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See detailThe interaction between Bovine Leukemia Virus and its target cell.
Burny, Arsène; Kettmann, Richard ULg; Willems, Luc ULg et al

in AIDS Research and Human Retroviruses (1992), 8

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S ... [more ▼]

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S., Portetelle, D., Berte, C., Franssen, J. D., Herion, P., and Burny, A. (1982) Virology 122, 342-352; Voneche, V., Portetelle., D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3810-3814) and suggest that a region encompassing residues 23 and 25 of gp51 is involved in this process (Portetelle, D., Couez, D., Bruck, C., Kettmann, R., Mammerickx, M., Van der Maaten, M., Brasseur, R., and Burny, A. (1989) Virology 169, 27-33; Mamoun, R., Morisson, M., Rebeyrotte, N., Busetta, B., Couez, D., Kettmann, R., Hospital, M., and Guillemain, B. (1990) J. Virol. 64, 4180-4188). X-ray diffraction studies performed on envelope glycoproteins of influenza virus indicate that the NH2-terminal part of the external glycoprotein lies very close to the fusion peptide. The same overall structure seems to exist in human immunodeficiency virus as suggested by site-directed mutagenesis followed by syncytia induction assays. Our theoretical studies indicate that a segment expanding between residues 19 and 27 of gp51 probably adopts an amphipathic beta-strand structure. We hypothesize that the amphipathic 19-27 structure of gp51 plays an important role in the process of membrane fusion by interacting with the fusion peptide or with another region of gp30. Mutational analysis disrupting the amphipathy of the 19-27 region strongly altered the fusogenic capacity of the gp51-gp30 complex. [less ▲]

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See detailInteraction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases
Prosperi-Meys, C.; Llabres, Gabriel ULg; De Seny, Dominique ULg et al

in FEBS Letters (1999), 443(2), 109-11

The most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders ... [more ▼]

The most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders of magnitude. A comparison of the kinetic parameters for the alpha and beta isomers of 6-iodopenicillanic acid shows that there is no general preference for the alpha isomer and that the efficient hydrolysis of imipenem by these enzymes must rest on other factors. [less ▲]

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See detailInteraction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure
Dorban, Gauthier ULg; Defaweux, Valérie ULg; Demonceau, Christine ULg et al

in Virchows Archiv (2007), 451(6), 1057-1065

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting ... [more ▼]

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuro-invasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process. [less ▲]

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See detailInteraction between dietary protein content and the source of carbohydrates along the gastrointestinal tract of weaned piglets.
Pieper, Robert; Boudry, Christelle ULg; Bindelle, Jérôme ULg et al

in Archives of Animal Nutrition (2014), 68

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability ... [more ▼]

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability along the gut is still unclear. The current study aimed at determining the impact of two different sources of carbohydrates in diets with low or very high protein content on microbial metabolite profiles along the gastrointestinal tract of piglets. Thirty-six piglets (n = 6 per group) were fed diets high (26%, HP) or low (18%, LP) in dietary protein and with or without two different sources of carbohydrates (12% sugar beet pulp, SBP, or 8% lignocellulose, LNC) in a 2 × 3 factorial design. After 3 weeks, contents from stomach, jejunum, ileum, caecum, proximal and distal colon were taken and analysed for major bacterial metabolites (D-lactate, L-lactate, short chain fatty acids, ammonia, amines, phenols and indols). Results indicate considerable fermentation of CHO and protein already in the stomach. HP diets increased the formation of ammonia, amines, phenolic and indolic compounds throughout the different parts of the intestine with most pronounced effects in the distal colon. Dietary SBP inclusion in LP diets favoured the formation of cadaverine in the proximal parts of the intestine. SBP mainly increased CHO-derived metabolites such as SCFA and lactate and decreased protein-derived metabolites in the large intestine. Based on metabolite profiles, LNC was partly fermented in the distal large intestine and reduced mainly phenols, indols and cadaverine, but not ammonia. Multivariate analysis confirmed more diet-specific metabolite patterns in the stomach, whereas the CHO addition was the main determinant in the caecum and proximal colon. The protein level mainly influenced the metabolite patterns in the distal colon. The results confirm the importance of CHO source to influence the formation of metabolites derived from protein fermentation along the intestinal tract of the pig. [less ▲]

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See detailInteraction between dietary protein level and source of fermentable carbohydrates in the gastrointestinal tract of pigs
Pieper, Robert; Boudry, Christelle ULg; Vahjen, Wilfried et al

in International workshop on nutrition and intestinal microbiota host interaction in the pig : Book of abstracts (2013, October 24)

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See detailInteraction between earthworms and soil fungi: volatiles attraction
Zirbes, Lara ULg; Thonart, Philippe ULg; Wathelet, Jean-Paul ULg et al

in 9th International Symposium on Earthworm Ecology (2010)

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See detailInteraction between eustacy and block-faulting in the Carboniferous of the Visé-Maastricht area (Belgium, the Netherlands)
Poty, Edouard ULg; Delculee, Sandrine ULg

in Zeitschrift der Deutschen Gesellschaft für Geowissenschaften [=ZDGG] (2011), 162(2), 117-126

The Visé–Maastricht sedimentation area (VSA) is situated at the eastern end of the Brabant Massif and suffered block-faulting tectonics during Lower Carboniferous time. The south edge of the VSA, the area ... [more ▼]

The Visé–Maastricht sedimentation area (VSA) is situated at the eastern end of the Brabant Massif and suffered block-faulting tectonics during Lower Carboniferous time. The south edge of the VSA, the area corresponding now to the vicinity of Visé, comprised three main tectonic blocks: the Hermalle-sous-Argenteau, Souvré and Bombaye blocks. They were bounded to south by the Booze–Val-Dieu block. To the north, in the vicinity of Maastricht, blocks are not well differ- entiated and are referred to as the Maastricht block system. From the end of the Tournaisian, the latter evolved into a rap- idly subsiding graben, recording mainly debris fl ows and limestone turbidites, whereas the southern blocks remained rela- tively high. Through much of Lower Carboniferous time, they were emergent, but during high eustatic sea levels, they were fl ooded and covered by limestone deposits. The differences in the nature and the age of the deposits between blocks result from the interaction between block-faulting and eustacy. In the VSA, the Upper Devonian and Lower Tournaisian (Hastarian) deposits are similar to those known in the north part of the Namur-Dinant Basin. But from the late Tournaisian (Ivorian), the uplift of the Booze–Val-Dieu block prevented all connections with the Namur-Dinant Basin and the VSA became linked with the Campine Basin. The Souvré block subsided from the latest Givetian to the late Frasnian and recorded a thick middle Frasnian limestone series, but was later emergent, so much that karstic cavities developed. The Souvré block was submerged for a short time at the top of the Tournaisian, during the very high highstand (HST) corresponding to eustatic sequence 4, and the caves fi lled up with sediments. The Hermalle-sous-Argenteau and the Bombaye blocks, situated respectively west and east of the Souvré block, evolved in the same way during the late Devonian. They subsided slightly from the earliest Tournaisian to the late Viséan (Warnan- tian), but usually remained emergent and recorded deposits only during times of high eustatic levels corresponding to the early Tournaisian (for the Bombaye block), the end of the Tournaisian (HST of sequence 4), the end of the early Viséan (HST of sequence 6), then the late Viséan (HST of sequences 9 and 10). In its southern part, the Hermalle-sous-Argenteau block recorded also lowermost Viséan limestones correlated with the highstand of the eustatic sequence 5, probably as a result of the tilting of the block to the south at this time. [less ▲]

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See detailInteraction between hippocampal and striatal systems predicts subsequent consolidation of motor sequence memory.
Albouy, Geneviève; Sterpenich, Virginie; Vandewalle, Gilles ULg et al

in PLoS ONE (2013), 8(3), 59490

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See detailInteraction between human breast adenocarcinoma cells and type I collagen matrix requires fibronectin.
Castronovo, Vincenzo ULg; Foidart, Jean-Michel ULg

in Biology and Chemistry of Basement Membranes. (1985)

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See detailInteraction between human papillomavirus (HPV) and natural killer (NK) cells
Renoux, Virginie ULg; Longton, Laurence; Dortu, Estelle ULg et al

Conference (2007, October 10)

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See detailThe interaction between maternal and post-hatch n-3 fatty acid supplementation in broiler diets
Koppenol, A.; Delezie, E.; Buyse, J. et al

in Journal of Animal Physiology and Animal Nutrition (2015)

Summary: This study investigated whether offspring from n-3-supplemented breeders have an enhanced performance and immune organ weight when fed a post-hatch n-3-enriched diet in comparison with their ... [more ▼]

Summary: This study investigated whether offspring from n-3-supplemented breeders have an enhanced performance and immune organ weight when fed a post-hatch n-3-enriched diet in comparison with their control-fed counterparts and the importance of timing of omega-3 supplementation. Therefore, 480 Ross-308 broiler breeder hens were fed one of four different diets (120/treatment). The control diet (CON) was a basal diet, rich in n-6 fatty acids (FA). The three other diets were enriched in n-3 FA, formulated to obtain a different EPA/DHA ratio of 1/1 (EPA = DHA), 1/2 (DHA) or 2/1 (EPA). At 33 weeks of age, eggs were incubated to obtain 1440 offspring. They were set up according to their maternal diet and sex in 48 pens of 30 chicks each (12 pens per maternal treatment: six male and six female). Half of the offspring were given a post-hatch control diet, whereas to other half received an n-3-supplemented diet. Zootechnical performance was followed for starter, grower and finisher phase, and at the end of each phase two, chicks per pen were sacrificed to determine the weight of the immune organs. No interaction was found between maternal and post-hatch n-3 treatment for zootechnical performance. An interaction arose between the maternal and post-hatch n-3 supplementation for proportional bursa weight at day 1 and day 14 and proportional liver weight at day 14, but effects on immune organ weight were rather limited. Offspring post-hatch n-3 supplementation did not enhance maternal n-3 supplementation. � 2015 Blackwell Verlag GmbH. [less ▲]

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See detailInteraction between modal domains: The case of the Subjunctive in Late Egyptian
Polis, Stéphane ULg

Conference (2010, March 09)

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See detailInteraction between monobactams and model D-alanyl-D-alanine-cleaving peptidases
Frère, Jean-Marie ULg; Klein, Daniel; Kelly, Judith A et al

in FEMS Microbiology Letters (1984), 21

Several monobactams reacted with the serine dd-peptidases of Streptomyces R61 and Actinomadura R39 in a manner similar to that of bicyclic penicillins and cephalosporins. The dissociation constants of the ... [more ▼]

Several monobactams reacted with the serine dd-peptidases of Streptomyces R61 and Actinomadura R39 in a manner similar to that of bicyclic penicillins and cephalosporins. The dissociation constants of the Michaelis complexes formed between the R61 enzyme and sulfazecin (32 μM) and between the R39 peptidase and SQ 26324 (0.35 μM) had the lowest values ever observed with any β-lactam compound, suggesting an excellent fit of these two monobactams with the active sites of the respective enzymes. Azthreonam had a very poor inactivating potency, confirming its high selective reactivity towards the penicillin binding protein No. 3 of Escherichia coli. The Zn2+dd-peptidase (from Streptomyces albus G) had a high intrinsic resistance to β-lactam compounds whether they possessed a mono- or a bicyclic structure. [less ▲]

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See detailInteraction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases
Kelly, Judith A.; Frère, Jean-Marie ULg; Klein, Daniel et al

in Biochemical Journal (1981), 199(1), 129-136

The Zn-contg. D-alanyl-D-alanine carboxypeptidase of Streptomyces albus G was slowly inactivated by 6-aminopenicillanic acid (I), reversibly inhibited by 7-aminocephalosporanic acid (II), and unaffected ... [more ▼]

The Zn-contg. D-alanyl-D-alanine carboxypeptidase of Streptomyces albus G was slowly inactivated by 6-aminopenicillanic acid (I), reversibly inhibited by 7-aminocephalosporanic acid (II), and unaffected by mecillinam (III), cefoxitin (IV), quinacillin, quinacillin sulfone, clavulanic acid (V), and N-formimidoylthienamycin (VI). IV and VI, which are potent antibacterial agents, inactivated the serine D-alanyl-D-alanine carboxypeptidase/transpeptidase of Actinomadura R39 (R39 enzyme) and, to a lesser extent, the corresponding serine enzyme of Streptomyces R61 (R61 enzyme). All of the other nonclassical β-lactams tested, including III, were slow inactivators of these serine enzymes. The intermediates formed between I and the R61 and R39 enzymes were long- and short-lived, resp., whereas those formed between II and the same R61 and R39 enzymes were short- and long-lived, resp. Breakdown of the short-lived intermediates thus obtained gave rise to several ninhydrin-pos. degrdn. products. The intermediates formed between V and the serine enzymes were long-lived. With the R39 enzyme, the inactivated complex formed in a 1st step underwent subsequent monomol. rearrangement to give rise to a 2nd species exhibiting a high absorbance at 276 nm. [less ▲]

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See detailInteraction between penicillin and its enzyme target
Ghuysen, Jean-Marie ULg; Frère, Jean-Marie ULg; Leyh-Bouille, Mélina et al

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (1979), 2

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See detailInteraction between penicillin and the DD-carboxypeptidase of the unstable L-form of Proteus mirabilis strain 19
Schilf, Wolfgang; Frere, Philippe; Frère, Jean-Marie ULg et al

in European Journal of Biochemistry (1978), 85(2), 325-330

Binding of penicillin to the DD-carboxypeptidase of the unstable spheroplast L-form of Proteus mirabilis results in the rapid formation of a modified enzyme-inhibitor complex which in turn undergoes rapid ... [more ▼]

Binding of penicillin to the DD-carboxypeptidase of the unstable spheroplast L-form of Proteus mirabilis results in the rapid formation of a modified enzyme-inhibitor complex which in turn undergoes rapid decay into reactivated enzyme and an antibiotically inactive penicillin degradation product. Major antibiotic metabolites recovered from such interactions were benzylpenicilloic acid and phenoxymethylpenicilloic acid from benzylpenicillin and phenoxymethylpenicillin, respectively, suggesting a second enzymic function of the DD-carboxypeptidase as a penicillinase of low efficiency. Statistical analyses made with the help of a linear regression program show that the enzyme interacts with the substrate UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-(L)-meso-2,6-diaminopimelyl -(L)-D-alanyl-D-alanine and either benzympenicillin or carbenicillin in a non-competitive manner. [less ▲]

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See detailInteraction between short-term and long-term memory in the musical domain: the impact of musical knowledge and musical expertise
Gorin, Simon ULg; Majerus, Steve ULg

Poster (2013, May 28)

While verbal short-term memory (STM) has received considerable research interest, STM for music has been given considerably less attention. The aim of this study is to show that STM for musical stimuli is ... [more ▼]

While verbal short-term memory (STM) has received considerable research interest, STM for music has been given considerably less attention. The aim of this study is to show that STM for musical stimuli is grounded in LTM, as has been shown for verbal STM. Interactions between LTM and musical STM were studied by exploring the impact of musical knowledge and musical expertise on STM performance. The role of musical knowledge was investigated by an implicit musical learning task, where participants were incidentally exposed to a sequence of tones whose succession was governed by an artificial musical grammar; after exposure, a musical STM task was presented where participants had to reproduce tone sequences of increasing length, half of the sequences being legal (obeying to the artificial musical grammar of the incidental learning task). The role of musical expertise was explored by administering the same task to two participant groups: adults with no musical training and adult musicians. For the role of newly acquired musical knowledge, the non-musician participants showed a significant advantage for reproducing legal musical sequences, showing that they had incidentally learned new musical knowledge and that this knowledge supports STM performance. The musicians did not present an incidental musical learning effect in STM recall, but overall outperformed the non-musicians for reproducing both legal and illegal tone sequences, showing an overall effect of musical expertise. This study is the first to document STM-LTM interactions in the musical domain, and this for both new and existing musical knowledge. [less ▲]

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