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See detailHow to manage a case of ischial tuberosity avulsion fracture?
Tyberghein, Maëlle; Kaux, Jean-François ULg; GODON, Bernard ULg et al

in The Future of Football Medicine (2017, May)

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle ... [more ▼]

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle attached to the apophysis. Indeed, before ossification, the apophyseal growth cartilage is the weakest point in the musculotendinous unit, making the apophysis vulnerable to injure. Athletes most commonly affected are soccer players when they tackle or shot powerful at goal and gymnasts during floor exercises which imposed sudden and excessive lengthening. Management of these fractures remains unclear. There are no guidelines between conservative and surgical approach even if most publications recommend a surgery if the diastasis exceeds 2cm and a conservative approach on the other hand. Case report A sixteen-year-old high-level player presented at the consultation with right ischial pain. Three months earlier, while he was sprinting, he had felt acute pain opposite the ischial tuberosity which compelled him to stop the training. He had already consulted another physician, who prescribed an X-ray which revealed an avulsion fracture of the ischial tuberosity with a maximal diastasis of 1.9 cm (Fig 1.a.). According to most publications (1,3), surgery is advisable from 2 cm of diastasis. 1.9 cm was within the range between a surgical and a conservative approach, and the conservative one was applied. An isokinetic assessment was planned. It highlighted hamstring strength imbalances with bilateral difference of 31% in concentric strength and 28% in eccentric strength in comparison with the healthy side. The mixed ratio of the hamstrings in eccentric mode at 30°/s to quadriceps in concentric mode at 240°/s was decreased to 0.8, while the lower limit in our clinical practice corresponded to 0.9. The patient was not allowed to resume competition and a rehabilitation by specific and progressive strengthening in both modes of contraction was initiated; in particular the eccentric training was initially submaximal and progressively intensified. Six weeks later, isokinetic assessment was repeated and showed significant improvement of right hamstring strength, particularly for eccentric contraction. The greatest improvement was the mixed Hecc/Qconc ratio wich had increased from 0.8 to 1.44. In regard to radiology, we observed no change since the previous X-Ray (Fig 1.b.). Intensified training on the field was allowed in order to resume competition. Less than one year after the injury, the patient restarted competition successfully with performance levels which were almost the same as before the injury. Discussion Many publications have discussed the surgical versus the conservative approach to treating ischiatic avulsion. Most of the published literature advocate the relevance of surgery when the diastasis exceeds 2 cm because widely displaced fractures may lead to chronic symptomatology if the treatment remains conservative. Different criteria, such as pain relief, ability to perform in sport, gross strength, activity score, X-Rays, are used by authors to demonstrate the recovery after treatment. No study accurately measured the hamstring strength before and after treatment. However, strength imbalance, especially as regards the H/Q mixed ratio, significantly increases the risk of sustaining hamstring injury in soccer player (2). For our patient, the rehabilitation enabled him to re-establish hamstring strength in six weeks with substantial improvement of eccentric assessment. The mixed Hecc/Qconc ratio increased from 0.8 to 1.44. This improvement significantly decreased the risk of recurrence of hamstring injury. Regarding X-Ray imagery, there was no evidence of healing. We advocate that radiological assessment should not be the main recovery criterion and that specific strengthening should be started even when avulsion persists on the X-Ray. Furthermore, hamstring strength should be measured accurately and objectively, e.g. by isokinetism, to be one of the main return to play criterion in association with clinical data. [less ▲]

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See detailHow to manage an isolated elevated PTH?
Souberbielle, Jean-Claude; CAVALIER, Etienne ULg; Cormier, Catherine

in Annales d'Endocrinologie (2015), 76(2), 134-141

The aim of this article is to discuss the diagnostic approach of an increased serum PTH concentration in a normocalcemic, normophosphatemicpatient. Detection of this biological presentation is frequent in ... [more ▼]

The aim of this article is to discuss the diagnostic approach of an increased serum PTH concentration in a normocalcemic, normophosphatemicpatient. Detection of this biological presentation is frequent in routine practice all the more that PTH reference values established in vitamin Dreplete subjects with a normal renal function are used by the clinical laboratories. The first step in this diagnostic approach will be to rule out acause of secondary hyperparathyroidism (SHPT). Among these, the most frequent are vitamin D deficiency, very low calcium intake, impairedrenal function, malabsorptions, drugs interfering with calcium/bone metabolism, such as lithium salts and antiresorptive osteoporosis therapies,hypercalciuria due to a renal calcium leak. If no cause of SHPT are evidenced, the diagnosis of normocalcemic primary hyperparathyroidism(PHPT) should be considered. A calcium load test is a very useful tool for this diagnosis if it shows that serum PTH is not sufficiently decreasedwhen calcemia rises frankly above the upper normal limit. In a normocalcemic patient with hypercalciuria and a high serum PTH concentration,a thiazide challenge test may help to differentiate SHPT due to a renal calcium leak from normocalcemic PHPT. Beyond the discussion of thisdiagnostic [less ▲]

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See detailHow to manage hair changes in cancer patients
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; RORIVE, Andrée ULg et al

in Handbook of skin care in cancer patients (2010)

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See detailHow to manage hair changes in cancer patients.
FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; RORIVE, Andrée ULg et al

in Vereecken, P.; Awada, A. (Eds.) Handbook of skin care in cancer patients. (2012)

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See detailHow to manage HTA in 2014?
Krzesinski, Jean-Marie ULg

Conference (2014, October 07)

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See detailHow to manage ischaemic mitral regurgitation.
Lancellotti, Patrizio ULg; Marwick, Thomas; Pierard, Luc ULg

in Heart (2008), 94(11), 1497-502

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See detailHow to manage obesity in growing giant dogs ?
Lhoest, Estelle; Jeusette, Isabelle; Claeys, Stéphanie ULg et al

in Proceedings of the 8th ESVCN International Conference (2004)

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See detailHow to manage recurrent orofacial herpes simplex virus-1 lesions
Gross, Gerd; Harding, Keith; Karlsmark, Tonny et al

in Pharmaceutical Journal (2009)

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See detailHow to measure accurately blood pressure in hemodialysis patients?
VANDERWECKENE, Pauline ULg; SAINT-REMY, Annie ULg; KRZESINSKI, Jean-Marie ULg

Conference (2016, October 29)

Objective : Blood pressure (BP) control in chronic hemodialysis (HD) patients is a major challenge and could explain the controversial results about its cardiovascular risk. Our study aimed to assess the ... [more ▼]

Objective : Blood pressure (BP) control in chronic hemodialysis (HD) patients is a major challenge and could explain the controversial results about its cardiovascular risk. Our study aimed to assess the contribution of two ambulatory techniques of measurements compared with office BP (OBP): ambulatory monitoring during a maximum of 44h interdialytic period (ABPM) and home blood pressure (HBPM) during a variable period of days in prevalent HD patients. Methodology : 43 prevalent chronically HD patients (M=28; F=15), mean age 68.3±13 years were submitted to a 44h monitoring of BP (Spacelabs 90207) from the end of an HD session to 10 minutes before the next session, immediately followed by a 7days HBPM (Omron M6). Office BP was the mean of pre-dialysis BP or post-dialysis-BP recorded over 2 weeks (6 HD sessions). Hypertension was defined as BP equal or higher than 140/90 mmHg for pre-HD, 130/80 mmHg for post-HD, 130/80 mmHg for 44 h ABPM and 135/85 mmHg for HBPM. Results : Good correlations were noted between ABPM and HBPM for the diagnosis of hypertension in HD patients. Both ambulatory techniques give the same proportion of masked hypertension and white coat hypertension compared with OBP (25%). The best diagnostic precision was noted for the longest periods of recordings (44h for ABPM and 7days for HBPM). Shorter periods were more practical for the patients but less precise for high BP identification. HBPM was more appreciated than ABPM by the patients Conclusion : ABPM and HBPM identified a quarter of patients with a particular phenotype of hypertension not correctly classified by OBP. HBPM should be first recommended in HD (at least 1 week/month). As ABPM provides unique information for nocturnal BP, it could be proposed 1 time/year in all patients. [less ▲]

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See detailHow to measure GFR in the year 2011?
DELANAYE, Pierre ULg

Conference (2011)

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See detailHow to Measure Insulin Action in Vivo
Scheen, A. J.; Paquot, Nicolas ULg; Castillo, M. J. et al

in Diabetes/Metabolism Reviews (1994), 10(2), 151-88

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See detailHow to measure Pomeron phase and discover odderon at HERA and RHIC
Ginzburg, Ilya; Ivanov, Igor ULg

in Acta Physica Polonica B (2006), 37

We suggest to measure the Pomeron phase and discover odderon via the measurement of charge asymmetry of pions in the diffractive processes ep\to e\pi +\pi - p, eA\to e\pi +\pi - A and in the processes AA ... [more ▼]

We suggest to measure the Pomeron phase and discover odderon via the measurement of charge asymmetry of pions in the diffractive processes ep\to e\pi +\pi - p, eA\to e\pi +\pi - A and in the processes AA\to AA\pi +\pi - with two rapidity gaps. [less ▲]

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See detailHow to measure quality in job transitions?
Levêque, Audrey ULg; Orianne, Jean-François ULg; Pichault, François ULg

Conference (2011, July 08)

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See detail"How to measure quality in job transitions?"
Levêque, Audrey ULg; Orianne, Jean-François ULg; Pichault, François ULg

Conference (2011, October 27)

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See detailHow to measure renal function?
DELANAYE, Pierre ULg

Conference (2016, October 14)

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See detailHow to minimise production costs at the preliminary design stage - scantling optimization
Rigo, Philippe ULg

in IMDC’2003, Eighth International Marine Design Conference, Grèce,Vol2 (2003, May)

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See detailHow to monitor NF-kappaB activation after photodynamic therapy.
Coupienne, Isabelle ULg; Piette, Jacques ULg; Bontems, Sébastien ULg

in Methods in Molecular Biology (Clifton, N.J.) (2010), 635

The nuclear factor-kappa B (NF-kappaB) is a multipotent factor involved in many cellular processes such as inflammation, immune response and embryonic development and it can be activated by a large number ... [more ▼]

The nuclear factor-kappa B (NF-kappaB) is a multipotent factor involved in many cellular processes such as inflammation, immune response and embryonic development and it can be activated by a large number of stimuli. Consequently, this transcription factor plays a pivotal role in many natural processes but also in different pathologies. For several years, photodynamic therapy (PDT) has emerged as an attractive alternative approach for the treatment of different affections involving various forms of cancer and an increasing number of reports have highlighted the activation of the NF-kappaB following PDT treatment. Furthermore, it has been shown that the mechanism of activation of the NF-kappaB as well as its target genes depends on the nature of the photosensitizers and the cell type used. As this transcription factor is known to be a key regulator of the immune response but also controls cell survival and proliferation, it is important to assess its activation status and its impact on the target genes. In this review, we will present different techniques allowing identification of the activation status of this factor, from the degradation of its inhibitor in the cytoplasm to its ability to induce the expression of a reporter gene under the control of a target promoter. As a working model we will present results obtained from a 5-aminolevulinic acid-PDT treatment on cervix adenocarcinoma cells. [less ▲]

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See detailHow to optimally load a set of containers into an aircraft
Schyns, Michael ULg; Limbourg, Sabine ULg; Laporte, Gilbert

E-print/Working paper (2012)

Detailed reference viewed: 84 (12 ULg)