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See detailIntegrin αvβ3 and RGD-based radiopharmaceuticals
WITHOFS, Nadia ULg; HUSTINX, Roland ULg

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2016), 40 (2016)

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in ... [more ▼]

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in particular, integrin αvβ3 are involved in numerous physiologic and pathologic processes, including angiogenesis. RGD-based radiopharmaceuticals targeting integrin αvβ3, expressed by activated endothelial cells, have been developed in order to quantify angiogenesis. However, integrin αvβ3 is also frequently expressed by tumour cells and/or tumour microenvironment cells, e.g., bone marrow derived cells and osteoclasts in bone. Upregulation of integrin αvβ3 by tumour cells promotes cell survival, proliferation, invasion, metastasis and resistance to treatment. Therefore, the PET signal related to RGD-based radiopharmaceuticals may not reflect angiogenesis only. Moreover, tumours may develop mechanisms other than angiogenesis to ensure blood supply such as vascular mimicry, vessel co-option and intussusceptive angiogenesis that might not be assessed with RGD PET/CT. In the setting of treatment assessment, a drop of the RGD PET signal certainly means tumour response (endothelial and/or tumour cell apoptosis and/or vessel normalisation). On the other hand, a stable or increased RGD PET signal may be related to absence of response or upregulation of integrin αvβ3 in adaptative response to therapy, promoting resistance. This review illustrates the complexity of the role of integrin αvβ3 in oncology and its role in non-oncologic diseases such as osteoarthtitis and cardiovascular diseases. [less ▲]

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See detailLes intégrines leucocytaires : de la biologie moléculaire à l'immunopathologie et l'immunorégulation
Louis, Edouard ULg

in Revue Médicale de Liège (1989), XLIV 20

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See detailIntégrité structurale sous actions exceptionnelles
Demonceau, Jean-François ULg; Luu, H.; Jaspart, Jean-Pierre ULg

in Actes du Colloque International: L'acier dans la construction 2ème édition (2005)

Detailed reference viewed: 36 (10 ULg)
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See detailIntegrity of the somatotrope GH/IGF-1 axis is required for normal thymus function: a clinical study in patients with adult GH deficiency
Morrhaye, Gabriel ULg; Kermani, Hamid; Cheynier, Rémi et al

in The Endocrine Society (Ed.) Proceedings of the 2009 Annual Meeting of the Endocrine Society (2009)

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See detailIntel Leveraging Rebates and the Goals of Article 102 TFEU
Petit, Nicolas ULg

in European Competition Journal (2015)

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See detailIntelectuales y anticomunismo: la revista 'Cadernos Brasileiros'(1959-1970)
Vanden Berghe, Kristine ULg

Book published by Leuven University Press (1997)

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See detailLa inteligencia
Richelle, Marc ULg

in Manuila, Alexandre (Ed.) Enciclopedia Salvat de la Salud (1981)

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See detailIntellectual disability and cancer susceptibility in a family with inherited 14q32.13q32.2 deletion.
JACQUINET, Adeline ULg; CABERG, Jean-Hubert ULg; BOURS, Vincent ULg et al

Poster (2013, June)

Located in 14q32.13, DICER1 codes for an RNase III endoribonuclease essential in the processing of microRNAs. These microRNAs are functional non-coding RNAs that regulate gene expression at a post ... [more ▼]

Located in 14q32.13, DICER1 codes for an RNase III endoribonuclease essential in the processing of microRNAs. These microRNAs are functional non-coding RNAs that regulate gene expression at a post-transcriptional level by interfering with translation and degradation of target messenger RNAs. Their deregulations have been implicated in several human diseases and cancers. Germline mutations in DICER1 are associated with a low susceptibility risk to tumor development. Inactivating mutations have been identified in patients and families with various benign and malignant tumors, especially pleuropulmonary blastoma, cystic nephroma and ovarian Sertoli-Leydig tumors. Germline DICER1 deletion has not been reported so far. We report a 7-year-old girl with an inherited DICER1 deletion. She was referred for mild intellectual deficiency, a medical history of cystic nephroma and dysmorphic features. Her father, two paternal uncles and the paternal grandmother had mild to moderate intellectual disabilities. The deceased grandmother had presented uterin and ovarian tumors. Array-CGH analysis identified a 5041kb deletion in 14q32.13-q32.2 in the patient, the father, the two uncles and the paternal grandmother. The deletion contained 50 coding genes and led to DICER 1 haploinsufficiency which was responsible for cancer susceptibility. Moreover, transmission of the deletion was related to intellectual disability in this family. The 14q32.13q32.2 locus has been previously associated with autosomal recessive mental retardation, suggesting the presence in the region of genes implicated in cerebral development and cognitive functions. [less ▲]

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See detailL'intellectuel critique aujourd'hui
Hamers, Jérémy ULg; Cormann, Grégory ULg; Englebert, Jérôme ULg et al

Article for general public (2014)

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See detailL'intellectuel de gauche et le Français moyen. Roland Barthes et la "pensée Greg"
Denis, Benoît ULg

in Provenzano, François; Sindaco, Sarah (Eds.) La Fabrique du Français moyen : productions culturelles et imaginaire social dans la France gaullienne (1958-1981) (2009)

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See detailL’intellectuel engagé et le chercheur scientifique : deux figures antagonistes ?
Fournier, Bernard ULg

in Hudon, Raymond; Pelletier, Réjean (Eds.) L’engagement intellectuel ; Mélanges en l’honneur de Léon Dion (1991)

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See detailIntellectuels
Durand, Pascal ULg

in Durand, Pascal (Ed.) Les Nouveaux Mots du Pouvoir. Abécédaire critique (2007)

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See detailIntellectuels
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (2007), 63(printemps), 59-62

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See detailIntellectuels belges, engagement et guerre
Geuens, Geoffrey ULg

Conference given outside the academic context (2003)

Detailed reference viewed: 13 (5 ULg)
See detailLes intellectuels catholiques
Jadoulle, Jean-Louis ULg

in J. PIROTTE et G. ZELIS (Ed.) Pour une histoire du monde catholique au 20e siècle. Wallonie - Bruxelles. Guide du chercheur (2003)

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See detailLes intellectuels dans la Grande Guerre ou le « désenchantement du monde ». M. Weber et R. Musil à l’épreuve de 14-18
Petteni, Oriane ULg

in Cahiers du GRM (2014), 6

The ambition of this paper is to evaluate the impact that World War I, a « moral and financial crash », had on intellectuals and to examinate how they re-evaluted their position in the society after the ... [more ▼]

The ambition of this paper is to evaluate the impact that World War I, a « moral and financial crash », had on intellectuals and to examinate how they re-evaluted their position in the society after the catastrophy. The article takes as guiding principle the weberian concept of « disenchantement with the world ». After a first look at the weberian diagnosis, the article tries to show how the work of R. Musil offers an original re-reading of Weber’s conclusions, influenced by the Vienna Circle and its « economical thaught » based on new epistemological paradigma. [less ▲]

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See detailIntellectuels malgré eux
Denis, Benoît ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1997), (79-81), 49-52

Detailed reference viewed: 9 (1 ULg)