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See detailLyapunov generation of entanglement and the correspondence principle
Petitjean, Cyril ULg; Jacquod, Ph

in PHYSICAL REVIEW LETTERS (2006), 97(19), 194103-4

We show how a classically vanishing interaction generates entanglement between two initially nonentangled particles, without affecting their classical dynamics. For chaotic dynamics, the rate of ... [more ▼]

We show how a classically vanishing interaction generates entanglement between two initially nonentangled particles, without affecting their classical dynamics. For chaotic dynamics, the rate of entanglement is shown to saturate at the Lyapunov exponent of the classical dynamics as the interaction strength increases. In the saturation regime, the one-particle Wigner function follows classical dynamics better and better as one goes deeper and deeper in the semiclassical limit. This demonstrates that quantum-classical correspondence at the microscopic level does not require coupling to a large number of external degrees of freedom. [less ▲]

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See detailLyapunov-based sufficient conditions for exponential stability in hybrid systems
Teel, Andrew; Forni, Fulvio ULg; Zaccarian, Luca

in IEEE Transactions on Automatic Control (2013)

Lyapunov-based sufficient conditions for exponential stability in hybrid systems are presented. The focus is on converting non-strict Lyapunov conditions, having certain observability properties, into ... [more ▼]

Lyapunov-based sufficient conditions for exponential stability in hybrid systems are presented. The focus is on converting non-strict Lyapunov conditions, having certain observability properties, into strict Lyapunov conditions for exponential stability. Both local and global results are considered. The utility of the results is illustrated through an example. [less ▲]

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See detailLe lycée Léonie de Waha
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2007), 115

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See detailThe Lyman-alpha telescope of the extreme ultraviolet imager on Solar Orbiter
Schühle, Udo; Halain, Jean-Philippe ULg; Meining, Stefan et al

in Proceedings of SPIE (2011), 8148

On the Solar Orbiter mission, the Extreme Ultraviolet Imager (EUI) set of filtergraph-telescopes consists of two high-resolution imagers (HRI) and one dual-band full Sun imager (FSI) that will provide ... [more ▼]

On the Solar Orbiter mission, the Extreme Ultraviolet Imager (EUI) set of filtergraph-telescopes consists of two high-resolution imagers (HRI) and one dual-band full Sun imager (FSI) that will provide images of the solar atmosphere in the extreme ultraviolet and in the Lyman-α line of hydrogen at 121.6 nm. The Lyman-α HRI, in particular, will provide imaging of the upper chromospheres/lower transition region of the Sun at unprecedented high cadence and at an angular resolution of one 1″ (corresponding to a spatial resolution of 200 km at perihelion). For vacuum-ultraviolet imaging of the Sun the main requirements for the instrumentation are high resolution, high cadence, and large dynamic range. We present here the novel solutions of the instrument design and show in detail the predicted performance of this telescope. We describe in detail how the high throughput and spectral purity at 121.6 nm is achieved. The technical solutions include multilayer coatings of the telescope mirrors for high reflectance at 121.6 nm, combined with interference filters and a multichannel-plate intensified CMOS active pixel camera. We make use of the design flexibilities of this camera to optimize the dynamic range in the focal plane. [less ▲]

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See detailLymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy.
Pierard, Claudine ULg; Goffin, Véronique ULg; Arrese Estrada, Jorge ULg et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15(2), 112-9

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and ... [more ▼]

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. METHOD: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. RESULTS: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. CONCLUSION: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg. [less ▲]

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See detailLymphangiogenesis
Paupert, Jenny ULg; Noël, Agnès ULg

in MacGraw-Hill Education Year Book of Sciences and Technology 2014 (2014)

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See detailLymphangiogenesis and extracellular matrix remodeling
Erpicum, Charlotte ULg; Detry, Benoît ULg; Paupert, Jenny ULg et al

Poster (2011)

Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft rejection. Our laboratory has previously identified MMP2 as a key regulator of lymphangiogenesis in vitro and in vivo. However, the exact function of MMP2 in this process is yet unknown. The present work aims at elucidating the mechanisms of MMP2 action during lymphangiogenesis. MMP2 could either act as a growth factor activator or as a regulator of matrix remodeling. To address this question, we studied the effect of MMP2 on lymphangiogenesis in an novel in vitro model of sprouting cells from small aggregates (spheroids) seeded in a collagen gel. In this model, quantification of the lymphangiogenic response is performed through computerized methods allowing the measurement of the distance of migration, but also the evaluation of how the cell are migrating. We evaluated the impact of MMP2 blockage through the use of physiological (TIMP2) or chemical inhibitors or by downregulating its expression with specific siRNA. The importance of extracellular matrix composition is evaluated by embedding these spheroids into different matrices (matrigel versus collagen; pepsinized collagen versus native collagen; different collagen concentrations). Our results reveal a modification of cell migration through collagen gel after MMP2 inhibition. The utilization of DQ collagen and microscopy refractance confirmed the importance of MMP2 collagenoyitic activity for lymphangiogenesis. [less ▲]

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See detailLymphangiogenesis and extracellular matrix remodeling
Erpicum, Charlotte ULg; Detry, Benoît ULg; Paupert, Jenny ULg et al

Conference (2013, January 28)

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See detailLymphangiogenesis in post-natal tissue remodeling: Lymphatic endothelial cell connection with its environment.
Paupert, Jenny ULg; Sounni, Nor Eddine ULg; Noël, Agnès ULg

in Molecular Aspects of Medicine (2011), 32(2), 146-158

The main physiological function of the lymphatic vasculature is to maintain tissue fluid homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with tissue inflammation in ... [more ▼]

The main physiological function of the lymphatic vasculature is to maintain tissue fluid homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with tissue inflammation in adults (i.e. wound healing, allograft rejection, tumor metastasis). Until recently, research on lymphangiogenesis focused mainly on growth factor/growth factor-receptor pathways governing this process. One of the lymphatic vessel features is the incomplete or absence of basement membrane. This close association of endothelial cells with the underlying interstitial matrix suggests that cell-matrix interactions play an important role in lymphangiogenesis and lymphatic functions. However, the exploration of interaction between extracellular matrix (ECM) components and lymphatic endothelial cells is in its infancy. Herein, we describe ECM-cell and cell-cell interactions on lymphatic system function and their modification occurring in pathologies including cancer metastasis. [less ▲]

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See detailLymphangiogenesis: in vitro and in vivo models
Bruyère, Françoise; Noël, Agnès ULg

in FASEB Journal (2010), 24(1), 8-21

Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft rejection. In addition, lymphatic hypoplasia characterizes lymphedema, usually a progressive and lifelong condition for which no curative treatment exists. Much progress has been made in recent years in identifying molecules specifically expressed on lymphatic vessels and in the setting up of in vitro and in vivo models of lymphangiogenesis. These new tools rapidly provided an abundance of information on the mechanisms underlying lymphatic development and the progression of diseases associated with lymphatic dysfunction. In this review, we describe the common in vitro and in vivo models of lymphangiogenesis that have proven suitable for investigating lymphatic biology and the interactions occurring between lymphatic vessels and other cells, such as immune cells and cancer cells. Their rationales and limitations are discussed and illustrated by the most informative findings obtained with them. [less ▲]

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See detailLymphatic microcirculation
QUATRESOOZ, Pascale ULg

in Measuring the skin (in press)

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See detailThe lymphatic ring assay: a 3D-culture model of lymphangiogenesis.
Bruyere, Françoise ULg; Melen-Lamalle, Laurence ULg; Berndt, Sarah ULg et al

in Nature Protocols (2008)

Lymphangiogenesis, the formation of new lymphatic vessels, is associated to numerous pathologies1 and understanding the molecular and cellular basis of this complex process is essential for the ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels, is associated to numerous pathologies1 and understanding the molecular and cellular basis of this complex process is essential for the development of novel therapeutic strategies. Studies on lymphangiogenesis have been hampered by difficulties in culturing lymphatic capillaries as three-dimensional (3D) structures in vitro that mimic the in vivo features of lymphatic vessels and lymphangiogenesis. The lymphatic ring assay described here phenocopies the different steps of lymphangiogenesis, including the spreading from a preexisting vessel, cell proliferation, migration and differentiation into capillaries. It consists on the adaptation of the aortic ring assay that has proved to be useful to investigate the molecular basis of angiogenesis2-4. The lymphatic ring model is an ideal assay for testing the activity of lymphangiogenic agonists or antagonists. The absence of inflammatory cells allows a simple interpretation of results and the determination of direct effects of compounds on lymphatic endothelial cell properties. Another advantage of the lymphatic ring assay is that cell outgrowing are primary cells which have not been modified by repeated passages or immortalization. This culture model bridges the gap between in vitro and in vivo studies and allows genetic analysis by using thoracic ducts from genetically modified mice. [less ▲]

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See detaillymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2006)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen-Lamalle, L; Blacher, Silvia ULg et al

in Acta Clinica Belgica (2008), 63

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2007)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2006)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Conference (2006)

Detailed reference viewed: 10 (2 ULg)