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See detailIl n'est jamais trop tard pour apprendre à (bien) lire ...
Bruyère, Olivier ULg

in Medi-Sphere (2013), 421

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See detailIl n'est jamais trop tard pour apprendre à (bien) lire ... La revue systématique
Beaudart, Charlotte ULg; Rabenda, Véronique ULg; Bruyère, Olivier ULg

in Ortho-Rhumato (2016), 14(6), 37-40

La revue systématique est généralement utilisée pour synthétiser les résultats de plusieurs études traitant d’un même sujet. Son intérêt est donc grand, particulièrement depuis ces dernières années où le ... [more ▼]

La revue systématique est généralement utilisée pour synthétiser les résultats de plusieurs études traitant d’un même sujet. Son intérêt est donc grand, particulièrement depuis ces dernières années où le nombre d’articles scientifiques publiés dans la littérature explose! La revue systématique est considérée comme une étude de haut niveau de preuve scientifique. En effet, elle se retrouve au sommet de la pyramide de l’evidence-based medicine. Elle est donc, lorsqu’elle est de qualité, d’un niveau de preuve supérieur aux études randomisées contrôlées, aux études de cohortes, aux études cas-témoins… [less ▲]

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See detailIl n'existe aucun traitement efficace de l'alcoolisme?
Blairy, Sylvie ULg; Pinto, Emmanuel ULg

in Seutin, Vincent; Scuvée-Moreau, Jacqueline; Quertemont, Etienne (Eds.) L'alcool en questions (2015)

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See detailIl n'existe aucun traitement efficace de l'alcoolisme?
Blairy, Sylvie ULg; Pinto, Emmanuel ULg

in Seutin, Vincent; Scuvée-Moreau, Jacqueline; Quertemont, Etienne (Eds.) L'alcool en questions (2015)

Detailed reference viewed: 44 (7 ULg)
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See detailIl ne suffit pas de lire les étiquettes, mais bien de discuter avec le producteur
Ozer, Pierre ULg

Article for general public (2014)

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See detail"Il vaut mieux prévenir que guérir", l'adage s'applique également aux plantes
Massart, Sébastien ULg

Article for general public (2017)

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See detailIl y a 250 ans paraissait "l'Homme machine". La Mettrie (1709-1753). Les origines du materialisme medical
Limet, Raymond ULg

in Revue Médicale de Liège (2000), 55(7), 740-4

Some 250 years ago, the publication of "L'Homme machine" established the fact that human body and brain functioning was to be approached by human study just as like as physics or chemistry.

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See detailIl y a 40 ans, une comète liégeoise
Manfroid, Jean ULg

Article for general public (2012)

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See detailIl y a cent ans, la « Lettre au Roi » de Jules Destrée
Lanneau, Catherine ULg

Article for general public (2012)

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See detailIl y a d’autres voies pour obtenir des produits animaux
Bindelle, Jérôme ULg; Hornick, Jean-Luc ULg

in Ellies, Marie-Pierre (Ed.) Les filières animales françaises (2014)

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See detailIl y a eu des révolutions avant Twitter et Facebook. Entretien avec François Colmant
Colmant, François ULg

in Wendy Bashi (Ed.) Politique, revue de débats (2012)

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See detailIl y a urgence!
Boularbah, Hakim ULg; Closset-Marchal, Gilberte; de Leval, Georges ULg et al

in Journal des Tribunaux (2009)

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See detailThe IL-10 homologue encoded by cyprinid herpesvirus 3 is essential neither for viral replication in vitro nor for virulence in vivo
Ouyang, Ping ULg; Rakus, Krzysztof ULg; Boutier, Maxime ULg et al

in Veterinary Research (2013)

Cyprinid herpesvirus 3 (CyHV-3), a member of the family Alloherpesviridae, is the causative agent of a lethal disease in common and koi carp. CyHV-3 ORF134 encodes an interleukin-10 (IL-10) homologue. The ... [more ▼]

Cyprinid herpesvirus 3 (CyHV-3), a member of the family Alloherpesviridae, is the causative agent of a lethal disease in common and koi carp. CyHV-3 ORF134 encodes an interleukin-10 (IL-10) homologue. The present study was devoted to this ORF. Transcriptomic analyses revealed that ORF134 is expressed as a spliced gene belonging to the early-late class. Proteomic analyses of CyHV-3 infected cell supernatant demonstrated that the ORF134 expression product is one of the most abundant proteins of the CyHV-3 secretome. To investigate the role of ORF134 in viral replication in vitro and in virulence in vivo, a deleted strain and a derived revertant strain were produced using BAC cloning technologies. The recombinant ORF134 deleted strain replicated in vitro comparably to the parental and the revertant strains. Infection of fish by immersion in water containing the virus induced comparable CyHV-3 disease for the three virus genotypes tested (wild type, deleted and revertant). Quantification of viral DNA by real time TaqMan PCR (in the gills and the kidney) and analysis of carp cytokine expression (in the spleen) by RT-qPCR at different times post-infection did not revealed any significant difference between the groups of fish infected with the three virus genotypes. Similarly, histological examination of the gills and the kidney of infected fish revealed no significant differences between fish infected with ORF134 deleted virus versus fish infected with the control parental or revertant strains. All together, the results of the present study demonstrate that the IL-10 homologue encoded by CyHV-3 is essential neither for viral replication in vitro nor for virulence in common carp. [less ▲]

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See detailIL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis.
Humblet-Baron, Stephanie; Franckaert, Dean; Dooley, James et al

in Journal of Allergy and Clinical Immunology (The) (2016), 138(1), 200-2098

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic ... [more ▼]

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic lymphohistiocytosis (FHL) forms. In both conditions, a sterile or infectious trigger is required for disease initiation, which then becomes self-sustaining and life-threatening. Recent studies have attributed the key distal event to excessive IFN-gamma production; however, the proximal events driving immune dysregulation have remained undefined. OBJECTIVE: We sought to investigate the role of regulatory T (Treg) cells in the pathophysiology of experimental FHL. METHODS: Because mutation in perforin is a common cause of FHL, we used an experimental FHL mouse model in which disease in perforin-deficient mice is triggered by lymphocytic choriomeningitis virus (LCMV). We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing systemic conditions in the mice. In addition, human blood samples were collected and analyzed during the HLH episode. RESULTS: We found no primary Treg cell defects in perforin-deficient mice. However, Treg cell numbers collapsed after LCMV inoculation. The collapse of Treg cell numbers in LCMV-triggered perforin-deficient, but not wild-type, mice was accompanied by the combination of lower IL-2 secretion by conventional CD4(+) T cells, increased IL-2 consumption by activated CD8(+) T cells, and secretion of competitive soluble CD25. Moreover low Treg cell numbers were observed in untreated patients experiencing HLH flares. CONCLUSION: These results demonstrate that excessive CD8(+) T-cell activation rewires the IL-2 homeostatic network away from Treg cell maintenance and toward feed-forward inflammation. These results also provide a potential mechanistic pathway for the progression of infectious inflammation to persistent inflammation in patients with HLH. [less ▲]

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