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See detailThe HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6.
Legros, S.; Boxus, Mathieu ULg; GATOT, Jean-Stéphane ULg et al

in Oncogene (2011)

Human T cell leukemia virus type-1 (HTLV-1) is the causative agent of a fatal adult T-cell leukemia. Through deregulation of multiple cellular signaling pathways the viral Tax protein has a pivotal role ... [more ▼]

Human T cell leukemia virus type-1 (HTLV-1) is the causative agent of a fatal adult T-cell leukemia. Through deregulation of multiple cellular signaling pathways the viral Tax protein has a pivotal role in T-cell transformation. In response to stressful stimuli, cells mount a cellular stress response to limit the damage that environmental forces inflict on DNA or proteins. During stress response, cells postpone the translation of most cellular mRNAs, which are gathered into cytoplasmic mRNA-silencing foci called stress granules (SGs) and allocate their available resources towards the production of dedicated stress-management proteins. Here we demonstrate that Tax controls the formation of SGs and interferes with the cellular stress response pathway. In agreement with previous reports, we observed that Tax relocates from the nucleus to the cytoplasm in response to environmental stress. We found that the presence of Tax in the cytoplasm of stressed cells prevents the formation of SGs and counteracts the shutoff of specific host proteins. Unexpectedly, nuclear localization of Tax promotes spontaneous aggregation of SGs, even in the absence of stress. Mutant analysis revealed that the SG inhibitory capacity of Tax is independent of its transcriptional abilities but relies on its interaction with histone deacetylase 6, a critical component of SGs. Importantly, the stress-protective effect of Tax was also observed in the context of HTLV-1 infected cells, which were shown to be less prone to form SGs and undergo apoptosis under arsenite exposure. These observations identify Tax as the first virally encoded inhibitory component of SGs and unravel a new strategy developed by HTLV-1 to deregulate normal cell processes. We postulate that inhibition of the stress response pathway by Tax would favor cell survival under stressful conditions and may have an important role in HTLV-1-induced cellular transformation.Oncogene advance online publication, 2 May 2011; doi:10.1038/onc.2011.120. [less ▲]

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See detailHTLV-1/BLV antisense-RNA dependent host gene perturbation in pre-leukemic and leukemic clones
Rosewick, Nicolas; Durkin, Keith ULg; Marçais, Ambroise et al

in Retrovirology (2015, August 28), 12(1),

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See detailHu, Luojia , Estimation of a censored dynamic panel data model,Econometrica. Journal of the Econometric Society
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (2002), 70(6), 2499--2517

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See detailHuancor: oubli et déclin d’un site d’art péruvien
Delnoÿ, David ULg; Otte, Marcel ULg

in Archeologia : Fouilles et Découvertes (2015), 528

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See detailHuaweï v. ZTE: Judicial Conservatism at the Patent-Antitrust Intersection
Petit, Nicolas ULg

in CPI Antitrust Chronicle (2015), 10(2),

This paper argues that the judgment of the Court of Justice of the EU in Huaweï v ZTE is of conservative craft. Huaweï v ZTE only extends by a razor-thin margin the zone of antitrust liability for patent ... [more ▼]

This paper argues that the judgment of the Court of Justice of the EU in Huaweï v ZTE is of conservative craft. Huaweï v ZTE only extends by a razor-thin margin the zone of antitrust liability for patent owners. The Court appears reluctant to relax its traditional case-law that affirms antitrust liability on patent owners only in “exceptional circumstances.” To be sure, the Court admits that SEPs covered by a FRAND pledge generate “particular circumstances,” which justify an extension of antitrust liability. But on careful read, the Court only expands antitrust liability in relation to a slice of cases of injunctions on FRAND-pledged SEPs that lead to exclusionary leveraging. This, in turn, relieves a number of upstream licensing entities from antitrust liability. [less ▲]

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See detailHubble observations of Jupiter’s north–south conjugate ultraviolet aurora
Gérard, Jean-Claude ULg; Grodent, Denis ULg; Radioti, Aikaterini ULg et al

in Icarus (2013), 226

Comparisons of the northern and southern far ultraviolet (UV) auroral emissions of Jupiter from the Hubble Space Telescope (HST) or any other ultraviolet imager have mostly been made so far on a ... [more ▼]

Comparisons of the northern and southern far ultraviolet (UV) auroral emissions of Jupiter from the Hubble Space Telescope (HST) or any other ultraviolet imager have mostly been made so far on a statistical basis or were not obtained with high sensitivity and resolution. Such observations are important to discriminate between different mechanisms responsible for the electron acceleration of the different components of the aurora such as the satellite footprints, the «main oval» or the polar emissions. The field of view of the ACS and STIS cameras on board HST is not wide enough to provide images of the full jovian disk. We thus compare the morphology of the north and south aurora observed 55 min apart and we point out similarities and differences. On one occasion HST pointed successively the two polar regions and auroral images were seen separated by only 3 min. This makes it possible to compare the emission structure and the emitted FUV power of corresponding regions. We find that most morphological features identified in one hemisphere have a conjugate counterpart in the other hemisphere. However, the power associated with conjugate regions of the main oval, diffuse or discrete equatoward emission observed quasi-simultaneously may be different in the two hemispheres. It is not directly nor inversely proportional to the strength of the B-field as one might expect for diffuse precipitation or field-aligned acceleration with equal ionospheric electron density in both hemispheres. Finally, the lack of symmetry of some polar emissions suggests that some of them could be located on open magnetic field lines. [less ▲]

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See detailHubble sans COSTAR
Grodent, Denis ULg; Dols, Vincent

Scientific conference (1994, June 23)

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See detailHubble Space Telescope far-ultraviolet imaging of Jupiter during the impacts of Comet Shoemaker-Levy 9
Clarke, J. T.; Prange, R.; Ballester, G. E. et al

in Highlights of Astronomy, Vol. 10 (1995)

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See detailHubble Space Telescope Goddard high-resolution spectrograph H2 rotational spectra of Jupiter's aurora
Clarke, John T; Ben Jaffel, Lotfi; Vidal-Madjar, Alfred et al

in Astrophysical Journal (1994), 430

We have observed the emission spectrum from Jupiter's north auroral atmosphere with 0.57 A spectral resolution over 1204-1241 A. Bright emissions have been detected from 50 deg to 60 deg latitude at ... [more ▼]

We have observed the emission spectrum from Jupiter's north auroral atmosphere with 0.57 A spectral resolution over 1204-1241 A. Bright emissions have been detected from 50 deg to 60 deg latitude at locations consistent with 6 to 30 R [SUB]J[/SUB] auroral ovals, with much fainter emissions away form the auroral ovals. The emission spectrum is well fitted by both laboratory spectra and theoretical models of optically thin electron excited H2, with added Doppler-broadened Lyman Alpha emission. The observed Lyman Alpha emission wings extend more than 1 A from line center and appear correlated in strength with the H2 brightness. Individual rotational lines in the H2 Werner band system are resolved, allowing a determination of the H2 rotational temperature at the altitude of the emission. We derive best-fit temperatures from 400-450 to 700-750 K, with the auroral emission layer temperature changing either across the auroral oval or over several days' time. These observations demonstrate for the first time the ability to measure the observed rapid H2 temperature variations across Jupiter's auroral atmosphere. [less ▲]

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See detailHubble Space Telescope imaging of Jupiter's UV aurora during the Galileo orbiter mission
Clarke, John T; Ben Jaffel, Lotfi; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (1998), 103

Hubble Space Telescope (HST) Wide-Field Planetary Camera 2 (WFPC 2) images of Jupiter's aurora have been obtained close in time with Galileo ultraviolet spectrometer (UVS) spectra and in situ particles ... [more ▼]

Hubble Space Telescope (HST) Wide-Field Planetary Camera 2 (WFPC 2) images of Jupiter's aurora have been obtained close in time with Galileo ultraviolet spectrometer (UVS) spectra and in situ particles, fields, and plasma wave measurements between June 1996 and July 1997, overlapping Galileo orbits G1, G2, G7, G8, and C9. This paper presents HST images of Jupiter's aurora as a first step toward a comparative analysis of the auroral images with the in situ Galileo data. The WFPC 2 images appear similar to earlier auroral images, with the main ovals at similar locations to those observed over the preceding 2 years, and rapidly variable emissions poleward of the main ovals. Further examples have been observed of the equatorward surge of the auroral oval over 140-180° longitude as this region moves from local morning to afternoon. Comparison of the WFPC 2 reference auroral ovals north and south with the VIP4 planetary magnetic field model suggests that the main ovals map along magnetic field lines exceeding 15R[SUB]J[/SUB], and that the Io footprint locations have lead angles of 0-10° from the instantaneous magnetic projection. There was an apparent dawn auroral storm on June 23, 1996, and projections of the three dawn storms imaged with HST to date demonstrate that these appear consistently along the WFPC 2 reference oval. Auroral emissions have been consistently observed from Io's magnetic footprints on Jupiter. Possible systematic variations in brightness are explored, within factor of 6 variations in brightness with time. Images are also presented marked with expected locations of any auroral footprints associated with the satellites Europa and Ganymede, with localized emissions observed at some times but not at other times. [less ▲]

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See detailHubble Space Telescope Near-IR Transmission Spectroscopy of the Super-Earth HD 97658b
Knutson, Heather A.; Dragomir, Diana; Kreidberg, Laura et al

E-print/Working paper (2014)

Recent results from the Kepler mission indicate that super-Earths (planets with masses between 1-10 times that of the Earth) are the most common kind of planet around nearby Sun-like stars. These planets ... [more ▼]

Recent results from the Kepler mission indicate that super-Earths (planets with masses between 1-10 times that of the Earth) are the most common kind of planet around nearby Sun-like stars. These planets have no direct solar system analogue, and are currently one of the least well-understood classes of extrasolar planets. Many super-Earths have average densities that are consistent with a broad range of bulk compositions, including both water-dominated worlds and rocky planets covered by a thick hydrogen and helium atmosphere. Measurements of the transmission spectra of these planets offer the opportunity to resolve this degeneracy by directly constraining the scale heights and corresponding mean molecular weights of their atmospheres. We present Hubble Space Telescope near-infrared spectroscopy of two transits of the newly discovered transiting super-Earth HD 97658b. We use the Wide Field Camera 3's scanning mode to measure the wavelength-dependent transit depth in thirty individual bandpasses. Our averaged differential transmission spectrum has a median 1 sigma uncertainty of 19 ppm in individual bins, making this the most precise observation of an exoplanetary transmission spectrum obtained with WFC3 to date. Our data are inconsistent with a cloud-free solar metallicity atmosphere at the 17 sigma level. They are a good match for flat models corresponding to either a metal-rich atmosphere or a solar metallicity atmosphere with a cloud or haze layer located at pressures of a mbar or higher. [less ▲]

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See detailHubble Space Telescope observations of variation of the O I 135.6 nm/ O I 130.4 nm ratio in Ganymede’s atmosphere
Molyneux, P. M.; Nichols, J. D.; Bannister, N. P. et al

Poster (2015, June)

We present new high-sensitivity HST/COS measurements of the atmospheric O I 135.6 nm/ O I 130.4 nm ratio at Ganymede, which we show exhibits significant spatial and temporal variability. Specifically, the ... [more ▼]

We present new high-sensitivity HST/COS measurements of the atmospheric O I 135.6 nm/ O I 130.4 nm ratio at Ganymede, which we show exhibits significant spatial and temporal variability. Specifically, the ratios observed on Ganymede’s leading hemispheres vary between 2.14±0.03 and 2.67±0.02, while on the trailing hemisphere the ratios are observed to be between 0.98±0.02 and 1.53±0.03. These high-sensitivity observations increase the signal to noise of these measurements by an order of magnitude over previous HST/STIS observations of the same [1], thus confirming that the temporal variation suggested by these previous observations is real. The emissions are excited through electron-impact excitation of Ganymede’s oxygen atmosphere by electrons which are locally accelerated within its magnetosphere [2,3]. The variation in the ratio magnitude may be explained either by variations in the ratio of atomic to molecular oxygen in the atmosphere or by a change in the temperature of the electrons exciting the emissions. An increase in the proportion of molecular oxygen acts to increase the ratio, as does a cooler electron temperature.References [1] Feldman, P. D., McGrath, M. A., Strobel, D. F., Moos, H. W., Retherford, K. D. and Wolven, B. C., HST/STIS ultraviolet imaging of polar aurora on Ganymede, Astrophys. J., Vol. 535, pp. 1085-1090, 2000. [2] Hall, D. T., Feldman, P. D., McGrath, M. A. and Strobel, D. F., The far-ultraviolet oxygen airglow of Europa and Ganymede, Astrophys. J., Vol. 499, pp. 475-481, 1998. [3] Eviatar, A., Strobel, D. F., Wolven, B. C., Feldman, P. D., McGrath, M. A. and Williams, D. J., Excitation of the Ganymede ultraviolet aurora, Astrophys. J., Vol. 555, pp. 1013-1019, 2001. [less ▲]

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See detailHubble Space Telescope search for the transit of the Earth-mass exoplanet α Centauri B b
Demory, Brice-Olivier; Ehrenreich, David; Queloz, Didier et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

Results from exoplanet surveys indicate that small planets (super-Earth size and below) are abundant in our Galaxy. However, little is known about their interiors and atmospheres. There is therefore a ... [more ▼]

Results from exoplanet surveys indicate that small planets (super-Earth size and below) are abundant in our Galaxy. However, little is known about their interiors and atmospheres. There is therefore a need to find small planets transiting bright stars, which would enable a detailed characterization of this population of objects. We present the results of a search for the transit of the Earth-mass exoplanet α Centauri B b with the Hubble Space Telescope (HST). We observed α Centauri B twice in 2013 and 2014 for a total of 40 h. We achieve a precision of 115 ppm per 6-s exposure time in a highly saturated regime, which is found to be consistent across HST orbits. We rule out the transiting nature of α Centauri B b with the orbital parameters published in the literature at 96.6 per cent confidence. We find in our data a single transit-like event that could be associated with another Earth-sized planet in the system, on a longer period orbit. Our programme demonstrates the ability of HST to obtain consistent, high-precision photometry of saturated stars over 26 h of continuous observations. [less ▲]

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See detailThe Hubble Space Telescope Treasury Program on the Orion Nebula Cluster
Robberto, M.; Soderblom, D. R.; Bergeron, E. et al

in Astrophysical Journal Supplement Series (2013), 207

The Hubble Space Telescope (HST) Treasury Program on the Orion Nebula Cluster (ONC) has used 104 orbits of HST time to image the Great Orion Nebula region with the Advanced Camera for Surveys (ACS), the ... [more ▼]

The Hubble Space Telescope (HST) Treasury Program on the Orion Nebula Cluster (ONC) has used 104 orbits of HST time to image the Great Orion Nebula region with the Advanced Camera for Surveys (ACS), the Wide-Field/Planetary Camera 2 (WFPC2), and the Near-Infrared Camera and Multi-Object Spectrograph (NICMOS) instrument in 11 filters ranging from the U band to the H band equivalent of HST. The program has been intended to perform the definitive study of the stellar component of the ONC at visible wavelengths, addressing key questions like the cluster initial mass function, age spread, mass accretion, binarity, and cirumstellar disk evolution. The scanning pattern allowed us to cover a contiguous field of approximately 600 arcmin[SUP]2[/SUP] with both ACS and WFPC2, with a typical exposure time of approximately 11 minutes per ACS filter, corresponding to a point source depth AB(F435W) = 25.8 and AB(F775W) = 25.2 with 0.2 mag of photometric error. We describe the observations, data reduction, and data products, including images, source catalogs, and tools for quick look preview. In particular, we provide ACS photometry for 3399 stars, most of them detected at multiple epochs; WFPC2 photometry for 1643 stars, 1021 of them detected in the U band; and NICMOS JH photometry for 2116 stars. We summarize the early science results that have been presented in a number of papers. The final set of images and the photometric catalogs are publicly available through the archive as High Level Science Products at the STScI Multimission Archive hosted by the Space Telescope Science Institute. [less ▲]

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See detailHubble Space Telescope/Advanced Camera for Surveys Observations of Europa's Atmospheric Ultraviolet Emission at Eastern Elongation
Saur, Joachim; Feldman, Paul D; Roth, Lorenz et al

in Astrophysical Journal (2011), 738

We report results of a Hubble Space Telescope (HST) campaign with the Advanced Camera for Surveys to observe Europa at eastern elongation, i.e., Europa's leading side, on 2008 June 29. With five ... [more ▼]

We report results of a Hubble Space Telescope (HST) campaign with the Advanced Camera for Surveys to observe Europa at eastern elongation, i.e., Europa's leading side, on 2008 June 29. With five consecutive HST orbits, we constrain Europa's atmospheric O I 1304 Å and O I 1356 Å emissions using the prism PR130L. The total emissions of both oxygen multiplets range between 132 ± 14 and 226 ± 14 Rayleigh. An additional systematic error with values on the same order as the statistical errors may be due to uncertainties in modeling the reflected light from Europa's surface. The total emission also shows a clear dependence of Europa's position with respect to Jupiter's magnetospheric plasma sheet. We derive a lower limit for the O[SUB]2[/SUB] column density of 6 × 10[SUP]18[/SUP] m[SUP]-2[/SUP]. Previous observations of Europa's atmosphere with the Space Telescope Imaging Spectrograph in 1999 of Europa's trailing side show an enigmatic surplus of radiation on the anti-Jovian side within the disk of Europa. With emission from a radially symmetric atmosphere as a reference, we searched for an anti-Jovian versus sub-Jovian asymmetry with respect to the central meridian on the leading side and found none. Likewise, we searched for departures from a radially symmetric atmospheric emission and found an emission surplus centered around 90° west longitude, for which plausible mechanisms exist. Previous work about the possibility of plumes on Europa due to tidally driven shear heating found longitudes with strongest local strain rates which might be consistent with the longitudes of maximum UV emissions. Alternatively, asymmetries in Europa's UV emission can also be caused by inhomogeneous surface properties, an optically thick atmospheric contribution of atomic oxygen, and/or by Europa's complex plasma interaction with Jupiter's magnetosphere. [less ▲]

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See detailHubble spectral observations of the Jovian aurora: precipitated flux and electron mean energy
Gérard, Jean-Claude ULg; Bonfond, Bertrand ULg; Grodent, Denis ULg et al

Conference (2015, June 02)

The FUV Jovian aurora is excited by collisions of energetic electrons accelerated along the magnetic field lines with the ambient upper atmosphere. The emission is dominated by the H2 Lyman and Werner ... [more ▼]

The FUV Jovian aurora is excited by collisions of energetic electrons accelerated along the magnetic field lines with the ambient upper atmosphere. The emission is dominated by the H2 Lyman and Werner bands extending from the extreme ultraviolet to about 170 nm. The wavelengths below about 135 nm are partly absorbed by the methane layer overlying the auroral emission layer. The long wavelength intensity is proportional to the precipitated energy flux carried by the auroral electrons. Spectral observations with the Hubble Space Telescope were made in 2014 using the long slit of the Space Telescope Imaging Spectrograph (STIS) in the timetag mode. During these observations, the slit projection scanned the polar region down to mid-latitudes. The combination of spectral and temporal measurements was used to build up the first spectral maps of the FUV Jovian aurora. The two-dimensional distribution of the intensity ratio of the two spectral regions has been obtained by combining spectral emissions in these wavelength ranges. They show that the amount of absorption by methane varies significantly between the different components of the aurora and in the polar region. Outputs from an electron transport model are used to create maps of the distribution of the characteristic electron energies. Using model atmospheres adapted to auroral conditions, we conclude that electron energies generally range between a few tens to several hundred keV. In this presentation, we analyze the relationship between the precipitated electron energy flux and the mean electron energy derived from these observations. Although globally, no correlation can be found, we show that the two quantities co-vary in some auroral components such as in the morning sector or in the striations observed along the main emission. By contrast, the auroral input in some high-latitude regions show no correlation with the electron characteristic energy. These aspects will be quantitatively discussed and possible processes explaining this dichotomy will be proposed. Comparisons of derived energies are in general agreement with those calculated from magnetosphere-ionosphere coupling models, but they locally exceed current model predictions. These results provide a basis for three-dimensional modeling of the distribution of particle heat sources into the high-latitude Jovian upper atmosphere. [less ▲]

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See detailHUBERT SUMLIN Portrait/Interview
Sacré, Robert ULg

Article for general public (1976)

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See detailHubert (Herman), ingénieur, professeur à l'Université de Liège (1849-1922)
Hanocq, Charles ULg

in Biographie nationale / Académie royale des sciences, des lettres et des beaux-arts de Belgique (1964)

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See detailHubert Damas (1910-1964) : 1948
Jeuniaux, Charles ULg

in Demoulin, Robert (Ed.) Liber memorialis. L'Université de Liège de 1936 à 1966, Tome II. Notices bibliographiques (1967)

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