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See detailLocalisation ultrastructurale d'hormones hypophysaires par reaction immunocytochimique sur coupes fines d'adenomes.
Beckers, Albert ULg; Courtoy, R.; Reznik, Michel ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1985), 179(3), 397-402

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti ... [more ▼]

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti-rabbit immunoglobulins linked to gold particles. Two PRL secreting adenomas, one GH and PRL secreting adenoma, one ACTH secreting adenoma and two non secreting adenomas were studied. The specificity and the limits of the method were discussed in relation with the results obtained in light microscopy with the PAP method. [less ▲]

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See detailLocalisation ultrastructurale du rDNA et du rRNA dans le nucléole
Thiry, Marc ULg

Scientific conference (1991)

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See detailLocalisations industrielles et milieu urbain
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1977), (13), 5-18

The report first analyses the causes and consequences of the recent de-urbanisation of industrial activities. On account of the problems created by this movement, the survey then puts forward new ... [more ▼]

The report first analyses the causes and consequences of the recent de-urbanisation of industrial activities. On account of the problems created by this movement, the survey then puts forward new solutions that aim for a better integration of industrial concerns. These proposals deal mainly with the types of industries that should be maintained or established as well as the terms and conditions of integration. In this connection, it seems impera¬tive to work out a new planning policy for urban space where the renovated secondary sector would find its place due to new formulas such as vertical industrial structures, individual buildings with an urbanised facade and small industrial estates. [less ▲]

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See detailLocalizable effective theories, bootstrap and the parameters of hadron resonances
Semenov-Tyan-Shanskiy, Kirill ULg; Vereshagin, Alexander; Vereshagin, Vladimir

in AIP Conference Proceedings (2004), 717

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See detailLocalization and Controls of Aromatase in the Quail Spinal Cord
Evrard, H.; Baillien, M.; Foidart, Agnès ULg et al

in Journal of Comparative Neurology (The) (2000), 423(4), 552-64

In adult male and female Japanese quail, aromatase-immunoreactive cells were identified in the spinal dorsal horns from the upper cervical segments to the lower caudal area. These immunoreactive cells are ... [more ▼]

In adult male and female Japanese quail, aromatase-immunoreactive cells were identified in the spinal dorsal horns from the upper cervical segments to the lower caudal area. These immunoreactive cells are located mostly in laminae I-III, with additional sparse cells being present in the medial part of lamina V and, at the cervical level exclusively, in lamina X around the central canal. Radioenzyme assays based on the measurement of tritiated water release confirmed the presence of substantial levels of aromatase activity throughout the rostrocaudal extent of the spinal cord. Contrary to what is observed in the brain, this enzyme activity and the number of aromatase-immunoreactive cells in five representative segments of the spinal cord are not different in sexually mature males or females and are not influenced in males by castration with or without testosterone treatment. The aromatase activity and the numbers of aromatase-immunoreactive cells per section are higher at the brachial and thoracic levels than in the cervical and lumbar segments. These experiments demonstrate for the first time the presence of local estrogen production in the spinal cord of a higher vertebrate. This production was localized in the sensory fields of the dorsal horn, where estrogen receptors have been identified previously in several avian and mammalian species, suggesting an implication of aromatase in the modulation of sensory (particularly nociceptive) processes. [less ▲]

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See detailLocalization and latency concepts applied to time simulation of large power systems
Fabozzi, Davide ULg; Van Cutsem, Thierry ULg

in Proceedings of the 2010 IREP Symposium (2010, August)

This paper reports on investigations to speed up time domain simulations of large electric power systems. First, a decomposed scheme is considered which exploits the bordered block diagonal structure of ... [more ▼]

This paper reports on investigations to speed up time domain simulations of large electric power systems. First, a decomposed scheme is considered which exploits the bordered block diagonal structure of the original Jacobian involved in the Newton iterations, and keeps the resulting “local” Jacobians constant over multiple iterations. Next, a localization technique is considered, allowing to perform less iterations on the system components with lower activity. Finally, a third scheme consists of visiting only a subset of components, identified as active, and skipping the other ones, identified as latent. The first two techniques solve the whole set of equations with the required accuracy, while the third one involves an adjustable degree of approximation. The methods are illustrated on a small system, while preliminary checks of computational savings from a large test system are reported. Additional results deal with the application of the localization and latency techniques to simplified simulation of the detailed model. [less ▲]

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See detailLocalization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines
Fuks, Bruno; Gillard, Michel; Michel, Philippe et al

in European Journal of Pharmacology (2003), 478(1), 11-19

Levetiracetam (2S-(2-oxo-1-pyrrolidinyl)butanamide, KEPPRA(R)), a novel antiepileptic drug, has been shown to bind to a specific binding site located in the brain (Eur. J. Pharmacol. 286 (1995) 137). To ... [more ▼]

Levetiracetam (2S-(2-oxo-1-pyrrolidinyl)butanamide, KEPPRA(R)), a novel antiepileptic drug, has been shown to bind to a specific binding site located in the brain (Eur. J. Pharmacol. 286 (1995) 137). To identify the protein constituent of the levetiracetam binding site in situ, we synthesized the photoaffinity label [H-3]ucb 30889 ((2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide), a levetiracetam analog with higher affinity for the levetiracetam binding site. This radioligand was used to map the levetiracetam binding site within the brain and to study its cellular and subcellular distribution. Autoradiography experiments using [H-3]ucb 30889 in rat brain revealed a unique distribution profile that did not match that of classical receptors known to be involved in the generation of epileptic seizures. There was a high level of binding in the dentate gyrus, the superior colliculus, several thalamic nuclei, the molecular layer of the cerebellum and to a lesser extent in the cerebral cortex, the striatum and the hypothalamus. The levetiracetam binding site was restricted to neuronal cell types, undifferentiated PC 12 cells and was highly enriched in synaptic vesicles. [H-3]ucb 30889 was also used in photoaffinity labelling studies and shown to bind covalently to a membrane protein with a molecular weight of approximately 90 kDa. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLocalization and quantification of damage in beam-like structures using sensitivities of principal component analysis results
Nguyen, Viet Ha ULg; Golinval, Jean-Claude ULg

in Mechanical Systems & Signal Processing (2010), 24(6), 1831-1843

Principal component analysis (PCA) is known as an efficient method for dynamic system identification and diagnosis. This paper addresses a damage diagnosis method based on sensitivities of PCA in the ... [more ▼]

Principal component analysis (PCA) is known as an efficient method for dynamic system identification and diagnosis. This paper addresses a damage diagnosis method based on sensitivities of PCA in the frequency domain for linear-form structures. The aim is not only to detect the presence of damage, but also to localize and to evaluate it. The Frequency response functions measured at different locations on the beam are considered as data for the PCA process. Sensitivities of principal components obtained from PCA to beam parameters are computed and inspected according to the location of sensors; their variation from the healthy state to the damaged state indicates damage locations. The damage can be evaluated next providing that a structural model is available; this evaluation is based on a model updating procedure. It is worth noting that the diagnosis process does not require a modal identification achievement. Both numerical and experimental examples are used for better illustration. [less ▲]

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See detailLocalization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product
Elmoualij, Benaïssa ULg; Duyckaerts, Claire ULg; Lamotte-Brasseur, J. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995)

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See detailLocalization by immunofluorescent microscopy of several collagen types and of a basement membrane proteoglycan in rat glomerular epithelial and mesangial cell cultures.
Foidart, J. B.; Foidart, Jean-Michel ULg; Hassell, J. et al

in Renal Physiology (1983), 6(4), 163-70

Confluent cultures of rat glomerular epithelial and mesangial cells were studied by immunofluorescent microscopy, using affinity-purified antibodies directed against collagen of type I-V or an antiserum ... [more ▼]

Confluent cultures of rat glomerular epithelial and mesangial cells were studied by immunofluorescent microscopy, using affinity-purified antibodies directed against collagen of type I-V or an antiserum directed against a basement membrane (BM) proteoglycan. The epithelial cells were stained by antibodies directed against type I, IV and V collagen, whereas the mesangial cells were stained by all the antibodies directed against the different collagenous antigens tested. Therefore, only mesangial cells contained antigenic determinants of type III collagen. On the contrary, both cell types possessed BM proteoglycan antigens. The data suggest that rat glomerular epithelial and mesangial cells may be implicated in the biosynthesis of different components of normal (and pathological) glomerular BM. [less ▲]

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See detailLocalization of DNA in nucleoli with and without fibrillar centers
Thiry, Marc ULg

Conference (1998)

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See detailLocalization of DNA within Ehrlich tumour cell nucleoli by immunoelectron microscopy.
Thiry, Marc ULg; Scheer, U.; Goessens, Guy ULg

in Biology of the Cell (1988), 63(1), 27-34

The distribution of DNA in Ehrlich tumour cell nucleoli was investigated by means of an immunocytochemical approach involving a monoclonal antibody directed against double- and single-stranded DNA ... [more ▼]

The distribution of DNA in Ehrlich tumour cell nucleoli was investigated by means of an immunocytochemical approach involving a monoclonal antibody directed against double- and single-stranded DNA. Immunolabelling was performed either before or after the embedding process. The postembedding labelling method allows better ultrastructural preservation than the preembedding labelling method. In particular, the various nucleolar components are well preserved and identifiable. In the nucleolus, labelling is particularly concentrated over the perinucleolar chromatin and over its intranucleolar invaginations, which penetrate the nucleolar body and often terminate at the fibrillar centres. In addition, aggregates of gold particles are found in the fibrillar centres, preferentially towards the peripheral regions. By contrast, the dense fibrillar component is completely devoid of labelling. The results seem to indicate that DNA containing the rDNA genes is located in the fibrillar centres, with a preference for the peripheral regions. This finding suggests that transcription of the rDNA genes should occur within the confines of the fibrillar centre, probably close to the boundary region of the surrounding dense fibrillar component. The results are discussed in the light of present knowledge of the functional organization of the nucleolus. [less ▲]

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See detailLocalization of DNase I sensitive sequences in specific regions of nuclear architecture
Thiry, Marc ULg

in Archives Internationales de Physiologie et de Biochimie (1990), 98

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See detailLOCALIZATION OF ENERGY IN A PERFECTLY SYMMETRIC BLADED DISK ASSEMBLY DUE TO NONLINEARITIES
Georgiades, Fotios; Peeters, Maxime ULg; Kerschen, Gaëtan ULg et al

in ASME Internaional Mechanical Engineering Congress and Exposition, Seattle, 2007 (2007, November)

Although a bladed disk is typically designed to have identical blades, manufacturing tolerances, wear, and other causes may cause random deviations among the blades. The blade-to-blade discrepancies ... [more ▼]

Although a bladed disk is typically designed to have identical blades, manufacturing tolerances, wear, and other causes may cause random deviations among the blades. The blade-to-blade discrepancies, denoted as mistuning, lead to vibratory responses mostly concentrated in small regions of the bladed-disk assembly, according to a phenomenon called localization. The resulting spatial confinement of the vibration energy causes the responses of some blades to become dangerously high and increases the amplitude of the bladed-disk assembly's overall response. The attendant increase in stresses can lead to premature high cycle fatigue (HCF) of the blades. In this study we investigate whether vibration localization in a perfectly symmetric bladed disk assembly may occur in the presence of nonlinearity. To this end, the nonlinear normal modes (NNMs) of a simplified model of a bladed disk assembly are computed. The NNMs are then carefully examined to highlight possible vibration localization phenomena. [less ▲]

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See detailLocalization of gonadotropins in pituitaries of various animals especies and in humans
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in de la Cruz, L. F.; Garcia Luna, M. T. (Eds.) Recent advances in growth and reproduction (1990)

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See detailLocalization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis
Jacquemin, Patrick; Depetris, Danielle; Mattei, Marie-Geneviève et al

in Genomics (1999), 55(1), 127-9

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and ... [more ▼]

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and characterization of the cosmid clones encoding the mouse ETF gene (Etdf) revealed thatEtdfspans approximately 17.9 kb and consists of 12 exons. The exon–intron structure ofEtdfclosely resembles that of theDrosophila scallopedgene, indicating that these genes may have evolved from a common ancestor. The multiple transcription initiation sites revealed by S1 protection and primer extension analyses are consistent with the absence of the canonical TATA and CAAT boxes in the 5′-flanking region, which contains many potential regulatory sequences, such as the E-box, N-box, Sp1 element, GATA-1 element, TAATGARAT element, and B2 short interspersed element (SINE) as well as several direct and inverted repeat sequences. TheEtdflocus was assigned to the proximal region of mouse chromosome 7 using fluorescencein situhybridization and linkage mapping analyses. These results provide the molecular basis for studying the regulation,in vivofunction, and evolution ofEtdf. *1 The approved gene symbol for embryonic TEA domain-containing factor (ETF) by MGD isEtdf.The nucleotide sequences reported in this paper have been deposited with the GenBank/EMBL/DDBJ Data Libraries under Accession Nos. D83586–D83596. Mapping data from this article have been deposited in the Mouse Genome Database under Accession Nos. MGD-CREX-618 for genetic mapping and MGD-INEX-21 forin situhybridization, respectively. [less ▲]

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See detailLocalization of interleukin 6 mRNA in human tonsils by in situ hybridization.
Bosseloir, A.; Hooghe-Peters, E. L.; Heinen, Ernst ULg et al

in European Journal of Immunology (1989), 19(12), 2379-81

We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 ... [more ▼]

We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles. [less ▲]

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See detailLocalization of Laminin, Fibronectin, E-Cadherin, and Integrins in Endometrium and Endometriosis
Beliard, Aude ULg; Donnez, J.; Nisolle, Michelle ULg et al

in Fertility and Sterility (1997), 67(2), 266-72

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study ... [more ▼]

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study. SETTING: University Hospital, Department of Gynecology and Department of Cell Biology. PATIENT(s): Eighteen endometriosis patients undergoing laparoscopy for pain or infertility and nine control patients undergoing laparoscopy for sterilization or hysterectomy. MAIN OUTCOME MEASURE(s): The expression of adhesion glycoproteins (laminin and fibronectin), their receptors alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, and alpha 6 beta 1, and E-cadherin was determined by immunohistochemistry on frozen sections. RESULT(s): The distribution of both adhesive glycoproteins, laminin and fibronectin, and their receptors was identical in endometriosis and endometrium. Fibronectin receptors (alpha 4 beta 1, alpha 5 beta 1) displayed distinct expression patterns in endometrium and endometriosis. No endometrial glands showed positive staining for the alpha 5 chain, whereas this integrin subunit was detected in almost all endometriotic lesions. The integrin alpha 4 chain was present in all endometriotic glands but was absent from endometrial glands in the proliferative phase of the cycle. CONCLUSION(s): No difference in cell adhesion molecule localization nor receptors was observed between endometriotic and endometrial samples, except for fibronectin receptors. Their expression persisted around endometriotic glands but not in endometrium. These results suggest that fibronectin receptors could play a role in the persistence of endometriotic lesions, despite menstruation in corresponding eutopic endometrium. [less ▲]

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