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See detailMentor 2 (1986-1990). Guide bibliographique de la religion grecque. Bibliographical Survey of Greek Religion
Motte, André ULg; Pirenne-Delforge, Vinciane ULg; Wathelet, Paul ULg

Book published by Centre International d'Etude de la Religion Grecque Antique (1998)

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See detailMentor. Guide bibliographique de la religion grecque. Bibliographical Survey of Greek Religion
Motte, André ULg; Pirenne-Delforge, Vinciane ULg; Wathelet, Paul ULg

Book published by Centre International d'Etude de la Religion Grecque Antique (1992)

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See detailLe menu des jeunes Moineaux domestiques, Passer domesticus L., et espagnols, Passer hispaniolensis TEMM., en Oranie.
Metzmacher, Maxime ULg

in Cahiers d’Ethologie Appliquée (1983), 3

The composition and the structure of the nestling sparrows were studied in the north-west of Algeria. The nestling's food of the two sparrows consisted mainly of animal food in the beginning of the ... [more ▼]

The composition and the structure of the nestling sparrows were studied in the north-west of Algeria. The nestling's food of the two sparrows consisted mainly of animal food in the beginning of the nestling period, the vegetable fraction of the diet become more important at the end of this period. Preys hierarchy can vary with nestling age, colony situation and season. The two sparrows, and their recognised age-classes, have similar diet structure. The distribution of preys between the different taxa revealed that the sparrows are generalist predators. The spanish sparrow,however, exhibit sometimes a strong specialisation. [less ▲]

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See detailUn menu qui pèse dans la balance climatique
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2009)

Un menu qui pèse dans la balance climatique Prenons un menu un brin festif: potage, plat, dessert. Calculons : ensemble, les denrées parcourent 218 000 kilomètres avant de tomber dans notre assiette. Et ... [more ▼]

Un menu qui pèse dans la balance climatique Prenons un menu un brin festif: potage, plat, dessert. Calculons : ensemble, les denrées parcourent 218 000 kilomètres avant de tomber dans notre assiette. Et émettent 37,5 kg de CO2. À ce prix, l’avion est-il vraiment inéluctable pour transporter la nourriture? [less ▲]

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See detailMepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis.
Gevaert, Philippe; Van Bruaene, Nicholas; Cattaert, Tom ULg et al

in Journal of Allergy and Clinical Immunology (The) (2011), 128(5), 989-9958

BACKGROUND: Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. OBJECTIVE: We sought ... [more ▼]

BACKGROUND: Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. OBJECTIVE: We sought to investigate the therapeutic potential of inhibiting IL-5 with a humanized mAb as treatment for severe nasal polyposis. METHODS: Thirty patients with severe nasal polyposis (grade 3 or 4 or recurrent after surgery) refractory to corticosteroid therapy were randomized in a double-blind fashion to receive either 2 single intravenous injections (28 days apart) of 750 mg of mepolizumab (n = 20) or placebo (n = 10). Change from baseline in NP score was assessed monthly until 1 month after the last dose (week 8). Computed tomographic scans were also performed at week 8. RESULTS: Twelve of 20 patients receiving mepolizumab had a significantly improved NP score and computed tomographic scan score compared with 1 of 10 patients receiving placebo at week 8 versus baseline. CONCLUSION: Mepolizumab achieved a statistically significant reduction in NP size for at least 1 month after dosing in 12 of 20 patients. IL-5 inhibition is a potential novel therapeutic approach in patients with severe eosinophilic nasal polyposis. [less ▲]

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See detailLa mer et les hommes
Dubuisson, Marcel ULg

Speech (1969)

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See detailMercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases
Lassaux, Patricia; Hamel, Matthieu; Gulea, Mihaela et al

in Journal of Medicinal Chemistry (2010), 53

In this paper, we investigated the inhibitory effect of mercaptophosphonate derivatives against the three subclasses of MBLs (B1, B2, and B3). All 14 tested mercaptophosphonates, with the exception of one ... [more ▼]

In this paper, we investigated the inhibitory effect of mercaptophosphonate derivatives against the three subclasses of MBLs (B1, B2, and B3). All 14 tested mercaptophosphonates, with the exception of one, behaved as competitive inhibitors for the three subclasses. <br />Apart from two compounds, all the mercaptophosphonates tested exhibit a good inhibitory effect on the subclass B2 MBL CphA with low inhibition constants (Ki<15 μM). Interestingly, compound 18 turned out to be a potent broad spectrum MBL inhibitor. <br />The crystallographic structures of the CphA-10a and CphA-18 complexes indicated that the sulfur atom of 10a and the phosphonato group of 18 interact with the Zn2þ ion, respectively. Molecular modeling studies of the interactions between two compounds and the VIM-4 (B1), CphA (B2), and FEZ-1 (B3) enzymes brought to light different binding modes depending on the enzyme and the inhibitor, consistent with the crystallographic structures. [less ▲]

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See detailMerchant-Rankine approach for the design of steel and composite sway building frames
Jaspart, Jean-Pierre ULg

in Festschrift Richard Greiner (2001)

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See detailMerciadri (LaTeX) packages: An overview
Merciadri, Luca ULg

in TUGboat (2011), 32(2), 206-210

I have written three LaTeX2e packages, namely bigints, dashundergaps, and plantslabels. Because there are so many submitted packages, TeX-information sources are so used that communications rapidly go to ... [more ▼]

I have written three LaTeX2e packages, namely bigints, dashundergaps, and plantslabels. Because there are so many submitted packages, TeX-information sources are so used that communications rapidly go to the archives, their respective emergences could have been unoticed by the majority of the Community. I here propose a brief summary about what they do, and how they could be useful for your work. [less ▲]

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See detailLe Mercosur et ses Etats membres: les asymétries interétatiques en tant que problème pour l'intégration?
Santander, Sébastian ULg

in Musset et Soria, Alain et Victor (Ed.) Alena - Mercosur: Enjeux et limites de l'intégration américaine (2001)

Mercosur est intégration régionale née en 1991. Elle se démarque par l'asymétrie entre ses Etats membres. L'article vise à identifier les différentes asymétries existantes et les répercutions de ces ... [more ▼]

Mercosur est intégration régionale née en 1991. Elle se démarque par l'asymétrie entre ses Etats membres. L'article vise à identifier les différentes asymétries existantes et les répercutions de ces dernières pour l'essor de l'intération régionale sud-américaine. et, partant, analyse L'article analyse les implications de cette asymétrie [less ▲]

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See detailMERCOSUR’s external relation policy: between the EU, FTAA and WTO
Santander, Sébastian ULg

in Center for International Studies (Ed.) Neo-Functional vs. Neo-Institutional Policies of Regional Cooperation: East Asian and European Experiences (2005)

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See detailMercosur: Modèle d'intégration européen ou globalisation?
Santander, Sébastian ULg

Master of advanced studies dissertation (1998)

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See detailMercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
Bellon, B.; Capron, M.; Druet, E. et al

in European Journal of Clinical Investigation (1982), 12(2), 127-33

Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG ... [more ▼]

Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms. [less ▲]

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See detailMercury immune toxicity in harbour seals: Links to in vitro toxicity
Das, Krishna ULg; Siebert, Ursula; Gillet, Audrey et al

in Environmental Health : A Global Access Science Source (2008), 7

Background Mercury is known to bioaccumulate and to magnify in marine mammals, which is a cause of great concern in terms of their general health. In particular, the immune system is known to be ... [more ▼]

Background Mercury is known to bioaccumulate and to magnify in marine mammals, which is a cause of great concern in terms of their general health. In particular, the immune system is known to be susceptible to long-term mercury exposure. The aims of the present study were (1) to determine the mercury level in the blood of free-ranging harbour seals from the North Sea and (2) to examine the link between methylmercury in vitro exposure and immune functions using seal and human mitogen-stimulated peripheral blood mononuclear cells (T-lymphocytes). Methods Total mercury was analysed in the blood of 22 harbour seals. Peripheral blood mononuclear cells were isolated from seals (n = 11) and from humans (n = 9). Stimulated lymphocytes of both species were exposed to functional tests (proliferation, metabolic activity, radioactive precursor incorporation) under increasing doses of methylmercury (0.1 to 10 µM). The expression of cytokines (IL-2; IL-4 and TGF-beta was investigated in seal lymphocytes by RT-PCR and by real time quantitative PCR (n = 5) at methylmercury concentrations of 0.2 and 1 µM. Finally, proteomics analysis was attempted on human lymphocytes (cytoplasmic fraction) in order to identify biochemical pathways of toxicity at concentration of 1 µM (n = 3). Results The results showed that the number of seal lymphocytes, viability, metabolic activity, DNA and RNA synthesis were reduced in vitro, suggesting deleterious effects of methylmercury concentrations naturally encountered in free-ranging seals. Similar results were found for human lymphocytes. Functional tests showed that a 1 µM concentration was the critical concentration above which lymphocyte activity, proliferation and survival were compromised. The expression of IL-2 and TGF-beta mRNA was weaker in exposed seal lymphocytes compared to control cells (0.2 and 1 µM). Proteomics showed some variation in the protein expression profile (e.g. vimentin). [less ▲]

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See detailMercury in blood of free-ranging seals Phoca vitulina from the North Sea: Time-trend and association with environmental factors
Das, Krishna ULg; Brochoire, Charlène ULg; Chambosse, Mélanie et al

Conference (2012, March 27)

The harbour seal (Phoca vitulina) population from the North Sea has experienced various fluctuations these last decades due to habitat loss, prey fluctuation and pollution of the marine environment ... [more ▼]

The harbour seal (Phoca vitulina) population from the North Sea has experienced various fluctuations these last decades due to habitat loss, prey fluctuation and pollution of the marine environment. Recently, development of monitoring programs and non-invasive sampling techniques, including seal catches allowed blood sampling on a regular basis together with measurements of blubber thickness, body mass, sex and body length. Concentrations of total mercury (T-Hg) and other trace elements (Cd, Pb, Zn, Cu, Fe) as well as ∂13C and ∂15N values were determined by mass spectrometry in blood of 75 wild harbour seals caught in the German Wadden Sea between 1997 and 2011. ∂13C and ∂15N mean values (-17.5‰ and 18.1 ‰ respectively) were strongly similar to that measured previously in the muscle of stranded harbour seals from the Wadden Sea. In contrast, ∂15N mean value was strikingly higher than that recorded in grey seals (Halichoerus grypus) from Scotland (14.1 ‰ respectively; Habran et al. submitted.) while ∂13C values remained similar between the two seal species. These values confirmed the high trophic position of the harbour seal in the North Sea. In contrast to Cd and Pb, T-Hg in blood harbour seals reached concentrations as high as 2.1 μg.g-1 dry weight (10 times higher than the 0.21 μg.g-1 dry weight recorded for grey seals from Scotland) but depended on several factors including ∂15N values, age group and the body mass. T-Hg was detected in juveniles confirming maternal transfer to offspring and time-trend revealed no decrease of T-Hg in blood of harbour seals these last 15 years. [less ▲]

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See detailMercury in the blood of free ranging pinnipeds: levels, sources of variation, toxicocinetic and potential impact using an in vitro model
Das, Krishna ULg; Gillet, Marie-Claire ULg; Habran, Sarah ULg et al

Conference (2007)

Despite 30 years of international regulations, Hg levels in marine mammals have not decreased. Various environmental models even suggest a rise of mercury in the biota during the next decades, linked to ... [more ▼]

Despite 30 years of international regulations, Hg levels in marine mammals have not decreased. Various environmental models even suggest a rise of mercury in the biota during the next decades, linked to climate change. The objective of this study is (1) to assess Hg levels in blood samples of free-ranging pinnipeds, (2) to understand level variation during different periods of life (gestation, lactation, fasting) and potential impact on lymphocytes using a preliminary in vitro model (peripheral blood mononuclear cells, PBMC). Blood samples were collected from harbour seals (Phoca vitulina n= 22) from the North Sea and from elephant seals from the Californian coast (Mirounga angustirostris 12 females and 12 pups). Harbour seal PBMC were isolated, set in medium culture and contaminated with methyl-Hg (1 µM). Biological tests and proteomic assay were realized on control and contaminated PBMC. Hg levels were from the same order of magnitude for the two species despite two different lifestyles and habitats: from 40 to 590 ng.g-1 fw in harbour seal and from 63 to 919 ng.g-1 fw in elephant seal. Hg concentrations in the blood depend upon several factors such as body weight, fasting and lactation duration for mothers and pups. After 21 days of lactation, female elephant seals doubled their blood Hg levels (from 308 to 593 ng.g-1fw) while a decrease is observed for pups. This increase is linked to mobilization from blubber and muscle during fasting associated to lactation. Cell model revealed an in vitro effect of Hg even at low concentration (1µM). Number of PBMC, viability, metabolic activity, DNA and RNA synthesis were reduced in vitro suggesting deleterious effects of Hg in concentrations encountered in free-ranging pinnipeds. Knowing that Hg methylation in the ocean is linked to temperature, one can wonder on Hg levels (and effects) in pinnipeds during the next decades. [less ▲]

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See detailMercury porosimetry applied to low density xerogels
Pirard, René ULg; Heinrichs, Benoît ULg; Pirard, Jean-Paul ULg

in Characterization of Porous Solids IV (1997)

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See detailMercury porosimetry applied to low density xerogels
Pirard, René ULg; Heinrichs, Benoît ULg; Van Cantfort, Olivier et al

Poster (1997)

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See detailMercury porosimetry applied to low density xerogels; relation between structure and mechanical properties
Pirard, René ULg; Heinrichs, Benoît ULg; Van Cantfort, Olivier et al

in Journal of Sol-Gel Science and Technology (1998), 13(1-3), 335-339

Samples of low density xerogels were submitted to mercury porosimetry at pressures up to 200 MPa. These samples show an unusual behavior: they are first crushed by the isostatic mercury pressure without ... [more ▼]

Samples of low density xerogels were submitted to mercury porosimetry at pressures up to 200 MPa. These samples show an unusual behavior: they are first crushed by the isostatic mercury pressure without mercury intrusion and are then intruded by the mercury above a certain pressure. This transition allows the easy determination of the one constant found in the buckling model that is used to interpret the crushing part of the mercury porosimetry experiment. The relation between this constant and the structure of the xerogels determined by TEM and nitrogen adsorption is discussed. [less ▲]

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See detailMercury porosimetry applied to porous silica materials: successive buckling and intrusion mechanisms
Alié, Christelle ULg; Pirard, René ULg; Pirard, Jean-Paul ULg

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2001), 187

Some silica low-density xerogels exhibit two successive volume variation mechanisms, compaction and intrusion when submitted to mercury porosimetry. The position of the pressure of transition P-t between ... [more ▼]

Some silica low-density xerogels exhibit two successive volume variation mechanisms, compaction and intrusion when submitted to mercury porosimetry. The position of the pressure of transition P-t between the two mechanisms is characteristic of the tested material and allows to compute the buckling constant used to determine the pore size distribution in the compaction part of the experiment. The analysis of the mercury porosimetry data of a low-density xerogel wrapped in a tight membrane by the buckling law (intrusion is prevented and the sample is crushed during the whole porosimetry experiment) leads to a continuous unimodal distribution similar to the distribution of the unwrapped sample obtained by applying the buckling law below P-t and the intrusion law above P-t. This experiment confirms the validity of the use of the buckling law. The behaviour of the low-density xerogels can be related to one of their morphological characteristics. As the size of the aggregates of silica particles increases, the strength towards crushing increases and the change of mechanism from crushing to intrusion takes place at a lower pressure. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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