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See detailImplications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis
Chi, Gamma; Manos-Turvey, Alexandra ULg; O’Connor, Patrick D. et al

in Biochemistry (2012), 51(24), 4868-4879

MbtI is the salicylate synthase that catalyzes the first committed step in the synthesis of the iron chelating compound mycobactin in Mycobacterium tuberculosis. We previously developed a series of ... [more ▼]

MbtI is the salicylate synthase that catalyzes the first committed step in the synthesis of the iron chelating compound mycobactin in Mycobacterium tuberculosis. We previously developed a series of aromatic inhibitors against MbtI based on the reaction intermediate for this enzyme, isochorismate. The most potent of these inhibitors had hydrophobic substituents, ranging in size from a methyl to a phenyl group, appended to the terminal alkene of the enolpyruvyl group. These compounds exhibited low micromolar inhibition constants against MbtI and were at least an order of magnitude more potent than the parental compound for the series, which carries a native enolpyruvyl group. In this study, we sought to understand how the substituted enolpyruvyl group confers greater potency, by determining cocrystal structures of MbtI with six inhibitors from the series. A switch in binding mode at the MbtI active site is observed for inhibitors carrying a substituted enolpyruvyl group, relative to the parental compound. Computational studies suggest that the change in binding mode, and higher potency, is due to the effect of the substituents on the conformational landscape of the core inhibitor structure. The crystal structures and fluorescence-based thermal shift assays indicate that substituents larger than a methyl group are accommodated in the MbtI active site through significant but localized flexibility in the peptide backbone. These findings have implications for the design of improved inhibitors of MbtI, as well as other chorismate-utilizing enzymes from this family. [less ▲]

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See detailImplications of differents design assumptions in direct displacement-based design of RC frames
Massena, B.; Bento, R.; Degée, Hervé ULg

in Proceedings of the 8th Sismica Conference (2010)

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See detailThe Implications of European Union for the Performance of Public Enterprises
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Administration : Journal of the Institute of Public Administration of Ireland (1993), 41(Summer), 149-165

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See detailImplications of finite one-loop corrections for seesaw neutrino masses
Aristizabal Sierra, Diego ULg

in Journal of Physics: Conference Series (2012)

In the standard seesaw model, finite corrections to the neutrino mass matrix arise from one-loop self-energy diagrams mediated by a heavy neutrino. We discuss the impact that these corrections may have on ... [more ▼]

In the standard seesaw model, finite corrections to the neutrino mass matrix arise from one-loop self-energy diagrams mediated by a heavy neutrino. We discuss the impact that these corrections may have on the different low-energy neutrino observables paying special attention to their dependence with the seesaw model parameters. It is shown that sizable deviations from the tri-bimaximal mixing pattern can be obtained when these corrections are taken into account. [less ▲]

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See detailImplications of Flavor Dynamics for Fermion Triplet Leptogenesis
Aristizabal Sierra, Diego ULg; Jernej Kamenik; Miha Nemevsek

in Journal of High Energy Physics [=JHEP] (2010), 2010(10),

We analyze the importance of flavor effects in models in which leptogenesis proceeds via the decay of Majorana electroweak triplets. We find that depending on the relative strengths of gauge and Yukawa ... [more ▼]

We analyze the importance of flavor effects in models in which leptogenesis proceeds via the decay of Majorana electroweak triplets. We find that depending on the relative strengths of gauge and Yukawa reactions the B − L asymmetry can be sizably enhanced, exceeding in some cases an order of magnitude level. We also discuss the impact that such effects can have for TeV-scale triplets showing that as long as the B − L asymmetry is produced by the dynamics of the lightest such triplet they are negligible, but open the possibility for scenarios in which the asymmetry is generated above the TeV scale by heavier states, possibly surviving the TeV triplet related washouts. We investigate these cases and discuss how they can be disentangled by using Majorana triplet collider observables and, in the case of minimal type III see-saw models even through lepton flavor violation observables. [less ▲]

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See detailThe implications of internationalisation on the management process of the Small or Medium-Sized Enterprise
Van Caillie, Didier ULg

in CEFIP-KEFIK (Ed.) The internationalisation of SMEs (still to be confirmed) (2012)

In the economic, political, social and financial context that has been a feature of the early 21st century, factors such as the deregulation of markets and commercial practices and the growing ... [more ▼]

In the economic, political, social and financial context that has been a feature of the early 21st century, factors such as the deregulation of markets and commercial practices and the growing interconnection of markets have resulted, virtually inevitably, with Small and Medium-Sized Enterprises having to get to grips with the phenomenon of internationalisation. This challenge is having inescapable consequences on the organisation and day-to-day operation of SMEs, forcing them in particular to make their management practices more professional, especially in terms of implementing systematic control procedures into their activities. SMEs have also had effectively to introduce a multicultural dimension linked closely to the internationalisation of their business to their management practices and processes, and to their way of making strategic choices. These changes are having an effect on the tools, rules, lines of conduct, internal directives, informal practices, etc. that together make up the system of processes deployed by SME managers to enable their companies to be managed with regular and recurrent performance in mind. This is characterised in particular by the fact that they need to be capable of achieving the financial, manufacturing and employment-related objectives that they set themselves. The aim of this contribution is to identify, through a structured framework of analysis, what the implications are that internationalisation may have on the system of processes within SMEs that are performing well. It is based on a summary of the elements highlighted in the specialist scientific and business literature devoted to the impact of internationalisation in the context of an SME. It is structured and uses the modelling of the (non-)performance of the SME proposed by Crutzen and Van Caillie (2009) as its organisational framework [less ▲]

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See detailImplications of microbial phenotypic heterogeneity in large-scale bioprocessing conditions
Delvigne, Frank ULg; Gorret, Nathalie; Molina-Jouve, Carole et al

Conference (2014, September)

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See detailImplications of reactivations and transmission of VZV infection
Rentier, Bernard ULg

Conference (1995)

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See detailImplications of Refined Altimetry on Estimates of Mesoscale Activity and Eddy-Driven Offshore Transport in the Eastern Boundary Upwelling Systems
Capet, Arthur ULg; Mason, Evan; Rossi, Vincent et al

in Geophysical Research Letters (2014), 41

We investigate the extent to which the recently upgraded version of the Ssalto/Duacs sea level anomaly product affects the description of mesoscale activity in the Eastern Boundary Upwelling Systems (EBUS ... [more ▼]

We investigate the extent to which the recently upgraded version of the Ssalto/Duacs sea level anomaly product affects the description of mesoscale activity in the Eastern Boundary Upwelling Systems (EBUS). Drifter observations confirm that the new data set released by Archiving, Validation and Interpretation of Satellite Oceanographic data (AVISO) in April 2014 (DT14) offers an enhanced description of mesoscale activity for the four EBUS. DT14 returns significantly higher eddy kinetic energy levels (+80%) within a 300 km coastal band, where mesoscale structures are known to induce important lateral physical and biogeochemical fluxes. When applied to DT14, an automatic eddy detection algorithm detects more eddies in the EBUS (+37%), and lower eddy radius estimates, in comparison with results using the former altimetry product (DT10). We show that despite higher eddy densities, the smaller eddy radii result in westward eddy transport estimates that are smaller than those obtained from DT10 ( −12%). [less ▲]

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See detailThe Implications of Socio-Economic Background for Moroccan Transnational Family Practices
Zickgraf, Caroline ULg

in Vailati, Alex; Rial, Carmen (Eds.) Migration of Rich Immigrants: Gender, Ethnicity, and Class (2016)

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See detailImplications of spatial and temporal variation in point technology in KwaZulu-Natal during the MSA
Bader, Gregor; Porraz, Guillaume; Rots, Veerle ULg et al

Poster (2016)

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See detailImplications of the adoption of a concept-based approach to instructional design
Verpoorten, Dominique ULg

Report (2011)

This document reports on an attempt to import a traditional distance course in a tool conceived to support a concept mapping procedure intended to facilitate, in a second phase, the implementation of ... [more ▼]

This document reports on an attempt to import a traditional distance course in a tool conceived to support a concept mapping procedure intended to facilitate, in a second phase, the implementation of adaptive rules and personal learning paths. This article does not ascertain the value of this approach per se (for those interested, see some reflection on this topic in Appendix 1). It just aims at sketching the time needed for such a work and to document encountered difficulties. The article resolutely takes the viewpoint of an average instructor. [less ▲]

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See detailImplications of the Pioneer Anomaly for the Laser Interferometer Space Antenna
Defrere, Denis ULg

Master's dissertation (2005)

The Doppler tracking data from two deep-space spacecraft, Pioneer 10 and 11, show an anomalous blueshift, which has been dubbed the “Pioneer anomaly”. The effect is most commonly interpreted as a real ... [more ▼]

The Doppler tracking data from two deep-space spacecraft, Pioneer 10 and 11, show an anomalous blueshift, which has been dubbed the “Pioneer anomaly”. The effect is most commonly interpreted as a real deceleration of the spacecraft - an interpretation that faces serious challenges from planetary ephemerides. The Pioneer anomaly could as well indicate an unknown effect on the radio signal itself. Several authors have made suggestions how such a blueshift could be related to cosmology. We consider this interpretation of the Pioneer anomaly and study the impact of an anomalous blueshift on the Laser Interferometer Space Antenna (LISA), a planned joint ESA-NASA mission aiming at the detection of gravitational waves. The relative frequency shift (proportional to the light travel time) for the LISA arm length is estimated to 10-16, which is much bigger than the expected amplitude of gravitational waves. The anomalous blueshift enters the LISA signal in two ways, as a small term folded with the gravitational-wave signal, and as larger term at low frequencies. A detailed analysis shows that both contributions remain undetectable and do not impair the gravitational-wave detection. This suggests that the Pioneer anomaly will have to be tested in the outer solar system regardless if the effect is caused by an anomalous blueshift or by a real force. [less ▲]

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See detailImplications of thermal sensitivity of the static internal friction angle
Hueckel, Tomasz; François, Bertrand ULg; Laloui, Lyesse

in 1st International Symposium on Computational Geomechanics (ComGeo I) (2009)

Thermal variability of the coefficient of the critical state, or the angle of internal friction is examined in view of experimental results obtained for clays and hard rocks. This sensitivity has several ... [more ▼]

Thermal variability of the coefficient of the critical state, or the angle of internal friction is examined in view of experimental results obtained for clays and hard rocks. This sensitivity has several implications for the evolution of what is considered as apparent preconsolidation pressure in constant stress heating tests. Failure conditions in soils at elevated temperatures appear to be strongly dependent on the history of application of stress and temperature, and hence are affected by the thermal sensitivity of the internal friction angle. Consequences to ranges of admissible processes are discussed. [less ▲]

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See detailImplications of tribimaximal lepton mixing for leptogenesis
Aristizabal Sierra, Diego ULg

Conference (2011, July)

In models featuring exact mixing patterns the mass matrices that define the effective light neutrino mass matrix -and the light neutrino matrix itself- are form-diagonalizable. We study leptogenesis in ... [more ▼]

In models featuring exact mixing patterns the mass matrices that define the effective light neutrino mass matrix -and the light neutrino matrix itself- are form-diagonalizable. We study leptogenesis in type I seesaw models in these contexts pointing out that the CP asymmetry in right-handed neutrino decays vanishes as a consequence of the mass matrices being form-diagonalizable. A non-vanishing CP asymmetry arises once deviations from the exact mixing scheme, induced by higher order effective operators, is allowed. Finally we discuss alternative pathways to viable leptogenesis in these kind of models. [less ▲]

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See detailImplications pathologiques du systeme neuroendocrinien digestif
Piette, Caroline ULg; Polus, Marc ULg; Louis, Edouard ULg

in Revue Médicale de Liège (2002), 57(8), 509-18

The neuroendocrine system is made of endocrine cells disseminated in various organs. In this article, we will focus on the implication of the neuroendocrine system in digestive pathology. First of all, we ... [more ▼]

The neuroendocrine system is made of endocrine cells disseminated in various organs. In this article, we will focus on the implication of the neuroendocrine system in digestive pathology. First of all, we will review the neuroendocrine tumors in every location and then describe their classification, epidemiology, symptomatology, diagnosis and treatment. Finally, we will consider the implications of the neuroendocrine system in the inflammatory and functional pathology of the digestive tract. [less ▲]

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See detailImplications pour la communauté d'un meilleur contrôle de la pression artérielle
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2002), 14(5), 186-190

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See detailImplications psychosociales des variations de l’âge au développement pubertaire
Glowacz, Fabienne ULg; Domine, Françoise ULg; Ledent, Annick et al

in Revue du Praticien (2008), 58

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See detailImplications virales dans l'etiopathogenie du diabete de type 1: donnees actuelles.
Radermecker, Régis ULg; Scheen, André ULg; Letiexhe, Michel ULg et al

in Revue Médicale de Liège (1998), 53(10), 597-602

Type 1 diabetes mellitus results from autoimmune destruction of pancreatic beta cells. After having described genetic, immunological and metabolic factors, some researchers have hypothezised that ... [more ▼]

Type 1 diabetes mellitus results from autoimmune destruction of pancreatic beta cells. After having described genetic, immunological and metabolic factors, some researchers have hypothezised that environmental factors might trigger the autoimmune process. Based on epidemiological, anatomoclinical and animal studies, they suggest a role for virus infections. [less ▲]

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