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See detailThe Minimal Fusion Peptide Of Simian Immunodeficiency Virus Corresponds To The 11 First Residues Of Gp32
Lorin, A.; Lins, Laurence ULg; Stroobant, V. et al

in Journal of Peptide Science (2008), 14(4), 423-8

We had previously predicted successfully the minimal fusion peptides (FPs) of the human immunodeficiency virus 1 (HIV-1) gp41 and the bovine leukemia virus (BLV) gp30 using an original approach based on ... [more ▼]

We had previously predicted successfully the minimal fusion peptides (FPs) of the human immunodeficiency virus 1 (HIV-1) gp41 and the bovine leukemia virus (BLV) gp30 using an original approach based on the obliquity/fusogenicity relationship of tilted peptides. In this paper, we have used the same method to predict the shortest FP capable of inducing optimal fusion in vitro of the simian immunodeficiency virus (SIV) mac isolate and of other SIVs and human immunodeficiency virus (HIV-2) isolates. In each case, the 11-residue-long peptide was predicted as the minimal FP. For the SIV mac isolate, liposome lipid-mixing and leakage assays confirmed that this peptide is the shortest peptide inducing optimal fusion in vitro, being therefore the minimal FP. These results are another piece of evidence that the tilted properties of FPs are important for the fusion process and that our method can be used to predict the minimal FPs of other viruses. [less ▲]

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See detailMinimal influence of the time interval between injection of regular insulin and food intake on blood glucose control of type 1 diabetic patients on a basal-bolus insulin scheme.
Scheen, André ULg; Letiexhe, Michel ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1999), 25(2), 157-62

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in ... [more ▼]

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in patients with type 1 diabetes on intensive insulin therapy. Fifteen C-peptide negative subjects were submitted, in a randomized order, to two 6-week treatment periods in which regular insulin was injected either 5 minutes or 30 minutes before each of the three main meals, in combination with a bedtime NPH insulin injection. The changes in plasma glucose excursions following a breakfast test (Cmax, Tmax, Cmin, Tmin, AUC0-240 min) were similar in the two experimental protocols. Furthermore, no significant changes were observed in daily insulin dosages nor in glucose profiles obtained using home blood glucose monitoring. Only a tendency to a greater 90-minutes postprandial increase in blood glucose levels was observed when regular insulin was injected 5 minutes rather than 30 minutes before meal. Glycated haemoglobin levels were similar after each treatment period (7.6 +/- 0.2% versus 7.5 +/- 0.2%; NS) and no differences in the incidence or severity of hypoglycaemic episodes were noticed between the two insulin schemes. In conclusion, in type 1 diabetic patients who are rather well controlled with a basal-bolus insulin scheme, the injection of regular insulin 30 minutes before each main meal provides no significant advantage as compared to the injection of regular insulin 5 minutes before meal. [less ▲]

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See detailMinimal Lepton Flavor Violating Realizations of Minimal Seesaw Models.
Aristizabal Sierra, Diego ULg; Degée, Audrey ULg; Kamenik, Jernej F.

in Journal of High Energy Physics [=JHEP] (2012), JHEP 1207 (2012) 135(2012), 135-156

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. In the context of minimal type I seesaw ... [more ▼]

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. In the context of minimal type I seesaw scenarios with a slightly broken U(1)R, we show that, depending on the R-charge assignments, two classes of generic models can be identi fied. Models where the right-handed neutrino masses and the lepton number breaking scale are decoupled, and models where the parameters that slightly break the U(1)R induce a suppression in the light neutrino mass matrix. We show that within the fi rst class of models, contributions of right-handed neutrinos to charged lepton flavor violating processes are severely suppressed. Within the second class of models we study the charged lepton flavor violating phenomenology in detail, focusing on \ mu->e \gamma , \mu->3e and \mu- e conversion in nuclei. We show that sizable contributions to these processes are naturally obtained for right-handed neutrino masses at the TeV scale. We then discuss the interplay with the eff ects of the right- handed neutrino interactions on primordial B- L asymmetries,fi nding that sizable right-handed neutrino contributions to charged lepton flavor violating processes are incompatible with the requirement of generating (or even preserving preexisting) B-L asymmetries consistent with the observed baryon asymmetry of the Universe. [less ▲]

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See detailMinimal Levels of Serum Estradiol Prevent Postmenopausal Bone Loss
Reginster, Jean-Yves ULg; Sarlet, Nathalie ULg; Deroisy, Rita ULg et al

in Calcified Tissue International (1992), 51

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 ... [more ▼]

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 healthy women including 158 patients receiving estrogen replacement therapy (ERT) for at least 6 months, 49 eugonadal women, and 55 untreated postmenopausal women. A significant (P < 0.001) correlation exists between serum E2 and Ca/Cr: Ca/Cr (mg/dl) = -0.00044 E2 (pg/ml) + 0.129 (n = 262; r = -0.37), serum E2 and OH/Cr: (OH/Cr (mg/g) = -0.049 E2 (pg/ml) + 18.76 (n = 262; r = -0.36), serum E1 and Ca/Cr: Ca/Cr (mg/dl) = -0.0003 E1 (pg/ml) + 0.127 (n = 261; r = -0.28) but not between serum E1 and OH/Cr. Women with circulating levels of E2 between 60 and 90 pg/ml have a significant (P < 0.01) reduction of Ca/Cr and OH/Cr when compared with those with lower levels of E2. Higher values of E2 do not provide additional benefit. We conclude that in postmenopausal women receiving an estrogen replacement therapy (ERT), a significant reduction of bone resorption is achieved when circulating levels of estradiol reach a value (60 pg/ml) corresponding to the one measured, in eugonadal women, during the last days of the early follicular phase of the menstrual cycle. We suggest that oral or percutaneous ERT should induce a minimal value of 60 pg/ml to prevent postmenopausal bone loss. [less ▲]

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See detailMinimal Reduction of Unscheduled Flows for Security Restoration: Application to Phase Shifter Control
Marinakis, Adamantios ULg; Glavic, Mevludin; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (2010), 25(1), 506-515

More and more transmission system operators, noticeably in Europe, equip their systems with phase shifting transformers to counteract transit flows that take place in a large meshed interconnection. This ... [more ▼]

More and more transmission system operators, noticeably in Europe, equip their systems with phase shifting transformers to counteract transit flows that take place in a large meshed interconnection. This paper proposes algorithms for the coordinated control of several phase shifters by one operator with the objective of reducing the unscheduled flow through its system. Minimum reduction of unscheduled flow and minimum deviation with respect to present operating point are sought in order to minimize the trouble caused, while ensuring secure operation. Attention is paid to combining pre and post-contingency controls. The resulting algorithms, simple and compatible with real-time applications, are illustrated on a realistic test system. [less ▲]

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See detailMinimal seesaw models and minimal lepton flavor violation.
Degée, Audrey ULg

in Frascati Physics Series Vol. LIV (2012), Frascati Phys.Ser. 55(2012), 31-36

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. Our discussion is done in the context of ... [more ▼]

We study the implications of the global U(1)R symmetry present in minimal lepton flavor violating implementations of the seesaw mechanism for neutrino masses. Our discussion is done in the context of explicit minimal type-I seesaw scenarios, where depending on the R-charge assignment different models can be constructed. We study the charged lepton flavor violating phenomenology of a concrete realization paying special attention to μ → eγ and μ → 3e [less ▲]

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See detailA minimalistic approach to identify substrate binding features in B1 Metallo-beta-lactamases
Poeylaut-Palena, Andres A; Tomatis, Pablo E; Karsisiotis, Andreas I et al

in Bioorganic & Medicinal Chemistry Letters (2007), 17(18), 5171-5174

The 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal P-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-p-lactamase Bell. None of ... [more ▼]

The 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal P-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-p-lactamase Bell. None of them was hydrolyzed by the enzyme. While the azetidinone was not able to bind Bell, aztreonam was shown to bind in a nonproductive mode. These results provide an explanation for the unability of Metallo-beta-lactamases to inactive monobactams and give some clues for inhibitor design. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMinimally-invasive spinal surgery to remove a broken epidural catheter fragment
Eap, C; Frappart, M; Litré, Claude Fabien ULg et al

in International Journal of Obstetric Anesthesia (2011)

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See detailMinimally-supervised extraction of domain-specific part–whole relations using Wikipedia as knowledge-base
Ittoo, Ashwin ULg; Bouma, Gosse

in Data & Knowledge Engineering (2013), 85

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See detailMinimally-supervised learning of domain-specific causal relations using an open-domain corpus as knowledge base
Ittoo, Ashwin ULg; Bouma, Gosse

in Data & Knowledge Engineering (2013)

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See detailMinimishing the nutritional deficit in ill preterm infants
SENTERRE, Thibault ULg

Conference (2013, October)

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See detailMinimising perceived latency in audio-conferencing systems over application-level multicast
Blundell, N.; Mathy, Laurent ULg

in Proceedings of MIPS Workshop (2004)

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See detailMinimization of Production Cost by use of an Automatic Cost Assessment Method and Simulation
Caprace, Jean-David ULg; Bair, Frédéric ULg; Losseau, Nicolas ULg et al

in The Euro-Asia Maritime Network (EAMARNET) (2007, January)

This paper will present different ways to minimize cost in shipbuilding industry. Amongst them we have the production simulation methods, the cost assessment methods and the optimization methods. Nowadays ... [more ▼]

This paper will present different ways to minimize cost in shipbuilding industry. Amongst them we have the production simulation methods, the cost assessment methods and the optimization methods. Nowadays, cost assessment is a key task of an integrated ship design. The various methods to estimate the production cost differ with the known information (input data). The less information is detailed, the earlier a method can be used in the design process. The more information is used, the better we can assess the differences between design alternatives. The methods presented here and the “design for production” concept promise to increase the productivity trough the following points: a more accurate cost estimation, an improvement in the deadlines planning and the production schedule, a progress in distribution of the workload between the various production workshops, a better knowledge of the individual costs that will permit to reduce the global cost. In order to illustrate our work, we present in this paper three methods to decrease the global cost of a ship. [less ▲]

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See detailMinimization of the shadow patterns produced by periodic mesh grids in extreme ultraviolet telescopes
Auchère, Frédéric; Rizzi, Julien; Philippon, Anne et al

in Journal of the Optical Society of America. A, Optics, Image Science, & Vision (2011), 28(1), 40-45

Thin metallic films are used as passband filters in space telescopes operating in the extreme ultraviolet (EUV). Because of their thinness, typically 100 to 200nm, they are very sensitive to static ... [more ▼]

Thin metallic films are used as passband filters in space telescopes operating in the extreme ultraviolet (EUV). Because of their thinness, typically 100 to 200nm, they are very sensitive to static pressure differentials and to mechanic and acoustic vibrations. Therefore, they are difficult to manage in all phases of a space program, from manufacturing to vacuum testing to launch. A common solution to this problem is to reinforce them with fine mesh grids with pitches ranging from a few hundred micrometers to a few millimeters. Depending on their location in the optical path, the main effect of these periodic grids is either to diffract light or to cast penumbral shadows on the focal plane. In this paper, we analyze the formation of the shadow modulation patterns and derive design rules to minimize their amplitude. The minimization principle is illustrated by an application to a solar EUV telescope. [less ▲]

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See detailLe minimum : une nouvelle utopie de l'écriture architecturale contemporaine
Dawans, Stéphane ULg

in Hyppolite, Pierre (Ed.) Architecture et littérature contemporaines (2012)

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See detailMinimum gradient support and geostatistics regularization approaches for inverting time-lapse data
Nguyen, Frédéric ULg; Hermans, Thomas ULg; Robert, Tanguy ULg

Conference (2013, December 05)

Inversion of time-lapse resistivity data allows obtaining ‘snapshots’ of changes occurring in monitored systems for applications such as aquifer storage, site remediation or tracer tests. Based on these ... [more ▼]

Inversion of time-lapse resistivity data allows obtaining ‘snapshots’ of changes occurring in monitored systems for applications such as aquifer storage, site remediation or tracer tests. Based on these snapshots, one can infer qualitative information on the location and morphology of changes occurring in the subsurface but also quantitative estimates on the degree of changes in certain property such as temperature or total dissolved solid content. Analysis of these changes can provide direct insight into flow and transport processes and controlling parameters. However, the reliability of the analysis is dependent on survey geometry, measurement schemes, data error, or regularization. Except regularization, survey design parameters may be optimized prior to the monitoring survey. Regularization, on the other hand, may be chosen depending on available information collected during the monitoring. Common approaches consider smoothing model changes both in space and/or time. We here propose to use two alternative regularization approaches which may be better suited to invert time-lapse data. The first approach is the minimum gradient support (MGS) regularization, which focus the changes in tomograms snapshots. MGS will limit the occurrences of changes in electrical resistivity but will also restrict the variations of these changes inside the different zones. The second approach is based on geostatistics and requires first to derive variogram parameters for the model changes. In this contribution, we demonstrate the benefits and limitations of these regularization approaches to time-lapse data on numerical benchmarks and three case studies. [less ▲]

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See detailMinimum standards in diagnosis and treatment of osteoporosis
Russell, AS; Recart, S; Reginster, Jean-Yves ULg et al

in Journal of Rheumatology (1998), 25(8), 1634-1637

Detailed reference viewed: 4 (1 ULg)