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See detailIdentification of Nonlinear Aeroelastic Systems
Dimitriadis, Grigorios ULg; Cooper, J. E.

in Proceedings of the 1998 International Conference on Noise and Vibration Engineering (1998, September)

The successful identification of nonlinear systems could find uses in many aerospace applications including the validation of finite element models and tracking the stability of aircraft during flight ... [more ▼]

The successful identification of nonlinear systems could find uses in many aerospace applications including the validation of finite element models and tracking the stability of aircraft during flight flutter testing. The effectiveness of existing nonlinear system identification techniques is limited by various factors such as the complexity of the system under investigation and the type of nonlinearities present. In this work, a new approach is introduced that is able to identify multi degree-of-freedom systems featuring any type of nonlinear function, including discontinuous functions. The method is shown to yield accurate identifications of three different simulated aeroelastic systems containing a wide range of structural nonlinearities. [less ▲]

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See detailIdentification of nonlinear frequency responses and bifurcations from experimental data
Noël, Jean-Philippe ULg; Gourc, Etienne ULg; Grappasonni, Chiara ULg et al

in Actes de CFA/VISHNO 2016 (2016, April)

The objective of the paper is to obtain the frequency response curves of nonlinear mechanical systems from broadband testing. The proposed approach consists in coupling an identification method with a ... [more ▼]

The objective of the paper is to obtain the frequency response curves of nonlinear mechanical systems from broadband testing. The proposed approach consists in coupling an identification method with a continuation method. Specifically, the frequency-domain nonlinear subspace identification (FNSI) method is first used to derive an experimental model of the structure in state-space from broadband measurements. The harmonic balance method coupled with arclength continuation then utilizes this experimental model to compute the frequency response curves of the system. The method is demonstrated using a numerical example. [less ▲]

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See detailIdentification of nonlinear modal inter. between elastic continua nonlinear attachments
Geogiadis, F.; Tsakirtzis, S.; Panagopoulos, P. et al

in 1st int. Conf. on Computational Dynaics and Earthquake Eng., Rethymno, 2007 (2007)

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See detailIdentification of nonlinear normal modes of engineering structures under broadband forcing
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Grappasonni, Chiara ULg et al

in Mechanical Systems & Signal Processing (2016)

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under ... [more ▼]

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under broadband forcing. The first step processes acquired input and output data to derive an experimental state-space model of the structure. The second step converts this state-space model into a model in modal space from which NNMs are computed using shooting and pseudo-arclength continuation. The method is demonstrated using noisy synthetic data simulated on a cantilever beam with a hardening-softening nonlinearity at its free end. [less ▲]

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See detailIdentification of nonlinear systems using the restoring force Surface method
Kerschen, Gaëtan ULg

in SEM Annual Conference, Cincinnati, 1999 (1999)

The objective of this paper is to demonstrate the performance of the restoring force surface method in the identification of nonlinear systems. The experimental application of the method has been studied ... [more ▼]

The objective of this paper is to demonstrate the performance of the restoring force surface method in the identification of nonlinear systems. The experimental application of the method has been studied and numerical results on a single degree-of-freedom system are described. [less ▲]

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See detailIdentification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma
Turtoi, Andrei ULg; Musmeci, Davide; Wang, Yinghong et al

in Journal of Proteome Research (2011), 10(9), 4302-13

Pancreas ductal adenocarcinoma (PDAC) remains a deadly malignancy with poor early diagnostic and no effective therapy. Although several proteomic studies have performed comparative analysis between normal ... [more ▼]

Pancreas ductal adenocarcinoma (PDAC) remains a deadly malignancy with poor early diagnostic and no effective therapy. Although several proteomic studies have performed comparative analysis between normal and malignant tissues, there is a lack of clear characterization of proteins that could be of clinical value. Systemically reachable ("potentially accessible") proteins, suitable for imaging technologies and targeted therapies represent a major group of interest. The current study explores potentially accessible proteins overexpressed in PDAC, employing innovative proteomics technologies. In the discovery phase, potentially accessible proteins from fresh human normal and PDAC tissues were ex vivo biotinylated, isolated and identified using 2D-nano-HPLC-MS/MS method. The analysis revealed 422 up-regulated proteins in the tumor, of which 83 (including protein isoforms) were evaluated as potentially accessible. Eleven selected candidates were further confirmed as up-regulated using Western blot and multiple reaction monitoring protein quantification. Of these, transforming growth factor beta-induced (TGFBI), latent transforming growth factor beta binding 2 (LTBP2), and asporin (ASPN) were further investigated by employing large scale immunohistochemistry-based validations. They were found to be significantly expressed in a large group of clinical PDAC samples compared to corresponding normal and inflammatory tissues. In conclusion, TGFBI, LTBP2, and ASPN are novel, overexpressed, and potentially accessible proteins in human PDAC. They bear the potential to be of clinical value for diagnostic and therapeutic applications and merit further studies using in vivo models. [less ▲]

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See detailIdentification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients.
Vits, L.; Beckers, D.; Craen, M. et al

in Clinical Genetics (2006), 70(4), 355-9

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See detailIdentification of novel biological markers of osteoarthritis by proteomic approach
Gharbi, M; DEBERG, Michelle ULg; Dubuc, JE et al

in Osteoarthritis and Cartilage (2009), 17(Suppl 1), 74

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See detailIdentification of novel prolactin releasing peptide receptors of Cyprinus carpio and Salmo salar expressed in the pituitary gland
Romero, A. P.; Montefusco, R.; Lopez, Mauricio et al

in Journal of Experimental Zoology. Part A, Comparative Experimental Biology (2006, February 01), 305A(2), 171

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See detailIdentification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH
Sriranganadane, D.; Waridel, P.; Salamin, K. et al

in Proteomics (2011), 11(22), 4422-4433

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See detailIdentification of odour sources in an industrial park from resident diaries statistics
Nicolas, Jacques ULg; Cors, M.; Romain, Anne-Claude ULg et al

in Atmospheric Environment (2010), 44

A methodology based on social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The ... [more ▼]

A methodology based on social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The studied area covers about 8 km2 and includes13 potential odour emitting facilities. The network involved 44 residents in the survey, among whom 19 were particularly considered for a detailed analysis. The questionnaire aimed at providing an odour rating twice-daily on a 6-level scale together with an odour type. The fact that the response rate corresponding to “no-odour” was high (79%) is particularly discussed. Some tests are proposed to check the plausibility of the answers, the coherence within clusters of residents and the individual performance of respondents to discriminate among odour ratings. The odour rose is presented as an attractive and visual tool, particularly suited in the case of multi-source areas, to map the different odour emissions, to point out the most worrying ones, to identify others creating less annoyance and possibly new unpredicted ones. The resident diary method has proven to be particularly useful, conjointly to other ones, to the case of multi-sources facilities in large areas, when the purpose is the assessment of the long-term evolution of odour annoyance. [less ▲]

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See detailIdentification of orphan G protein-coupled receptors
Vassart, G.; Parmentier, M.; Libert, M. et al

in Clinical Neuropharmacology (1992), 15

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See detailIdentification of patients at high risk for recurrence of sustained ventricular tachycardia after healing of acute myocardial infarction.
Rodriguez, L M; Oyarzun, R; Smeets, J et al

in American Journal of Cardiology (1992), 69(5), 462-4

A prognostic index for nonfatal recurrences of ventricular tachycardia (VT) was developed using a retrospective analysis of a group of 206 patients with sustained monomorphic VT or ventricular ... [more ▼]

A prognostic index for nonfatal recurrences of ventricular tachycardia (VT) was developed using a retrospective analysis of a group of 206 patients with sustained monomorphic VT or ventricular fibrillation (VF) after healing of acute myocardial infarction. 74 patients (36%) (64 with VT and 10 with VF) had recurrences of sustained monomorphic VT during 3.4 +/- 9 years of follow-up. Three clinical variables were selected and weighted by stepwise logistic discriminant analysis of the study group. They were coded as follows: interval of myocardial infarction to arrhythmia (less than 2 months = 1; 2 to 6 months = 2; greater than 6 months = 3), drug therapy with or without sotalol (with = 1, without = 2), and VT or VF as the presenting arrhythmia (VT = 1, VF = 2). The prognostic index was: 3.41 - (0.56 x interval) - (1.94 x therapy) + (0.86 x arrhythmia). This index was validated prospectively in a test group of 158 consecutive patients with VT or VF after healing of acute myocardial infarction. Patients were allocated into different classes with decreasing prognostic index values associated with increasing risk for recurrences of VT. In the test group, 27 of 158 (17%) patients (22 with VT and 5 with VF) had recurrences of VT (follow-up of 2 +/- 2 years). Two risk classes of patients were identified: high risk for recurrences of VT (61%) corresponding to patients with a negative index; and low risk (4%) consisting of those with a positive index. Thus, using O as the cutoff point, the sensitivity, specificity, and positive and negative predictive values were 81, 89, 62 and 96%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailIDENTIFICATION OF PLACENTAL HUMAN GROWTH-HORMONE AS THE GROWTH HORMONE-V GENE-EXPRESSION PRODUCT
Frankenne, Francis ULg; Scippo, Marie-Louise ULg; Van Beeumen, Jos et al

in Journal Of Clinical Endocrinology And Metabolism (1990), 71(1), 15-18

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See detailIdentification of plasma growth hormone binding proteins (GHBPs) in cattle
Devolder, Anne; Renaville, Robert ULg; Massart, Serge et al

Poster (1992)

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See detailIdentification of pollutant gases with a multisensorial arrange.
Negri, Martin; Reich, S.; Fernandez, D. et al

in Weimar, Udo (Ed.) proceedings of ISOEN 99 (1999)

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See detailIdentification of Post-Transplant Anti-Alpha 5 (Iv) Collagen Alloantibodies in X-Linked Alport Syndrome
Dehan, Pierre ULg; Van den Heuvel, L. P.; Smeets, H. J. et al

in Nephrology Dialysis Transplantation (1996), 11(10), 1983-8

X-linked Alport syndrome (AS) is a heritable disorder which is associated with mutations in the type IV collagen alpha 5 (IV) chain gene (COL4A5) located on chromosome X. Following renal transplantation ... [more ▼]

X-linked Alport syndrome (AS) is a heritable disorder which is associated with mutations in the type IV collagen alpha 5 (IV) chain gene (COL4A5) located on chromosome X. Following renal transplantation, an average of 6% of male AS patients develop anti-GBM nephritis. We studied the specificity of the antibodies against type IV collagen in the serum of a patient with COL4A5 partial deletion. The specificity of these alloantibodies was determined against collagenase-digested GBM, as well as against recombinant non-collagenous (NC1) domains of the type IV collagen alpha 1(IV)-alpha 6(IV) chains expressed in escherichia coli. Immunoblotting and ELISA demonstrated that these antibodies bound specifically to the NC1 domain of alpha 5(IV) collagen. There was no binding to the NC1 domain of the other chains, including the Goodpasture antigen. Competitive ELISA confirmed the results obtained by ELISA and immunoblotting. This patient developed alloantibodies directed against antigens present in the grafted kidney, but absent from his Alport kidney. The pathogenesis of post-transplantation glomerulonephritis in the Alport patient studied is thus similar to that of Goodpasture syndrome, with the exception that the pathogenic antibodies are targeted to another alpha chain of type IV collagen. [less ▲]

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