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See detailLocal acceptance of windmills and lessons learned for nuclear projects
Rossignol, Nicolas ULg; Schröder, Jantinne

Conference (2013, May 31)

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See detailLocal administration of nicotinamide enhances neutrophil apoptosis and decreases mice endotoxin-induced airway inflammation
Fernandes, C. A.; Fievez, Laurence ULg; Ucakar, B. et al

in Société Belge de Sciences Pharmaceutiques (2009)

Detailed reference viewed: 19 (5 ULg)
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See detailLocal administration of nuclear factor-kB decoy oligodeoxinucleotides prevents allergic airway inflammation
Bureau, Fabrice ULg; Gosset, P.; Desmet, Christophe ULg et al

in 12th European Respiratory Society Annual Congress (2002)

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See detailLocal and global ship vibrations
Constantinescu, A.; Rigo, Philippe ULg; Chirica, I. et al

in IMPROVE Workshop (EU Project FP6 n°031382), DUBROVNIK 17-18 Sept. 2009, Croatia, Editor V. Zanic – Univ. of Zagreb, pp41-45 (Vol I) + Powerpoint (Vol II) (2009, September)

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See detailLocal and interactive post-buckling of RHS thin-walled members - Comparing a new special beam finite element with shell FE models
Degée, Hervé ULg; Boissonnade, Nicolas; Rossi, Barbara ULg

in International Journal of Structural Stability & Dynamics (2007), 7(2), 213-241

This paper presents a special thin-walled plane beam. nite element that accounts for the in-plane cross-section local deformation. The element is based on the superposition of a classical beam ... [more ▼]

This paper presents a special thin-walled plane beam. nite element that accounts for the in-plane cross-section local deformation. The element is based on the superposition of a classical beam displacement field and of an additional field describing local e. ects, with an approximation on the local second-order membrane stress. eld. The theoretical formulation is summarized and an application of the resulting numerical tool to the post-buckling analysis of RHS thin-walled members with moderate local and global slenderness susceptible to both global and local buckling is then performed. Different types of analyses are presented (computation of critical bifurcation loads, geometrically non-linear analysis, geometrically and materially non-linear analysis). The results obtained with the proposed beam. nite element are compared to values provided by shell FE models. [less ▲]

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See detailLocal and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.
Moermans, Catherine ULg; HEINEN, Vincent ULg; NGUYEN DANG, Delphine ULg et al

in Cytokine (2011), 56(2), 298-304

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also ... [more ▼]

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also features systemic inflammation. The purpose of our study was to compare airway and systemic inflammation in COPD to that seen in healthy subjects and to relate the inflammation with the disease severity. METHODS: Ninety-five COPD patients, encompassing the whole severity spectrum of the disease, were recruited from our outpatient clinic and rehabilitation center and compared to 33 healthy subjects. Induced sputum and blood samples were obtained for measurement of inflammatory cell count. Interleukin (IL)-4, IL-6, IL-10, TNF-alpha and IFN-gamma produced by 24h sputum and blood cell cultures were measured. RESULTS: Compared to healthy subjects, COPD exhibited a prominent airway neutrophilic inflammation associated with a marked IL-10, IL-6 and TNF-alpha release deficiency that contrasted with a raised IFN-gamma production. Neutrophilic inflammation was also prominent at blood level together with raised production of IFN-gamma, IL-10 and TNF-alpha. Furthermore, sputum neutrophilia correlated with disease severity assessed by GOLD stages. Likewise the extent of TNF-alpha release from blood cells also positively correlated with the disease severity but negatively with that of sputum cell culture. Blood release of TNF-alpha and IL-6 negatively correlated with body mass index. Altogether, our results showed a significant relationship between cellular marker in blood and sputum but poor relationship between local and systemic release of cytokines. CONCLUSIONS: COPD is characterized by prominent neutrophilic inflammation and raised IFN-gamma production at both bronchial and systemic level. Overproduction of TNF-alpha at systemic level correlates with disease severity and inversely with body mass index. [less ▲]

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See detailLocal Anesthetics
Chavarria Bolanos, Daniel ULg

Scientific conference (2014, March 29)

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See detailLocal applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions.
Hubert, Pascale ULg; Doyen, Jean ULg; Capelle, Xavier ULg et al

in American Journal of Reproductive Immunology (2010), 64(2), 126-136

Abstract Problem Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished ... [more ▼]

Abstract Problem Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished capacity to capture viral antigens and to induce a protective immune response. Method of study To test if a cervical application of GM-CSF could restore an immune response against HPV in women with cervical low-grade squamous intraepithelial lesions (LSIL). We performed two clinical trials with11 healthy women and 15 patients with LSIL. Results GM-CSF applications were well tolerated in all enrolled women and no difference in toxicity between the treated and placebo groups was observed during the follow up (until 30 months). Interestingly, in the GM-CSF treated group, a significant increased APC and cytotoxic T lymphocyte infiltration was observed in the cervical biopsies with no change in regulatory T cell numbers. All the HPV16+ patients exhibited an immune response against HPV16 after GM-CSF applications, as shown by NK and/or T cells producing IFN-γ whereas no cellular immune response was observed before the treatment. Moreover, the anti-VLP antibody titers also increased after the treatment. Conclusion These encouraging results obtained from a limited number of subjects justify further study on the therapeutic effect of APC in cervical (pre)neoplastic lesions. [less ▲]

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See detailLocal assimilation of sea surface temperature and elevation in a two-way nested model of the Gulf of Lions, using a single multigrid state vector
Vandenbulcke, Luc ULg; Barth, Alexander ULg; Ben Bouallegue, Z. et al

Conference (2005, April)

A three fold nested model is built, covering (a) the Mediterranean Sea (resolution 1/4 degree) (b) its North-Western part (resolution 1/20 degree), and (c) the Gulf of Lions (resolution 1/100 degree). The ... [more ▼]

A three fold nested model is built, covering (a) the Mediterranean Sea (resolution 1/4 degree) (b) its North-Western part (resolution 1/20 degree), and (c) the Gulf of Lions (resolution 1/100 degree). The GHER hydrodynamic model (see e.g. [1]) is used for a simulation of the springs of 1997 and 1998. As the model allows mode splitting, the timestep in each grid is 3 seconds for the barotropic modes, and 3 minutes for the baroclinic modes. ECMWF atmospheric forcings and MODB4/MEDAR climatic data are used. This simulation is run with one-directionnal and bi-directionnal nesting (i.e. without and with statevector feedback), and results are compared. The output of the 1997 and 1998 simulations (3D temperature and salinity fields, and sea surface elevation field) are then used to build 3D multivariate EOFs over the 3 grids alltogether. This guarantees perfect correlations between points from different grids, that are physically at the same location. The following twin experiment is then set up. The simulation from 1998 serves as a control run. A delayed state of this run, serves as initial conditions for the perturbed run. The first 40 EOFs are used to build a reduced-rank model errorspace. Sea surface temperature and sea surface elevation from the reference run, physically located in the Gulf of Lions, are then assimilated in the perturbed run, using a reduced-rank optimal interpolation assimilation scheme. A previous experiment showed non-physical long-range corrections (far outside the Gulf of Lions); these corrections are removed by multiplying the corrections with a radial Gaussian function centered on the corresponding observations. The multivariate statevector ensures corrections are made to temperature, salinity and sea surface elevation fields. Using the corrected fields, the geostrophic equilibrium is used to calculate corrections to the velocity field. In this above twin experiment, observations are assimilated all at once in the 3 grids since a single statevector is used. The results are compared to classic approaches where each grid has a corresponding statevector, and observations are assimilated in a single grid (or in different grids separately). Finally, ongoing research about statistical predictors is presented. Indeed, primitive equation models are too costly to evolve the errorspace in time, even when reducedrank assimilation schemes are used. Statistical methods aim to replace the hydrodynamic model by a much faster method, that would then be used to evolve in time each of the directions of the errorspace, or alternately, the members of an ensemble method. Statistical methods need to be trained on real results; they are thus first tested on the model itself rather than on the errorspace. Preliminary results are presented. [less ▲]

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See detailLocal Buckling Check According to Eurocode-3 for Plastic-hinge Analysis of 3D Steel Frames
Hoang, Van Long ULg; Nguyen, Dang Hung

in Engineering Structures (2008), 30

Detailed reference viewed: 86 (8 ULg)
See detailLocal buckling in case of fire
Franssen, Jean-Marc ULg; Talamona, Didier

Conference (2000, October 13)

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See detailLocal buckling of structures in case of fire
Franssen, Jean-Marc ULg; Talamona, Didier

Conference (2000)

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See detailLocal buckling of structures in case of fire
Talamona, D.; Franssen, Jean-Marc ULg

in Proceedings of the 4th annual workshop Targeted Research Action - Environmentally Friendly Construction Technologies, ECCREDI (2000)

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See detailLocal climatological modeling of ionospheric irregularities detected by GPS in mid-latitude region
Wautelet, Gilles ULg; Warnant, René ULg

in Journal of Atmospheric & Solar-Terrestrial Physics (2012), 89

Detailed reference viewed: 43 (5 ULg)
See detailLocal Consultative Bodies for Foreign Residents
Martiniello, Marco ULg; Gsir, Sonia ULg

Book published by Council of Europe Publishing (2004)

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See detailLocal control of non-adiabatic dissociation dynamics
Bomble, Laëtitia; Chenel, Aurélie; Meier, Chris et al

in Journal of Chemical Physics (2011), 134

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See detailLocal control of nonadiabatic photodissociation dynamics using Møller operators
Vranckx, Stéphane; Meier, Christoph; Bomble, Laetitia et al

in Journal of Physics: Conference Series (2012), 388(11), 112009

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See detailLocal Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution.
Dhulesia, A.; Cremades, N.; Kumita, J. R. et al

in Journal of the American Chemical Society (2010)

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular ... [more ▼]

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding process at low pH for three different lysozyme variants, the wild-type protein and the mutants I56T and I59T, which show variable stabilities and propensities to aggregate in vitro. Using a range of biophysical techniques that includes differential scanning calorimetry and nuclear magnetic resonance spectroscopy, we demonstrate that thermal unfolding under amyloidogenic solution conditions involves a cooperative loss of native tertiary structure, followed by progressive unfolding of a compact, molten globule-like denatured state ensemble as the temperature is increased. The width of the temperature window over which the denatured ensemble progressively unfolds correlates with the relative amyloidogenicity and stability of these variants, and the region of lysozyme that unfolds first maps to that which forms the core of the amyloid fibrils formed under similar conditions. Together, these results present a coherent picture at atomic resolution of the initial events underlying amyloid formation by a globular protein. [less ▲]

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