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See detailMetformin revisited: A critical review of the benefit-risk balance in at-risk patients with type 2 diabetes.
SCHEEN, André ULg; Paquot, Nicolas ULg

in Diabètes & Métabolism (2013)

Metformin is unanimously considered a first-line glucose-lowering agent. Theoretically, however, it cannot be prescribed in a large proportion of patients with type 2 diabetes because of numerous ... [more ▼]

Metformin is unanimously considered a first-line glucose-lowering agent. Theoretically, however, it cannot be prescribed in a large proportion of patients with type 2 diabetes because of numerous contraindications that could lead to an increased risk of lactic acidosis. Various observational data from real-life have shown that many diabetic patients considered to be at risk still receive metformin and often without appropriate dose adjustment, yet apparently with no harm done and particularly no increased risk of lactic acidosis. More interestingly, recent data have suggested that type 2 diabetes patients considered at risk because of the presence of traditional contraindications may still derive benefit from metformin therapy with reductions in morbidity and mortality compared with other glucose-lowering agents, especially sulphonylureas. The present review analyzes the benefit-risk balance of metformin therapy in special populations, namely, patients with stable coronary artery disease, acute coronary syndrome or myocardial infarction, congestive heart failure, renal impairment or chronic kidney disease, hepatic dysfunction and chronic respiratory insufficiency, all conditions that could in theory increase the risk of lactic acidosis. Special attention is also paid to elderly patients with type 2 diabetes, a population that is growing rapidly, as older patients can accumulate several comorbidities classically considered contraindications to the use of metformin. A review of the recent scientific literature suggests that reassessment of the contraindications of metformin is now urgently needed to prevent physicians from prescribing the most popular glucose-lowering therapy in everyday clinical practice outside of the official recommendations. [less ▲]

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See detailLa metformine: une molecule antidiabetique dotee de proprietes anti-cancereuses.
BECK, Emmanuel ULg; Scheen, André ULg

in Revue medicale de Liege (2013), 68(9), 444-9

Numerous epidemiological cohort and case-control studies showed that type 2 diabetes is a risk factor for cancer and that metformin therapy is associated with a significant reduction in the incidence of ... [more ▼]

Numerous epidemiological cohort and case-control studies showed that type 2 diabetes is a risk factor for cancer and that metformin therapy is associated with a significant reduction in the incidence of cancer and cancer-related death when compared to other glucose-lowering agents. Such beneficial effect is observed whatever the type of cancer, but seems to be more prominent in case of gastrointestinal and breast cancers. In general, the protective effect was more evident in observational cohort studies (however, more exposed to bias due to confounding factors) than in case-control studies. However, the results of the rather rare controlled clinical trials available are not conclusive, but none of them was performed with the objective to specifically assess cancer risk. Several meta-analyses recently confirmed that metformin therapy reduces the incidence of cancers (including colorectal cancer, hepatocarcinoma, breast cancer) and cancer-related mortality. Metformin may exert its anti-cancer activity by a direct effect (insulin) and an indirect effect (AMPK and mTOR). Considering all promising clinical information in patients with type 2 diabetes, further clinical trials are currently ongoing with the aim of assessing the role of metformin in oncology, especially as adjuvant in breast cancer therapy. [less ▲]

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See detail(Meth)acrylates pseudo-living radical polymerization in the presence of transition metal complexes: the Kharasch reaction revisited
Granel, Claude; Moineau, George; Lecomte, Philippe ULg et al

in Polymer Preprints (1997), 38(1), 450-451

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See detailMethacholine bronchoprovocation test:a useful ancillary test for diagnosis of hyperresponsiveness in horses ?
Frippiat, Thibault ULg; Frellstedt, Linda ULg; Bustin, Jean-Clément ULg et al

in Proceedings of the European Veterinary Conference - Voorjaarsdagen (2012)

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See detailMéthadone - Détermination du délai entre le prélèvement et la consommation
Dubois, Nathalie ULg

Scientific conference (2009, December)

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See detailLa méthadone : une réflexion interdisciplinaire
Cellule Drogues de l'Université de Liège; Gosset, Christiane ULg

Report (1992)

Detailed reference viewed: 38 (9 ULg)
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See detailMethadone Maintenance Treatment: Is It Possible to Adapt the Daily Doses to the Metabolic Activity of the Patient?
Charlier, Corinne ULg; Dessalles, M. C.; Plomteux, Guy ULg

in Therapeutic Drug Monitoring (2001), 23(1), 1-3

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated ... [more ▼]

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated with the amount of drug available at the receptor level, it could be interesting to predict the methadone daily doses necessary to reach such a serum concentration. The authors have attempted to correlate the serum methadone level with the daily intake, considering the metabolic activity of the patients. A poor correlation was found between methadone doses and methadone serum concentrations (r2 = 0.0409, p = 0.048). The test used to determine the metabolic activity of patients is the 6-OH cortisol/17-OH corticosteroids ratio in urine. This urinary 6-OH cortisol/17-OH corticosteroids ratio was tested because cortisol is metabolized through the same P450 cytochromes as methadone, namely cytochrome P450 3A4. This determination could be of interest because it could be tested before methadone administration to predict optimal doses. But when the authors tried to correlate the methadone serum concentration with the steroid ratio, they failed to find a significant correlation (r2 = 0.0046, N.S.), even when they took into account the daily doses (r2 = 0.0015, N.S.), most probably because of some limitations of the cortisol ratio. [less ▲]

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See detailMethane production in sediments: the results of a theoretical model
François, Louis ULg; Walker, J. C. G.

in Crutzen, P. J.; Gérard, J.-C.; Zander, R. (Eds.) Our Changing Atmosphere, Proceedings of the 28th Liège International Astrophysical Colloquium (1989)

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See detailMethanol dissociative adsorption on Pt(1 0 0) as studied by nonlinear vibrational spectroscopy
Vidal, Franck; Busson, B.; Six, C. et al

in Journal of Electroanalytical Chemistry (2004), 563

The methanol dissociative adsorption on Pt(1 0 0) at low potentials in the hydrogen region is studied using nonlinear vibrational sum-frequency generation (SFG) spectroscopy. It is shown that adsorbed ... [more ▼]

The methanol dissociative adsorption on Pt(1 0 0) at low potentials in the hydrogen region is studied using nonlinear vibrational sum-frequency generation (SFG) spectroscopy. It is shown that adsorbed hydrogen atoms effectively block atop sites at the surface. In the hydrogen potential region, CO produced by the methanol dissociation adsorbs at step-edges and in bridge sites on terraces as shown by the characteristic stretching frequencies observed for adsorbed CO. [less ▲]

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See detailMethIS I : Réalité et Représentation
Cormann, Grégory ULg; Dozo, Björn-Olav ULg; Letawe, Céline ULg

Book published by Editions de l’Université de Liège (2008)

Detailed reference viewed: 44 (20 ULg)
See detailMethIS V. La valeur de la science. Pourquoi évaluer la recherche
Cormann, Grégory ULg; Dozo, Björn-Olav ULg; Polis, Stéphane ULg

Book published by Presses universitaires de Liège (in press)

Actes du colloque du 10 et 11 décembre 2009 qui s'est tenu à Liège à l'initiative du personnel scientifique

Detailed reference viewed: 43 (15 ULg)
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See detailMETHis VI. Images fixes / Images en mouvement
Bert, Mathilde ULg; Falque, Ingrid ULg; Hagelstein, Maud ULg

Book published by Presses Universitaires de Liège (2014)

Detailed reference viewed: 28 (4 ULg)
See detailMethIS, 2 : Pratiques du document
Letawe, Céline ULg; Polis, Stéphane ULg; Stasse, Bauduin ULg et al

Book published by CEFAL/Editions de l'ULg (2009)

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See detailA method allowing long term culture and expansion of chicken primordial germ cells
Tonus, Céline ULg; Waroux, Olivier ULg; Grobet, Luc ULg

Conference (2013, March 12)

We developed an original method allowing long term culture (up to 20 month) of undifferentiated chicken PGCs, with good proliferation rates. We use a co-culture system: PGCs are cultivated in cell culture ... [more ▼]

We developed an original method allowing long term culture (up to 20 month) of undifferentiated chicken PGCs, with good proliferation rates. We use a co-culture system: PGCs are cultivated in cell culture inserts, in the presence of irradiated Buffalo Rat Liver cells. According to our own experience, physical separation of PGCs and feeder cells limits the differentiation of PGCs. Our PGCs lines keep their original phenotype including their gonadal colonization ability. We also developed a novel cryopreservation method based on vitrification, in complement of a slow rate freezing. [less ▲]

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See detailA method and an apparatus for separating a first amount of liquid
Vandewalle, Nicolas ULg; Gilet, Tristan; Jérôme, Christine ULg et al

Patent (2010)

The invention relates to a method for separating a first amount of liquid into a plurality of second amounts of liquid, the method comprising the steps of bringing the first amount of liquid (210) into ... [more ▼]

The invention relates to a method for separating a first amount of liquid into a plurality of second amounts of liquid, the method comprising the steps of bringing the first amount of liquid (210) into contact with at least one first fibre (110) being arranged substantially vertical, allowing the first amount of liquid to drain of the first fibre, thereby forming a coating film on the fibre, allowing the coating film to decompose, thereby forming a plurality of second amounts of liquid (220), and allowing the second amounts of liquid to drain of the first fibre and being captured at a crossing point (130) being constituted by the first fibre and at least one second fibre (120) being arranged substantially perpendicular to the first fibre and touching the first fibre. Furthermore, the invention relates to an apparatus for separating a first amount of liquid into a plurality of second amounts of liquid. [less ▲]

Detailed reference viewed: 27 (13 ULg)