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See detailLong-term precision of quantitative digital radiology
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Albert, Adelin ULg et al

in Revue du Rhumatisme et des Maladies Osteo-Articulaires (1992), 59

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See detailLong-term prognosis of congestive heart failure in patients with acromegaly
Bihan, H.; Valdes Socin, Hernan Gonzalo ULg; Levasseur, S. et al

in The 85th Annual Meeting of the Endocrine Society - Abstract book (2003)

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See detailLong-term prognostic significance of high-sensitivity C-reactive protein before and after coronary angioplasty in patients with stable angina pectoris
Gach, Olivier ULg; Legrand, Victor ULg; Biessaux, Yves ULg et al

in American Journal of Cardiology (2007), 99(1), 31-35

We examined whether an increase in high-sensitivity C-reactive protein (hs-CRP) after percutaneous coronary intervention (PCI) predicts long-term prognosis in patients with stable angina pectoris. hs-CRP ... [more ▼]

We examined whether an increase in high-sensitivity C-reactive protein (hs-CRP) after percutaneous coronary intervention (PCI) predicts long-term prognosis in patients with stable angina pectoris. hs-CRP is an inflammatory marker that predicts future cardiovascular events in healthy subjects and patients with unstable and stable coronary syndromes. Long-term evaluation of pre- and postprocedural inflammatory markers has not been widely reported. In particular, the effect of the magnitude of increase in hs-CRP after PCI in stable patients is unknown. We prospectively analyzed 89 stable patients treated by PCI for stable angina pectoris. Patients were recruited between August 1998 and May 1999, and the population was followed until August 2005 (mean follow-up 79.5 +/- 10.3 months). A major adverse cardiac event (MACE) was defined as the occurrence of cardiac death, myocardial infarction, or recurrent angina requiring repeat PCI or coronary artery bypass grafting. During the follow-up period, 36 patients presented with > or =1 MACE. In multivariate analysis, independent predictors of the occurrence of MACEs were previous myocardial infarction and a significant increase in hs-CRP after PCI (p = 0.004 and 0.003, respectively). A significant increase in hs-CRP after PCI was found to be more predictive of MACEs than hs-CRP before and after PCI. In conclusion, in stable coronary artery disease, inflammation is associated with long-term adverse events, but the magnitude of the inflammatory reaction after PCI appears more predictive than the baseline value. [less ▲]

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See detailLong-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep
Kerkhofs, P.; GATOT, Jean-Stéphane ULg; Knapen, K. et al

in Journal of General Virology (2000), 81

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See detailLong-term protective effect of wheel-running on cocaine reactivity
Lespine, Louis-Ferdinand ULg; Tirelli, Ezio ULg

Poster (2013, September)

Chronic running activity performed during adolescence in C57BL/6J mice induce a protective long term effect on psycho-stimulating effect of cocaine

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See detailLong-term results of cardiac and general health status in children after neonatal arterial switch operation.
Hovels-Gurich, Hedwig H; SEGHAYE, Marie-Christine ULg; Ma, Qing et al

in Annals of Thoracic Surgery (2003), 75(3), 935-43

BACKGROUND: The purpose of this study was to assess cardiac and general health status 8 to 14 years after neonatal arterial switch operation for transposition of the great arteries. METHODS: Sixty ... [more ▼]

BACKGROUND: The purpose of this study was to assess cardiac and general health status 8 to 14 years after neonatal arterial switch operation for transposition of the great arteries. METHODS: Sixty unselected children with intact ventricular septum (78.3%) or ventricular septal defect (21.7%) without or with aortic isthmic stenosis (5.1%) were examined 10.5 +/- 1.6 (mean +/- SD) years after neonatal switch and 5.3 +/- 1.6 years after mid-term evaluation. Complete clinical examination, standard and 24-hour Holter electrocardiogram, M-mode, 2D-, Doppler, and color Doppler echocardiography were performed. Results were compared with normal values and to mid-term follow-up results. RESULTS: Rates of reoperation after arterial switch operation and operation to correct concomitant coarctation were 3.3% and 5.1%, respectively. No patient needed medication, and 93.3% had no limitation of physical activity. All children had normal height and weight; 31.6% had abnormal thoracic configuration after median sternotomy. Most patients (91.7%) were in sinus rhythm. Incidence of complete right bundle branch block (10.0%) was unchanged, as was prevalence of ectopic activity (occasional atrial ectopy 20.0%, ventricular ectopy: occasional 21.7%; frequent 1.7%). Left ventricular dimensions and shortening fraction did not change over time. Diameters of neo-aortic valve annulus and neo-aortic root did not increase, and z-scores decreased between mid-term and present evaluation. Incidence of neo-aortic insufficiency was 13.3% and remained unchanged in comparison with the pre-examination value. Neo-aortic stenosis was not seen. Compared with mid-term follow-up, incidence (41.6%) and degree of supravalvular pulmonary stenosis increased. CONCLUSIONS: Good cardiac results persist 10 years after neonatal arterial switch operation for transposition of the great arteries. Encouraging findings include preservation of left ventricular function, low incidence of rhythm disturbances, lack of further neo-aortic root dilatation, and unchanged incidence of neo-aortic insufficiency compared with mid-term follow-up. Increased incidence and degree of supravalvular pulmonary stenosis are of concern. [less ▲]

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See detailLong-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis.
Fleischmann, Roy; Tannenbaum, Hyman; Patel, Neha P et al

in BMC Musculoskeletal Disorders (2008), 9

BACKGROUND: The efficacy, safety and tolerability of lumiracoxib, a novel selective cyclooxygenase-2 (COX-2) inhibitor, has been demonstrated in previous studies of patients with osteoarthritis (OA). As ... [more ▼]

BACKGROUND: The efficacy, safety and tolerability of lumiracoxib, a novel selective cyclooxygenase-2 (COX-2) inhibitor, has been demonstrated in previous studies of patients with osteoarthritis (OA). As it is important to establish the long-term safety and efficacy of treatments for a chronic disease such as OA, the present study compared the effects of lumiracoxib at doses of 100 mg once daily (o.d.) and 100 mg twice daily (b.i.d.) with those of celecoxib 200 mg o.d. on retention on treatment over 1 year. METHODS: In this 52-week, multicentre, randomised, double-blind, parallel-group study, male and female patients (aged at least 40 years) with symptomatic primary OA of the hip, knee, hand or spine were randomised (1:2:1) to lumiracoxib 100 mg o.d. (n = 755), lumiracoxib 100 mg b.i.d. (n = 1,519) or celecoxib 200 mg o.d. (n = 758). The primary objective of the study was to demonstrate non-inferiority of lumiracoxib at either dose compared with celecoxib 200 mg o.d. with respect to the 1-year retention on treatment rate. Secondary outcome variables included OA pain in the target joint, patient's and physician's global assessments of disease activity, Short Arthritis assessment Scale (SAS) total score, rescue medication use, and safety and tolerability. RESULTS: Retention rates at 1 year were similar for the lumiracoxib 100 mg o.d., lumiracoxib 100 mg b.i.d. and celecoxib 200 mg o.d. groups (46.9% vs 47.5% vs 45.3%, respectively). It was demonstrated that retention on treatment with lumiracoxib at either dose was non-inferior to celecoxib 200 mg o.d. Similarly, Kaplan-Meier curves for the probability of premature discontinuation from the study for any reason were similar across the treatment groups. All three treatments generally yielded comparable results for the secondary efficacy variables and all treatments were well tolerated. CONCLUSION: Long-term treatment with lumiracoxib 100 mg o.d., the recommended dose for OA, was as effective and well tolerated as celecoxib 200 mg o.d. in patients with OA. TRIAL REGISTRATION: clinicaltrials.gov NCT00145301. [less ▲]

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See detailLong-term sediment management for sustainable hydropower
Dewals, Benjamin ULg; Rulot, François ULg; Erpicum, Sébastien ULg et al

in Sayigh, A (Ed.) Comprehensive Renewable Energy. Vol. 6 (2012)

Since the second half of the 20th century and for decades to come, sedimentation in reservoirs is challenging our ability to maintain the storage capacity needed for water supply, flood mitigation and ... [more ▼]

Since the second half of the 20th century and for decades to come, sedimentation in reservoirs is challenging our ability to maintain the storage capacity needed for water supply, flood mitigation and hydroelectricity production. This complex issue needs to be accounted for from the early stages of the design of dams and reservoirs, until the definition of operation rules oriented towards sustainable management of water and sediments. With reference to the widely-used Driver, Pressure, State, Impact, Response (DPSIR) analytical framework (European Commission 2003), the present chapter reviews key figures and trends in worldwide reservoirs sedimentation, as well as analyzes contemporary sediment management strategies. Besides setting some fundamentals of reservoir sedimentation and summarizing up-to-date background information on rate and distribution of loss of storage in the world, we identify some key driving forces of soil erosion, such as land use, urban development, agriculture and deforestation. Main mechanisms of watershed erosion and sediment yield to reservoirs are also discussed, with a focus on their spatial and temporal variation. Means for quantifying the magnitude of this pressure on reservoirs sustainability are presented, including reservoir surveys, fluvial measurements and combined approaches with numerical modelling. After a review of sedimentation impacts, both locally and downstream as well as upstream of the reservoir, we describe current experience and future opportunities of response to reservoir sedimentation. Possible measures are classified into three broad categories: sediment yield reduction, sediment routing (bypass and pass-through) and sediment removal (dredging and flushing). Pro and contras are presented for the different modes of reservoir operation, as well as their expected efficiency and some specific constraints. Predicting the sedimentation pattern as well as grain sorting processes is a prerequisite for developing optimal sediment evacuation strategies, involving for instance flushing operations. Sound modelling of sediment transport and deposition in reservoirs is highlighted as highly beneficial to support sediment management in the perspective of achieving reservoir sustainability. The chapter also illustrates how spatially distributed numerical modelling may succeed in enhancing decision-making for selecting optimal sediment management measures. [less ▲]

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See detailLong-term series of tropospheric water vapour amounts and HDO/H2O ratio profiles above Jungfraujoch
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Schneider, Matthias et al

in Geophysical Research Abstracts (2012), 14

Water vapour is a crucial climate variable involved in many processes which widely determine the energy budget of our planet. In particular, water vapour is the dominant greenhouse gas in the Earth’s ... [more ▼]

Water vapour is a crucial climate variable involved in many processes which widely determine the energy budget of our planet. In particular, water vapour is the dominant greenhouse gas in the Earth’s atmosphere and its radiative forcing is maximum in the middle and upper troposphere. Because of the extremely high variability of water vapour concentration in time and space, it is challenging for the available relevant measurement techniques to provide a consistent data set useful for trend analyses and climate studies. Schneider et al. (2006a) showed that ground-based Fourier Transform Infrared (FTIR) spectroscopy, performed from mountain observatories, allows for the detection of H2O variabilities up to the tropopause. Furthermore, the FTIR measurements allow the retrieval of HDO amounts and therefore the monitoring of HDO/H2O ratio profiles whose variations act as markers for the source and history of the atmospheric water vapour. In the framework of the MUSICA European project (Multi-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water, http://www.imk-asf.kit.edu/english/musica.php), a new approach has been developed and optimized by M. Schneider and F. Hase, using the PROFFIT algorithm, to consistently retrieve tropospheric water vapour profiles from high-resolution ground-based infrared solar spectra and so taking benefit from available long-term data sets of ground-based observations. The retrieval of the water isotopologues is performed on a logarithmic scale from 14 micro-windows located in the 2600-3100 cm-1 region. Other important features of this new retrieval strategy are: a speed dependant Voigt line shape model, a joint temperature profile retrieval and an interspecies constraint for the HDO/H2O profiles. In this contribution, we will combine the quality of the MUSICA strategy and of our observations, which are recorded on a regular basis with FTIR spectrometers, under clear-sky conditions, at the NDACC site (Network for the Detection of Atmospheric Composition Change, http://www.ndacc.org) of the Jungfraujoch International Scientific Station (Swiss Alps, 46.5°N, 8.0°E, 3580m asl). Information content analysis of the retrieved H2O products allows us to produce a long-term trend from 1996 to 2011 for different tropospheric levels. We will compare the annual cycle of tropospheric HDO/H2O ratio profiles with those already produced at other sites (Schneider et al., 2010). We will also focus on the diurnal variability of water vapour to determine a time limit in the inter-comparison of different water vapour measurement techniques. [less ▲]

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See detailA Long-Term Slip-Rate Study Along The North Anatolian Fault, Eksik, Turkey Using Cosmogenic 36Cl
Kozaci, O; Dolan, J; Finkel, R et al

in EOS : Transactions, American Geophysical Union (2004, December)

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See detailLong-term Spectroscopic Variability of Two Oe Stars
Rauw, Grégor ULg; Nazé, Yaël ULg; Marique, P. X. et al

in Information Bulletin on Variable Stars (2007), 5773

HD 45314 and HD 60848 are poorly studied Oe-type stars. Spectroscopic monitoring over 5 years reveals strong variations in the strength of the emission lines and for HD 45314 in the V/R ratio of the ... [more ▼]

HD 45314 and HD 60848 are poorly studied Oe-type stars. Spectroscopic monitoring over 5 years reveals strong variations in the strength of the emission lines and for HD 45314 in the V/R ratio of the double-peaked emissions. Part of these long-term variations could be recurrent. [less ▲]

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See detailLong-term stability of classical photometry
Hensberge, H.; Manfroid, Jean ULg; Sterken, C.

in The Messenger (1992), 70

Not Available

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See detailLong-term stratospheric carbon tetrafluoride (CF4) increase inferred from 1985-2004 infrared space-based solar occultation measurements
Rinsland, Curtis P.; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Geophysical Research Letters (2006), 33(2),

The long-term stratospheric carbon tetrafluoride (CF4) increase has been determined from infrared high spectral resolution solar occultation Fourier transform spectrometer measurements between 3 and 50 ... [more ▼]

The long-term stratospheric carbon tetrafluoride (CF4) increase has been determined from infrared high spectral resolution solar occultation Fourier transform spectrometer measurements between 3 and 50 hPa (similar to 20 to 40 km altitude) and latitudes from 50 degrees N to 50 degrees S during 1985, 1992, 1993, 1994, and 2004. The 1985 to 1994 measurements were recorded from the ATMOS ( Atmospheric Trace MOlecule Spectroscopy) instrument at 0.01 cm(-1) resolution and in 2004 by the Atmospheric Chemistry Experiment ( ACE) instrument at 0.02 cm(-1) resolution. Stratospheric volume mixing ratios, inferred from a polynomial fit to averages from the time periods considered here, increased from 49.37 +/- 2.60 pptv (10(-12) per unit volume) in 1985 to 58.38 +/- 4.14 pptv in 1992, 60.46 +/- 2.97 pptv in 1993, 60.11 +/- 3.60 pptv in 1994 and to 70.45 +/- 3.40 pptv in 2004. The stratospheric CF4 mixing ratio has continued to increase but at a slower rate than in previous years, for example, (1.14 +/- 0.68)% yr(-1) in 2004 as compared to (2.77 +/- 0.47)% yr(-1) in 1985, 1 sigma. Correlations of CF4 with N2O taking into account the increase of N2O with time also show the increase in the stratospheric CF4 burden over the two decade measurement time span. Our space-based measurements show that the slowdown in the rate of CF4 accumulation previously reported from surface measurements through 1997 has propagated to the stratosphere and is continuing. Citation: Rinsland, C. P., E. Mahieu, R. Zander, R. Nassar, P. Bernath, C. Boone, and L. S. Chiou (2006), Long-term stratospheric carbon tetrafluoride (CF4) increase inferred from 1985-2004 infrared space-based solar occultation measurements, Geophys. Res. Lett., 33, L02808, doi:10.1029/2005GL024709. [less ▲]

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See detailLong-term study of biogenic volatile organic compound exchanges in a forest ecosystem
Laffineur, Quentin ULg

Doctoral thesis (2012)

The terrestrial biosphere, especially forest ecosystems, emits large quantities of volatile organic compounds (VOCs) which have a significant impact on the atmosphere’s chemical and physical ... [more ▼]

The terrestrial biosphere, especially forest ecosystems, emits large quantities of volatile organic compounds (VOCs) which have a significant impact on the atmosphere’s chemical and physical characteristics. In particular, VOCs are precursors in the formation of ozone and sec-ondary organic aerosols. Isoprene and monoterpenes dominate the total VOC emissions, and methanol is one of the most abundant atmospheric VOCs due to its longer half-life than the other two. The main objective of this thesis was to investigate (using the eddy covariance technique and a proton-transfer-reaction mass spectrometer) the mechanisms of VOC (isoprene, monoterpene and methanol) emission and/or deposition at the scale of a temperate climate forest ecosystem (Vielsalm, Belgium) comprising several species (Fagus sylvatica, Abies alba, Picea Abies and Pseudotsuga menziessi). The eddy covariance technique is very suitable for studying VOC emission/deposition mechanisms at ecosystem level as it does not interfere with the functioning of the ecosystem and it has very good temporal resolution (half an hour). It was used for several months at the Vielsalm site without any major interruption to the measurements. The first measurement period ran from early July to late November 2009 and the second from late March to late November 2010. As well as measuring the VOC exchanges by eddy covari-ance, the climate parameters controlling the exchange mechanisms were also measured. During both these periods the methanol, acetaldehyde, acetone, isoprene, methyl vinyl ke-tone/methacrolein, monoterpene, acetic acid (2010) and formic acid (2010) fluxes were meas-ured. The highest emission levels observed were isoprene and monoterpenes along with methanol, which unlike the first two also showed depositions. The thesis therefore naturally focused on studying these three fluxes, in view of the important role played by these three compounds in atmospheric chemistry and hence the scientific community’s interest in refining the parametrisation of these compounds’ ecosystem/atmosphere exchange models. The study of the isoprene, monoterpene and methanol fluxes has been written up in three original articles which form the main body of this thesis. Because of the heterogeneity of the ecosystem studied, the first essential study concerned the identification of VOC-emitting species. This was done with the aid of a flux footprint model combined with a map of the species occurring on the site. This analysis showed that the main monoterpene emitter was Fagus sylvatica followed, to a lesser extent, by Abies alba, Picea Abies and Pseudotsuga menziessi. In contrast to the literature, the analysis showed Abies alba to be a probable isoprene emitter but the presence of Picea Abies, a known isoprene emitter, ruled out absolute certainty on that point. The isoprene fluxes were observed by day only, unlike the monoterpene fluxes which were observed both day and night. Diurnal flux analysis clearly showed temperature and light to be the two main variables controlling emissions. Combining this analysis with a study of the close relationship between isoprene/monoterpene emissions and photosynthesis revealed the plants’ de novo biosynthetic production mechanisms, an original aspect at ecosystem scale. From the occurrence of nocturnal monoterpene emissions it was possible to determine that de novo monoterpene production emitted directly into the atmosphere (as in the case of isoprene) was not the only source of the emissions observed. Withdrawals from monoterpene sinks located in plant organs or in the soil can also be monoterpene sources. Studying the relationship between isoprene/monoterpene fluxes and light, distinguishing between cloudy and sunny conditions, showed that for the same light intensity the emissions were higher in cloudy con-ditions than in sunshine. Similarly, a study of the relationship between isoprene fluxes and photosynthesis in cloudy/sunny conditions suggested that de novo isoprene production is greater in leaves above the canopy than in leaves within the canopy. Long-term measurement of isoprene and monoterpene emissions enabled seasonal changes in the mechanisms observed to be studied and more fully understood. As well as providing an understanding of the mechanisms, this research also resulted in quantification of the seasonal changes in the key parameters for modelling isoprene/monoterpene emissions. Methanol exchanges were generally positive (emissions) by day and negative (depositions) at night. Overall, methanol depositions were predominant in summer and autumn but in the mi-nority in spring. On average, the Vielsalm site behaved like a methanol sink, which contradicts all the other research published to date. An original model was developed for identifying the mechanisms responsible for short-term and long-term methanol emissions/depositions. The consistency between the measurements and the model simulations suggested that the main processes controlling methanol exchanges in summer could be attributed, in the short term, to (water-soluble) methanol adsorption/desorption occurring in the films of water on leaf surfaces and/or on the soil surface and, in the long term, to methanol destruction by a biological and/or chemical degradation process also occurring on the surface of leaves and/or the soil. A study of the difference between the measurements and the model, in spring, indicated the possibility of biosynthetic methanol production by the plants. This production was apparently controlled mainly by temperature, but it could not be shown in summer when methanol adsorption/desorption processes dominated. The literature on ecosystem-atmosphere exchanges of isoprene, monoterpenes and, to a lesser extent, methanol is extensive. Nevertheless, what makes this research original is the spatio-temporal scale used. We are in fact working at ecosystem scale, and not at leaf or branch scale as in most other cases. Moreover, our measurements cover a timescale from half an hour to a full growing season, which is rarely found in the literature. This has resulted in a better under-standing of these compounds’ production and exchange mechanisms. To be precise, the methanol flux study is currently unique in its description and understanding of the deposition mechanisms. [less ▲]

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See detailLong-term treatment of postmenopausal osteoporosis with strontium ranelate: Results at 8 years.
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg; Sawicki, A. et al

in BONE (2009), 45

OBJECTIVES: Strontium ranelate 2 g/day has proven efficacy against vertebral and nonvertebral fracture over 5 years in postmenopausal osteoporosis, though many women require longer-term treatment. This ... [more ▼]

OBJECTIVES: Strontium ranelate 2 g/day has proven efficacy against vertebral and nonvertebral fracture over 5 years in postmenopausal osteoporosis, though many women require longer-term treatment. This article describes the efficacy, safety, and tolerability of this agent over 8 years. METHODS: Postmenopausal osteoporotic women having participated in the 5-year efficacy trials SOTI and TROPOS were invited to enter a 3-year open-label extension study. The results presented here focus on patients who received strontium ranelate for 8 years. RESULTS: At the extension baseline, the population treated for 8 years (n=879; 79.1+/-5.6 years) had femoral neck T-score of -2.61+/-0.71. The cumulative incidences of new vertebral and nonvertebral fractures (13.7% and 12.0%, respectively) over years 6 to 8 were non-statistically different from the cumulative incidences in the first 3 years of the original studies (11.5% and 9.6%). Lumbar spine, femoral neck, and total hip bone mineral density (BMD) increased throughout the 8-year period. Annual relative change in BMD was significant at every visit, except the 8-year visit for femoral neck and total hip BMD. Strontium ranelate was safe and well tolerated over 8 years. CONCLUSIONS: Long-term treatment with strontium ranelate 2 g/day in postmenopausal osteoporotic women leads to continued increases in BMD at all sites. The data also provide some evidence for a sustained antifracture efficacy. [less ▲]

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See detailLong-term treatment of postmenopausal osteoporotic women with strontium ranelate : results at 10 years
Reginster, Jean-Yves ULg; Kaufman, J. M.; Devogelaer, J. D. et al

in Annals of the Rheumatic Diseases (2011), 70(S3), 167

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