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See detailHPV infection, squamo-columnar junction and potential cancer prevention
Herfs, Michael ULg

Conference (2015, October 26)

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See detailHPV triggers NK cell cytotoxic activity and cytokine secretion
Jacobs, Nathalie ULg; Renoux, Virginie ULg; Bisig, Bettina ULg et al

Conference (2011)

Background The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumor development as demonstrated by a higher tumor prevalence in immunodeficient patients ... [more ▼]

Background The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumor development as demonstrated by a higher tumor prevalence in immunodeficient patients. Around 90% of HPV-infected women will clear the virus within two years. However, it remains unclear which immune cells are implicated in this process and no study has been performed evaluating the direct interaction between HPV and Natural Killer (NK) cells although these cells play a key role in host resistance to virus and tumor. Methods/Results By immunochemistry, we demonstrated an NK cell infiltration in HPV+ squamous pre-neoplasic lesions. Since HPV cannot grow in vitro, virus-like particles (VLP) were used as a model for studying the NK cell response against the virus. Interestingly, NK cells displayed a higher cytotoxic activity (CD107 and chromium release assays) and cytokine production (TNF-α and IFN-γ) in the presence of HPV-VLP. Uptake of HPV-VLP by dendritic cells (DC) has been shown to induce their activation, therefore, we investigated by flow cytometry and microscopy whether the stimulation of NK cell activity is linked to VLP internalization. We observed a faster entry into these cells compared to DC. Furthermore, virus uptake by NK cells is mediated by macropinocytosis, whereas this entry is dependent on clathrin or caveolin endocytosis pathways in DC. Using NK cell lines expressing or not CD16 and blocking antibody, we demonstrated that CD16 is necessary for HPV-VLP internalization, but also for degranulation and cytokine production. Conclusion Thus, we show for the first time that NK cells interact with HPV and could participate in the immune response against HPV-induced tumors. [less ▲]

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See detailHR 7674: a low-amplitude cepheid?
Manfroid, Jean ULg; Renson, Pierre ULg; Burnet, M.

in Information Bulletin on Variable Stars (1997), 4453

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See detailHR Carinae - A luminous blue variable surrounded by an arc-shaped nebula
Hutsemekers, Damien ULg; van Drom, E.

in Astronomy and Astrophysics (1991), 248

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes ... [more ▼]

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes spectral variations apparently correlated with the light variations similarly to the other LBVs. Most striking are the very broad emission wings (FWZI of about 3000 km/s) of the Balmer lines, reminiscent from the broad lines observed in the spectra of Of and WR stars. A kinematic distance of 5.4 kpc and a bolometric magnitude of -9.4 put HR Car among the most luminous stars of the Galaxy. The narrow band filter imagery also reveals an arc-shaped jet like nebula associated with HR Car. Spectroscopic observations of this nebula reveal an emission nature with very low excitation. Like the star itself, the nebula is characterized by a significant N/O overabundance, probably due to the presence of nuclear processed material ejected by the star. [less ▲]

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See detailHR managers views and practices in SME's regarding return to work of sick listed employees
Mairiaux, Philippe ULg; Lequeux, Sarah; Lambreghts, C et al

Poster (2012, October 24)

Background Little is known about the return to work (RTW) policies implemented in small and medium size enterprises (SME) which have limited resources to define and apply such policies. This study aimed ... [more ▼]

Background Little is known about the return to work (RTW) policies implemented in small and medium size enterprises (SME) which have limited resources to define and apply such policies. This study aimed at assessing the existing return to work practices in SME’s and exploring their view regarding the help they could receive from their occupational health service. Methods HR managers of 46 SME’s (23 in Flanders, 23 in Wallonia) employing 100 to 200 employees were contacted for an interview. The manager was asked to fill in a written questionnaire and to comment his/her answers in an open discussion with the researcher. The questionnaire involved three parts: 1°) describing existing rules or procedures when returning to work after sick leave, 2) assessing the manager knowledge of the RTW legal regulations within the occupational health care system, 3) assessing the occupational health physician (OP) involvement in RTW and the enterprise expectations for the future. Results Participation to the survey was accepted in 38 SME’s. In slightly more than half of them a sick leave related policy has been defined. While almost all SME’s have a well-defined procedure for the RTW examination by the OP, only 22 (out of 38) have defined procedures for maintaining a contact with the worker during the sick leave period, only 17 are informing their employees about the possibility to meet the OP during that period, and only 6 are systematically organising a worker-supervisor meeting when the worker comes back at work. Knowledge about RTW regulations is rather poor: 10 managers wrongly think that the OP may check the sick leave medical validity; only 14 managers know that the employer must inform the OP about any sick leave longer than 4 weeks; less than half of the managers have a good knowledge of the pre-return to work visit. Various expectations have been put forward as regard the role of the OH service: knowledge transfer about the regulations, coaching of the supervisors, training managers in carrying RTW talks with the worker, suggesting procedures, etc. Conclusions The lack of knowledge about RTW regulations underlines the need for information campaigns focused on the employers. The participating RH managers are awaiting a more proactive role from their OH service. [less ▲]

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See detailHREELS Signal Processing Via Wavelets.
Charles, Catherine ULg; Leclerc, Gervais; Rasson, Jean-Paul

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailHRM practices in a process of organisational change: A contextualist perspective
Pichault, François ULg; Schoenaers, Frédéric ULg

in Applied Psychology : An International Review = Psychologie Appliquée : Revue Internationale (2003), 52(1), 120-143

This paper explores the interactions between HRM practices and contextual factors in a process of organisational change. We first present a typology of HRM models, in line with Mintzberg's organisational ... [more ▼]

This paper explores the interactions between HRM practices and contextual factors in a process of organisational change. We first present a typology of HRM models, in line with Mintzberg's organisational configurations. We then develop a contingent view on HRM issues-highlighting the influence of some contextual factors-followed by a more political view which reveals the power games between the different stakeholders, each of them enacting specific contextual factors. Finally, we give a more concrete understanding of the contextualist framework discussing its application to a case study in the alimentary sector. [less ▲]

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See detailHRM Practices in a Process of Organizational Change: A Contextualist View
Pichault, François ULg; Schoenaers, Frédéric ULg

in Munduate, L.; Bennebroek Gravenhorst, K.M. (Eds.) Power Dynamics and Organizational Change III (1999)

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See detailHRM-Based Reforms in Public Organizations: Problems and Perspectives
Pichault, François ULg

in Human Resource Management Journal (2007), 17/3

Many attempts at modernisation have been launched in public organisations during the last decade, focused on a renewal of HR policies and devices. Via an in-depth exploration of three case studies in ... [more ▼]

Many attempts at modernisation have been launched in public organisations during the last decade, focused on a renewal of HR policies and devices. Via an in-depth exploration of three case studies in Belgium, this paper develops an analytical framework likely to explain their contrasting performances. Our main hypothesis is that a lack of coherence (a) within the content itself of HRM-based reforms, (b) between this content and the context in which it is introduced, or (c) the process by which it is implemented, could explain a large part of the problems encountered. The paper also suggests some key recommendations for the management of HRM- based reforms in the public sphere. [less ▲]

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See detailHRS4R : quel apport pour les établissements, quelle plus-value pour les chercheurs ?
Halleux, Isabelle ULg

Scientific conference (2017, March 30)

La communication est destinée à présenter les nouveautés du processus de HR stratégie en recherche proposé par la Commission Européenne pour mettre en œuvre le principes de la charte européenne du ... [more ▼]

La communication est destinée à présenter les nouveautés du processus de HR stratégie en recherche proposé par la Commission Européenne pour mettre en œuvre le principes de la charte européenne du chercheur, ainsi que les bénéfices pour les institutions et les chercheurs [less ▲]

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See detailHRT in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg

in Jaarbook 2000 (2001)

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See detailHRTEM study of Al-rich chlorites in Visean K-bentonites from Belgium.
Anceau, Annick ULg; Amouric, Marc; Olives-Banos, Jean

Poster (1997, June)

Detailed reference viewed: 32 (18 ULg)
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See detailHS-SPME - GCMS characterization of volatile secondary products from 37 Trichoderma strains
Delvigne, Frank ULg; Verscheure, M.; Palm, Rodolphe ULg et al

Poster (2004, February)

Detailed reference viewed: 23 (6 ULg)
See detailHSP25 expression in the nervous system of the adult rat
Plumier, Jean-Christophe ULg

Conference (1995)

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See detailHsp27 in the nervous system: expression in pathophysiology and in the aging brain.
Krueger-Naug, A. M. R.; Plumier, Jean-Christophe ULg; Hopkins, D. A. et al

in Progress in Molecular and Subcellular Biology (2002), 28

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See detailHsp2è expression following cortical depolarization in the aduklt rat
Plumier, Jean-Christophe ULg; Robertson, Harold A.; Currie, R. William

Poster (1996)

Detailed reference viewed: 3 (0 ULg)