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See detailLe melanome cutane: innovations conceptuelles et therapeutiques, fruit de la recherche translationnelle.
Pierard, Gérald ULg; Quatresooz, Pascale ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2008), 63(10), 579-84

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are ... [more ▼]

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are presented. The concept of the duality between fast-growing (high malignancy) and slow-growing (reduced malignancy) melanoma is stressed. A new international multicentric approach using adjuvant therapy for stage III melanomas involves the clinical oncology department of the CHU of Liege. It concerns a targeted immunotherapy directed to the Mage A3 protein. [less ▲]

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See detailLe melanome cutane: une seule maladie?
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2012), 67(9), 458-60

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations ... [more ▼]

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations, histopathology and molecular genetics point to the fact that malignant melanoma is not a single monolithic pathological condition. Different types of melanomas are distinguished based on distinct origins and contrasted prognoses. The management and information for the patient should be handled individually. [less ▲]

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See detailLe melanome du sujet age.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(1), 34-40

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are ... [more ▼]

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are more often affected, and chronic sun exposure is the main cause. The diagnosis relies on the clinical, dermoscopic and dermatopathologic examinations. Surgical excision is recommended but alternative treatments are possible in case of contra-indication. [less ▲]

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See detailLe melanome metastatique: un vent d'espoir porte par l'ipilimumab et le vemurafenib.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(2), 64-8

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In ... [more ▼]

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In addition, translational research fueled the development of new treatments with at last increased efficacy in the metastatic stage. Such therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the beneficial effects. [less ▲]

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See detailLes mélanomes cutanés, un spectre de cancers émergents chez la femme en région wallonne
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Cornil, F. et al

in Revue Médicale de Liège (1999), 54(5), 495-499

The Mosan Study Group of Pigmented Neoplasms was founded about 15 years ago. It has collected more than 20.000 cutaneous malignancies including melanoms and basal and squamous cell carcinomas. The ... [more ▼]

The Mosan Study Group of Pigmented Neoplasms was founded about 15 years ago. It has collected more than 20.000 cutaneous malignancies including melanoms and basal and squamous cell carcinomas. The incidence of these cancers in on the rise in Wallonia. In particular, malignant melanoms represent a spectrum of emerging cancers characterized by a proteiform biological outcome. They mostly affect young women. The major risk factor appears to be iterative and unwise ultraviolet exposures. The prevention of malenomas is basically founded on such a dogma and accordingly relies on sunscreens. However, controversies about their beneficial effects are rife and fueled by axiomas and contradictory sophisms. At the exception of surgery, the therapeutic options for the diverse types of melanomas do not yet fulfill the scope of evidence-based medicine. [less ▲]

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See detailMelanotan-associated melanoma
NIKKELS, Arjen ULg

in British Journal of Dermatology (2011)

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See detailMelatonin can Phase Shift the Endogenous Circadian Rhythm of Heart Rate and its Variability
Vandewalle, Gilles ULg; Middleton, B; Rajaratnam, SW et al

in Journal of Sleep Research (2004), 13(Suppl. 1),

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See detailMelatonine. I. Physiologie de la secretion
Bruls, E.; Crasson, Marion ULg; Legros, Jean-Jacques ULg

in Revue Médicale de Liège (2000), 55(8), 785-92

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The best known function of melatonin in mammals is to transmit information concerning light-dark ... [more ▼]

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The best known function of melatonin in mammals is to transmit information concerning light-dark cycles playing the role of an active neuroendocrine transducer of environmental information. Although melatonin circadian rhythm is endogenous, based on 25 hour cycles, it is modulated by light-dark cycle. During the day, the light signal is sent to the pineal gland through a special neuronal pathway and inhibits melatonin secretion. During the night, the last neuron of this pathway which is coming from the cervical ganglion superior releases nonadrenalin in the interstitium. Nonadrenalin stimulates melatonin synthesis through cAMP accumulation. Some factors other than light can also influence melatonin levels. Electromagnetic fields, age, male sex, Cushing syndrome, hypogonadotrophic hypogonadism, alcoholism seem to be associated with lower melatonin secretion. Female sex, hypergonadotrophic hypogonadism, sport and fasting seem to be linked to higher melatonin secretion. Some pathologies and drugs can modulate some steps of the neuroanatomic pathway of melatonin synthesis. Stress has no effect. The influence of weight and height is still investigated. Once released, melatonin can act on different organs through specific receptors (retina, supra-chiasmatic nucleus, hypophysis, brain, blood vessels, digestive tract, ovaries). [less ▲]

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See detailMelatonine. II. Actions physiologiques et therapeutiques
Bruls, E.; Crasson, Marion ULg; Van Reeth, O. et al

in Revue Médicale de Liège (2000), 55(9), 862-70

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The most known function of melatonin in mammals is to transmit information concerning light-dark ... [more ▼]

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The most known function of melatonin in mammals is to transmit information concerning light-dark cycles playing the role of an active neuroendocrine transducer of environmental information. Given this chronobiologic role of pineal melatonin, it seems to be useful in the management of shift work, jet lag and some sleep disorders. In vitro like in vivo melatonin seems to be effective as an antioxidant and oncostatic agent. Melatonin may provide protection against aging process, degenerative diseases, cancer and play a role also in sexual maturation, reproduction, immune function and psychiatric illness. The administration of melatonin in the jet-lag syndrome is well codified. Further clinical research is needed for a better understanding and definition of other indications, treatment regimens and safety of the hormone. The aim of this paper is to review the current knowledge on its clinical implications. [less ▲]

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See detailMéléagre dans les Argonautiques
Renaud, Jean-Michel ULg

in Uranie : Mythes et Littératures (1994), 4

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See detailMéléagre et les femmes
Renaud, Jean-Michel ULg

Scientific conference (1995, February 15)

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See detailLe mélèze en Région wallonne. Etat des lieux et stations potentielles
Claessens, Hugues ULg; Lecomte, H.; Pauwels, D.

in Forêt Wallonne (2002), (61), 4-9

Le mélèze a été introduit en Belgique dans la deuxième moitié du XVIIIe siècle. Il s’agissait alors du mélèze d’Europe, surtout implanté à des fins esthétiques ou d’enrichissement de forêts feuillues ... [more ▼]

Le mélèze a été introduit en Belgique dans la deuxième moitié du XVIIIe siècle. Il s’agissait alors du mélèze d’Europe, surtout implanté à des fins esthétiques ou d’enrichissement de forêts feuillues. Quant au mélèze du Japon, il a été importé en Europe à la fin du XIXe siècle. Ce n’est qu’à partir des années ’50 que les mélèzes ont eu du succès auprès des sylviculteurs. Ils l’ont planté le plus souvent par parquets purs après d’autres résineux ou en transformation de peuplements feuillus de faible qualité sylvicole. Mais comme le montrera l’inventaire forestier wallon en 1980, ce succès fut de courte durée. [less ▲]

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See detailLe Mélèze
Jourez, Benoît ULg; Pauwels, Dominique; Jacques, Dominique et al

in Courrier du Bois (1999), 125

De la famille des pinacées, le Mélèze, ou plutôt les Mélèzes, car ils sont trois chez nous à se partager ce titre générique, produisent un bois à la durabilité reconnue et à l'esthétique appréciée. Leurs ... [more ▼]

De la famille des pinacées, le Mélèze, ou plutôt les Mélèzes, car ils sont trois chez nous à se partager ce titre générique, produisent un bois à la durabilité reconnue et à l'esthétique appréciée. Leurs qualités technologiques sont susceptibles de satisfaire les exigences des utilisateurs dans des domaines très variés, tant en usage intérieur qu'extérieur. Cette essence n'a cependant pas la popularité qu'elle mérite auprès des sylviculteurs, malgré un potentiel de croissance élevé. [less ▲]

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See detailLe mélèze, un atout dans les objectifs de diversification de notre sylviculture.
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(2), 6-12

Le présent article s'attachera à présenter l'essence, son tempérament, son écologie, quelques critères permettant d'orienter le choix de la station et de l'espèce ainsi que les qualités et usages qu'on ... [more ▼]

Le présent article s'attachera à présenter l'essence, son tempérament, son écologie, quelques critères permettant d'orienter le choix de la station et de l'espèce ainsi que les qualités et usages qu'on peut en attendre. Cette présentation ne se veut pas exhaustive, elle est volontairement destinée à l'usage pratique des gestionnaires et propriétaires forestiers désireux de planter du mélèze. [less ▲]

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See detailLe mélèze, un bois de qualité aux multiples usages
Charron, Stéphane; Hebert, Jacques ULg; Jourez, Benoît ULg

in Forêt Wallonne (2002), (61), 37-41

Réputé pour son aspect esthétique, sa résistance mécanique et sa durabilité naturelle, le mélèze est une essence polyvalente, apte à de multiples usages tant intérieurs qu’extérieurs. Pourtant ... [more ▼]

Réputé pour son aspect esthétique, sa résistance mécanique et sa durabilité naturelle, le mélèze est une essence polyvalente, apte à de multiples usages tant intérieurs qu’extérieurs. Pourtant, l’industrie de la transformation belge ne s’y est pas beaucoup intéressée. <br />Plusieurs explications peuvent être évoquées : faibles volumes commercialisés, mauvaise réputation en raison de quelques expériences malheureuses, <br />etc. Actuellement, les préjugés s’estompent et la demande en bois de mélèze est croissante. [less ▲]

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See detailLe mélèze, un résineux à (re) découvrir
Rondeux, Jacques ULg

in Forêt Wallonne (2002), (61), 3

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See detailLe mélèze, une essence à haut potentiel de production
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(3), 6-10

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze ... [more ▼]

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze méritait, à plusieurs égards, d'être davantage prise en compte en Région wallonne et ce, pour autant qu'une sylviculture adaptée à l'essence et aux conditions du milieu soit appliquée. Les lignes qui suivent sont consacrées à des résultats originaux résultant d'une étude menée par l'Unité de Gestion et Economie forestières de la Faculté universitaire des Sciences agronomiques de Gembloux, sur la croissance des mélèzes en Région wallonne. Le potentiel de croissance du mélèze a été évalué à partir d'analyses de tiges ou de mesures réalisées au sein de placettes de production (figure 1) remesurées tous les 3 ans. A partir d'une exploitation appropriée de ces données, on a déduit une gamme de traitements sylvicoles capables de rencontrer les objectifs de production que l'essence permet d'atteindre. [less ▲]

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See detailLes mélèzes
Rondeux, Jacques ULg; Pauwels, D.

in Fiche technique (2001)

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See detailLes mélèzes, un nouveau défi pour la sylviculture des résineux en Wallonie
Rondeux, Jacques ULg

Book (2003)

The larch is a really worth considering species in the walloon region especially in forests from which sustained management and multi-functional aspects are sought. Because of its rapid growth rate, its ... [more ▼]

The larch is a really worth considering species in the walloon region especially in forests from which sustained management and multi-functional aspects are sought. Because of its rapid growth rate, its wood of high quality and its environmental effects (landscape) as well as its ecological impact (biodiversity enhancement, wildlife habitat improvement) larch has to pay a role in the achievement of most management purposes. However its silviculture in terms of method, severity and timing of thinning is not sufficiently related to its ecology and its high juvenile growth. Among the three larch species the hybrid larch is quite promising but adequate silviculture has to be applied during the course of its development. The present paper gives some guidelines for constructing silvicultural scenarios able to ensure economic returns and a proper balance between the non marketed forms of production like aesthetic value, biodiversity, game and recreation. [less ▲]

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