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See detailIgE-mediated anaphylaxis after first intravenous infusion of cyclosporine.
Ebo, D. G.; Piel, Géraldine ULg; Conraads, V. et al

in Annals of Allergy, Asthma & Immunology (2001), 87(3), 243-5

BACKGROUND: Intravenous administration of cyclosporine, which contains Cremophor EL (a polyethoxylated castor oil; BASF, Berlin, Germany), has occasionally resulted in an anaphylactic reaction. An ... [more ▼]

BACKGROUND: Intravenous administration of cyclosporine, which contains Cremophor EL (a polyethoxylated castor oil; BASF, Berlin, Germany), has occasionally resulted in an anaphylactic reaction. An apparent hypersensitivity reaction (bronchospasm and decrease in blood pressure) had occurred during heart transplantation in a 59-year-old woman after intravenous infusion of cyclosporine. Subsequent oral administration of cyclosporine precipitated no reaction. OBJECTIVE: The purpose of this study was to attempt to ascertain the mechanism responsible for the anaphylactic reaction. METHODS: Hypersensitivity investigations, including total serum IgE and allergen-specific IgE quantifications, skin testing, and basophil activation tests by flow cytometric determination of CD63 upregulation were undertaken in the study patient and in two healthy control subjects who were free of medication. RESULTS: The results of intradermal testing with Cremophor EL were positive after 15 minutes in the study patient only. Both cyclosporine and Cremophor EL induced considerable activation of the basophils from our study patient, with an upregulation of CD63 expression from 1% to 39% and 55%, respectively. In contrast, the expression of CD63 on basophils from the two control subjects remained essentially unchanged. CONCLUSIONS: The negative investigative findings in the control subjects, the patient's clinical manifestations in temporal relationship to the infusion, her positive results on intradermal testing with Cremophor, the basophil activation test results, and her uneventful course after oral administration of cyclosporine strongly support the presence of IgE antibodies to Cremophor EL in our patient. [less ▲]

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See detailThe IGF system in in-vitro human decidualization
Ganeff, Corinne ULg; Chatel, G.; Munaut, Carine ULg et al

in Molecular Human Reproduction (2009), 15(1), 27-38

Decidualization of endometrial stromal cells (ESCs) is critical for a successful pregnancy but the molecular mechanisms of the process are poorly understood. In this study, we investigated whether the ... [more ▼]

Decidualization of endometrial stromal cells (ESCs) is critical for a successful pregnancy but the molecular mechanisms of the process are poorly understood. In this study, we investigated whether the insulin-like growth factor (IGF) network is involved in this cellular process. Expression kinetics of members of the IGF system was examined at both mRNA and protein levels during in-vitro decidualization of cultured human ESCs. We found a significant up-regulation of IGF-II as well as of IGF-I receptor and the A and B insulin receptor (InsR) isoforms. In addition, levels of the key adaptor proteins insulin receptor substrate 1 (IRS-1) and IRS-2 increased, suggesting a potential involvement of the IGF signalling pathway in the decidualization process. Expression of two IGF binding proteins, IGFBP-1 and IGFBP-4, which can inhibit IGF action, also increased. In order to determine whether IGF signalling was activated during decidualization, the phosphorylation status of the receptors and the adaptor proteins was estimated. Only IRS-2 was slightly phosphorylated in decidualized cells and was further activated by the addition of exogenous IGF-II. These results suggest that the IGF signalling pathway could play a crucial role in the functions of decidualized endometrial cells [less ▲]

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See detailIGF-1 but not IL-1bêta effects on the proteoglycan production by chondrocytes are regulated by strontium salts
Henrotin, Yves ULg; Labasse, A; Zheng, X et al

in Osteoarthritis and Cartilage (1997), 5

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See detailIGF-I and IGFBP-3 increase independently of testosterone release during the onset of puberty in cattle
Renaville, Robert ULg; Sneyers, Myriam; Massart, Serge et al

in Growth Regulation (1994), 4(suppl 1), 116

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See detailIGF-I and IGFBP-3 increase independently of testosterone release during the onset of puberty in cattle.
Renaville, Robert ULg; Sneyers, Myriam; Massart, Serge et al

Poster (1994)

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See detailIGF-I and IGFBPs in plasma of growing Landrace and large withe pigs.
Messina, M.; Prandi, A.; Nicolas, Nathalie et al

in Proceedings of the 14th IPVS Congress (1996, July)

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See detailIGF-I and IGFBPs in plasma of growing Landrace and Largewhite pigs
Messina, Maria; Prandi, Alberto; Kettmann, Richard ULg et al

in 14th International Pig Veterinary Society Congress (1995)

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See detailIGF-I and their binding proteins in growing horses
Gerin, Daniele; Messina, Maria; Renaville, Robert ULg et al

in 3° Internat. Conf. farm Anim. Endocrinol. (1998)

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See detailIGF-I and their binding proteins in growing horses.
Gerin, Daniele; Messina, Mariella; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 34

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See detailIGF-I, IGFBP-2 and IGFBP-3 but not GH consentrations are different in normal and poor growing piglets
Saleri, Roberta; Baratta, Mario; Mainardi, G. L. et al

in Reproduction Nutrition Development (2001), 41

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See detailIGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement.
Winkler, Rose ULg; Delacroix, Laurence ULg; Bensbaho, K. et al

in Hormone & Metabolic Research (1999), 31(2-3), 148-54

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary ... [more ▼]

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary human colon cancers. Here we show that the IGF-II peptide content is increased in six primary colon cancers compared to the corresponding healthy tissues. The IGF-II transcripts in healthy and cancerous colon tissues were identified by Northern blotting and RT-PCR. Promoters P3 and P4 were active in most tissues. Relaxation of parental imprinting was observed in two tumors and one healthy tissue, without any correlation with the IGF-II transcript levels. Rearrangements of the IGF-II gene in two tumors containing very high amounts of IGF-II mRNA are described. Fragments containing the breakpoints were cloned by the vectorette-PCR strategy. In both tumors, the breakpoints occurred in repetitive sequences. In one tumor (T11), the breakpoint was localized 2 kb downstream the end of exon 9. The second tumor (T18) contains two modified alleles. In one rearranged allele the breakpoint is located in exon 9. The exact position of the breakpoint in the second rearranged allele has not been identified. In future experiments, the correlation between the gene rearrangements and IGF-II mRNA overexpression will be studied. [less ▲]

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See detailIgf2 expression is required for complete immunological tolerance to insulin
Hansenne, Isabelle; Renard, Chantal; Geenen, Vincent ULg

Poster (2007, July)

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See detailIgG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68.
Rosa, Gustavo T; Gillet, Laurent ULg; Smith, Christopher M et al

in PLoS ONE (2007), 2(6), 560

BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question ... [more ▼]

BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor(+) cells. PRINCIPAL FINDINGS: Immune sera blocked murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged, but the infection was not abortive and new virus production soon overwhelmed infected cultures. Lytically infected macrophages down-regulated MHC class I-restricted antigen presentation, endocytosis and their response to LPS. CONCLUSIONS: IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68. [less ▲]

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See detailIgG4-related disease causing rapid evolution of a severe aortic valvular stenosis
BRULS, Samuel ULg; Courtois, Audrey ULg; DELVENNE, Philippe ULg et al

in The Annals of Thoracic Surgery (2016)

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See detailLa Iglesia católica y los movimienos feministas en Bélgica
Henneau, Marie-Elisabeth ULg

in Famerée, Joseph (Ed.) Misión y lugar de las mujeres en las Iglesias (2011)

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See detailIgneous charnockites and related rocks from the Bjerkreim-Sogndal layered intrusion (Southwest Norway): a jotunite (hypersthene monzodiorite)-derived A-type granitoid suite
Duchesne, Jean-Clair ULg; Wilmart, Edith

in Journal of Petrology (1997), 38(3), 337-369

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and ... [more ▼]

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and geochemistry (major and trace elements) of 8 main rock types (88 samples) are considered. The rocks form a suite of K2O-rich alkali-calcic granitoids of A-type, deriving from jotunitic magma. Two trends of inferred liquids are distinguished: the main liquid line of descent which passes from jotunites through 2-pyroxene quartz mangerites to amphibole charnockites, the second one which encompasses olivine-bearing quartz mangerites and charnockites and is rooted into mangeritic liquids. Comparison with the Tellnes rock series reveals that contamination by leucogranitic material has taken place simultaneously with fractional crystallization in both BKSK trends. Zr, Rb, Cs, and Th are particularly sensitive to assimilation and the higher water content in BKSK. Zircon and apatite have saturated at the liquidus of quartz mangerite around 900°C, close to the FMQ buffer. The two-pyroxene quartz mangerites cannot have been equilibrated with the mangerite cumulates on which they rest. A major influx of magma took place when mangeritic cumulates were being deposited. It mingled and partly mixed with the resident contaminated magma. [less ▲]

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See detailIgneous layering in basaltic magma chambers
Namur, O.; Abily, B.; Boudreau, A. et al

in Charlier, Bernard; Namur, Olivier; Latypov, Rais (Eds.) et al Layered Intrusions (2015)

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See detailIgnorance et maîtrise de la bête. Lefort critique de l'éducation "humaniste".
Mancuso, Eva ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailLes iguanodons de Bernissart: leur évolution diagénétique et les processus de dégradation
Leduc, Thierry ULg

Doctoral thesis (2012)

About thirty complete articulated skeletons of iguanodons have been excavated from Bernissart. This unique collection is conserved at the RBINS. The bones excavated were the object of diverse physical and ... [more ▼]

About thirty complete articulated skeletons of iguanodons have been excavated from Bernissart. This unique collection is conserved at the RBINS. The bones excavated were the object of diverse physical and chemical treatments to protect them from their degradation. These bones were not the object of detailed mineralogical analyses allowing to understand either diagenetic mechanisms involved or to understand the specific mechanisms of their change. This work thus aims at filling this lack. It integrates petrographic (POM, SEM), mineralogical (DRX, Raman Spectroscopy) and chemical (EDS, X-ray fluorescence, microprobe) techniques. By these methods, 30 different minerals were identified. The diagenesis of Iguanodon bones is the result of cumulative physical, chemical and biological processes that will modify the original chemical and/or structural properties of this organic object. Bone diagenesis is a complex process that includes the degradation of organic matter, the dissolution and recrystallization of bone apatite, the enrichment in trace elements, the precipitation of new minerals in the bone cavities (permineralisation), the fracturation process. A plan is proposed positioning in a relative timescale minerals formed during 3 diagenetic stages and the degradation processes engaged following the bones exhumation. During burial variable recrystallisation took place: the slightly crystallized carbonated hydroxylapatite (the mineral phase of fresh bone tissue) was replaced by well crystallized carbonated fluorapatite currently present in the Iguanodon bones. Whereas some minerals infiltrated in the bone during cavity filling by the sediment (“mainly” quartz, “argillaceous” phyllosilicates), others are authigenic and precipitated in the cavities during burial (pyrite, barite, sphalerite, celestine, iron oxi-hydroxides, authigenic apatite, calcium sulfate and to a lesser extent vivianite). Pyrite is the most abundant authigenic mineral in the Iguanodon fossil bones. It occurs in different morphologies (crystals, framboids, sticks, fibroradial structure, thin coating…). Four kind of pyrite were determined according to the diagenesis phase during which they were formed and the source of iron and sulfur. Besides pyrite barite is the second most abundant phase. When both minerals are present pyrite has been formed first. The distribution of these minerals within bones is more controlled by micro-environments than by particular structure of the bone. Since their discovery the Iguanodon fossil bones were treated for conservation in several ways. This however did not prevent the alteration of pyrite into an assemblage of 16 different secondary minerals. The ferrous sulfates (szomolnokite and rozenite) are the most abundant of these minerals and can be found in nearly all samples sulfatized. Other sulfates were formed as the result of alteration of the wealdian shale by acid produced by pyrite oxidation: e.g. tschermigite, natrojarosite and halotrichite. Gypsum, anhydrite, iron phosphate and diadochite are the result of dissolution of bone apatite. The variations of relative humidity in collections and in showrooms are responsible for the pursuit of the bones degradation (sulfatation of the residual sulfides ; fracturing by dilation / contraction). The relative humidity, conjugated to the temperature variations are the parameters to be controlled for a better preservation of these invaluable fossils. Techniques implementing some chemicals products proposed in the literature are applicable only to certain objects of limited size. [less ▲]

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