Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise.

in Mediators of Inflammation (1996), 5(3), 230-4

To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E(2) (PGE(2)), ten healthy male ... [more ▼]

To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E(2) (PGE(2)), ten healthy male subjects were studied. Using a double-blind randomized crossover design, each subject performed two isokinetic tests separated by a period of at least 6 weeks: once with placebo, and once with piroxicam (Feldene((R))). They were given one capsule containing either placebo or piroxicam (20 mg) per day for 6 days with initial doses given starting 3 days prior to isokinetic testing. Exercise consisted of eight stages of five maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases, on a Kin Trex device at 60( degrees )/s angular velocity. The subjective presence and intensity of DOMS were evaluated using a visual analogue scale immediately after, and 24 and 48 h after each test. The mean plasma concentration of PGE(2) measured at rest and after exercise was significantly lower in the group treated with piroxicam (p < 0.05). However, statistical analysis (two-way ANOVA test) revealed that exercise did not cause any significant change of mean plasma PGE(2) over time in either of the two groups. Eccentric work was followed by severe muscle pain in extensor and flexor muscle groups. Maximal soreness was noted 48 h postexercise. Serum creatine kinase activity and the serum concentration of myoglobin increased significantly, and reached peak values 48 h after exercise in both experimental conditions (p < 0.001). By paired t-test, it appeared that there were no significant differences in the serum levels of these two markers of muscle damage between the two groups at any time point. We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results. [less ▲]

PISA 2000 : lire ou ne pas lire : état de la question

Report (2002)

PISA 2003 : au-delà des moyennes, des constats qui forcent à l'action

in Les infos de l'Agers - Tables rondes (2005), 1

PISA 2003 : Quels défis pour notre système éducatif ?

E-print/Working paper (2004)

PISA 2003 Data Analysis Manual : spss users

Book published by OECD (2005)

PISA 2006. Exemples de questions de culture scientifique

E-print/Working paper (2008)

PISA : une enquête en suspicion légitime

in Lettre de la DFLM (2002), 30

PISA Student Non Response Adjustment Procedures

Conference (2009, September)

PISA test format assessment and the local independence assumption

in Ieri Monographs Series. Issues and Methodologies in Large-Scale assessments. (2011), 4

PISA, instrument ou témoin du changement : évolution des performances en lecture et des politiques éducatives dans cinq systèmes européens

in Education Comparée (2012), 7

The current study focusses on five education systems (Belgium French-speaking, Germany, Poland, Portugal, Sweden) where significant improvement of the reading performance in PISA or a significant decline ... [more ▼]

The current study focusses on five education systems (Belgium French-speaking, Germany, Poland, Portugal, Sweden) where significant improvement of the reading performance in PISA or a significant decline in equity was observed between 2000 and 2009. Firstly, the changes in education policy are documented for each of the systems; the paper then tries to link the kind of changes in education policy with the trends observed through PISA. [less ▲]