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See detailMiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Grosso, S.; Doyen, J.; Parks, S. K. et al

in Cell Death & Disease (2013), 4

The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of hypoxia-inducible factor (HIF)-dependent transcriptional ... [more ▼]

The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of hypoxia-inducible factor (HIF)-dependent transcriptional regulation, involving modulation of a specific set of micro RNAs (miRNAs), including miR-210, has emerged. We have recently shown that HIF-1 induction of miR-210 also stabilizes HIF-1 through a positive regulatory loop. Therefore, we hypothesized that by stabilizing HIF-1 in normoxia, miR-210 may protect cancer cells from radiation. We developed a non-small cell lung carcinoma (NSCLC)-derived cell line (A549) stably expressing miR-210 (pmiR-210) or a control miRNA (pmiR-Ctl). The miR-210-expressing cells showed a significant stabilization of HIF-1 associated with mitochondrial defects and a glycolytic phenotype. Cells were subjected to radiation levels ranging from 0 to 10 Gy in normoxia and hypoxia. Cells expressing miR-210 in normoxia had the same level of radioresistance as control cells in hypoxia. Under hypoxia, pmiR-210 cells showed a low mortality rate owing to a decrease in apoptosis, with an ability to grow even at 10 Gy. This miR-210 phenotype was reproduced in another NSCLC cell line (H1975) and in HeLa cells. We have established that radioresistance was independent of p53 and cell cycle status. In addition, we have shown that genomic double-strand breaks (DSBs) foci disappear faster in pmiR-210 than in pmiR-Ctl cells, suggesting that miR-210 expression promotes a more efficient DSB repair. Finally, HIF-1 invalidation in pmiR-210 cells removed the radioresistant phenotype, showing that this mechanism is dependent on HIF-1. In conclusion, miR-210 appears to be a component of the radioresistance of hypoxic cancer cells. Given the high stability of most miRNAs, this advantage could be used by tumor cells in conditions where reoxygenation has occurred and suggests that strategies targeting miR-210 could enhance tumor radiosensitization. [less ▲]

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See detailMira's role in RR Tel revisited
Heck, A.; Manfroid, Jean ULg

in Cool Stars with Excesses of Heavy Elements (1985)

The present uvby data, IUE FES measurements and American Association of Variable Star Observers visual estimates of the very slow nova RR Tel show that the object has gone through periodic variations in ... [more ▼]

The present uvby data, IUE FES measurements and American Association of Variable Star Observers visual estimates of the very slow nova RR Tel show that the object has gone through periodic variations in visual light since it started fading in 1949 after the outburst it incurred in 1944. The period is, however, not constant, and varies between 350 and 410 days, confirming Mayall's (1957) statement and contradicting the conclusions of later investigators. Synchronized variations of a Mira in the infrared and of a blue component indicate that the Mira mass outflow probably varies in a phase with its pulsations. Large variations occur in visual light on a time scale of a few weeks. [less ▲]

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See detailLe miracle 'flamand' n'est pas prêt-à-porter…
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 9-10

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See detailLe Miracle d'Amis et Amille. Etude d'une transposition dramatique
Henrard, Nadine ULg

Master's dissertation (1984)

Etude du 23e des Miracles par personnages du recueil Cangé, Amis et Amille, joué à Paris, au milieu du XIVe siècle. Analyse de la transposition de la source épique, essai de reconstitution de la mise en ... [more ▼]

Etude du 23e des Miracles par personnages du recueil Cangé, Amis et Amille, joué à Paris, au milieu du XIVe siècle. Analyse de la transposition de la source épique, essai de reconstitution de la mise en scène. Le travail s'accompagne d'une édition révisée du texte, avec examen linguistique. [less ▲]

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See detailLe miracle de l’agneau néo-zélandais
Collignon, Fabrice; De Wit, Pierre; Leloup, David et al

Article for general public (2007)

C’est Pâques. L’agneau néo-zélandais débarque en masse dans toutes les grandes surfaces européennes à des prix défiant toute concurrence locale. Et ce, malgré un transport de quelque 20.000 kilomètres ... [more ▼]

C’est Pâques. L’agneau néo-zélandais débarque en masse dans toutes les grandes surfaces européennes à des prix défiant toute concurrence locale. Et ce, malgré un transport de quelque 20.000 kilomètres, souvent par avion. Le GIEC doit être ravi. Un texte du Collectif « Avion Rouge ». [...] [less ▲]

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See detailLe miracle de l’agneau néo-zélandais
Collignon, Fabrice; De Wit, Pierre; Leloup, David et al

Article for general public (2007)

Ça y est, les fêtes de Pâques sont à nos portes. Au moment de passer à table, nous dégusterons l'agneau pascal … de Nouvelle-Zélande. Et ce, que nous soyons à Bruxelles, Paris, Rome ou Berlin. En effet ... [more ▼]

Ça y est, les fêtes de Pâques sont à nos portes. Au moment de passer à table, nous dégusterons l'agneau pascal … de Nouvelle-Zélande. Et ce, que nous soyons à Bruxelles, Paris, Rome ou Berlin. En effet, partout en Europe, cet agneau est actuellement proposé à des centaines de millions de consommateurs à un prix ridiculement bas, très largement inférieur à celui de l'agneau local , atteignant un record de 5,30 € le kg dans les hypermarchés français. [...] [less ▲]

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See detailLe miracle de l’agneau néo-zélandais
Collignon, Fabrice; De Wit, Pierre; Leloup, David et al

Article for general public (2007)

Ca y est, les fêtes de Pâques sont à nos portes, avec leurs congés ou leurs vacances. Mais aussi et surtout avec les oeufs de Pâques que les cloches de Pâques venues directement de Rome larguent dans nos ... [more ▼]

Ca y est, les fêtes de Pâques sont à nos portes, avec leurs congés ou leurs vacances. Mais aussi et surtout avec les oeufs de Pâques que les cloches de Pâques venues directement de Rome larguent dans nos jardins. Puis, au moment de passer à table, nous dégusterons l’agneau pascal… de Nouvelle-Zélande. Et ce, que nous soyons à Bruxelles, Paris, Rome ou Berlin. [...] [less ▲]

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See detailMiracles de Nostre Dame par personnages
Parussa, Gabriella; Henrard, Nadine ULg; De Crécy, Marie-Claude et al

Book published by Garnier (2013)

Detailed reference viewed: 44 (8 ULg)
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See detailLes Miracles de saint Mengold de Huy, témoignage privilégié d'un culte à la fin du XIIe siècle
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1986), CLII

nouvelle édition des miracles de Mengold (XIIe siècle)

Detailed reference viewed: 9 (0 ULg)
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See detailLes Miracles de saint Quirin de Malmedy, un livret médiéval au coeur du XVIe siècle
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1998), CLXIV

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See detailLes miracles miroirs des corps
George, Philippe ULg

in Moyen Age (Le) (1985)

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See detailMiradas que se cruzan desde España. El entusiasmo de Manuel Vázquez Montalbán y la crítica de Ignacio Vidal-Folch
Vanden Berghe, Kristine ULg

in Vanden Berghe, Kristine; Huffshmid, Anne; Lefere, Robin (Eds.) EL EZLN y sus intérpretes. Resonancias del zapatismo en la academia y en la literatura. (2011)

Detailed reference viewed: 39 (3 ULg)
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See detailMirages caused by a gravitational lens
Surdej, Jean ULg

in Kleczek, J. (Ed.) Exercises in astronomy...Revised and extended edition of "Practical work in elementary astronomy" by M. G. J. Minnaert. D. ReidelPublishing Co., Dordrecht, The Netherlands. 24+339 pp. Price Dfl. 140.00, US 64.00, £ 49.50 cloth; Dfl. 59.00, US 19.50, £ 18.00 paper (1987). ISBN 90-277-2409-1 cloth, ISBN 90-277-2423-7 paper. (1987)

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated ... [more ▼]

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated by the editor in collaboration with the contributing authors D. A. Allen, Z. Ceplechka, S. Ferraz Mello, K. J. Gordon, L. Houziaux, C. Jaschek, Z. Kopal, J. Manfroid, J. Palous, J. Podolský, G. R. Quast, J. Surdej, A. B. Underhill, J. M. Vreux, D. G. Wentzel.The exercises are organized in the following sections:A. The planetary system: 1. Space and time, instruments. 2. The motions of celestial bodies. 3. Planets and satellites.B. The stars: 1. The Sun. 2. Stars and nebulae. 3. Stellar systems. [less ▲]

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See detailLes mirages gravitationnels (II)
Surdej, Jean ULg; Surdej, Anna ULg

Article for general public (2000)

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See detailLes mirages gravitationnels (III)
Surdej, Jean ULg; Surdej, Anna ULg

Article for general public (2000)

Detailed reference viewed: 22 (7 ULg)
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See detailLes mirages gravitationnels (IV)
Surdej, Jean ULg; Surdej, Anna ULg

Article for general public (2001)

Detailed reference viewed: 9 (6 ULg)
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See detailLes mirages gravitationnels
Surdej, Jean ULg; Surdej, Anna ULg

Article for general public (2000)

Detailed reference viewed: 22 (8 ULg)
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See detailMircea Eliade et la pensée mythique au Paléolithique supérieur
Noiret, Pierre ULg

in Arheologia Moldovei (2013), XXXVI

Avec le Paléolithique supérieur, de nombreuses données éclairent les fonctions symboliques. Au-delà des seules activités techniques, il est possible de restituer certains éléments d’une pensée mythique ... [more ▼]

Avec le Paléolithique supérieur, de nombreuses données éclairent les fonctions symboliques. Au-delà des seules activités techniques, il est possible de restituer certains éléments d’une pensée mythique, analogue à celle décrite par les ethnologues ou les historiens des religions. Leur étude ne permet pas de retrouver les mythes racontés, mais bien d’envisager lucidement leur nature et leur rôle fondamental pour le fonctionnement des sociétés paléolithiques. Dans les années 1990, la découverte de la grotte Chauvet a remis en cause l’évolution linéaire de l’art pariétal établie par André Leroi-Gourhan. La découverte récente de peintures très similaires en Roumanie, dans la grotte de Coliboaia, permet de compléter l’approche des phases initiales de cet art. Les similitudes entretenues entre les images de ces deux grottes poussent à retourner vers la notion de mythe. [less ▲]

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See detailLe mirmillon et le rétiaire ou comment concilier la domanialité publique et l'urbanisme
Pâques, Michel ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006)

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See detailmiRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients
Zadran, Sohila; Remacle, Françoise ULg; Levine, R. D.

in Proceedings of the National Academy of Sciences (2013), 110(47), 19160-19165

Toward identifying a cancer-specific gene signature we applied surprisal analysis to the RNAs expression behavior for a large cohort of breast, lung, ovarian, and prostate carcinoma patients. We ... [more ▼]

Toward identifying a cancer-specific gene signature we applied surprisal analysis to the RNAs expression behavior for a large cohort of breast, lung, ovarian, and prostate carcinoma patients. We characterize the cancer phenotypic state as a shared response of a set of mRNA or microRNAs (miRNAs) in cancer patients versus noncancer controls. The resulting signature is robust with respect to individual patient variability and distinguishes with high fidelity between cancer and noncancer patients. The mRNAs and miRNAs that are implicated in the signature are correlated and are known to contribute to the regulation of cancer-signaling pathways. The miRNA and mRNA networks are common to the noncancer and cancer patients, but the disease modulates the strength of the connectivities. Furthermore, we experimentally assessed the cancer-specific signatures as possible therapeutic targets. Specifically we restructured a single dominant connectivity in the cancer-specific gene network in vitro. We find a deflection from the cancer phenotype, significantly reducing cancer cell proliferation and altering cancer cellular physiology. Our approach is grounded in thermodynamics augmented by information theory. The thermodynamic reasoning is demonstrated to ensure that the derived signature is bias-free and shows that the most significant redistribution of free energy occurs in programming a system between the noncancer and cancer states. This paper introduces a platform that can elucidate miRNA and mRNA behavior on a systems level and provides a comprehensive systematic view of both the energetics of the expression levels of RNAs and of their changes during tumorigenicity. [less ▲]

Detailed reference viewed: 14 (0 ULg)