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See detailLe syndrome de détresse respiratoire chez le veau nouveau-né : la clé de l’énigme?
Rollin, Frédéric ULg; Danlois, Fabien; Aliaoui, Hamani et al

in Proceedings: De la recherche à la clinique, Société Française de Buiatrie (2003)

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See detailLe syndrome de la traversée cervico-thoraco-brachiale : une lourde hérédité anatomique
CARLIER, Alain ULg; Ronsmans, C; BRILMAKER, Julien ULg et al

in e-mémoires de l'Académie Nationale de Chirurgie (2008), 7(3), 49-55

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See detailLe syndrome de Lynch et l'instabilité des microsatellites : revue de littérature.
Desselle, Françoise; VERSET, Gontran ULg; POLUS, Marc ULg et al

in Revue Médicale de Liège (2012), 67(12), 638-642

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See detaille syndrome de Pasqualini (Fertile eunuch syndrome)
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2014, November 12)

Pasqualini’s syndrome: hypoandrogenism with spermatogenesis Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in Revista de la Asociación Médica Argentina ... [more ▼]

Pasqualini’s syndrome: hypoandrogenism with spermatogenesis Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in Revista de la Asociación Médica Argentina. The hypoandrogenism with spermatogenesis syndrome included: (a) eunuchoidism, (b) testis with normal spermatogenesis and full volume, with mature spermatozoids in a high proportion of seminiferous tubes and undifferentiated and immature Leydig cells (c) full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total urinary gonadotrophins within normal limits (e) this definition supposes the normal activity of the pituitary and the absence of congenital malformations in general. A first step in the understanding of the physiopathogeny of Pasqualini syndrome or the so called “fertile eunuch" syndrome was the absence of LH in plasma and urine of patients. The second breakthrough was the functional and genetic studies that validated the hypothesis of a functional deficit of LH in these men: it will then also be described in some women. Different groups including ours demonstrated in these cases a LH with varying degrees of immunological activity but biologically inactive in most of the patients, due to one or more inactivating mutations in the LHB gene. Finally, the full comprehension of Pasqualini syndrome allowed to reverse the hypoandrogenic phenotype and to restore fertility in these patients through the use of chorionic gonadotropin and the modern in-vitro fertility techniques. This conference is an historical review and a tribute to the memory of Rodolfo Q. Pasqualini. [less ▲]

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See detailLe syndrome Thyro-Gastrique: de l’auto-immunité thyroïdienne aux tumeurs gastriques neuroendocriniennes.
VALDES SOCIN, Hernan Gonzalo ULg; BECKERS, Albert ULg

Scientific conference (2011, June 17)

THE THYRO-GASTRIC SYNDROME: FROM THYROID AUTOIMMUNITY TO NEUROENDOCRINE GASTRIC TUMORS. In 1849, Prof Addison described a fatal case of anemia, or anemia perniciosa. Dr Biermer expanded this original ... [more ▼]

THE THYRO-GASTRIC SYNDROME: FROM THYROID AUTOIMMUNITY TO NEUROENDOCRINE GASTRIC TUMORS. In 1849, Prof Addison described a fatal case of anemia, or anemia perniciosa. Dr Biermer expanded this original description in 1872. Nowadays, this pathological condition associating a megaloglastic anemia associated with a metabolic polyneuropathy is recognized as Biermer disease. Biermer anemia or anemia perniciosa and its associated polyneuropathy are the consequence of vitamine B12 malabsorption, due to autoimmune gastritis. Autoimmune gastritis is caused by lymphocitc infiltration and the generation of parietal gastric antibodies and intrinsic factor antibodies. Parietal gastric antibodies are cytotoxic: they specifically recognize the gastric proton pump, causing mucosal gastric atrophia and acloridia. This pathological condition can later degenerate into gastrin enterochromaffin cell hyperplasia , progressing to gastrin neuroendocrine tumors in nearly 10% of cases. In 1912 Dr Hakaru Hashimoto described the thyroid of four women affected by a struma lymphomatosa. This disease was later recognized as Hashimoto thyroiditis, being one of the most frequent causes of autoimmune hypothyroidism. Thyroid peroxodase (TPO) autoantibodies and lymphocytic infiltration are responsible for autoimmune thyroiditis and subsequent thyroid destruction. The thyrogastric syndrome was described in the seventies, in patients which the serum crossreacted both with parietal gastric antigens and thyroid TPO antigens. Whereas autoimmune polyendocrinopathies type 1 and 2 are rare, the real prevalence of the thyrogastric autoimmune syndrome is unknown. We conducted a prospective study to determine the prevalence of vitamine B12 malabsorption and gastric autoimmunity in patients with Hashimoto Thyroiditis seen in our clinical practice. A second end point of the study was to analyse gastric histological characteristics in such patients. A total of 240 consecutive patients with Hashimoto Thyroiditis were studied in our clinic from 2008 to 2009. Patients underwent TSH, FT4, FT3, ATPO, ATG, parietal cell autoantibodies (PCA), intrinsic factor antibodies (IFA), gastrine, vitamin B12 determinations and thyroid ultrasound. Patients with PCA and/or IFA were invited to have a gastric endoscopy and biopsies for histology and immunohistochemical studies. Patients with Hashimoto thyroiditis and gastric autoimmunity had a mean age of 52±19 years (28F/4M) at inclusion. Mean TSH was 21 ±28 µUI/ml (0.5-4) and 47% (15/32) of patients received levothyroxine treatment. Mean thyroid volume was 9.2±7 ml. Parietal cell autoantibodies were present in 13% (32/240). Intrinsic factor autoantibodies were found in 37.5% (6/16).In 3/6 patients with intrinsic factor antibodies we did not found PCA. Hypergastrinemia (>120 pg/ml) was present in 37 % (12/32) of patients with a mean of 323±507pg/ml. No patient had megaloblastic anemia, whereas only two patients had macrocytosis. Vitamine B12 was less than 200 pg/ml in 18% (6/32) of patients. A total of 59% (19/32) with PCA underwent a gastroscopy, with mucosal abnormalities in 79% (15/19) gastroscopies. Gastric and duodenal biopsies shown in 68% (13/19) histological signs of lymphocitosis infiltration, 42% (8/19) had signs of metaplasia and ECC hyperplasia and 21% (4/19) had signs of mucosal atrophy. Interestingly, H. pylori infection was found in 16% (3/19) of patients. No gastric carcinoid was found in this prospective series. In this oral presentation, we discuss the potential role of cross reacting epitopes between gastric proton pump ATP ase, thyroid autoantibodies and H pylori suggesting some physiopathological clues to explain this syndrome. Although the prevalence of the thyrogastric syndrome seems higher in our study, much of the previous studies were retrospective. Moreover, in these previous studies the physiopathological role of H pylori was not explored. Interestingly, in our experience, H. pylori can mimick gastric autoimmunity but this is reversible, after eradication. The high prevalence of autoimmune gastritis and vitamin B12 deficiency in this series provide a strong rationale for an early serologic screening and gastroscopic diagnosis in patients with Hashimoto's thyroiditis. The physiopathological model of the thyrogastric , or as already suggested gastro-thyroideal syndrome, shoud be revised in light of these new data. References H Valdes-Socin, L Lutteri, A Latta, L Vroonen, D Betea, P Petrossians, V Geenen, A Beckers. Prévalence de gastrite auto-immune et études histologiques dans une série prospective de 240 patients avec thyroïdite de Hashimoto. Abstract book. ENEA (Liège) 2010. H Valdes-Socin, L Lutteri, A Latta, L Vroonen, D Betea, P Petrossians, V Geenen, A Beckers. Prévalence de gastrite auto-immune et études histologiques dans une série prospective de 240 patients avec thyroïdite de Hashimoto. In XXVII Congrès de la SFE Abstract book. Annales d’Endocrinologie (Paris) 2010. H Valdes-Socin, A Beckers. Conférence pour médecins généralistes: «Le syndrome thyro-gastrique : de la carence en vitamine B12 aux tumeurs carcinoïdes de l’estomac». 18 mai 2011 à 20H00. Lieu : « Centre d’Endocrinologie d’Oupeye », Rue du Roi Albert, 261 – 4680 Oupeye. [less ▲]

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See detailLe syringomes à cellules claires
Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1990), 9(8), 676

Clear cell syringoma us a rare disease, most often present in diabetic patients. The histological and immunohistochemical aspects of such lesion are reviewed.

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See detailLe Système d'informations sur la Biodiversité en Wallonie.
Dufrêne, Marc ULg

in Les cahiers des Réserves Naturelles RNOB (1997), 11

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See detailLe système de télécommunication du nanosatellite OUFTI-1
Crosset, Nicolas ULg; Marchal, Nicolas; Pisane, Jonathan ULg et al

Scientific conference (2010, March 25)

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See detailLe système non-visuel chez l'être humain : lumière, oeil et cerveau
Daneault, V; Vandewalle, Gilles ULg; Dumont, M et al

Poster (2011, March)

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See detailLe système politique belge : quelle efficience pour quelle efficacité ?
Grandjean, Geoffrey ULg

Conference given outside the academic context (2013)

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See detailLe tabac et ses effets sur le système endocrinien
VALDES SOCIN, Hernan Gonzalo ULg; VROONEN, Laurent ULg; Latta, A. et al

in Revue Médicale de Liège (2010), 65(9), 498-501

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See detailLe télescope pour l'ultraviolet extrême EIT
Koeckelenberg, A.; Rochus, Pierre ULg

in Nouvelles de la Science et des Technologies (1990), 8

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See detailLe témoignage et l'objectivité intraitable : quelles fictions pour quels savoirs ? (A propos de "Rwanda 1994 et de la couverture du génocide par le journal "Le Soir")
Servais, Christine ULg

in Halen, Pierre; Walter, Jacques (Eds.) Les Langages de la mémoire. Littérature, médias et génocide au Rwanda (2005)

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See detailLe test de Bailey
Battisti, Oreste ULg

Learning material (2011)

video montrant la réalisation d'un test de Bailey

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See detailLe théâtre du pauvre. De Mallarmé à Kahn
Durand, Pascal ULg

in Basch, Sophie (Ed.) Gustave Kahn (1859-1936) (2009)

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See detailLe tourisme culturel, moteur de la renaissance urbaine ?
Teller, Jacques ULg

in Cahiers de l'Urbanisme (Les) (2005), 57

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See detailLe traité d'alliance romano-cnidien de 45 av. J.-C.
Famerie, Etienne ULg

in Cahiers du Centre Gustave Glotz (2011), 20 (2009, publ. 2011)

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