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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Transplant International (2015, November), 28(S4), 1027

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Methods: 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5–3 9 106/kg third party MSC on post-operative day 3 ` 2. These patients were prospectively compared to a group of 10 control liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. This study is in part supported by an ESOT Senior Clinical Research Grant and by the University of Liege. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 29

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Patients & Methods: Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post-operative day 3±2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detailInfusion of third-party mesenchymal stromal cells after liver transplantation: a phase 1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

Poster (2015, March 27)

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases ... [more ▼]

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases. Mesenchymal stromal cells (MSC) are multipotent and self-renewing bone marrow progenitors that have been shown both in vitro and in vivo as capable of (i) immunomodulation, (ii) anti-inflammation in case of ischemia/reperfusion injury, and (ii) stimulation of tissue repair. MSC could therefore be very interesting in organ recipients to limit chronic graft damage and to allow tolerance. This study aimed to be the first clinical evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled, phase I study. Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post- operative day 3 ± 2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. This phase I study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detail«‘Ingegno’, ‘giudizio’, ‘ambizione’. Ritratti di aristocratici fiorentini nelle Storie Fiorentine e nella Storia d'Italia»
Moreno, Paola ULg

in Moreno, Paola; Palumbo, Giovanni (Eds.) Francesco Guicciardini. Tra ragione e inquietudine. Actes du Colloque international. (2005)

Detailed reference viewed: 39 (5 ULg)
See detailIngénierie de formation en enseignement des langues
Lucchini, Silvia ULg

Scientific conference (2011)

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See detailIngénierie des ambiances urbaines: développement d'un dispositif pédagogique mixant approche numérique et créativité
Nguyen, Ngoc Luan ULg; Reiter, Sigrid ULg

Poster (2016)

Le présent poster décrit le dispositif pédagogique mis en œuvre pour accompagner les étudiants dans la conception et l’évaluation d’ambiances urbaines grâce à la combinaison d’un apprentissage par projet ... [more ▼]

Le présent poster décrit le dispositif pédagogique mis en œuvre pour accompagner les étudiants dans la conception et l’évaluation d’ambiances urbaines grâce à la combinaison d’un apprentissage par projet et de la modélisation numérique des projets développés à l’échelle du quartier. Cette activité de formation répond aux sept critères essentiels d’une situation-problème en apprentissage par projet. Ce poster résume l’expérience accumulée dans l’application de ce dispositif pédagogique innovant. [less ▲]

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See detailIngénierie des matériaux métalliques: Solidification des métaux et alliages - Traitement thermique
Lecomte-Beckers, Jacqueline ULg

Learning material (2008)

Solidification des métaux et alliages. Traitements thermiques et thermomécaniques des métaux et alliages. Corrosion des métaux. Traitements de surface.

Detailed reference viewed: 43 (0 ULg)
See detailIngéniérie des projets d'investissement
Corhay, Albert ULg; Mbangala, Mapapa ULg

Book published by Les Editions de l'Université de Liège (2010)

La décision d'investir naît de la nécessité ou de l'intérêt à réaliser un investissement. Ce dernier exige que l'investisseur prenne des décisions stratégiques qui engagent le projet pour de longues ... [more ▼]

La décision d'investir naît de la nécessité ou de l'intérêt à réaliser un investissement. Ce dernier exige que l'investisseur prenne des décisions stratégiques qui engagent le projet pour de longues périodes en mobilisant des ressources considérables de manière irréversible. Cela veut dire que lorsqu'un « porteur de projet » réalise un investissement, il renonce aujourd'hui à des ressources qui, investies dans un projet, devraient générer des gains futurs. Dans ce contexte, un investissement ne sera entrepris que si l'espérance des gains futurs est supérieure à l'investissement initial. Etant donné l'incertitude qui entoure les flux futurs et le nombre élevé des risques et d'obstacles liés au lancement d'une activité nouvelle, il est fortement recommandé de procéder à une évaluation financière des projets d'investissement. Cette étape revêt une grande importance puisqu'elle permet d'éclairer les décideurs sur les perspectives de rentabilité financière. Malheureusement, beaucoup de débutants la négligent avec des conséquences regrettables telles que l'abandon d'activités ou le dépôt de bilan, par exemple. Pourtant, il ressort de diverses études effectuées sur l'esprit d'entreprise qu'un entrepreneur bien préparé aura plus de chance de réussir que celui qui s'improvise. En somme, une bonne préparation peut éviter beaucoup d'erreurs et réduire les imprévus. Pour cela, il existe un certain nombre de critères susceptibles d'aider le décideur dans son choix. Parmi ces méthodes, on peut citer la valeur actualisée nette, le taux de rentabilité interne, le délai de récupération, etc. Ces méthodes ne constituent pas des remèdes miracles et doivent être utilement intégrées dans la stratégie globale du projet. Qui plus est, l'aboutissement heureux de tout projet d'investissement doit toujours être compris comme le résultat d'un « construit » par rapport à une situation de référence car il dépend de plusieurs facteurs dont notamment les motivations et les objectifs de l'investisseur, le secteur d'activité du projet, l'environnement dans lequel le projet s'inscrit, etc. Outre le projet d'investissement productif, on peut être amené à investir dans un actif financier (actions, obligations, contrats dérivés, ...). En effet, l'évolution économique de ces dernières années a fortement contribué au développement et à la popularité des marchés financiers et plusieurs investisseurs (particuliers, institutions, gouvernements) y recourent abondamment pour le placement des épargnes et de couverture des risques. Tout investisseur rationnel se doit de choisir le portefeuille de risque minimum pour un niveau de rendement espéré. Ce choix est lié au concept de la diversification qui consiste simplement pour un investisseur à ne pas investir tout dans un seul titre, mais à répartir ses investissements sur plusieurs titres, ce qui lui permet d'atteindre un meilleur rapport rendement/risque. Le modèle d'évaluation des actifs financiers fournit une estimation de valeur théorique d'un actif financier. [less ▲]

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See detailIngéniérie entre recherche et formation
Job, Pierre; Schneider-Gilot, Marguerite ULg

in Education et Didactique (in press)

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See detailIngénierie génétique d'une β2-intégrine LFA-1 bovine résistante à la leucotoxine de Mannheimia haemolytica
Fett, Thomas ULg

Doctoral thesis (2012)

Domesticated bovines are known since decades to be prone to bacterial pneumonias. Among the causative agents, a consensus emerged stating that Mannheimia haemolytica is the most frequent bacterium ... [more ▼]

Domesticated bovines are known since decades to be prone to bacterial pneumonias. Among the causative agents, a consensus emerged stating that Mannheimia haemolytica is the most frequent bacterium isolated from bovine lungs throughout the world. Moreover, it appeared that its virulence specifically targets ruminant lungs in vivo and ruminant leucocytes in vitro. When the thesis was started, the two main actors underlying this species-specific virulence were known: the leukotoxin (LKT) on the pathogen side and the beta2-integrin LFA-1 on the host side. The objective of the thesis was to contribute to the understanding of the LKT/LFA 1 interaction at the molecular level. Using a between-species perspective, we showed that (i) the CD11a subunit of the LFA-1 heterodimer was not involved in the LKT-specificity for ruminant LFA-1, (ii) the EGF-3 module within the CD18 controls the susceptibility of any given CD18 to LKT and (iii) a non cleavable signal peptide conjugated to a LKT susceptible EGF-3-containing CD18 exacerbates LKT pronecrotic effects. [less ▲]

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See detailIngenierie genetique. Strategie et perspectives en agronomie.
Portetelle, Daniel ULg; Burny, A.; Hilger, F.

Book (1981)

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See detailL'ingénierie patrimoniale dans les relations franco-belges : perspective de droit international privé belge
Wautelet, Patrick ULg

in Derème, François (Ed.) Ingénierie patrimoniale. Questions particulières dans un contexte franco-belge (2009)

In this paper I review the possibilities offered by private international rules in force both in Belgium and in France for three selected tools of estate planning : the marriage contract, gift and ... [more ▼]

In this paper I review the possibilities offered by private international rules in force both in Belgium and in France for three selected tools of estate planning : the marriage contract, gift and donation and wills. The purpose is to examine how much freedom the legal framework in place in the two countries offers to private individuals. Specific attention is devoted to the issue of recognition in one country of acts (such as marriage contracts) drafted in the other country. [less ▲]

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See detailL'ingénierie patrimoniale dans les relations franco-belges : perspectives de droit international privé belge
Wautelet, Patrick ULg

in Dereme, François (Ed.) Ingénierie patrimonial. Questions particulières dans un contexte franco-belge (2013)

Cette contribution s'attache aux questions de droit international privé qui peuvent intéresser la pratique des relations patrimoniales franco-belges. Elle présente succinctement les lignes de force de la ... [more ▼]

Cette contribution s'attache aux questions de droit international privé qui peuvent intéresser la pratique des relations patrimoniales franco-belges. Elle présente succinctement les lignes de force de la réglementation de droit international privé dans les principales branches susceptibles d'intéresser le praticien. L'optique étant celle de la planification successorale, la contribution met l'accent sur l'espace de liberté dont disposent les parties. Plus précisément, la question qui fera figure de fil rouge est celle de savoir quelle marge de manœuvre le droit international privé accorde aux parties qui envisagent l'une ou l'autre opération patrimoniale. Cette question est abordée à propos de trois grands moments de la vie : le mariage et les relations qui y sont assimilées, le décès et les libéralités à cause de vif. [less ▲]

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See detailUne ingénierie pour l’étude de la proportionnalité par confrontation à la non-proportionnalité via des manipulations
Lambrecht, Pauline; Henry, Valérie ULg

in Quaderni di Ricerca in didattica (2014), 24(1), 388

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See detailIngenierie tissulaire du parenchyme renal : une hypothese therapeutique ?
JOURET, François ULg; Pirson, Yves

in Medecine Sciences : M/S (2008), 24(6-7), 561-3

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See detailL'ingénieur et la résistance au feu en Belgique
Franssen, Jean-Marc ULg

Scientific conference (1998, March 04)

Detailed reference viewed: 9 (1 ULg)