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See detailLe méthotrexate en rhumatologie: une révolution thérapeutique
Kaye, O.; Ribbens, Clio ULg; Hauwaert, Christian ULg et al

in Revue Médicale de Liège (1995), 50(11), 453-457

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See detailMethyl Oleate Modulates Lip2 Expression In The Lipolytic Yeast Yarrowia Lipolytica
Fickers, Patrick; Destain, Jacqueline ULg; Thonart, Philippe ULg

in Biotechnology Letters (2005), 27(22),

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See detailMethyl-laudanosine: A new pharmacological tool to investigate the function of small-conductance Ca2+-activated K+ channels
Scuvée-Moreau, Jacqueline ULg; Liégeois, Jean-François ULg; Massotte, Laurent ULg et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2002), 302(3), 1176-1183

Small-conductance Ca(2+)-activated K(+) channels (SK channels) underlie the prolonged postspike afterhyperpolarization (AHP) observed in many central neurons and play an important role in modulating ... [more ▼]

Small-conductance Ca(2+)-activated K(+) channels (SK channels) underlie the prolonged postspike afterhyperpolarization (AHP) observed in many central neurons and play an important role in modulating neuronal activity. However, a lack of specific and reversible blockers of these channels hampers their study in various experimental conditions. Because previous work has shown that bicuculline salts block these channels, we examined whether related alkaloids, namely laudanosine quaternary derivatives, would produce similar effects. Intracellular recordings were performed on rat midbrain dopaminergic neurons and hippocampus CA1 pyramidal cells. Binding experiments were performed on rat cerebral cortex membranes. Laudanosine, methyl-laudanosine, and ethyl-laudanosine blocked the apamin-sensitive AHP of dopaminergic neurons with mean IC(50) values of 152, 15, and 47 microM, respectively. The benzyl and butyl derivatives were less potent. Methyl-laudanosine had no effect on the I(h) current, action potential parameters, or membrane resistance of dopaminergic cells, or on the decrease in input resistance induced by muscimol, indicating a lack of antagonism at GABA(A) receptors. Interestingly, 100 microM methyl-laudanosine induced a significant increase in spiking frequency of dopaminergic neurons but not of CA1 pyramidal cells, suggesting the possibility of regional selectivity. Binding experiments on laudanosine derivatives were in good agreement with electrophysiological data. Moreover, methyl-laudanosine has no affinity for voltage-gated potassium channels, and its affinity for SK channels (IC(50) 4 microM) is superior to its affinity for muscarinic (IC(50) 114 microM) and neuronal nicotinic (IC(50) > or =367 microM) receptors. Methyl-laudanosine may be a valuable pharmacological tool to investigate the role of SK channels in various experimental models. [less ▲]

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See detailMethylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.
Katrincsakova, Beata; Takeda, Haruko ULg; Urbankova, Helena et al

in Epigenetics : Official Journal of the DNA Methylation Society (2009), 4(7), 469-75

Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given ... [more ▼]

Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given that deletion of this region could lead to inactivation of a monoallelically expressed tumor suppressor gene, our study aimed at determination of the parental origin of del(14q/IGH). The designed allele-specific methylation study of the DLK1/GTL2 intergenic differentially methylated region allowed us to determine the parental origin of del(14q/IGH) in 9/20 analyzed cases. In six cases del(14q/IGH) was of the paternal origin and in three cases of the maternal origin. These findings argue against the concept that a TSG/anti-oncomir located in the imprinted region is systematically inactivated by a targeted deletion of its functional allele. [less ▲]

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See detailMethylene blue: An old-timer or a compound ready for revival?
Donati, A.; Preiser, Jean-Charles ULg

in Critical Care Medicine (2006), 34(11), 2862-2863

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See detailMethylmercury and selenium in vitro effects on harbor seal (Phoca vitulina) lymphocytes : a multidisciplinary approach
Dupont, Aurélie ULg; Bouquegneau, Jean-Marie ULg; Das, Krishna ULg et al

Poster (2010, May 26)

Methylmercury (MeHg) bioaccumulates along the food web, leading to the highest levels in tissues of predatory species. It constitutes the predominant form present in the blood of marine mammals. The blood ... [more ▼]

Methylmercury (MeHg) bioaccumulates along the food web, leading to the highest levels in tissues of predatory species. It constitutes the predominant form present in the blood of marine mammals. The blood cells, including the immune cells, are therefore exposed to the toxic properties of that chemical. Nevertheless, selenium (Se) is an essential element absorbed concomitantly to MeHg which seems to modulate this toxicity. The goal of this study is to evaluate the immunotoxicity of MeHg on the harbor seal (Phoca vitulina) T lymphocytes, highly important in the adaptive immune response, and to investigate the modulating effect of Se on that toxicity. In parallel, the concentrations of MeHg, total mercury (T-Hg) and Se are determined in free-ranging harbour seal blood in order to follow their contamination levels. The T lymphocytes were isolated from the whole blood, exposed to various MeHg and Se concentrations and the exposure effects were estimated by functional tests including the evaluation of viability, proliferation, metabolic activity, DNA and protein synthesis, and by morphological analysis by transmission electron microscopy. The mean T-Hg concentration was 172 ± 143 µg/l of whole blood. The T lymphocytes cultures in vitro displayed a decreasing number of viable cells with increasing concentrations of MeHg, and numerous ultrastructural defects. The cells exposed to MeHg notably displayed distortion of the plasmic membrane, nucleus fragmentations, chromatin compaction, swelling mitochondrias and cytoplasmic vacuolisations. Those results highlighted various immunotoxic effects of MeHg, both at the functional and ultrastructural levels. The antagonistic role of Se on MeHg immunotoxicity is discussed. [less ▲]

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See detailMethylmercury in vitro exposure of harbor seal (Phoca vitulina) lymphocytes: a multidisciplinary approach
Dupont, Aurélie ULg; Siebert, Ursula; Rosenberger, Tanja et al

Poster (2009, June 08)

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See detailUn métier à tisser thérapeutique
Triffaux, Jean-Marc ULg; Gayetot, Delphine ULg; Izzi, Isabelle

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2008), 10

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See detailLe métier d'ingénieur du son selon Jean-Pierre Duret et Benoit De Clerck
Tomasovic, Dick ULg

Conference given outside the academic context (2012)

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See detailLe métier de gestionnaire de recherche
Jeandrain, Denys ULg

Conference (2012, September 25)

Detailed reference viewed: 21 (9 ULg)
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See detaille métier de journaliste à l’heure des réseaux sociaux-. Entretien avec François Colmant
Charlotte Collot; Colmant, François ULg

Article for general public (2012)

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See detailLe métier de médiateur scolaire en Communauté française de Belgique
Dethier, Baptiste ULg

Scientific conference (2011, November 04)

Dans le contexte d’un pluralisme normatif croissant et d’une école qui subit d’importantes mutations à travers une crise de l’autorité et de la légitimité, la médiation scolaire est apparue comme une ... [more ▼]

Dans le contexte d’un pluralisme normatif croissant et d’une école qui subit d’importantes mutations à travers une crise de l’autorité et de la légitimité, la médiation scolaire est apparue comme une réponse à la difficulté d’adéquation entre la société et le milieu scolaire. L’étude que nous avons réalisée sur les dispositifs et les acteurs de la médiation scolaire en Belgique francophone permet de mieux saisir les caractéristiques et surtout l’hétérogénéité du travail de ces nouveaux acteurs. Issus de réponses politiques ou d’initiatives locales, ils se réapproprient de multiples façons le concept de médiation et les directives imprécises qui leur sont données. À ce titre, les apports récents de la sociologie des professions nous aideront dans l’analyse de leur « situation professionnelle ». [less ▲]

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See detailLe métier de parents : Evolution des ouvrages d'éducation
Mougenot, Catherine ULg; Mormont, Marc ULg

Book published by Institut des Sciences Politiques et Sociales (1974)

La diffusion du savoir éducatif. De l'éducation traditionnelle aux conditions sociales d'apparition et de diffusion d'une éducation moderne.

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See detailLes métiers du conseil : une profession consultante ?
Orianne, Jean-François ULg; Draelants, Hugues

in SociologieS (2010)

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See detailLes métiers du Département du Patrimoine : richesse et diversité
Paquet, Pierre ULg

in Les Cahiers de l’Urbanisme (2010), 76

Présentation synthétique des différents métiers effectifs au sein du Département du patrimoine en Wallonie.

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See detailLes métiers en pénurie : un contexte favorable à une gestion des âges pro-active ?
Dieu, Anne-Marie ULg; Randaxhe, David ULg; Cornet, Annie ULg et al

in Scouarnec, A. (Ed.) Ouvrage en l’honneur de Luc Boyer : Management et métier – Vision d’experts (2010)

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See detailLes métiers en pénurie : un contexte favorable à une gestion des âges pro-active?
Dieu, Anne-Marie ULg; Randaxhe, David ULg; Cornet, Annie ULg et al

in scouarnec, alice (Ed.) Management et métiers : vision d'experts, Mélanges en l'honneur de Luc BOYER (2010)

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See detailLes métiers en pénurie : un contexte favorable à une gestion des âges pro-active ?
Dieu, Anne-Marie ULg; Randaxhe, David ULg; Cornet, Annie ULg et al

Conference (2009, March 16)

La gestion des âges sur le marché du travail est devenue depuis quelques années une question centrale, débattue tant au sein du monde politique que scientifique. Elle s’articule autour de différents ... [more ▼]

La gestion des âges sur le marché du travail est devenue depuis quelques années une question centrale, débattue tant au sein du monde politique que scientifique. Elle s’articule autour de différents thèmes dont les principaux sont les modalités de maintien au travail des personnes de plus de 45/50 ans, les relations intergénérationnelles dans l’entreprise et la gestion des compétences à travers les âges (transfert des compétences et tutorat, développement et mise à jour des compétences), implication et motivation au travail. Dans le cadre d’un projet financé par le Fonds Social Européen, nous avons développé un outil d’auto-diagnostic en matière de gestion des âges et des compétences à destination des services des ressources humaines ou des responsables d’entreprises. Cet outil a pour objectif de sensibiliser les entreprises à la gestion des âges et de l’aider à réfléchir aux actions à mettre en place en fonction du diagnostic posé. La première version de cet outil a été testée dans deux entreprises. Cette phase de test nous a permis de mettre à jour une série de questions soulevées par le mise en œuvre d’une politique de gestion des ressources humaines tenant compte de l’âge au regard d’une situation particulière : les métiers en pénurie. [less ▲]

Detailed reference viewed: 134 (36 ULg)