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See detailMucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.
Arijs, Ingrid; De Hertogh, Gert; Machiels, Kathleen et al

in American Journal of Gastroenterology (2011)

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See detailMucosal gene expression profiling differentiates early from late ileal Crohn's disease
Arijs, I; Van Lommel, L; De Hertogh, G et al

in Acta Gastro-Enterologica Belgica (2011)

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See detailMucosal gene expression profiling to predict response to infliximab in patients with ulcerative colitis
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Gut (2007), 56(Suppl III), 19

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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Acta Gastro-Enterologica Belgica (2008)

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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 64

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See detailMucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease.
Arijs, I.; Van Lommel, L.; Van Steen, Kristel ULg et al

in Gastroenterology (2008), 134

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See detailMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Arijs, I.; Li, K.; Toedter, G. et al

in Gut (2009), 58(12), 1612-9

BACKGROUND AND AIMS: Infliximab is an effective treatment for ulcerative colitis with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti ... [more ▼]

BACKGROUND AND AIMS: Infliximab is an effective treatment for ulcerative colitis with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-tumour necrosis factor alpha (anti-TNFalpha) is unknown. This study used colonic mucosal gene expression to provide a predictive response signature for infliximab treatment in ulcerative colitis. METHODS: Two cohorts of patients who received their first treatment with infliximab for refractory ulcerative colitis were studied. Response to infliximab was defined as endoscopic and histological healing. Total RNA from pre-treatment colonic mucosal biopsies was analysed with Affymetrix Human Genome U133 Plus 2.0 Arrays. Quantitative RT-PCR was used to confirm microarray data. RESULTS: For predicting response to infliximab treatment, pre-treatment colonic mucosal expression profiles were compared for responders and non-responders. Comparative analysis identified 179 differentially expressed probe sets in cohort A and 361 in cohort B with an overlap of 74 probe sets, representing 53 known genes, between both analyses. Comparative analysis of both cohorts combined, yielded 212 differentially expressed probe sets. The top five differentially expressed genes in a combined analysis of both cohorts were osteoprotegerin, stanniocalcin-1, prostaglandin-endoperoxide synthase 2, interleukin 13 receptor alpha 2 and interleukin 11. All proteins encoded by these genes are involved in the adaptive immune response. These markers separated responders from non-responders with 95% sensitivity and 85% specificity. CONCLUSION: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-)response to infliximab. Further study of the pathways involved should allow a better understanding of the mechanisms of resistance to infliximab therapy in ulcerative colitis. ClinicalTrials.gov number, NCT00639821. [less ▲]

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See detailMucosal Healing Predicts Long-term Outcome of Maintenance Therapy with Infliximab in Crohn's Disease
Schnitzler, F.; Fidder, H.; Ferrante, M. et al

in Inflammatory Bowel Diseases (2009), 15(9), 1295-1301

Background: Infliximab (IFX) treatment induces mucosal healing (MH) in patients with Crohn's disease (CD) but the impact of MH oil the long-term outcome of IFX treatment in CID is still debated. Methods ... [more ▼]

Background: Infliximab (IFX) treatment induces mucosal healing (MH) in patients with Crohn's disease (CD) but the impact of MH oil the long-term outcome of IFX treatment in CID is still debated. Methods: We studied MH during long-term treatment with IFX in 214 CID patients. A total of 193 patients (85.5%) responded to induction therapy and 31 patients (14.5%) were primary nonresponders. They underwent lower gastrointestinal (GI) endoscopy within a median of 0.7 months (interquartile range [IQR] 0.1-6.9) prior to first IFX and after a median of 6.7 months (IQR 1.4-24.6) after start of IFX and were further analyzed. The relationship between the outcome of IFX treatment long-term and MH was studied. Results: MH was observed in 67.8% of the 183 initial responders (n = 124), with 83 patients having complete healing (45.4%) and 41 having partial healing (22.4%). Scheduled IFX treatment from the start resulted in MH more frequently (76.9% MH rate) than episodic treatment (61.0% MH rate; P = 0.0222, odds ratio [OR] 2.14, 95% confidence interval [CI] 1.11-4.12). Concomitant treatment with corticosteroids (CS) had a negative impact on MH (37.9% in patients with CS versus 63.2% in patients without CS; P = 0.021, OR 0.36, 95% CI 0.16-0.80). MH was associated with a significantly lower need for major abdominal surgery (MAS) during long-term follow-up (14.1% of patients with MH needed MAS versus 38.4% of patients Without MH: P < 0.0001). Conclusions: MH induced by long-term maintenance IFX treatment is associated with an improved long-term outcome of the I disease especially with a lower need for major abdominal surgeries. [less ▲]

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See detailMucosal junctions: open doors to HPV and HIV infections?
Herfs, Michael ULg; Hubert, Pascale ULg; Moutschen, Michel ULg et al

in Trends in microbiology (2011), 19(3), 114-120

Throughout adult life, new developmental commitment of adult stem cells causes reversible epithelial replacements in various mucosal surfaces, including the uterine cervix and the anal canal. Located at ... [more ▼]

Throughout adult life, new developmental commitment of adult stem cells causes reversible epithelial replacements in various mucosal surfaces, including the uterine cervix and the anal canal. Located at the squamocolumnar junctions, these metaplastic conversions are associated with chronic inflammation and deregulated expression of soluble and cell-membrane factors important for antiviral immune response. In this paper, we propose that these histological and immunological features increase the susceptibility of these metaplastic microenvironments to human papillomavirus and human immunodeficiency virus infections. Identification of the anatomical sites and cell populations within the anogenital tract, which is the site primary infected by these viruses, is crucial for the understanding of the pathogenesis of viral disease and development of antiviral strategies. [less ▲]

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See detailMuddy Mouth : Beckett’s Poetics of Tastelessness
Delville, Michel ULg

in Litteraria Pragensia (2009), 17

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See detailMuḥibb al-dīn al-Ṭabarī
Bauden, Frédéric ULg

in Encyclopédie de l'Islam (1998)

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See detailMuḥibb al-dīn al-Ṭabarī (ob. 694/1295). Un auteur mésestimé ?
Bauden, Frédéric ULg

in Annales Islamologiques (2000), XXXIV

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See detailMujeres, indígenas y el EZLN en 'Lo que está en mi corazón', de Marcela Serrano
Vanden Berghe, Kristine ULg

in Contribuciones desde Coatepec (2009), 17

This contribution presents an analysis of the novel Lo que está en mi corazón (2001), written by the Chilean author Marcela Serrano. After presenting the story and the feminine themes in it, we analyse ... [more ▼]

This contribution presents an analysis of the novel Lo que está en mi corazón (2001), written by the Chilean author Marcela Serrano. After presenting the story and the feminine themes in it, we analyse the images of the indigenous population in Chiapas. This theme allows us to link the portrayal of the feminine characters to the literary construction of the Zapatista Army of National Liberation [less ▲]

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See detailMujinga ou la soumission inconsciente à l’idéologie régnante
Vanhaegendoren, Koen ULg

in Congo-Meuse. Revue des lettres belges et congolaises de langue française (2000), 4-5

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See detailMullite coatings on ceramic substrates: Stabilisation of Al2O3-SiO2 suspensions for spray drying of composite granules suitable for reactive plasma spraying
Schrijnemakers, Audrey ULg; Andre, Sophie; Lumay, Geoffroy ULg et al

in Journal of the European Ceramic Society (2009), 29(11), 2169-2175

The present work deals with the preparation of stable alumina + silica suspensions with high solid loading for the production of spray-dried composite powders. These composite powders are to be used for ... [more ▼]

The present work deals with the preparation of stable alumina + silica suspensions with high solid loading for the production of spray-dried composite powders. These composite powders are to be used for reactive plasma spraying whereby the formation of mullite and the coating on a ceramic substrate are achieved in a single step process. Electrostatic stabilisation of alumina and silica suspensions has been studied as a function of pH. Silica suspensions are most stable at basic pH whereas alumina suspensions are stable at acidic pH. The addition of ammonium polymethacrylate (APMA) makes it possible to stabilise alumina and prepare a stable 50 wt% alumina + silica suspension at pH 10. The optimum amounts of dispersant and binder have been determined by zeta potential, viscosity and sedimentation measurements. Spray drying of the suspension yields composite powders whose morphology, size distribution and flowability have been characterized before realizing reactive plasma spraying tests. (C) 2009 Elsevier Ltd. All fights reserved. [less ▲]

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See detailMullite plasma spraying for in situ repair of cracks in mullite refractories: Simultaneous optimization of porosity and thickness by statistical design of experiments
Schrijnemakers, Audrey ULg; Francq, B. G.; Cloots, Rudi ULg et al

in Journal of Thermal Spray Technology (2013), 22(7), 1133-1139

We report a laboratory-scale study about the suitability of the plasma spraying process for "in situ" repair of cracks in mullite refractories of industrial furnaces. The "design of experiments" approach ... [more ▼]

We report a laboratory-scale study about the suitability of the plasma spraying process for "in situ" repair of cracks in mullite refractories of industrial furnaces. The "design of experiments" approach is used to investigate how the coating porosity and thickness are influenced by six experimental parameters. Arc current, secondary gas (H 2) flow rate, and stand-off distance are the most significant parameters for both responses. Several interaction terms also affect significantly the thickness response. The validity of the model equations is discussed both from a statistical point of view and regarding the physical credibility of the main model terms. Additional experiments confirm that the measured properties lie into the prediction intervals provided by the model. Using a set of parameters optimized for minimal porosity and high thickness (relevant for the crack repair application), coatings with 6% porosity and 1070 μm thickness can be prepared reproducibly. © 2013 ASM International. [less ▲]

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See detailLe mulot de îles d'Hyères: un cas de gigantisme insulaire
Libois, Roland ULg

in Vie et milieu (1990), 40(2-3), 217-222

A sample of woodmice caught on the Porquerolles island, 2 km off the French coast (Var), has been studied and compared with other ones collected in Corsica and on the mainland. Some yellow-necked wood mie ... [more ▼]

A sample of woodmice caught on the Porquerolles island, 2 km off the French coast (Var), has been studied and compared with other ones collected in Corsica and on the mainland. Some yellow-necked wood mie (A. flavicollis) from Belgium are also included in the comparisons. Sixteen biometrical characters were measured on each wood mouse skull and statistical analyses performed: ANOVA, Student t-test and principal composent analysis. A. sylvaticus are all significantly smaller than the Porquerolles island wood mouse, nearly for all the tested variables. In fact, the size of the Porquerolles island wood mouse is quite comparable to that of the yellow-necked wood mouse. The masticatory system of the Porquerolles island wood mouse is nevertheless more developed than in the yellow-necked, making these forms clearly distinct from each other. Gigantism may be an evolutionary trend developed in response to the depletion of the predator/competitor on the island. [less ▲]

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See detailMultatuli in Frankrijk. Van anarchist tot altermondialist
Andringa, Kim ULg

in Over Multatuli (2007)

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