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See detailMarker imputation with low-density marker panels in Dutch Holstein cattle.
Zhang, Zhiyan; Druet, Tom ULg

in Journal of Dairy Science (2010), 93(11), 5487-94

The availability of high-density bovine genotyping arrays made implementation of genomic selection possible in dairy cattle. Development of low-density single nucleotide polymorphism (SNP) panels will ... [more ▼]

The availability of high-density bovine genotyping arrays made implementation of genomic selection possible in dairy cattle. Development of low-density single nucleotide polymorphism (SNP) panels will allow the extension of genomic selection to a larger portion of the population. Prediction of ungenotyped markers, called imputation, is a strategy that allows using the same low-density chips for all traits (and for different breeds). In the present study, we evaluated the accuracy of imputation with low-density genotyping arrays in the Dutch Holstein population. Five different sizes of genotyping arrays were tested, from 384 to 6,000 SNP. According to marker density, the overall allelic imputation error rate obtained with the program DAGPHASE, which relies on linkage disequilibrium and linkage, ranged from 11.7 to 2.0%, and that obtained with the program CHROMIBD, which relies on linkage and the set of all genotyped ancestors, ranged from 10.7 to 3.3%. However, imputation efficiency was influenced by the relationship between low-density and high-density genotyped animals. Animals with both parents genotyped had particularly low imputation error rates: <1% with 1,500 SNP or more. In summary, missing marker alleles can be predicted with 3 to 4% errors with approximately 1 SNP/Mb (approximately 3,000 markers). The CHROMIBD program proved more efficient than DAGPHASE only at lower marker densities or when several genotyped ancestors were available. Future studies are required to measure the effect of these imputation error rates on accuracy of genomic selection with low-density SNP panels. [less ▲]

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See detailMarker vaccines and the impact of their use on diagnosis and prophylactic measures
Vannier, P.; Capua, I.; Le Potier, M. F. et al

in Revue Scientifique et Technique-Office International des Epizooties (2007), 26(2), 351-372

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of ... [more ▼]

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of their use on the diagnosis and prevention of major infectious diseases. Gene-deleted vaccines, DIVA strategies (differentiating infected from vaccinated animals) and similar methods have been successfully applied in the control and eradication of Aujeszky's disease, infectious bovine rhinotracheitis, classical swine fever, foot and mouth disease and, recently, avian influenza. The efficacy and performance of existing marker vaccines and their companion diagnostic tools (which should be assesed by an independent body) are discussed, as are the ways in which these tools are deployed by competent authorities. The limits and the advantages of the use of marker vaccines are carefully analysed in the light of practical experiences. Although these vaccines can limit the speed and the extent of virus dissemination and thus reduce the number of animals slaughtered, marker vaccines are no substitute for sanitary measures. Early detection and warning systems and the quick implementation of sanitary measures, including stamping out, remain key issues in the control of highly contagious diseases. [less ▲]

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See detailMarkers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
Vasikaran, S.; Eastell, R.; Bruyère, Olivier ULg et al

in Osteoporosis International (2011), 22

Summary The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker of bone formation (serum procollagen ... [more ▼]

Summary The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker of bone formation (serum procollagen type I N propeptide, s-PINP) and a marker of bone resorption (serum C-terminal telopeptide of type I collagen, s-CTX) are used as reference analytes for bone turnover markers in clinical studies. Introduction Bone turnover markers (BTM) predict fracture risk, and treatment-induced changes in specific markers account for a substantial proportion of fracture risk reduction. The aims of this report were to determine their clinical potential in the prediction of fracture risk and for monitoring the treatment of osteoporosis and to set an appropriate research agenda. Methods Evidence from prospective studies was gathered through literature review of the PUBMED database between the years 2000 and 2010 and the systematic review of the Agency for Healthcare Research and Quality up to 2001. Results High levels of BTMs may predict fracture risk independently from bone mineral density in postmenopausal women. They have been used for this purpose in clinical practice for many years, but there is still a need for stronger evidence on which to base practice. BTMs provide pharmacodynamic information on the response to osteoporosis treatment, and as a result, they are widely used for monitoring treatment in the individual. However, their clinical value for monitoring is limited by inadequate appreciation of the sources of variability, by limited data for comparison of treatments using the same BTM and by inadequate quality control. IOF/IFCC recommend one bone formation marker (s-PINP) and one bone resorption marker (s-CTX) to be used as reference markers and measured by standardised assays in observational and intervention studies in order to compare the performance of alternatives and to enlarge the international experience of the application of markers to clinical medicine. Conclusion BTM hold promise in fracture risk prediction and for monitoring treatment. Uncertainties over their clinical use can be in part resolved by adopting international reference standards. [less ▲]

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See detailMarkers of tumor invasion are major predictive factors for the long-term outcome of corticotroph microadenomas treated by transsphenoidal adenomectomy.
Vallette-Kasic, S.; Dufour, H.; Mugnier, M. et al

in European Journal of Endocrinology (2000), 143(6), 761-8

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN ... [more ▼]

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN: Prospective study of 53 corticotroph microadenomas treated by enlarged adenomectomy. Patients followed for at least 2 years were classified into two groups: those in long-term remission and uncured patients (immediate failures and recurrences). Pre-, per- and postoperative parameters were analyzed as predictors of the long-term outcome. METHODS: Baseline hormone assessments were performed preoperatively, 8 days after surgery and every 6-12 months thereafter. Pituitary magnetic resonance imaging (MRI) allowed analysis of possible tumor extension to adjacent structures. Apparent completeness of the surgical removal was determined, and fragments labeled either 'tumor' or 'surrounding pituitary tissue' were submitted to serial sectioning. RESULTS: Immediate control of hypercortisolism was achieved in 43/53 patients (81%). However, later recurrences were observed in five patients (9%). Preoperative MRI showed tumor extension into adjacent structures with good specificity (91%) for prediction of surgical failure. Evidence of local invasion at surgery was also significantly predictive of the long-term outcome. A corticotroph adenoma was found at histological examination in 96% of the patients, and 26% had irregular limits, a feature significantly correlated with a poor outcome. Immediate postoperative plasma cortisol did not allow discrimination between long-term remissions and recurrences. CONCLUSION: Surgical failure was best predicted by signs of tumor 'invasiveness' at MRI, confirmed by peroperative examination and histology. [less ▲]

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See detailMarkers of vitamin C and K-3 induced autoschizis of urologic tumors
Jamison, J; Gilloteaux, J; Taper, HS et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (2004), 52

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See detailMarket - Etudes et recherches en marketing : fondements, méthodes
Choffray, Jean-Marie ULg; Pras, Bernard; Evrard, Yves et al

Book published by Editions Nathan (1997)

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See detailMarket area of intermodal rail-road container terminals embedded in a hub-and-spoke network
Limbourg, Sabine ULg

Conference (2009)

This paper presents a methodology able to compare road and rail-road intermodal market areas that takes the network structures, the operation costs and the location of the rail-road terminals into account ... [more ▼]

This paper presents a methodology able to compare road and rail-road intermodal market areas that takes the network structures, the operation costs and the location of the rail-road terminals into account.Aparticular way to model rail-road transport on hub-and-spoke networks is outlined and illustrated on the trans-European networks. The market area of an optimal eight hubs network configuration is presented both for the p-hub median and the p-hub centre problem. This is followed by a discussion about the evolution of the market area according to the number and locations of the implemented hubs. [less ▲]

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See detail« Market area of intermodal rail-road container terminals embedded in a hub-and–spoke network
Limbourg, Sabine ULg; Jourquin, Bart

in Papers in Regional Science (2010), 89(1), 135154

This paper presents a methodology able to compare road and rail-road intermodal market areas that takes the network structures, the operation costs and the location of the rail-road terminals into account ... [more ▼]

This paper presents a methodology able to compare road and rail-road intermodal market areas that takes the network structures, the operation costs and the location of the rail-road terminals into account.Aparticular way to model rail-road transport on hub-and-spoke networks is outlined and illustrated on the trans-European networks. The market area of an optimal eight hubs network configuration is presented both for the p-hub median and the p-hub centre problem. This is followed by a discussion about the evolution of the market area according to the number and locations of the implemented hubs. [less ▲]

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See detailMarket dynamics driven by the decision-making power producers
Ernst, Damien ULg; Minoia, Anna; Marija, Ilic

in Proceedings of 2004 IREP Symposium - Bulk Power System Dynamics and Control - VI (2004)

In this paper we consider a tool for analyzing the market outcomes when competitive agents (power producers) interact through the market place. The market clearing mechanism is based on the locational ... [more ▼]

In this paper we consider a tool for analyzing the market outcomes when competitive agents (power producers) interact through the market place. The market clearing mechanism is based on the locational marginal price scheme. A model of the strategic behavior is formulated for the agents. Each agent chooses its bid in order to maximize its profit by assuming that the other agents will post the same bid as at the previous session of the market, and by knowing the network characteristics. The income of each agent over a certain temporal horizon for different power system configurations (the addition of new transmission capabilities, new power plants) is evaluated according to this market dynamics and by integrating this dynamics over the chosen temporal horizon. The mathematical formulation, for the sake of simplicity, is related to a two node power system. In the simulations, the influence of different conditions (line transfer capacity, the number and size of generators, the presence of portfolio) on market outcomes is analyzed, and interesting and sometimes counterintuitive results are found. [less ▲]

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See detailMarket dynamics driven by the decision-making of both power producers and transmission owners
Minoia, Anna; Ernst, Damien ULg; Ilic, Marija

in Proceedings of the IEEE Power Engineering Society General Meeting 2004 (2004)

In this paper we consider an electricity market in which not only the power producers but also the transmission owners can submit a bid. The market is cleared at each stage by minimizing the sum of the ... [more ▼]

In this paper we consider an electricity market in which not only the power producers but also the transmission owners can submit a bid. The market is cleared at each stage by minimizing the sum of the production prices and the transmission prices. A model of the strategic behavior is formulated for the different agents of the system. This strategic behavior modelling leads to a market dynamics that can be used to determine the different payoffs of the agents over a temporal horizon. Simulations are carried out for several configurations of this two node power system. The influence of the transfer capacity and the market structure on the payoffs of the different agents is discussed. [less ▲]

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See detailThe market for solar cooling: perceptions, response and strategy implications
Choffray, Jean-Marie ULg; Lilien, Gary L.

in TIMS Studies in the Management Sciences (1978), 10

Solar cooling provides an energy alternative for the fastest growing component of US energy use. This paper outlines the use of an industrial marketing decision support system aimed at pinpointing areas ... [more ▼]

Solar cooling provides an energy alternative for the fastest growing component of US energy use. This paper outlines the use of an industrial marketing decision support system aimed at pinpointing areas of improvement in product design and at enhancing the effectiveness of the associated communication strategies. [less ▲]

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See detailMarket index specification and estimation of risk on the Brussels Stock Exchange
Corhay, Albert ULg

in Recherches Economiques de Louvain (1992), 58(1), 85-107

Cet article démontre que le degré d'autocorrélation dans les rendements des indices de marché de la Bourse de Bruxelles dépend du nombre de titres qui interviennent dans le calcul de ces indices ainsi que ... [more ▼]

Cet article démontre que le degré d'autocorrélation dans les rendements des indices de marché de la Bourse de Bruxelles dépend du nombre de titres qui interviennent dans le calcul de ces indices ainsi que du délai d'ajustement du prix de ces titres à toute nouvelle information. Il examine également la relation entre la valeur du risque systématique, le choix d'un indice de marché et la longueur de l'intervalle utilisé pour calculer les rendements. De plus, les résultats obtenus révèlent l'existence de fluctuations saisonnières dans les coefficients d'autocorrélation et la valeur des coefficients betas. [less ▲]

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See detailMarket integration: trade vs. economic geography
Tharakan, Joseph ULg; Thisse, Jacques

in Jovanovic, Miroslav (Ed.) International Handbook on the Economics of Integration (2011)

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See detailMarket Maker
Bodson, Laurent ULg

in Wankel, Charles (Ed.) Encyclopedia of Business in Today's World (2008)

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See detailMarket Planning for New Industrial Products
Choffray, Jean-Marie ULg; Lilien, Gary

Book published by John Wiley (1980)

Detailed reference viewed: 212 (7 ULg)
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See detailMarket potential, productivity and foreign direct investment: some evidence from three case studies
Artige, Lionel ULg; Nicolini, Rosella

in European Planning Studies (2010), 18(2), 147-168

This paper aims at analysing the importance of local determinants to foreign direct investment (FDI) in three European regional case studies. The originality of the approach lies in the use of ... [more ▼]

This paper aims at analysing the importance of local determinants to foreign direct investment (FDI) in three European regional case studies. The originality of the approach lies in the use of disaggregated data by sector and by region. The results are threefold. First, regional demand and productivity are fundamental FDI determinants, confirming most studies with national data. Second, regional FDI inflows are more dependent on regional than national determinants. Finally, the effect of market potential measured with absolute GDP on regional FDI diminishes linearly with distance and does not when measured with GDP per capita. [less ▲]

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See detailMarket Power in the Credit Rating Industry: State of Play and Proposal for Reforms
Candelon, Bertrand; Gautier, Axel ULg; Petit, Nicolas ULg

in CPI Antitrust Chronicle (2014), 2

In recent years, the Credit Rating Agencies (“CRAs”) have been in the eye of the storm. Some argue that CRA rating errors—symptomatized by rating inflation or deflation—originate in excessive competition ... [more ▼]

In recent years, the Credit Rating Agencies (“CRAs”) have been in the eye of the storm. Some argue that CRA rating errors—symptomatized by rating inflation or deflation—originate in excessive competition. This paper argues that the low level of competition in credit rating is a better explanation for rating this phenomenon. [less ▲]

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See detailMarket Stock Liquidity and Corporate Governance
Sougné, Danielle ULg; Ajina, Aymen ULg

Conference (2012, June 14)

Detailed reference viewed: 46 (20 ULg)