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See detailMithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors.
Otjacques, Eléonore ULg; Binsfeld, Marilène ULg; Rocks, Natacha ULg et al

in PLoS ONE (2013), 8(5), 62818

Mithramycin (MTM), a cytotoxic compound, is currently being investigated for its anti-angiogenic activity that seems to be mediated through an inhibition of the transcription factor SP1. In this study we ... [more ▼]

Mithramycin (MTM), a cytotoxic compound, is currently being investigated for its anti-angiogenic activity that seems to be mediated through an inhibition of the transcription factor SP1. In this study we evaluated its anti-myeloma effects in the syngenic 5TGM1 model in vitro as well as in vivo. In vitro, MTM inhibited DNA synthesis of 5TGM1 cells with an IC50 of 400 nM and induced an arrest in cell cycle progression at the G1/S transition point. Western-blot revealed an up-regulation of p53, p21 and p27 and an inhibition of c-Myc, while SP1 remained unaffected. In rat aortic ring assays, a strong anti-angiogenic effect was seen, which could be explained by a decrease of VEGF production and an up-regulation of anti-angiogenic proteins such as IP10 after MTM treatment. The administration of MTM to mice injected with 5TGM1 decreased 5TGM1 cell invasion into bone marrow and myeloma neovascularisation. These data suggest that MTM displays anti-myeloma and anti-angiogenic effects that are not mediated by an inhibition of SP1 but rather through c-Myc inhibition and p53 activation. [less ▲]

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See detailMitigating transported conflicts
Perrin, Nathalie ULg; Martiniello, Marco ULg

in Féron, Elise; Orrnert, Anna (Eds.) The INFOCON Mousebook. Transnational Communities and Conflicts. Challenges and how to address them (2011)

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See detailMitigation of ionospheric effects on GNSS
Warnant, René ULg; Foelsche, Ulrich; Aquino, Marcio et al

in Annals of Geophysics (2009), 52(3-4), 373-390

The effects of the ionosphere remain one of the main factors which limit the precision and the reliability of many GNSS applications. It is therefore indispensable on the one hand to improve existing ... [more ▼]

The effects of the ionosphere remain one of the main factors which limit the precision and the reliability of many GNSS applications. It is therefore indispensable on the one hand to improve existing mitigation techniques and on the other hand to assess their remaining weaknesses. Mitigation techniques depend on the type of application considered. Therefore, specific mitigation techniques have to be developed. The paper summarizes work performed on this topic in the frame of WP 3.2 “Mitigation techniques” of COST296. [less ▲]

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See detailMitigation of seismic soft storey failures of RC structures by composite steel-concrete columns
Plumier, André ULg; Doneux, Catherine; Stoychev, Lyubomir

in Proceedings of the EUROSTEEL Conference 2005 (2005)

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See detailMitigation of soft storey failures of RC structures under earthquake by encased steel profiles
Plumier, André ULg; Doneux, Catherine; Stoychev, Lyubomir et al

in Proceedings of the ICASS'05 Conference (2005)

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See detailMitigation Potential of Artificial Ocean Alkalinization For Ocean Acidification and Atmospheric CO2
Ilyina, Tatiana; Wolf-Gladrow, Dieter; Munhoven, Guy ULg et al

Poster (2012, September)

Fossil fuel CO2 emissions result in climate change and ocean acidification. Enhanced weathering or artificial ocean alkalinization (AOA) has been proposed as a geoengineering method to mitigate further ... [more ▼]

Fossil fuel CO2 emissions result in climate change and ocean acidification. Enhanced weathering or artificial ocean alkalinization (AOA) has been proposed as a geoengineering method to mitigate further increase of atmospheric CO2 and decrease of ocean pH. A variant of AOA involves reacting carbonates and adding the dissolved materials into the upper ocean. The net effect of this approach is to increase ocean alkalinity, thereby increasing the oceanic capacity to store fossil fuel CO2. Another effect of adding alkalinity would be to drive seawater to higher pH values and thus counteract the ongoing ocean acidification. We test implications of AOA for marine carbon cycle using the global ocean biogeochemical model HAMOCC. In our model scenarios we add alkalinity in the amounts proportional to fossil fuel emissions. We show that large-scale AOA scenarios in which large amounts of alkalinity are added would be necessary to avoid a significant increase in atmospheric CO2 and to hold the global seawater pH close to today’s value. Even a short-term AOA would have long-lasting effects on seawater chemistry. When AOA stops, atmospheric CO2 (and pH) reverts back to rising (decreasing) at the rate determined by the fossil fuel CO2 emissions growth, but the effect of AOA is permanent. Hence, in contrast to SRM, effects of AOA on seawater chemistry and atmospheric CO2 retain after stopping alkalinity addition; AOA would not involve a long-term commitment. [less ▲]

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See detailMitigation strategies versus Adaptation strategies
Gengler, Nicolas ULg

Conference (2014, August 17)

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See detailIl mito culturale di Cartagine nel primo Novecento tra letteratura e cinema
Curreri, Luciano ULg

in Alovisio, Silvio; Barbera, Alberto (Eds.) Cabiria & Cabiria (2006)

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See detailMito y realidad de la Responsabilidad Social Corporativa en Colombia RSC. ¿Estamos preparados para la ISO26000?
Parra Santamaria, Lusmiriam Andrea ULg

Book published by Editions Educosta - 1e éd. (2010)

La Responsabilidad Social Corporativa o RSC podría definirse como un compromiso (no vinculante) que asumen voluntariamente las empresas para con el desarrollo sostenible, el respeto a todos los recursos ... [more ▼]

La Responsabilidad Social Corporativa o RSC podría definirse como un compromiso (no vinculante) que asumen voluntariamente las empresas para con el desarrollo sostenible, el respeto a todos los recursos de trabajo y naturales, y las normas legales vigentes de los países receptores de empresas multinacionales. Concierne a todos los actores empresariales (stakeholders, shareholders, gobiernos, trabajadores, demás entes), lo que se ha venido acompañando por la consolidación de instrumentos que permiten medir el grado de responsabilidad social de las empresas. Mucho se ha difundido acerca del tema de la globalización y de la nueva distribución internacional que esta trajo consigo. Mucho se dijo, igualmente, acerca del hecho de que la prueba más contundente de su existencia es la presencia de compañías multinacionales a lo largo y ancho del planeta. Es definitivamente claro, y ya nadie se atreve a ponerlo en duda, que la globalización trajo consigo la eliminación de todas las barreras físicas para el desarrollo de los negocios en cualquier lugar del mundo. El mundo empresarial, dejó de tener límites. Hoy en día las compañías pueden establecer y desarrollar sus operaciones simultáneamente en diferentes partes del mundo si esa es su visión. Mediante un estudio comparativo de las acciones de RSC de cuatro compañías multinacionales en Colombia (dos del sector de la distribución al menudeo: CARREFOUR y MAKRO; dos del sector petrolero: OCCIDENTAL PETROLEUM COMPANY (OXY) y BRITISH Petroleum Company (BP)), se observa y analiza (desde un marco general) cómo los lineamientos de las actividades de estas cuatro multinacionales cumplen los principios de responsabilidad social universalmente aceptados y contenidos en la nueva certificación de RSC ISO26000. Esto nos ha permitido establecer si las multinacionales en Colombia están preparadas para el arribo de la certificación en cuestión. Aquí se entiende por acciones de RSC las contenidas en las declaraciones oficiales de dichas compañías al respecto de la Responsabilidad Social Corporativa. El criterio que define oficial en este sentido es la presentación pública de las mismas en espacios de acceso masivo a la información como la página web de esas compañías. Es así como desde un marco específico se busca demostrar que existen diferencias entre los aspectos privilegiados por las mismas y que dichas diferencias tienen que ver con el sector en el que se desarrolle su operación. [less ▲]

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See detailMitoc-Malu Galben: étude de l'industrie lithique
Otte, Marcel ULg; Noiret, Pierre ULg; Chirica, Vasile et al

in Otte, Marcel; Chirica, Vasile; Haesaerts, Paul (Eds.) L'Aurignacien et le Gravettien de Mitoc-Malu Galben (Moldavie roumaine) (2007)

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See detailMitoc-Malu Galben: industrie osseuse et témoins esthétiques
Chirica, Vasile; Noiret, Pierre ULg

in Otte, Marcel; Chirica, Vasile; Haesaerts, Paul (Eds.) L'Aurignacien et le Gravettien de Mitoc-Malu Galben (Moldavie roumaine) (2007)

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See detailMitochondrial and cytoplasmic asparaginyl-tRNA synthetases from S. cerevisiae.
Landrieu, Isabelle; Vandenbol, Micheline ULg; Hartlein, M. et al

Poster (1997)

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See detailMitochondrial Asparaginyl-Trna Synthetase Is Encoded By The Yeast Nuclear Gene Ycr24c
Landrieu, I.; Vandenbol, Micheline ULg; Hartlein, M. et al

in European Journal of Biochemistry (1997), 243(1-2),

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See detailThe mitochondrial ATP synthase of chlorophycean algae contains eight subunits of unknown origin involved in the formation of an atypical stator-stalk and in the dimerization of the complex
Vazquez-Acevedo, Miriam; Cardol, Pierre ULg; Cano-Estrada, Araceli et al

in Journal of Bioenergetics & Biomembranes (2006), 38(5-6), 271-282

Mitochondrial F1FO-ATP synthase of Chlamydomonas reinhardtii and Polytomella sp. is a dimer of 1,600,000 Da. In Chlamydomonas the enzyme lacks the classical subunits that constitute the peripheral stator ... [more ▼]

Mitochondrial F1FO-ATP synthase of Chlamydomonas reinhardtii and Polytomella sp. is a dimer of 1,600,000 Da. In Chlamydomonas the enzyme lacks the classical subunits that constitute the peripheral stator-stalk as well as those involved in the dimerization of the fungal and mammal complex. Instead, it contains eight novel polypeptides named ASA1 to 8. We show that homologs of these subunits are also present in the chlorophycean algae Polytomella sp. and Volvox carterii. Blue Native Gel Electrophoresis analysis of mitochondria from different green algal species also indicates that stable dimeric mitochondrial ATP synthases may be characteristic of all Chlorophyceae. One additional subunit, ASA9, was identified in the purified mitochondrial ATP synthase of Polytomella sp. The dissociation profile of the Polytomella enzyme at high-temperatures and cross-linking experiments finally suggest that some of the ASA polypeptides constitute a stator-stalk with a unique architecture, while others may be involved in the formation of a highly-stable dimeric complex. The algal enzyme seems to have modified the structural features of its surrounding scaffold, while conserving almost intact the structure of its catalytic subunits. [less ▲]

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See detailMitochondrial comparative proteomics: Strenghts and Pitfalls
Mathy, Grégory ULg; Sluse, Francis ULg

in Biochimica et Biophysica Acta-Bioenergetics (2008), 1977

In this review, we describe the various techniques available to carry out valid comparative proteomics, their advantages and their disadvantages according to the goal of the research. Two-dimensional ... [more ▼]

In this review, we describe the various techniques available to carry out valid comparative proteomics, their advantages and their disadvantages according to the goal of the research. Two-dimensional electrophoresis and 2D-DIGE are compared to shotgun proteomics and SILE. We give our opinion on the best fields of application in the domain of comparative proteomics. We emphasize the usefulness of these new tools, providing mass data to study physiology and mitochondrial plasticity when faced with a specific mitochondrial insufficiency or exogenic stress. We illustrate the subject with results obtained in our laboratory specifying the importance of an approach of comparative proteomics combined from mitochondria and from the cell, which makes it possible to obtain important information on the status of the mitochondrial function at the cellular level. Finally, we draw attention to the dangers of the extrapolation of proteomic data to metabolic flows which requires the greatest care [less ▲]

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See detailMitochondrial complex I encephalomyopathy and cerebral 5-methyltetrahydrofolate deficiency
RAMAEKERS, Vincent ULg; Wels, J.; Sequeira, J. M. et al

in Neuropediatrics (2007), 38(4), 184-187

Folate transport to the brain depends on ATP-driven folate receptor-mediated transport across choroid plexus epithelial cells. Failure of ATP production in Kearns-Sayre syndrome syndrome provides one ... [more ▼]

Folate transport to the brain depends on ATP-driven folate receptor-mediated transport across choroid plexus epithelial cells. Failure of ATP production in Kearns-Sayre syndrome syndrome provides one explanation for the finding of low spinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF) levels in this condition. Therefore, we suspect the presence of reduced folate transport across the blood-spinal fluid barrier in other mitochondrial encephalopathies. In the present patient with mitochondrial complex I encephalomyopathy a low 5-methyltetrahydrofolate level was found in the CSF. Serum folate receptor autoantibodies were negative and could not explain the low spinal fluid folate levels. The epileptic seizures did not respond to primidone monotherapy, but addition of ubiquinone-10 and radical scavengers reduced seizure frequency. Add-on treatment with folinic acid led to partial clinical improvement including full control of epilepsy, followed by marked recovery from demyelination of the brainstem, thalamus, basal ganglia and white matter. Cerebral folate deficiency is not only present in Kearns-Sayre syndrome but may also be secondary to the failure of mitochondrial ATP production in other mitochondrial encephalopathies. Treatment with folinic acid in addition to supplementation with radical scavengers and cofactors of deficient respiratory enzymes can result in partial clinical improvement and reversal of abnormal myelination patterns on neuro-imaging. © Georg Thieme Verlag KG Stuttgart. [less ▲]

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See detailMitochondrial diseases associated with cerebral folate deficiency
Garcia-Cazorla, A.; Quadros, E. V.; Nascimento, A. et al

in Neurology (2008), 70(16), 1360-1362

Detailed reference viewed: 11 (1 ULg)