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See detailLarge review finds no clinically important effect of glucosamine or chondroitin on pain in people with osteoarthritis of the knee or hip but results are questionable and likely due to heterogeneity
Bruyère, Olivier ULg

in Evidence-Based Medicine (2010)

Context Treatment of osteoarthritis with unspecifi c symptomatic agents is not satisfactory and burdened with safety issues. The use of glucosamine and/or chondroitin as diseasemodifying agents is ... [more ▼]

Context Treatment of osteoarthritis with unspecifi c symptomatic agents is not satisfactory and burdened with safety issues. The use of glucosamine and/or chondroitin as diseasemodifying agents is increasingly popular, despite conflicting clinical trial evidence with the many available products. Wandel and colleagues produced a systematic review and a meta-analysis with relatively new statistical methods. [less ▲]

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See detailLarge ring 1,3-bridged 2-azetidinones: experimental and theoretical studies
Urbach, Allan; Dive, Georges ULg; Tinant, Bernard et al

in European Journal of Medicinal Chemistry (2009), 44

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See detailLarge Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease.
Wei, Zhi; Wang, Wei; Bradfield, Jonathan et al

in American Journal of Human Genetics (2013)

We performed risk assessment for Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), by using data from the International IBD Genetics Consortium's ... [more ▼]

We performed risk assessment for Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), by using data from the International IBD Genetics Consortium's Immunochip project. This data set contains ?17,000 CD cases, ?13,000 UC cases, and ?22,000 controls from 15 European countries typed on the Immunochip. This custom chip provides a more comprehensive catalog of the most promising candidate variants by picking up the remaining common variants and certain rare variants that were missed in the first generation of GWAS. Given this unprecedented large sample size and wide variant spectrum, we employed the most recent machine-learning techniques to build optimal predictive models. Our final predictive models achieved areas under the curve (AUCs) of 0.86 and 0.83 for CD and UC, respectively, in an independent evaluation. To our knowledge, this is the best prediction performance ever reported for CD and UC to date. [less ▲]

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See detailLarge scale 2D numerical modelling of reservoirs sedimentation and flushing operations
Dewals, Benjamin ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Proceedings of the 9th International Symposium on River Sedimentation (2004)

The quasi-3D flow solver WOLF has been developed at the University of Liege for almost a decade. It has been used to carry out the simulation of silting processes in large reservoirs and to predict the ... [more ▼]

The quasi-3D flow solver WOLF has been developed at the University of Liege for almost a decade. It has been used to carry out the simulation of silting processes in large reservoirs and to predict the efficiency of flushing operations. Besides briefly depicting the mathematical and numerical model, the present paper demonstrates its applicability on the case of a large hydropower project in India. The silting process of the reservoir has been simulated by means of the quasi-3D flow model with a quasi-steady approach. For simulating flushing events, both the topography changes and their interactions with the flow have been carefully handled in a strongly coupled approach. This narrow coupling has required the development of a suitable upwind numerical scheme. Results are presented with 2D- and 3D-views, completed by cross-sections and curves of the variation of key variables. The numerous observations based on those results lead to a global assessment of the silting mechanism and of the flushing efficiency. [less ▲]

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See detailLarge Scale Correlations of Quasar Polarization Vectors: Hints of Extreme Scale Structures?
Cabanac, R. A.; Hutsemekers, Damien ULg; Sluse, Dominique ULg et al

in Astronomical Polarimetry: Current Status and Future Directions. ASPC 343 (2005, December 01)

A survey measuring quasar polarization vectors has been started in two regions towards the North and South Galactic Poles. Here, we review the discovery of significant correlations of orientations of ... [more ▼]

A survey measuring quasar polarization vectors has been started in two regions towards the North and South Galactic Poles. Here, we review the discovery of significant correlations of orientations of polarization vectors over huge angular distances. We report new results including a larger sample of the quasars confirming the existence of coherent orientations at redshifts z>1. [less ▲]

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See detailLarge scale enzymatic synthesis of ADP-glucose
Zervosen, Astrid ULg; Elling, Lothar

Poster (1997, September 22)

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See detailLarge scale experimental study of piano key weirs
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow ... [more ▼]

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow conditions on such structures. With the goal to fill some of these lacks, a combined experimental and numerical study has been undertaken at the Laboratory of Structures Hydraulics of the University of Liege. This paper presents the goals and the scientific strategy of this research. The first results of experiments being carried out on a large physical model of PKW are also depicted. These experiments lead to characterization of the flow behavior for low heads and enable to highlight the influence of the crest thickness and the outlet slope on the release capacity. [less ▲]

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See detailLarge scale network and restoration of peatbogs and wetlands in Southern Belgium
Dufrêne, Marc ULg; Dierstein, Axelle; Frankard, Philippe et al

Conference (2008)

Detailed reference viewed: 33 (3 ULg)
See detailLarge scale phenotypic analysis of known and unknown yeast genes
Bianchi, M.; Ngo, S.; Vandenbol, Micheline ULg et al

Poster (2000)

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See detailLarge scale phenotypic analysis of known and unknown yeast genes.
Bianchi, M.; Ngo, S.; Vandenbol, Micheline ULg et al

in Last Eurofan Meeting (2000)

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See detailLarge scale phylogenetic patterns of diversification in Bryophytes
Laenen, Benjamin ULg

Doctoral thesis (2013)

Detailed reference viewed: 35 (6 ULg)
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See detailLarge Scale Preparation of [18]Fluoromethoxybenzyl Bromides, Key Precursors for 2-[18F]Fluoro-L-Tyrosine and 6-[18F]Fluoro-L-Dopa
Libert, Lionel ULg; Lemaire, Christian ULg; Wouters, Ludovic ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 292

Detailed reference viewed: 66 (9 ULg)
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See detailLarge Scale Preparation of Purified Exocellular DD-carboxypeptidase-Transpeptidase of Streptomyces Strain R61
Fossati, P.; Saint-Ghislain, M.; Sicard, P. J. et al

in Biotechnology and Bioengineering (1978), 20

The exocellular DD-carboxypeptidase–transpeptidase that Streptomyces R61 excretes during growth has been produced in large fermentation units of 15 m3 total capacity. The yield from 15,000 liter culture ... [more ▼]

The exocellular DD-carboxypeptidase–transpeptidase that Streptomyces R61 excretes during growth has been produced in large fermentation units of 15 m3 total capacity. The yield from 15,000 liter culture filtrate was 1.080 g purified enzyme (92% purity) with a total recovery of 29% and at least a 2000-fold increased specific activity. [less ▲]

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See detailLarge scale production of 13-hydroperoxilinolenic acid using soybean lipoxygenase
Fauconnier, Marie-Laure ULg; Dessart, V.; Marlier, M.

Conference (1996, September 26)

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See detailLarge scale serological detection in Belgium of enzootic bovine leucosis.
Mammerickx, Marc; Otte, J.; Rase, F. et al

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1978), 25

Detailed reference viewed: 10 (0 ULg)
See detailLarge Scale Structural Optimization by Finite Elements
Fleury, Claude ULg

in Atrek, E.; Zienkiewicz, O. C.; Ragsdell, K. M. (Eds.) et al New Directions in Optimum Structural Design (1984)

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See detailLarge scale surface – subsurface hydrological model to assess climate change impacts on groundwater reserves
Goderniaux, Pascal ULg; Brouyère, Serge ULg; Fowler, Hayley J. et al

in Journal of Hydrology (2009), 373

Estimating the impacts of climate change on groundwater represents one of the most difficult challenges faced by water resources specialists. One difficulty is that simplifying the representation of the ... [more ▼]

Estimating the impacts of climate change on groundwater represents one of the most difficult challenges faced by water resources specialists. One difficulty is that simplifying the representation of the hydrological system often leads to discrepancies in projections. This study provides an improved methodology for the estimation of the impacts of climate change on groundwater reserves, where a physically-based surface – subsurface flow model is combined with advanced climate change scenarios for the Geer basin (465 km²), Belgium. Coupled surface–subsurface flow is simulated with the finite element model HydroGeoSphere. The simultaneous solution of surface and subsurface flow equations in HydroGeoSphere, as well as the internal calculation of the actual evapotranspiration as a function of the soil moisture at each node of the defined evaporative zone, improve the representation of interdependent processes like recharge, which is crucial in the context of climate change. More simple models or externally coupled models do not provide the same level of realism. Fully integrated surface – subsurface flow models have recently gained attention, but have not been used in the context of climate change impact studies. Climate change simulations were obtained from 6 regional climate model (RCM) scenarios assuming the SRES A2 emission (medium-high) scenario. These RCM scenarios were downscaled using a quantile mapping bias-correction technique that, rather than applying a correction only to the mean, forces the probability distributions of the control simulations of daily temperature and precipitation to match the observed distributions. The same corrections are then applied to RCM scenarios for the future. Climate change scenarios predict hotter and drier summer and warmer and wetter winters. The combined use of an integrated surface – subsurface modelling approach, a spatial representation of the evapotranspiration processes and sophisticated climate change scenarios improves the model realism and projections of climate change impacts on groundwater reserves. For the climatic scenarios considered, the integrated flow simulations show that significant decreases are expected in the groundwater levels (up to 8 meters) and in the surface water flow rates (between 9% and 33%) by 2080. [less ▲]

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See detailA LARGE STRAIN ELASTO-VISCOPLASTIC NUMERICAL MODEL
Careglio, Claudio; Canales Cardenas, Cristian ULg; Ribero, Melisa et al

in Bustamante, Roger (Ed.) Proceedings of PACAM XIV (2014)

A large strain elasto-viscoplastic Perzyna model was proposed by Ponthot. The resultant numerical model computes the elastic response using an hypoelastic model. A viscoplastic multiplier was proposed ... [more ▼]

A large strain elasto-viscoplastic Perzyna model was proposed by Ponthot. The resultant numerical model computes the elastic response using an hypoelastic model. A viscoplastic multiplier was proposed, then both inviscid (elastoplastic) and elastic limiting cases can be easily recovered. More recently the authors have included this viscoplastic model in a large strain constitutive model based on hyperelasticity and multiplicative decomposition of deformation gradient tensor. In this work a brief summary of both, hypoelastic and hyperelastic based large strain models of viscoplasticity is provided. Large strain examples are simulated in order to test the discussed models. Different parameters of the constitutive model are tested in order to study the sensitivity of the resultant algorithm. From the obtained results can be said that both models show a very good agree and represent very well the characteristic of the viscoplastic constitutive model. [less ▲]

Detailed reference viewed: 39 (16 ULg)