Perspective in the treatment of insulin resistance.

in Human Reproduction (1997), 12 Suppl 1

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including ... [more ▼]

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including upper body adiposity, glucose intolerance, hypertension, dyslipidaemia, etc.) in industrialized countries and its dramatic consequences for public health. Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Currently available pharmacological means mainly include the biguanide compound metformin and possibly anti-obesity agents, such as (d-) fenfluramine, fluoxetine and benfluorex. New compounds aiming at improving the action of insulin are in development, especially the thiazolidinedione derivatives (e.g. troglitazone), known as 'insulin sensitizers'. Treatment of insulin resistance may have important gynaecological applications, essentially in polycystic ovary syndrome and, possibly, after menopause. Hopefully, improving insulin sensitivity could ameliorate the cardiovascular prognosis of numerous individuals having some or all components of insulin resistance syndrome. [less ▲]

"La perspective interculturelle dans l'enseignement d'une langue étrangère: le cas du français au Maroc" (cycle de conf.)

Scientific conference (2008, March)

Perspective taking to assess self-personality: What's modified in Alzheimer's disease?

in Neurobiology of Aging (2009), 30(10), 1637-1651

Personality changes are frequently described by caregivers of patients with Alzheimer's disease, while they are less often reported by the patients. This relative anosognosia of Alzheimer disease (AD ... [more ▼]

Personality changes are frequently described by caregivers of patients with Alzheimer's disease, while they are less often reported by the patients. This relative anosognosia of Alzheimer disease (AD) patients for personality changes might be related to impaired self-judgment and to decreased ability to understand their caregiver's perspective. To investigate this issue, we explored the cerebral correlates of self-assessment and perspective taking in patients with mild AD, elderly and young volunteers. All subjects assessed relevance of personality traits adjectives for self and a relative, taking either their own or their relative's perspective, during a functional imaging experiment. The comparison of subject's and relative's answers provided congruency scores used to assess self-judgment and perspective taking performance. The self-judgment "accuracy" score was diminished in AD, and when patients assessed adjectives for self-relevance, they predominantly activated bilateral intraparietal sulci (IPS). Previous studies associated IPS activation with familiarity judgment, which AD patients would use more than recollection when retrieving information to assess self-personality. When taking a third-person perspective, patients activated prefrontal regions (similarly to young volunteers), while elderly controls recruited visual associative areas (also activated by young volunteers). This suggests that mild AD patients relied more on reasoning processes than on visual imagery of autobiographical memories to take their relative's perspective. This strategy may help AD patients to cope with episodic memory impairment even if it does not prevent them from making some mind-reading errors. [less ▲]

La perspective, entre projet plastique et projection intellectuelle

in SIC! (2009), 4

De nature à la fois technique et philosophique, le problème de la perspective importe ici pour deux raisons au moins. D’abord en tant qu’il est lié à la pratique du dessin: l’effet de la perspective ... [more ▼]

De nature à la fois technique et philosophique, le problème de la perspective importe ici pour deux raisons au moins. D’abord en tant qu’il est lié à la pratique du dessin: l’effet de la perspective repose sur un jeu de lignes participant à la construction de la représentation — lignes vouées, en général, à disparaître sous la couche picturale. Ensuite, le problème de la perspective apparaît comme une variation du thème — désormais fameux — de la double signification du disegno (dessin/dessein) mise en évidence par Robert Klein dans la forme et l’intelligible, critiquée par Georges Didi-Huberman dans "Devant l’image". En effet, le terme «perspective» semble relever d’une même ambivalence sémantique. Il désigne tout à la fois une technique de représentation picturale et une opération intellectuelle (celle qui consiste, pour le dire d’abord platement, à prendre de la distance, à «mettre les choses en perspective»). Il y aurait donc deux axes au «paradigme perspectif»: l’un pictural et processuel, l’autre cognitif. Ces deux axes seront ici décrits dans leur croisement. [less ▲]

Perspectives

in Demidenko, Yuri; Otte, Marcel; Noiret, Pierre (Eds.) Siuren I Rock-Shelter. From Late Middle Paleolithic and Early Upper Paleolithic to Epi-Paleolithic in Crimea (2012)

Perspectives : Compromis tragiques ou défense stérile des identités politiques

in Fournier, Bernard; Reuchamps, Min (Eds.) Le fédéralisme en Belgique et au Canada (2009)

Perspectives chinoises

in La Wallonie (1980)

Perspectives d'avenir

in Actes de la Journée d'études sur le boulon dans la construction métallique (1994)

Perspectives d'avenir pour les oléo-protéagineux

Conference (1989)

Perspectives d'utilisation de la tomographie dans la description du fonctionnement des réacteurs à trois phases

Scientific conference (1997, June 19)