Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation.
MASSION, Paul ; PETERS, Pierre ; LEDOUX, Didier et al
in Intensive Care Medicine (2012), 38(8), 1326-35
PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation ... [more ▼]
PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation for patients with severe sepsis, and time courses of coagulation abnormalities in septic shock are poorly documented. Therefore, the aim of this prospective observational cohort study was to describe the coagulation profile of patients with septic shock and to determine whether alterations of the profile are associated with hospital mortality. METHODS: Thirty-nine patients with septic shock on ICU admission were prospectively included in the study. From admission to day 7, analytical coagulation tests, thrombin generation (TG) assays, and thromboelastometric analyses were performed and tested for association with survival. RESULTS: Patients with septic shock presented on admission prolongation of prothrombin time, activated partial thromboplastin time (aPTT), increased consumption of most procoagulant factors as well as both delay and deficit in TG, all compatible with a hypocoagulable state compared with reference values (P < 0.001). Time courses revealed a persistent hypocoagulability profile in non-survivors as compared with survivors. From multiple logistic regression, prolonged aPTT (P = 0.007) and persistence of TG deficit (P = 0.024) on day 3 were strong predictors of mortality, independently from disease severity scores, disseminated intravascular coagulation score, and standard coagulation tests on admission. CONCLUSIONS: Patients with septic shock present with hypocoagulability at the time of ICU admission. Persistence of hypocoagulability assessed by prolonged aPTT and unresolving deficit in TG on day 3 after onset of septic shock is associated with greater hospital mortality. [less ▲]Detailed reference viewed: 27 (9 ULg)
Persistent infection of thymic epithelial cells with coxsackievirus B4 results in a decreased expression of insulin-like growth factor 2
; ; et al
in Journal of Virology (2012), 86
It has been hypothesized that a disturbance of central self-tolerance to islet β-cell may play a role in the enteroviral pathogenesis of type 1 diabetes. Whether enteroviruses can induce an impaired ... [more ▼]
It has been hypothesized that a disturbance of central self-tolerance to islet β-cell may play a role in the enteroviral pathogenesis of type 1 diabetes. Whether enteroviruses can induce an impaired expression of β-cell self-antigens in thymic epithelial cells has been investigated in a murine thymic epithelial (MTE) cell line. This cell line was permissive to the diabetogenic strain CV-B4 E2 and spontaneously expressed type 2 insulin-like growth factor (Igf2), the dominant self-antigen of the insulin family. In this model, a persistent replication of CV-B4 E2 was obtained as attested by the prolonged detection of intracellular positive and negative-strand viral RNA by RT-PCR, and capsid protein VP1 by IF and by the release of infectious particles in culture supernatant fluids. The chronic stage of the infection was characterized by a low proportion of VP1-positive cells (1-2%) whereas many cells harbored enteroviral RNA as displayed by RT-PCR without extraction applied directly on a few cells. Igf2 mRNA and IGF-2 protein were dramatically decreased in CV-B4 E2-infected MTE cultures compared with mock-infected cultures, whereas housekeeping and Il6 genes expression were maintained and Igf1 mRNA was decreased but at a lower extent. Inoculation of CV-B3-, CV-B4 JVB- or Echovirus 1 resulted in a low level of IGF-2 in culture supernatant fluids as well, whereas HSV-1 stimulated the production of the protein. Thus, a persistent infection of a thymic epithelial cell line with enteroviruses, like CV-B4 E2 can result in a disturbed production of IGF-2, a protein involved in central self-tolerance towards islet β-cells. [less ▲]Detailed reference viewed: 33 (9 ULg)
Persistent Ischemic Mitral Regurgitation After Annuloplasty can be Predicted by Pre-operative Echocardiography.
Magne, Julien ; ; et al
Conference (2006)Detailed reference viewed: 11 (1 ULg)
Persistent organic pollutants and methoxylated PBDEs in harbour porpoises from the North Sea from 1990 until 2008. Young wildlife at risk?
; ; Das, Krishna et al
in Science of the Total Environment (2010), 409
n the European North Sea, harbour porpoises are top predators with relatively long life spans and a limited capacity for metabolic biotransformation of contaminants compared to some other marine mammal ... [more ▼]
n the European North Sea, harbour porpoises are top predators with relatively long life spans and a limited capacity for metabolic biotransformation of contaminants compared to some other marine mammal species. As such, they are exposed to a mixture of persistent pollutants, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), DDT and metabolites (DDXs), hexachlorobenzene (HCB) and chlordanes (CHLs) that bioaccumulate in their tissues. We report here on the levels of persistent organic pollutants and of the naturally-produced methoxylated PBDEs (MeO-PBDEs) in blubber, liver and kidney of harbour porpoise neonates (n = 3), calves (n = 15), juveniles (n = 6) and adults (n = 4) of the southern North Sea. Concentrations of almost all contaminant classes decrease slightly in all age groups over the period 1990–2008. For some classes (e.g. PCBs and DDXs) however, levels seem to increase little in harbour porpoise calves. In all animals, blubber had the highest concentrations, followed by liver and kidney, whereas liver and kidney were the preferred tissues for several compounds, such as octa- and deca-PCBs. Our data suggest that harbour porpoises calves are exposed to higher or comparable concentrations of POPs and of MeO-PBDEs and somewhat different patterns of selected POPs than adults, potentially placing them, and the entire population, at a disproportionate risk for exposure-related health effects. [less ▲]Detailed reference viewed: 14 (6 ULg)
Persistent organic pollutants in wild seabass (Dicentrarchus labrax) from the Northeast atlantic coastal regions and relationship with thyroid hormone levels
Schnitzler, Joseph ; Thomé, Jean-Pierre ; Das, Krishna
Poster (2008, October 30)
Polychlorinated biphenyls (PCBs) and organochlorine pesticides like Dichloro-Diphenyl-Trichloroethane (DDTs), Hexachlorocyclohexanes (HCHs), Aldrin and Dieldrin were analysed in the muscle of sea bass ... [more ▼]
Polychlorinated biphenyls (PCBs) and organochlorine pesticides like Dichloro-Diphenyl-Trichloroethane (DDTs), Hexachlorocyclohexanes (HCHs), Aldrin and Dieldrin were analysed in the muscle of sea bass (Dicentrarchus labrax) sampled in coastal regions near several important European river mouths (Garonne, Charente, Loire, Seine and Scheldt). These organochlorinated compounds are known to influence the endocrine system of many fish species and mammals and are thus qualified as endocrine disrupters. To highlight a potentially harmful effect of these compounds on the thyroid function of these fishes, we measured the muscular concentrations of thyroid hormones T3 and T4 by Radio-Immuno-Assay. The contamination levels were as follows: the highest concentrations were measured in individuals collected from the coastal region near the Scheldt > Seine > Loire > Charente and the lowest levels were observed in sea bass from coastal regions near the Garonne (from 2422 to 6188 ng.g-1 lw). The measured levels were generally higher than those reported in literature in sea bass from other regions in the Mediterranean Sea. Contamination patterns were different depending on the sampling area and thus the river input of pollutants. The multivariate statistical analysis revealed a significant relationship between the measured persistent organic pollutants and thyroid hormones in muscle. We cannot exclude the assumption that an endocrine disruption of the thyroid related to these pollutants could be the origin of these modifications of the thyroid hormone concentrations. [less ▲]Detailed reference viewed: 18 (3 ULg)
Persistent organochlorine pollutants, dioxins and polychlorinated biphenyls
Scippo, Marie-Louise ; Eppe, Gauthier ; Saegerman, Claude et al
in Contaminant and Residue Analysis, Comprehensive Analytical Chemistry of Elsevier (2008)Detailed reference viewed: 114 (31 ULg)
Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ; Beguin, Yves ; Fassotte, Marie-France et al
in Haematologica (2000), 85(6), 613-8
BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]
BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]Detailed reference viewed: 16 (2 ULg)
Persistent varicella-zoster virus infection in the nervous system: in vitro and in vivo models
Sadzot-Delvaux, Catherine ; Merville, Marie-Paule ; et al
in Acta Neurologica Belgica (1988), 88Detailed reference viewed: 10 (0 ULg)
The Person and Justice in Tunisian Souq: A Reflection upon the Linkages Between Justice, Impartiality and Respect for the Person
in DUPRET, Baudouin (Ed.) Standing Trial. Law and the Person in the Modern Middle East (2004)Detailed reference viewed: 12 (0 ULg)
Person familiarity and name-retrieval failures: How they are related ?
in Current Psychology of Cognition [=CPC] = Cahiers de Psychologie Cognitive [=CPC] (1996), 15(1), 113-119Detailed reference viewed: 18 (3 ULg)
Person recognition: Effects of face and voice learning on access to semantic information from names.
Barsics, Catherine ;
Conference (2010, May 28)
Several studies showed that it is more difficult to retrieve semantic information from recognized voices than from recognized faces. However, earlier studies that investigated the recall of biographical ... [more ▼]
Several studies showed that it is more difficult to retrieve semantic information from recognized voices than from recognized faces. However, earlier studies that investigated the recall of biographical information following person recognition used stimuli that were pre-experimentally familiar to the participants, such as famous people’s voices and faces. The present study was designed in order to allow a stricter control of frequency exposure with both types of stimuli (voices and faces). In the present study, subjects had to associate lexical (i.e., name) and semantic information (i.e., occupation) with faces or voices. When asked later to recall semantic information being cued by the person’s names, participants provided significantly more occupations for the targets that had been previously associated with faces than with voices. These results and their implications for current Interactive Activation and Competition person recognition models are discussed. Finally, the potential role of the relative distinctiveness of voices and faces is also considered. [less ▲]Detailed reference viewed: 42 (10 ULg)
Person und Gemeinschaft im Mittelalter. Mélanges Karl Schmid
in Mediävistik (1990)Detailed reference viewed: 2 (0 ULg)
Personal interview on National Radio Kiev (Ukraine) on the occasion of the 35th Conference of the Kommission für Volksdichtung as the first international conference hosted by the Ryslky Institute of Arts, Folklore and Ethnology (Academy of Sciences) since the Orange Revolution
Diverse speeche and writing (2005)Detailed reference viewed: 7 (0 ULg)
Personal Interview on the invitation of Canadian Broadcating Corporation and on the occasion of the issue of Emile Benoît's CD entitled 'Vive la rose'
Diverse speeche and writing (1992)Detailed reference viewed: 2 (0 ULg)
Personality and mental time travel: a differential approach to autonoetic consciousness.
Quoidbach, Jordi ; Hansenne, Michel ;
in Consciousness & Cognition (2008), 17(4), 1082-92
Recent research on autonoetic consciousness indicates that the ability to remember the past and the ability to project oneself into the future are closely related. The purpose of the present study was to ... [more ▼]
Recent research on autonoetic consciousness indicates that the ability to remember the past and the ability to project oneself into the future are closely related. The purpose of the present study was to confirm this proposition by examining whether the relationship observed between personality and episodic memory could be extended to episodic future thinking and, more generally, to investigate the influence of personality traits on self-information processing in the past and in the future. Results show that Neuroticism and Harm Avoidance predict more negative past memories and future projections. Other personality dimensions exhibit a more limited influence on mental time travel (MTT). Therefore, our study provide an additional evidence to the idea that MTT into the past and into the future rely on a common set of processes by which past experiences are used to envision the future. [less ▲]Detailed reference viewed: 131 (36 ULg)
Personality modulation of (un)conscious processing: Novelty seeking and performance following supraliminal and subliminal reward cues
Bustin, Gaëlle ; ; Hansenne, Michel et al
Poster (2012, January)
This study provides evidence that personality traits associated with responsiveness to conscious reward cues also influence responsiveness to unconscious reward cues. Participants with low and high levels ... [more ▼]
This study provides evidence that personality traits associated with responsiveness to conscious reward cues also influence responsiveness to unconscious reward cues. Participants with low and high levels of Novelty Seeking (NS) performed updating tasks in which they could either gain 1 euro or 5 cents. Gains were presented either supraliminally or subliminally at the beginning of each trial. Results showed that low NS participants performed better in the high-reward than in the low-reward condition, whereas high NS participants’ performance did not differ between reward conditions. Interestingly, we found that low NS participants performed significantly better when rewards were presented unconsciously, whereas high NS participants’ performance did not differ whether reward cues were presented subliminally or supraliminally. Our findings highlight the necessity to take personality into account in unconscious cognition research. They also suggest that whether implicit and explicit motives have similar or complementary influences might be determined by individual differences. [less ▲]Detailed reference viewed: 41 (10 ULg)
Personality modulation of P300 wave recorded within an emotional oddball protocol.
; Hansenne, Michel
in Neurophysiologie Clinique = Clinical Neurophysiology (2009), 39(1), 41-8
OBJECTIVES: Several studies reported that personality modulates responses to emotional stimuli, including cognitive and attentional aspects of the emotional response. The aim of this study was to refine ... [more ▼]
OBJECTIVES: Several studies reported that personality modulates responses to emotional stimuli, including cognitive and attentional aspects of the emotional response. The aim of this study was to refine these results while using visual event-related potentials (ERPs) and referring to Cloninger's personality model. METHODS: ERPs were recorded in 46 normal subjects within a visual oddball protocol with checkerboards as the standard stimuli and pictures selected as neutral, pleasant or unpleasant from the International Affective Picture System as the target stimuli. RESULTS: N200 amplitude was smaller and P300 amplitude was larger following the presentation of pleasant pictures in low-harm avoidance but not high-harm avoidance subjects. CONCLUSIONS: These results support the idea that both automatic and selective cognitive processing of emotional pictures is modulated by personality. [less ▲]Detailed reference viewed: 46 (4 ULg)
Personality profile and drug of choice; a multivariate analysis using Cloninger's TCI on heroin addicts, alcoholics, and a random population group.
; ; et al
in Drug and Alcohol Dependence (2004), 73(2), 175-82
As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of ... [more ▼]
As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of choice may help screen future patients before drug consumption. The present study compared three groups: 42 patients with heroin dependence (mean age: 31.2; standard deviation (SD): 5.5; 10 females), 37 patients with alcohol dependence (mean age 44.2; SD: 9.1; 9 females) and 83 subjects from a random population sample (mean age: 38.8; SD: 6.9; 20 females). Personality was measured by Cloninger's Temperament and Character Inventory (TCI). Pillai's MANCOVA with age as a covariate and gender as a cofactor was highly significant. Univariate ANOVA analyses using TCI dimensions as dependent variable showed most variables to vary in parallel for the two patient groups in comparison with controls. Post-hoc tests showed heroin patients to score higher in Novelty-Seeking and Self-Directedness than alcohol patients. Sub-dimensions Exploratory Excitability, Fear of the Uncertain, Responsibility, Congruent Second Nature and Transpersonal Identification were also significantly different in the two patient samples. Logistic regression showed Exploratory Excitability to segregate up to 76% of heroin patients from alcohol patients. In conclusion, personality profiles were linked to some preferential choice of drug and personality screening might be tested in preventive strategies. [less ▲]Detailed reference viewed: 66 (11 ULg)