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See detailMembrane-Type 4 Matrix Metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumor vascular architecture
Chabottaux, Vincent; Ricaud, Stéphanie; Host, Lorin et al

in Journal of Cellular & Molecular Medicine (2009)

The present study aims at investigating the mechanism by which MT4-MMP, a membrane-anchored MMP expressed by human breast tumor cells promotes the metastatic dissemination into lung. We applied ... [more ▼]

The present study aims at investigating the mechanism by which MT4-MMP, a membrane-anchored MMP expressed by human breast tumor cells promotes the metastatic dissemination into lung. We applied experimental (intravenous) and spontaneous (subcutaneous) models of lung metastasis using human breast adenocarcinoma MDA-MB-231 cells overexpressing or not MT4-MMP. We found that MT4-MMP does not affect lymph node colonization nor extravasation of cells from the bloodstream, but increases the intravasation step leading to metastasis. Ultrastructural and fluorescent microscopic observations coupled with automatic computer-assisted quantifications revealed that MT4-MMP expression induces blood vessel enlargement and promotes the detachment of mural cells from the vascular tree, thus causing an increased tumor vascular leak. On this basis, we propose that MT4-MMP promotes lung metastasis by disturbing the tumor vessel integrity and thereby facilitating tumor cell intravasation. [less ▲]

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See detailMembrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
Chabottaux, Vincent; Sounni, Nor Eddine ULg; Pennington, C. J. et al

in Cancer Research (2006), 66(10), 5165-5172

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been ... [more ▼]

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-MMP, a glycosylphosphatidylinositol-anchored protease, in breast cancer progression. Interestingly, immunohistochemical analysis shows that MT4-MMP production at protein level is strongly increased in epithelial cancer cells of human breast carcinomas compared with normal epithelial cells. Positive staining for MT4-MMP is also detected in lymph node metastases. In contrast, quantitative reverse transcription-PCR analysis reveals similar MT4-MMP mRNA levels in human breast adenocarcinomas and normal breast tissues. Stable transfection of MT4-MMP cDNA in human breast adenocarcinoma MDA-MB-231 cells does not affect in vitro cell proliferation or invasion but strongly promotes primary tumor growth and associated metastases in RAG-1 immunodeficient mice. We provide for the first time evidence that MT4-MMP overproduction accelerates in vivo tumor growth, induces enlargement of i.t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies. [less ▲]

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See detailMembrane-type matrix metalloproteinase-1 expression at the site of human placentation
Nawrocki, B.; Polette, M. E.; Marchand, V. et al

in Placenta (1996), 17(8), 565-72

Human trophoblast implantation is a highly regulated process of invasion that requires action of proteolytic enzymes to degrade extracellular matrix components of the endometrium. Among these enzymes ... [more ▼]

Human trophoblast implantation is a highly regulated process of invasion that requires action of proteolytic enzymes to degrade extracellular matrix components of the endometrium. Among these enzymes, matrix metalloproteinases (MMPs) seem to be particularly important in this degradative process. We previously showed that gelatinase A is extensively expressed in vivo in the human placenta. A new MMP, MT-MMP-1 (membrane-type matrix metalloproteinase-1), which is thought to activate progelatinase A, has recently been described. In this study, we examined the expression of MT-MMP-1, by immunohistochemistry and in situ hybridization, in human placental bed biopsies taken during the first trimester of gestation. Human first trimester intermediate trophoblasts synthesized MT-MMP-1 mRNAs and the protein. The MT-MMP-1 pattern of distribution in placental beds was similar to that of gelatinase A, suggesting a pivotal role for MT-MMP-1 in placentation, perhaps by activating progelatinase A. [less ▲]

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See detailmembre rebelle
Claes, Hubert; Andrianne, Robert ULg

Book published by Roularta Books (2005)

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See detailMême galvaudé, le terme ‘politique’ ne suggère-t-il pas le pouvoir ?
Grandjean, Geoffrey ULg

Conference given outside the academic context (2012)

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See detailMême le silence a une fin
Claisse, Frédéric ULg

Article for general public (2011)

Detailed reference viewed: 31 (11 ULg)
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See detailMémento de conception mécanique
Debongnie, Jean-François ULg

Book published by DEBONGNIE (JEAN-FRANCOIS) (2013)

Normal numbers. Tolerances. Alloy designation. Antifriction bearings. Journal bearings. Assembling of a shaft and a hub. Bolts. Welds. Riveted joints. Shafts. Fatigue. Hertzian contacts. Wear. Belts ... [more ▼]

Normal numbers. Tolerances. Alloy designation. Antifriction bearings. Journal bearings. Assembling of a shaft and a hub. Bolts. Welds. Riveted joints. Shafts. Fatigue. Hertzian contacts. Wear. Belts. Gearings. Illustrated lexicon. [less ▲]

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See detailMemento of useful tips and tricks for HP50g
Merciadri, Luca ULg

E-print/Working paper (2009)

This document presents a short list of math. important commands on HP50g. There is not much documentation about HP50g on Internet, so it completes the user’s manual.

Detailed reference viewed: 299 (17 ULg)
See detailMémoire
Brédart, Serge ULg; Van der Linden, Martial ULg

in Rondal, Jacques (Ed.) Introduction à la psychologie scientifique (1999)

Detailed reference viewed: 35 (9 ULg)
See detailMémoire à ciel ouvert. Une histoire de l’Espagne : 1931-1981
Molina Marmol, Maïté ULg; Muñoz, Ángeles

Book published by Territoires de la Mémoire (2014)

Detailed reference viewed: 28 (4 ULg)
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See detailMémoire à court terme et pathologies du langage
Poncelet, Martine ULg; Majerus, Steve ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2001), 208

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See detailMémoire à court terme verbale : cause ou conséquence du développement du langage ?
Majerus, Steve ULg; Poncelet, Martine ULg

in Metz-Lutz, M. (Ed.) Développement cognitif et troubles des apprentissages : évaluer, comprendre, rééduquer et prendre en charge (2004)

Detailed reference viewed: 179 (28 ULg)
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See detailMémoire à court terme verbale et développement lexical chez l'enfant normal et l'enfant avec troubles spécifiques du langage
Majerus, Steve ULg; Poncelet, Martine ULg

in Hommet, C. (Ed.) Neuropsychologie de l'enfant et troubles du développement (2005)

Detailed reference viewed: 385 (23 ULg)
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See detailMémoire associative dans le vieillissement normal : Effet de l’unification des associations
Simon, Jessica ULg; Collette, Fabienne ULg; Genon, Sarah ULg et al

in Proceedings of the XIIème Colloque International sur le Vieillissement Cognitif (2012)

Detailed reference viewed: 47 (9 ULg)
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See detailMémoire de concours sur la torsion: rapport de F. Folie
Folie, François ULg

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1879), 2e série, t. 48(12), 594-598

The author summurizes a thesis about the torsion and analyzes the different parts.

Detailed reference viewed: 8 (0 ULg)
See detailLa mémoire de la Révolution française en Belgique. Entre Liège et Wallonie.
Raxhon, Philippe ULg

Book published by Labor (1996)

Detailed reference viewed: 28 (4 ULg)
See detailLa mémoire de travail : une approche neuropsychologique et par imagerie cérébrale
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Thérapie (2000), 55(4), 455-460

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible ... [more ▼]

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible for the storage and processing of the information stored in working memory. Many neuropsychological and functional imagery data are consistent with that formulation of working memory. Moreover, many cognitive tasks have been specifically designed to explore particular aspects of working memory functioning. Taken as a whole, these data confirm that the working memory model remains a useful theoretical framework to explore memory functioning both in normal subjects and in pathological conditions. [less ▲]

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See detailMémoire de travail et administrateur central: conceptions théoriques récentes
Collette, Fabienne ULg

Scientific conference (2006, April)

Detailed reference viewed: 10 (2 ULg)
See detailMémoire de travail et langage
Comblain, Annick ULg

in Rondal, Jean-Adolphe; Seron, Xavier (Eds.) Les troubles du langage. Diagnostic et rééducation (2000)

Detailed reference viewed: 39 (3 ULg)