKGROUND: Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). PATIENTS AND METHODS: We measured the silent period (SP) induced by transcranial magnetic stimulation in AD patients in the very early stage of the disease, and we explored whether and in which way the pharmacologic manipulation of the cholinergic system could modify it. RESULTS: An increase in the duration of the SP was observed in AD patients in the early stage in comparison to controls. After 2 months of treatment with donepezil, the duration did not differ significantly from that of normal subjects. The results of our study show a fragmentation and an enlargement of the SP in the presence of multiple late excitatory potentials (LEPs) in early untreated AD patients. These LEPs were also modulated by donepezil. CONCLUSIONS: The results suggest an early functional impairment of cholinergic neurotransmission in AD. The disturbance in acetylcholine output in early AD leads to a decrease in excitability of the motor system. [less ▲]

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See detailInvestigation of the links between mass transfer conditions, dissolved hydrogen concentration and biohydrogen production by the pure strain Clostridium butyricum CWBI1009
Beckers, L.; Masset, J.; Hamilton, C. et al

in Biochemical Engineering Journal (2015), 98

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen ... [more ▼]

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen Potential (BHP) tests and in a 2.5L anaerobic sequenced batch reactor (AnSBR) under different operating conditions regarding liquid-to-gas mass transfer. Through the addition of both stirring up to 400rpm and nitrogen sparging, the yields were enhanced from 1.6 to 3.1molH2molglucose -1 and the maximum hydrogen production rates from 140 to 278mLh-1. These original results were achieved with a pure Clostridium strain. They showed that hydrogen production was improved by a higher liquid-to-gas hydrogen transfer resulting in a lower dissolved hydrogen concentration in the culture medium and therefore in a lower bacterial inhibition. In addition, biohydrogen partitioning between the gas and the liquid phase did not conform to Henry's Law due to critical supersaturation phenomena up to seven-fold higher than the equilibrium conditions. Therefore, dissolved hydrogen concentration should be systematically measured instead of the headspace hydrogen partial pressure. A model was proposed to correlate H2 production yield and rate by the pure C. butyricum strain CWBI1009 with mass transfer coefficient KLa. [less ▲]

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See detailInvestigation of the physics of wind interactions in colliding-wind massive binaries through XMS high resolution X-ray spectroscopy
De Becker, Michaël ULg

Conference (2011, June 14)

Binary systems made of two massive stars offer the opportunity to investigate the physics of quite extreme stellar environments. The powerful stellar winds collide, producing so-called wind interaction ... [more ▼]

Binary systems made of two massive stars offer the opportunity to investigate the physics of quite extreme stellar environments. The powerful stellar winds collide, producing so-called wind interaction regions, and the shocked gas is heated up to temperatures that can reach values as high as several tens of MK, leading to the production of copious amounts of thermal X-rays. The properties of the X-ray spectrum of such systems are intimately related to the orbitally modulated physical conditions in the wind interaction region. The study of the hydrodynamics of the colliding-wind phenomenon is a crucial issue in the sense that it constitutes the basement for the study of higher level physical processes at work in these systems, such as particle acceleration or even dust production. High-resolution X-ray spectroscopy with ATHENA/XMS is undoubtedly expected to be the most powerful tool to probe the physics of such environments over the next two decades, allowing a detailed confrontation to state-of-the-art theoretical models aiming at simulating the complex physics of colliding-wind massive binaries (CWBs). [less ▲]

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier Caroline; Lambert, Stéphanie ULg; Gaigneaux Eric et al

Poster (2005, June)

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier Caroline; Lambert, Stéphanie ULg; Gaigneaux Eric et al

in Applied Catalysis B : Environmental (2007), 70

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition–precipitation is discussed through ... [more ▼]

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition–precipitation is discussed through comparison of the samples prepared by this method and others prepared by anion adsorption method. The influence of the pH and of the origin of TiO2 support used are additionally addressed. The difference of gold dispersion observed between the two methods is attributed to a difference of mobility of the gold precursors during the thermal treatment rather than to a difference of dispersion over the uncalcined samples. The mechanism of gold deposition–precipitation actually involves the reactions of gold hydroxy-chloride species with the surface. Another part of the work, thus, concerned the use of the deposition–precipitation method to prepare a Au/MnO2 catalyst. It is shown that the activity of g-MnO2 is directly proportional to its surface area and that the deposition–precipitation procedure decreases the surface and activity of MnO2. However, the deposition of gold allows to avoid a too deep sintering of g-MnO2 and, thus, helps to somehow preserve its activity. [less ▲]

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier, Caroline; Lambert, Stéphanie ULg; Gaigneaux, Eric M. et al

in Applied Catalysis B : Environmental (2007), 70(1-4), 406-416

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition-precipitation is discussed through ... [more ▼]

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition-precipitation is discussed through comparison of the samples prepared by this method and others prepared by anion adsorption method. The influence of the pH and of the origin of TiO2 support used are additionally addressed. The difference of gold dispersion observed between the two methods is attributed to a difference of mobility of the gold precursors during the thermal treatment rather than to a difference of dispersion over the uncalcined samples. The mechanism of gold deposition-precipitation actually involves the reactions of gold hydroxy-chloride species with the surface. Another pan of the work, thus, concerned the use of the deposition-precipitation method to prepare a Au/MnO2 catalyst. It is shown that the activity of gamma-MnO2 is directly proportional to its surface area and that the deposition-precipitation procedure decreases the surface and activity of MnO2. However, the deposition of gold allows to avoid a too deep sintering of gamma-MnO2 and, thus, helps to somehow preserve its activity. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 39 (4 ULg)