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See detailLack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Willems, Luc ULg; Kerkhofs, P.; Burny, A. et al

in Virology (1995), 206(1),

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See detailLack Of Mutation In The Waf1/Cip1 Gene During Bovine Leukemia Virus-Induced Leukemogenesis
Dequiedt, Franck ULg; Willems, Luc ULg; Kerkhofs, P. et al

in Veterinary Immunology and Immunopathology (1997), 59(3-4),

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See detailLack of P2X1 ion channels increases endotoxemia associated coagulation and organ damage through neutrophil hyperresponsiveness.
Lecut, Christelle ULg; Faccinetto, Céline ULg; Evans, Richard J et al

in Journal of Thrombosis and Haemostasis [=JTH] (2011), 9(suppl S2),

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in ... [more ▼]

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in this study we found that lack or inhibition of P2X1 channels enhanced neutrophil respiratory burst activity ex vivo. <br />To study the consequence of P2X1 deficiency on neutrophil function in vivo, P2X1-/- mice were used in a model of endotoxin-induced sepsis. Upon injection of lipopolysaccharides (LPS), plasma myeloperoxidase (MPO) concentrations reached higher levels in the P2X1-/- mice, and circulating neutrophils expressed higher levels of surface CD11b compared to wild-type mice. Neutrophil relocalization into the lungs of LPS-treated P2X1-/- mice was also significantly augmented, reflecting a higher activation state of P2X1-/- neutrophils under conditions of sepsis. Accordingly, more extensive lipid peroxidation was observed in the liver of LPS-treated P2X1-/- mice, indicative of exaggerated oxidative damage. Concomitantly, the levels of thrombin-antithrombin complexes were higher in the plasma of LPS-treated P2X1-/- mice and thrombocytopenia was worsened as compared to wild type mice. Elevated numbers of microthrombi were also found in the lungs of these mice. These observations coincided with a higher susceptibility of P2X1-/- mice to LPS-induced septic shock than wild type animals. <br />Our results strongly suggest that P2X1 ion channels play a protective role in sepsis by negatively regulating systemic neutrophil activation, thereby limiting oxidative damage, activation of coagulation and platelet accumulation into the lungs. Therefore, since antagonists of P2X1 ion channels may not only target platelets but also affect neutrophils, inhibiting these channels in the highly inflammatory environment of severe sepsis or of acute coronary syndromes might be detrimental. [less ▲]

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See detailThe lack of relationship between DST nonsuppression in the dexamethasone suppression test and EEG abnormalities.
Pitchot, William ULg; Hansenne, Michel ULg; Ansseau, Marc ULg

in European Archives of Psychiatry & Clinical Neuroscience (1991), 241(3), 193-4

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 ... [more ▼]

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 major depressive inpatients. A total of 23 patients exhibited DST nonsuppression (44%) and 18 patients had EEG abnormalities (35%). No relationship existed between DST and EEG results. [less ▲]

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See detailLack of resolution in the animal phylogeny: Closely spaced cladogeneses or undetected systematic errors?
Baurain, Denis ULg; Brinkmann, Henner; Philippe, Hervé

in Molecular Biology and Evolution (2007), 24(1), 6-9

A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic ... [more ▼]

A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic events." Here, we propose that this lack of resolution is rather due to the mutual cancellation of the phylogenetic signal (historical) and the nonphylogenetic signal (due to systematic errors) that results from inadequate taxon sampling and/or model of sequence evolution. Starting with a data set of comparable size, we use 3 different strategies to reduce the nonphylogenetic signal: 1) increasing the number of species; 2) replacing a fast-evolving species by a slowly evolving one; and 3) using a better model of sequence evolution. In all cases, the phylogenetic resolution is markedly improved, in agreement with our hypothesis that the originally reported lack of resolution was artifactual. [less ▲]

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See detailLack of risk of transmission of caprine arthritis-encephalitis virus (CAEV) after an appropriate embryo transfer procedure
Ali Al Ahmad, M. Z.; Chebloune, Y.; Bouzar, Amel ULg et al

in Theriogenology (2008)

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See detailLack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins
Villet, S.; Faure, C.; Bouzar, Amel ULg et al

in Virology (2003)

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See detailLack of universality in 2-dimensional multicomponent spreading phenomena
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(4), 3447-3454

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states ... [more ▼]

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states and are coupled or not via an energy J, as in the Potts model, thus leading to a competition between species. The internal cluster spreading is found to result from a competition between growing domains. Complex mechanisms such as trapping, jamming and coalescence occur between the growing domains. A large variety of critical and nanuniversal regimes, from subcritical to self-organized critical behaviors, are obtained depending on nonuniversal parameters such as the lattice structure, the number of internal degrees of freedom q, and the coupling J. For the square lattice, the fractal dimension is 1.50 and the mass distribution exponent tau is 1.63. For the triangular lattice, the fractal dimension varies from 1.70 to 1.83 depending on the coupling value and the mass distribution exponent tau also varies from 1.67 to 1.98 depending on the coupling value. The correspondence and differences with respect to the percolation phenomenon are outlined. [less ▲]

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See detailLactase Insufficiency Revisited
Forget, P; Lombet, Jacques; Grandfils, Christian ULg et al

in Journal of Pediatric Gastroenterology and Nutrition (1985), 4

The definition of "insufficient" small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and ... [more ▼]

The definition of "insufficient" small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test. Primary "insufficient" lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test. The lactase activity of 22 "normal" children ranged from 0.77 to 4.57 U/g wet weight, while five children showed primary lactase insufficiency as defined above. Small bowel lactase activity in the latter patients was < 0.74 U/g wet weight. Sucrase and maltase activities were similar in both groups of patients. We conclude that children with a normal small bowel histology should be considered to have primary lactase insufficiency when small bowel lactase activity is below 0.75 U/g wet weight. [less ▲]

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See detailThe Lactate Dehydrogenase of the Icefish Heart: Biochemical Adaptations to Hypoxia Tolerance
Feller, Georges ULg; Pauly, J. P.; Smal, A. et al

in Biochimica et Biophysica Acta (1991), 1079(3), 343-7

Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or ... [more ▼]

Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehydrogenases. A model involving a dual oxidative-anaerobic metabolism of the icefish heart is proposed. [less ▲]

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See detailLa lactation : rappels physiologiques et induction. Applications à l'espèce bovine.
Hanzen, Christian ULg

in Annales de Médecine Vétérinaire (1979), 123

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See detailLa lactation de saint Bernard
Oger, Cécile ULg

in Duchesne, Jean-Patrick (Ed.) L'art sacré dans tous ses états à travers les collections de l'Université (2012)

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See detailLactation effect on stable isotope ratios and mercury levels in the blood of northern elephant seals
Habran, Sarah ULg; Debier, Cathy; Lepoint, Gilles ULg et al

Poster (2006, October 27)

Female northern elephant seals, Mirounga angustirostris, fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Stable carbon and nitrogen isotope ratios ... [more ▼]

Female northern elephant seals, Mirounga angustirostris, fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Stable carbon and nitrogen isotope ratios (d13C and d15N used as diet markers) and total mercury concentrations (Hg) were measured in tissues (blood cells, serum, full blood, milk and blubber) from 20 mother-pup pairs on day 4 and 21 of lactation. A systematic difference was observed between isotopic values in blood cells and serum of the mothers, linked to diet and distinct biochemical composition between blood components. d13C differed between inner and outer blubber layers and were similar between inner blubber and milk. High Hg concentrations (up to 350 ng.g-1 ww at the beginning of lactation) were found in the blood of mother elephant seals linked to their high d15N values in blood cells. Hg transfer through placenta and milk was observed between mothers and pups. A significant increase of blood Hg concentration in mothers (+285 ng.g-1ww) and a decrease in pups (-93 ng.g-1ww) were observed between days 4 and 21 of lactation. Both processes were explained by a remobilization of proteins and lipids during fasting and milk production in mothers and by a dilution of Hg in pups due to their high mass increase during this period. To conclude, physiological processes and body condition should be considered carefully when interpreting stable isotope ratios and Hg concentrations in the framework of biomonitoring. [less ▲]

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See detailLactation effect on the trace element dynamics in northern elephant seals (Mirounga angustirostris)
Habran, Sarah ULg; Debier, Cathy; Lepoint, Gilles ULg et al

Conference (2007, November 30)

Northern elephant seals, Mirounga angustirostris, are exceptional mammals: females fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Females thus lose ... [more ▼]

Northern elephant seals, Mirounga angustirostris, are exceptional mammals: females fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Females thus lose approximately a third of body mass and produce energy-rich milk with a high fat content. Stable carbon and nitrogen isotope ratios (d13C and d15N used as diet markers) and total mercury concentrations (Hg) were measured in tissues (blood cells, serum, full blood, milk and blubber) from 20 mother-pup pairs on days 4 and 21 of lactation. A systematic difference was observed between isotopic values in blood cells and serum of the mothers, linked to diet and distinct biochemical composition between blood components. d13C differed between inner and outer blubber layers and were similar between inner blubber and milk. High Hg concentrations (up to 350 ng.g-1ww at the beginning of lactation) were found in the blood of mother elephant seals linked to their high d15N values in blood cells. Hg transfer through placenta and milk was observed between mothers and pups. A significant increase of blood Hg concentration in mothers (+285 ng.g-1ww) and a decrease in pups (-93 ng.g-1ww) were observed between days 4 and 21 of lactation. Both processes were explained by a remobilization of proteins and lipids during fasting and milk production in mothers and by a dilution of Hg in pups due to their high mass increase during this period. This study confirms that lactation modifies stable nitrogen isotope ratios in tissues, as well as mercury levels in blood from mothers and pups, and highlights the existence of a transplacental and transmammary transfer of mercury in northern elephant seals. Therefore, physiological processes and body condition should be considered carefully when interpreting stable isotope ratios and Hg concentrations in the framework of biomonitoring. [less ▲]

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See detailLactobacillus acidophilus encapsulation by spray drying
Zgoulli, Slim; Sabri, Ahmed ULg; Thonart, Philippe ULg

Poster (1993, June)

Detailed reference viewed: 59 (3 ULg)
See detailLactobacillus Acidophilus microencapsulation by spray-drying.
Zgoulli, S.; Gilsoul, J. J.; Gerard, J. et al

Poster (1993, June)

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See detailLactone end-capped poly(ethylene oxide) as a new building block for biomaterials
Rieger, Jutta ULg; Bernaerts, Katrien V.; Du Prez, Filip E et al

in Macromolecules (2004), 37(26), 9738-9745

This paper reports on the synthesis of a novel poly(ethylene oxide) (PEO) macromonomer, which can be copolymerized with epsilon-caprolactone (epsilon-CL) by ring-opening polymerization (ROP). PEO chains ... [more ▼]

This paper reports on the synthesis of a novel poly(ethylene oxide) (PEO) macromonomer, which can be copolymerized with epsilon-caprolactone (epsilon-CL) by ring-opening polymerization (ROP). PEO chains end-capped by an epsilon-caprolactone unit (gammaPEO(.)CL) have been synthesized by living anionic ring-opening polymerization of ethylene oxide (EO) initiated by the potassium alkoxide of 1,4-dioxaspiro[4.5]decan-8-ol, followed by derivatization of the acetal into a ketone and the Baeyer-Villiger oxidation of the ketone into a lactone. The end-capping of PEO by epsilon-CL was assessed by FTIR, MALDI-TOF, and H-1 NMR spectroscopy. This type of macromonomer is a precursor of amphiphilic comblike copolymers consisting of a biodegradable hydrophobic backbone of poly-(epsilon-caprolactone) (PCL) and hydrophilic PEO grafts. Copolymerization of gammaPEO(.)CL with epsilon-CL was successfully initiated by aluminum alkoxide. [less ▲]

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