Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailImpact of components of the metabolic syndrome on knee osteoarthritis progression in the SEKOIA study
Eymard, F; Edwards, M; Parsons, C et al

in Osteoarthritis and Cartilage (2014), 22(1), 376

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailImpact of components of the metabolic syndrome on progression of knee osteoarthritis in the SEKOIA study
Edwards, MH; Parsons, C; Eymard, F et al

in Rheumatology (2014), 53(1), 31

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailImpact of components of the metabolic syndrome on progression of knee osteoarthritis in the Sekoia study
Parsons, C; Edwards, MH; Eymard, F et al

in Osteoporosis International (2014), 25(2), 230

Detailed reference viewed: 28 (4 ULg)
Full Text
Peer Reviewed
See detailThe impact of concomitant rhinitis on asthma-related quality of life and asthma control.
Vandenplas, O.; Dramaix, M.; Joos, G. et al

in Allergy (2010)

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]

Detailed reference viewed: 32 (4 ULg)
Peer Reviewed
See detailImpact of contaminants on thyroid and immune system of harbour porpoise (Phocoena phocoena) from the Northeast Atlantic
Das, Krishna ULg; Siebert, Ursula

Poster (2004, May)

This Marie-Curie project integrates in the research framework of transport pathway and impact of pollutant studies in the marine ecosystem and aims to understand the effects of some pollutants on the ... [more ▼]

This Marie-Curie project integrates in the research framework of transport pathway and impact of pollutant studies in the marine ecosystem and aims to understand the effects of some pollutants on the general health status, the endocrine and immune systems of the harbour porpoise (Phocoena phocoena). Pollutants such as trace metals, or organochlorines which have been recognised to have endocrine or immune disrupting effects on other species will be examined. These investigations will examine if some endocrine and immune functions are impaired by those pollutants to the extend that harbour porpoises are susceptible to infectious agents which may decrease the population size. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailImpact of contaminated-sediment resuspension on phytoplankton in the Biguglia lagoon (Corsica, Mediterranean Sea)
Lafabrie, Céline; Garrido, Marie ULg; Leboulanger, Christophe et al

in Estuarine Coastal & Shelf Science (2013)

In shallow human-impacted systems, sediment resuspension events can result in pulsed exposures of pelagic organisms to multiple contaminants. Here, we examined the impact of the resuspension of ... [more ▼]

In shallow human-impacted systems, sediment resuspension events can result in pulsed exposures of pelagic organisms to multiple contaminants. Here, we examined the impact of the resuspension of contaminated sediment on phytoplankton in the Biguglia lagoon (Corsica, Mediterranean Sea), by conducting an in situ microcosm experiment over a 96-hour period. Natural phytoplankton was exposed to elutriates prepared from a contaminated sediment resuspension simulating process, and its functional and structural responses were compared with those of non-exposed phytoplankton. The elutriates displayed moderate multiple contamination by trace metals and PAHs. Our results show that elutriate exposure induced both functional and structural phytoplankton changes. Elutriates strongly stimulated phytoplankton growth after 24 h of exposure. They also enhanced phytoplankton photosynthetic performance during the first hours of exposure (up to 48 h), before reducing it towards the end of the experiment. Elutriates were also found to slightly stimulate Bacillariophyceae, and conversely to slightly inhibit Dinophyceae in the short term. Additionally, they stimulated phycocyanin-rich picocyanobacteria in the short term (8-48 h) before inhibiting it in the longer term (72-96 h), and to inhibit eukaryotic nanophytoplankton at short term (8-48 h) before stimulating it in the longer term (72-96 h). Sediment resuspension is thus likely to have a significant effect on the global dynamics of phytoplankton in contaminated coastal environments. [less ▲]

Detailed reference viewed: 38 (1 ULg)
Full Text
See detailImpact of contamination on empirical and theoretical error
Ruwet, Christel ULg; Haesbroeck, Gentiane ULg

Conference (2009, June 18)

Classification analysis allows to group similar objects into a given number of groups by means of a classification rule. Many classification procedures are available : linear discrimination, logistic ... [more ▼]

Classification analysis allows to group similar objects into a given number of groups by means of a classification rule. Many classification procedures are available : linear discrimination, logistic discrimination, etc. Focus in this poster will be on classification resulting from a clustering analysis. Indeed, among the outputs of classical clustering techniques, a classification rule is provided in order to classify the objects into one of the clusters. More precisely, let F denote the underlying distribution and assume that the generalized kmeans algorithm with penalty function is used to construct the k clusters C1(F), . . . ,Ck(F) with centers T1(F), . . . , Tk(F). When one feels that k true groups are existing among the data, classification might be the main objective of the statistical analysis. Performance of a particular classification technique can be measured by means of an error rate. Depending on the availability of data, two types of error rates may be computed: a theoretical one and a more empirical one. In the first case, the rule is estimated on a training sample with distribution F while the evaluation of the classification performance may be done through a test sample distributed according to a model distribution of interest, Fm say. In the second case, the same data are used to set up the rule and to evaluate the performance. Under contamination, one has to replace the distribution F of the training sample by a contaminated one, F(eps) say (where eps corresponds to the fraction of contamination). In that case, thetheoretical error rate will be corrupted since it relies on a contaminated rule but it may still consider a test sample distributed according to the model distribution. The empirical error rate will be affected twice: via the rule and also via the sample used for the evaluation of the classification performance. To measure the robustness of classification based on clustering, influence functions of the error rate may be computed. The idea has already been exploited by Croux et al (2008) and Croux et al (2008) in the context of linear and logistic discrimination. In the computation of influence functions, the contaminated distribution takes the form F(eps) = (1 − eps)*Fm + eps* Dx, where Dx is the Dirac distribution putting all its mass at x. It is interesting to note that the impact of the point mass x may be positive, i.e. may decrease the error rate, when the data at hand is used to evaluate the error. [less ▲]

Detailed reference viewed: 65 (25 ULg)
Full Text
See detailImpact of contamination on the TCLUST procedure
Ruwet, Christel ULg; García-Escudero, Luis Angel; Gordaliza, Alfonso et al

Conference (2011, December 18)

The TCLUST procedure is a robust clustering procedure that performs clus- tering with the aim of tting clusters with di erent scatters and weights. As the corresponding objective function can be unbounded ... [more ▼]

The TCLUST procedure is a robust clustering procedure that performs clus- tering with the aim of tting clusters with di erent scatters and weights. As the corresponding objective function can be unbounded, a restriction is added on the eigenvalues-ratio of the scatter matrices. The robustness of the method is guaranteed by allowing the trimming of a given proportion of observations. The resistance to contamination of that procedure will be studied. Results con- cerning breakdown points and some new criteria in robust cluster analysis, such as the dissolution point and the isolation robustness, will be presented. [less ▲]

Detailed reference viewed: 14 (6 ULg)
Full Text
Peer Reviewed
See detailImpact of contamination on training and test error rates in statistical clustering
Ruwet, Christel ULg; Haesbroeck, Gentiane ULg

in Communications in Statistics : Simulation & Computation (2011), 40(3), 394-411

The k-means algorithm is one of the most common nonhierarchical methods of clustering. It aims to construct clusters in order to minimize the within cluster sum of squared distances. However, as most ... [more ▼]

The k-means algorithm is one of the most common nonhierarchical methods of clustering. It aims to construct clusters in order to minimize the within cluster sum of squared distances. However, as most estimators defined in terms of objective functions depending on global sums of squares, the k-means procedure is not robust with respect to atypical observations in the data. Alternative techniques have thus been introduced in the literature, e.g. the k-medoids method. The k-means and k-medoids methodologies are particular cases of the generalized k-means procedure. In this paper, focus is on the error rate these clustering procedures achieve when one expects the data to be distributed according to a mixture distribution. Two different definitions of the error rate are under consideration, depending on the data at hand. It is shown that contamination may make one of these two error rates decrease even under optimal models. The consequence of this will be emphasized with the comparison of influence functions and breakdown points of these error rates. [less ▲]

Detailed reference viewed: 128 (44 ULg)
Full Text
Peer Reviewed
See detailImpact of contractile reserve on acute response to cardiac resynchronization therapy
Moonen, Marie ULg; Senechal, Mario; Cosyns, Bernard et al

in Cardiovascular Ultrasound (2008), 6(65),

Background: Cardiac resynchronization therapy (CRT) provides benefit for congestive heart failure, but still 30% of patients failed to respond to such therapy. This lack of response may be due to the ... [more ▼]

Background: Cardiac resynchronization therapy (CRT) provides benefit for congestive heart failure, but still 30% of patients failed to respond to such therapy. This lack of response may be due to the presence of significant amount of scar or fibrotic tissue at myocardial level. This study sought to investigate the potential impact of myocardial contractile reserve as assessed during exercise echocardiography on acute response following CRT implantation. Methods: Fifty-one consecutive patients with heart failure (LV ejection fraction 27% ± 5%, 67% ischemic cardiomyopathy) underwent exercise Doppler echocardiography before CRT implantation to assess global contractile reserve (improvement in LV ejection fraction) and local contractile reserve in the region of the LV pacing lead (assessed by radial strain using speckle tracking analysis). Responders were defined by an increase in stroke volume ≥15% after CRT. Results: Compared with nonresponders, responders (25 patients) showed a greater exercise-induced increase in LV ejection fraction, a higher degree of mitral regurgitation and a significant extent of LV dyssynchrony. The presence of contractile reserve was directly related to the acute increase in stroke volume (r = 0.48, p<0.001). Baseline myocardial deformation as well as contractile reserve in the LV pacing lead region was greater in responders during exercise than in nonresponders (p<0.0001). Conclusions: Heart failure patients referred to CRT have less chance of improving under therapy if they have no significant mitral regurgitation, no LV dyssynchrony and no contractile myocardial recruitment at exercise. [less ▲]

Detailed reference viewed: 72 (7 ULg)
Full Text
See detailImpact of cooking and species on intestinal fermentation patterns of vegetables in a humanized in vitro model of the gastro-intestinal tract
Kalala Bolokango, Gaetan ULg; Kambashi Mutiaka, Bienvenu ULg; Njeumen Lemotio, Georges Patrick ULg et al

Poster (2016, June 21)

Obesity and associated pathologies have dramatic consequences on patients’lives as well as high societal costs. Because of the role of intestinal dysbiosis and microbiota make-up on the pathogenesis of ... [more ▼]

Obesity and associated pathologies have dramatic consequences on patients’lives as well as high societal costs. Because of the role of intestinal dysbiosis and microbiota make-up on the pathogenesis of obesity, several strategies such as eating prebiotics and dietary fibre supplements are being investigated to reshape the intestinal microbial communities of obese patients. Beyond supplement, dietary fibre is supplied through plant ingredients in the meals. In the framework of the multidisciplinary research project Food4Gut, the use of vegetables rich in specific targeted dietary fiber, namely fructans, is being scrutinized for its ability to induce positive changes in the intestinal ecophysiology. Because expected effect might differ according the content in dietary fibre and fructans, the soluble:insoluble ratio, as well as the cooking of the vegetables, the fermentation patterns of several vegetables are being investigated in an dual in vitro model combining enzymatic hydrolysis to an in vitro fermentation step using faecal inoculums from humans, to evaluate the performance of gut microbiota, modulation of metabolic functions. Six vegetables were sampled in triplicates (N=3) and steamed for 20 to 30 min.: Jerusalem artichoke, salsify, asparagus, pumpkin, fennel and swede. They were chosen because they display a variety of contents in fructans, soluble (SDF) and insoluble dietaryfibre (IDF). Steamed vegetable samplesand burgers from local fast food restaurants (negative control) were hydrolyzed in vitro why porcine pepsin and pancreatin to mimic digestion in the upper gut and indigested fiber residues were recover using a 6kDa dialysis membrane.Subsequently, in vitro fermentation is being run with independent fecal inoculums from obese and lean patients (N=4). Fermentation kinetics over 24h as well as short-chain fatty acid production and profiles will be compared according to the individual donor and the vegetable species and multivariate analysis will be used to explore the relationships between donor, vegetable species and composition and fermentation patterns. [less ▲]

Detailed reference viewed: 60 (28 ULg)
Full Text
Peer Reviewed
See detailImpact of cord blood banking technologies on clinical outcome: a Eurocord/Cord Blood Committee (CTIWP), European Society for Blood and Marrow Transplantation and NetCord retrospective analysis
Saccardi, Riccardo; Tucunduva, Luciana; Ruggeri, Annalisa et al

in Transfusion (2016), 56(8), 2021-2029

BACKGROUND Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without ... [more ▼]

BACKGROUND Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without altering the biologic properties of the graft. A large-scale, registry-based assessment of the impact of the banking variables on the clinical outcome is currently missing. STUDY DESIGN AND METHODS A total of 677 single cord blood transplants (CBTs) carried out for acute leukemia in complete remission in centers affiliated with the European Society for Blood and Marrow Transplantation were selected. An extensive set of data concerning CBU banking were collected and correlations with clinical outcome were assessed. Clinical endpoints were transplant-related mortality, engraftment, and graft-versus-host disease (GVHD). RESULTS The median time between collection and CBT was 4.1 years (range, 0.2-16.3 years). Volume reduction (VR) of CBUs before freezing was performed in 59.2% of available reports; in half of these the frozen volume was less than 30 mL. Cumulative incidences of neutrophil engraftment on Day 60, 100-day acute GVHD (II-IV), and 4-year chronic GVHD were 87, 29, and 21 ± 2%. The cumulative incidence of nonrelapse mortality (NRM) at 100 days and 4-year NRM were, respectively, 16 ± 2 and 30 ± 2%. Neither the variables related to banking procedures nor the interval between collection and CBT influenced the clinical outcome. CONCLUSION These findings indicate a satisfactory validation of the techniques associated with CBU VR across the banks. Cell viability assessment varied among the banks, suggesting that efforts to improve the standardization of CBU quality controls are needed. [less ▲]

Detailed reference viewed: 70 (16 ULg)
Peer Reviewed
See detailThe impact of corporate disclosures on information asymmetry and stock-market liquidity in France
Sougné, Danielle ULg; Ajina, Aymen ULg

Conference (2011, May 30)

This paper aims at studying the effect of the extent of disclosure on information asymmetry and stock-market liquidity in France. Our sample includes196 French listed firms over a period ranging from 2004 ... [more ▼]

This paper aims at studying the effect of the extent of disclosure on information asymmetry and stock-market liquidity in France. Our sample includes196 French listed firms over a period ranging from 2004 to 2007, the results show that the extent of disclosure in annual reports positively influence the liquidity of the French market. This is explained by the negative effect of the disclosure on the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. This result should encourage French authorities to further improve their information environment as essential to reduce the costs of asymetric information and prevent the risk of illiquidity. [less ▲]

Detailed reference viewed: 101 (20 ULg)
Full Text
Peer Reviewed
See detailImpact of cotransplantation of mesenchymal stem cells on lung function after unrelated allogeneic hematopoietic stem cell transplantation following non-myeloablative conditioning
MOERMANS, Catherine ULg; LECHANTEUR, Chantal ULg; BAUDOUX, Etienne ULg et al

in Transplantation (2014), 98(3), 348-353

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal ... [more ▼]

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal models, MSC were shown to cause pulmonary alterations after systemic administration. The impact of MSC infusion on lung function has not been studied in humans. The objective of the study was to investigate the impact of MSC co-infusion on lung function and airway inflammation as well as on the incidence of pulmonary infections and cytomegalovirus (CMV) reactivation after HSCT. Methods: We have prospectively followed 30 patients who underwent unrelated HSCT with MSC co-infusion after non-myeloablative conditioning (NMA). Each patient underwent detailed lung function testing (FEV1, FVC, FEV1/FVC, RV, TLC, DLCO and KCO) and measurement of exhaled nitric oxide before HSCT and 3, 6 and 12 months posttransplant. The incidence of pulmonary infections and CMV reactivation were also monitored. This group was compared with another group of 28 patients who underwent the same type of transplantation but without MSC co-infusion. Results: Lung function tests did not show important modifications over time and did not differ between the MSC and control groups. There was a higher 1-year incidence of infection, particularly of fungal infections, in patients having received a MSC co-infusion. There was no difference between groups regarding the 1-year incidence of CMV reactivation. Conclusions: MSC co-infusion does not induce pulmonary deterioration 1 year after HSCT with NMA conditioning. MSC appear to be safe for the lung but close monitoring of pulmonary infections remains essential. [less ▲]

Detailed reference viewed: 164 (32 ULg)
See detailThe impact of countries of origin on civic participation in the host countries
Gsir, Sonia ULg

Scientific conference (2014)

Detailed reference viewed: 9 (0 ULg)
See detailThe impact of countries of origin on social interaction in the host countries
Gsir, Sonia ULg

Scientific conference (2014)

Detailed reference viewed: 13 (0 ULg)
Full Text
See detailIMPACT OF COVER CROP AND CROP RESIDUE MANAGEMENT ON CROP PRODUCTION
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2013, July 03)

The aim of this project is to study the crop development in relation to soil tillage and organic residue management and to understand its impact on crop production but also on the dynamics of weed ... [more ▼]

The aim of this project is to study the crop development in relation to soil tillage and organic residue management and to understand its impact on crop production but also on the dynamics of weed populations and intensity of fungal diseases occurring on the crops. Various cropping systems with different tillage methods dedicated to bury the residues from the previous crop and/or from the intercropping and to prepare the implantation of following crop are studied. [less ▲]

Detailed reference viewed: 54 (9 ULg)
Full Text
See detailIMPACT OF COVER CROP MANAGEMENT ON CROP PRODUCTION: A FIELD EXPERIMENT IN WALLONIA CONTEXT
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2014, February)

Minimal soil tillage methods, crop rotation, cover crop and continuous plant residue cover are the main pillars of sustainable agriculture. Lower energy consumption, costs and time are some direct ... [more ▼]

Minimal soil tillage methods, crop rotation, cover crop and continuous plant residue cover are the main pillars of sustainable agriculture. Lower energy consumption, costs and time are some direct benefits in favor to the adaptation of this agriculture. This practices aims also directly at protecting the soil from wind and water erosion by covering the soil. Lower disruption of the soil aims at developping the micro- and macro-fauna activity that increases soil fertility and carbon and nitrogen sequestration in soils. Unfortunately, some of the great constraints to the adaptation of conservation agriculture remain weed management, fungal diseases and pest management, that has been shown to be a problem in non-ploughed fields. The aim of our study is to evaluate, on a same field (Wallonia context), contrasted tillage methods for managing the cover crop and the implantation of the main crop. The following measurements were taken: germination rate, root and shoot biomass development, root notation (size and shape), leaf area index and quality of harvested product. Preliminary results indicate that the different tillage methods did not have a significant impact on crop production or development. However changes in germination dynamics were observed, the reduced tillage inducing slower germination. Regarding weeds populations, some difference were observed in weed occurrences. Since a field exp [less ▲]

Detailed reference viewed: 72 (9 ULg)
Full Text
Peer Reviewed
See detailImpact of cristallinity index on the stability and physical properties of inulin during moisture uptake.
Ronkart, Sébastien; Paquot, Michel ULg; Fougnies, C. et al

Poster (2008, April)

Detailed reference viewed: 17 (2 ULg)