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See detailThe infrared spectra of the Planetary Nebulae BD+30°3639, NGC 6572, and NGC 6543
Swings, Polydore ULg; Jose, P. D.

in Publications of the Astronomical Society of the Pacific [=PASP] (1949), 61

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See detailInfrared spectroscopic measurements of halogenated sink and reservoir gases in the stratosphere with the ATMOS instrument
Raper, O. F.; Farmer, C. B.; Zander, Rodolphe ULg et al

in Journal of Geophysical Research. Atmospheres (1987), 92(D8), 9851--9858

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See detailInfrared spectroscopic measurements of halogenated source gases in the stratosphere with the ATMOS instrument
Zander, Rodolphe ULg; Rinsland, C. P.; Farmer, C. B. et al

in Journal of Geophysical Research. Atmospheres (1987), 92(D8), 9836--9850

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See detailInfrared Spectroscopic Measurements of the Vertical Column Abundance of Sulfur Hexafluoride, SF6, From the Ground
Zander, Rodolphe ULg; Rinsland, C.P.; Demoulin, Philippe ULg

in Journal of Geophysical Research (1991), 96(D8), 15447-15454

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International ... [more ▼]

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, and at the National Solar Observatory facility on Kitt Peak in Arizona. Series of monthly mean total vertical column abundances of SF6 above both stations, deduced from that feature with line-by-line nonlinear least squares fitting methods, are reported over the time intervals from June 1986 to June 1990 for the Jungfraujoch and from March 1981 to June 1990 for Kitt Peak. Assuming an exponential growth model for fitting these series of measurements, it is found that the vertical column abundances have increased at mean rates of 6.9 +- 2.8 %/yr above the Jungfraujoch (calculated columns of 2.99 x 10E13 molecules/cm2 in June 1986 and 3 94 x 10E13 molecules/cm2 in June 1990) and 6.6 +- 7.2 %/yr above Kitt Peak (calculated columns equal to 2.97 x 10E13 molecules/cm2 in June 1981 and 5.38 x 10E13 molecules/cm2 in June 1990), the uncertainties corresponding to 2 sigma confidence levels. These results are further discussed within the context of variability and compared with previously published measurements. [less ▲]

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See detailThe infrared spectrum of P Cygni
Swings, Polydore ULg

in Publications of the Astronomical Society of the Pacific [=PASP] (1944), 56

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See detailL’infrastructure éditoriale
Durand, Pascal ULg; Winkin, Yves ULg

in Berg Chr.; Halen P. (Eds.) Littératures belges de langue française (2000)

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See detailInfrastructure Reform in Developing Economies: Evidence from a Survey of Economic Performance Measures
Estache, Antonio; Perelman, Sergio ULg; Trujillo, Lourdes

in Coelli, Tim; Lawrence, Denis (Eds.) Performance Measurement and Regulation of Network Utilities (2007)

This paper surveys the growing literature on developing countries’ infrastructure performance measured through frontier analysis techniques. The focus is generally on assessments of operators’ efficiency ... [more ▼]

This paper surveys the growing literature on developing countries’ infrastructure performance measured through frontier analysis techniques. The focus is generally on assessments of operators’ efficiency and productivity growth as part of benchmarking exercises. Two broad types of benchmarks are identified in the literature. The first is based on cross-country or cross regional performance comparisons, the second compares performance before and after reforms, including privatization. These benchmarks are often used to assess the impact of potential or actual policy reforms in specific countries. In a growing number of instances, they are also being conducted in the context of tariff revisions to assess the efficiency gains that can be shared with users as part of these revisions. The main policy conclusions are that there is a difference in the performance effect of key reforms, in particular privatization, between the transport sector and the utilities sector but that generally incentive based regulation delivers efficiency in both sectors The main technical conclusion is that even if in developing economies data problems are constraining, these constraints are not as binding as often argued. [less ▲]

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See detailInfrastructures routières et développement socioeconomique dans le Mayombe (RDC)
Bonkena Bokombola, Papy ULg

Book published by L'Harmattan (2015)

La présente étude se consacre à la réflexion sur la corrélation entre l’infrastructure routière et le développement socioéconomique. C’est en s’appuyant sur un ensemble très large de variables sociales et ... [more ▼]

La présente étude se consacre à la réflexion sur la corrélation entre l’infrastructure routière et le développement socioéconomique. C’est en s’appuyant sur un ensemble très large de variables sociales et économiques jugées pertinentes que cette étude tente de contribuer à la construction d’un dispositif des variables aptes à saisir les changements entraînés par l’intervention du projet routier basée sur la technologie HIMO. Malgré quelques différences, la plupart des variables/indicateurs gardent les mêmes tendances évolutives dans ces différentes régions. Au-delà de notes de succès socioéconomique enregistré, des points d’attention subsistent et méritent des réflexions correctives dans une logique de poursuite et d’extension des activités de réhabilitation routière, notamment la persistance d’inégalités de genre dans les chances d’accès au travail, l’absence d’actions complémentaires devant appuyer les activités agropastorales et la persistance de la problématique de prise en charge de l’entretien du réseau réhabilité par les ressources tant locales, provinciales que nationales. L’étude repose essentiellement sur les données secondaires consignées dans les différents documents et rapports en les analysant dans une approche comparative avec les résultats obtenus par d’autres études réalisées en République Démocratique du Congo et dans d’autres régions en Afrique subsaharienne, dont particulièrement le Burkina Faso et le Bénin. [less ▲]

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See detailInfusing reflective practice in eLearning courses - can widgets help?
Verpoorten, Dominique ULg; Westera, W.; Specht, M.

in International Journal of Technology Enhanced Learning (2011), 3(1), 93-109

The paper investigates the potential of using widgets-based reflection amplifiers in e-learning courses. Reflection amplifiers are structured opportunities for students to examine and evaluate aspects of ... [more ▼]

The paper investigates the potential of using widgets-based reflection amplifiers in e-learning courses. Reflection amplifiers are structured opportunities for students to examine and evaluate aspects of their learning experience. The paper deliberately chooses a non-technical viewpoint. It takes the teachers' voices as a starting point. The study reports the results of a survey that asked open educational resources (OERs) course creators about their opinions on different types of reflection amplifiers. The outcomes demonstrate that several reflection techniques are recognised and acknowledged by these practitioners as being of relevance for their courses. Yet, practical application in their courses is quite rare. Results of the survey are subsequently used to inspect possible contributions of widgets technology to the implementation and dissemination of a selection of reflection techniques. The set-up of an experiment intended to test feasibility and relevance of widgets-based reflection amplifiers is eventually outlined. [less ▲]

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See detailInfusing SoTL components in staff training - A faculty development continuum at the university of Liège
Verpoorten, Dominique ULg; Jérôme, Françoise ULg; Delfosse, Catherine ULg et al

Conference (2015, October 29)

This presentation documents the attempt of the University of Liège (Belgium) to establish a "pedagogical development continuum" by offering three nested programs, each likely to be credited in the next ... [more ▼]

This presentation documents the attempt of the University of Liège (Belgium) to establish a "pedagogical development continuum" by offering three nested programs, each likely to be credited in the next one, thanks to a single overarching competency framework (the CREER model). At a proper level of intensity, each program builds upon components of SoTL, defined after Potter & Kustra (2011) as: "the systematic study of teaching and learning, using established or validated criteria of scholarship, to understand how teaching (beliefs, behaviours, attitudes, and values) can maximize learning, and/or develop a more accurate understanding of learning, resulting in products that are publicly shared for critique and use by an appropriate community". [less ▲]

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See detailL'infusion chronique et centrale d'ocytocine améliore la résistance à l'insuline induite par une nourriture riche en lipides chez le rat
Deblon, Nicolas; Veyrat-Durebex, Christelle; Legros, Jean-Jacques ULg et al

Conference (2011, March 23)

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See detailInfusion of clinical-grade enriched regulatory T cells delays experimental xenogeneic graft-versus-host disease
Hannon, Muriel ULg; LECHANTEUR, Chantal ULg; Lucas, Sophie et al

in Transfusion (2014), 54(February), 353-363

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See detailInfusion of CliniMACS (Myltenyi Biotec) Enriched Regulatory T Cells Delays Experimental Xenogeneic Graft-versus-Host Disease
Hannon, Muriel ULg; Lechanteur, C.; Somja, Joan ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 15

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See detailInfusion of third party mesenchymal stem cells (MSC) after kidney and liver transplantation: a phase I-II, open-label, clinical study
DETRY, Olivier ULg; DELBOUILLE, Marie-Hélène ULg; LECHANTEUR, Chantal ULg et al

Conference (2012, October 19)

MSC cells have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aims to be the first evaluation of the safety and tolerability of third party MSC ... [more ▼]

MSC cells have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aims to be the first evaluation of the safety and tolerability of third party MSC infusion after cadaveric kidney and liver transplantation in a prospective phase I-II study, taking advantage of our centre expertise and experience in MSC use in graft-versus-host disease (GVHD) after bone marrow transplantation and using an already functioning GMP-compliant laboratory producing clinical-grade MSC. Secondary end-points will help to evaluate the immunosuppressive potential of MSC after organ transplantation, and the opportunity to develop larger randomised, controlled, phase III trials. After successful transplantation, 10 liver and 10 kidney transplant recipients under standard immunosuppression (tacrolimus, MMF, steroids) will receive an intravenous infusion of 1.5-3x106/kg of third-party MSC on post-operative day 3±2. These patients will be prospectively compared to 10 liver and 10 kidney recipients who meet the inclusion criteria but deny MSC infusion. Safety will be assessed by recording side effects, including opportunistic infections and cancers. Immunosuppressive potential will be evaluated by rejection episode rates, by graft/patient survivals, by immunohistology of 3-months kidney and 6-month liver graft biopsies and by in vitro evaluation of the immunity profile of the recipients. In a second step, reduction (kidney) and progressive weaning (liver) of immunosuppression will be attempted in recipients who received MSC. This ongoing study is supported by research grants from the CHU of Liège, University of Liège, and by the Senior Clinical Research Grant from ESOT. The first patients were included and treated in early 2012, and final results expected in late 2013. [less ▲]

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See detailINFUSION OF THIRD-PARTY MESENCHYMAL STEM CELLS (MSC) AFTER KIDNEY AND LIVER TRANSPLANTATION: A PHASE I-II, OPEN-LABEL, CLINICAL STUDY (EudraCT 2011-001822-81 & NCT01429038)
DETRY, Olivier ULg; DELBOUILLE, Marie-Hélène ULg; LECHANTEUR, Chantal ULg et al

Poster (2013, May 30)

MSC cells have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aims to be the first evaluation of the safety and tolerability of third party MSC ... [more ▼]

MSC cells have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aims to be the first evaluation of the safety and tolerability of third party MSC infusion after cadaveric kidney and liver transplantation in a prospective phase I-II study, taking advantage of our centre expertise and experience in MSC use in graft-versus-host disease (GVHD) after bone marrow transplantation and using an already functioning GMP-compliant laboratory producing clinical-grade MSC. Secondary end-points will help to evaluate the immunosuppressive potential of MSC after organ transplantation, and the opportunity to develop larger randomised, controlled, phase III trials. After successful transplantation, 10 liver and 10 kidney transplant recipients under standard immunosuppression (tacrolimus, MMF, steroids) will receive an intravenous infusion of 1.5-3x106/kg of third-party MSC on post-operative day 3±2. These patients will be prospectively compared to 10 liver and 10 kidney recipients who meet the inclusion criteria but deny MSC infusion. Safety will be assessed by recording side effects, including opportunistic infections and cancers. Immunosuppressive potential will be evaluated by rejection episode rates, by graft/patient survivals, by immunohistology of 3-months kidney and 6-month liver graft biopsies and by in vitro evaluation of the immunity profile of the recipients. In a second step, reduction (kidney) and progressive weaning (liver) of immunosuppression will be attempted in recipients who received MSC. This ongoing study is supported by research grants from the CHU of Liège, University of Liège, and by the Senior Clinical Research Grant from ESOT. The first patients were included and treated in early 2012, and final results expected in late 2013. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Transplant International (2015, November), 28(S4), 1027

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Methods: 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5–3 9 106/kg third party MSC on post-operative day 3 ` 2. These patients were prospectively compared to a group of 10 control liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. This study is in part supported by an ESOT Senior Clinical Research Grant and by the University of Liege. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 29

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Patients & Methods: Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post-operative day 3±2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detailInfusion of third-party mesenchymal stromal cells after liver transplantation: a phase 1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

Poster (2015, March 27)

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases ... [more ▼]

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases. Mesenchymal stromal cells (MSC) are multipotent and self-renewing bone marrow progenitors that have been shown both in vitro and in vivo as capable of (i) immunomodulation, (ii) anti-inflammation in case of ischemia/reperfusion injury, and (ii) stimulation of tissue repair. MSC could therefore be very interesting in organ recipients to limit chronic graft damage and to allow tolerance. This study aimed to be the first clinical evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled, phase I study. Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post- operative day 3 ± 2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. This phase I study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

Detailed reference viewed: 37 (4 ULg)