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See detailLa leucemie bovine: systeme modele de leucemogenisation par un retrovirus.
Burny, A.; Kettmann, Richard ULg; Mammerickx, M. et al

in Annales de Médecine Vétérinaire (1986), 130(4),

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See detailLeucémie myéloblastique aiguë : sécrétion paranéoplasique de GH et de PRL ?
VALDES SOCIN, Hernan Gonzalo ULg; Potorac, Iulia ULg; DE PASQUAL, Aurelie ULg et al

in Abstract book - Annales d'Endocrinologie : 31ème Congrès de la Société Françaose d'Endocrinologie, Lyon 5-8 novembre 2014 (2014, October)

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See detailLeucémie myélomonocytaire chronique : diagnostic et thérapeutique
HAFRAOUI, Kaoutar ULg; DE PRIJCK, Bernard ULg; Beguin, Yves ULg

in Revue Médicale Suisse (2013), 9

Chronic myelomonocytic leukemia (CMML) is a disease typically of the elderly. It is suspected when monocytosis reaches IOOO/fil. It may be associated with «B» symptoms (fever, sweating, and weight loss ... [more ▼]

Chronic myelomonocytic leukemia (CMML) is a disease typically of the elderly. It is suspected when monocytosis reaches IOOO/fil. It may be associated with «B» symptoms (fever, sweating, and weight loss) but also visceral, skin and autoimmune complications. Current treatment strategies aim at reducing the symptoms and have no curative goals. In this context hypomethylating agents have shown a good efficacy. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative option but remains difficult to perform in elderly patients population, even if transplantation with a reduced intensity conditioning has reduced the risks. A new prognostic scoring helps to recognize the patients with poor prognosis and to better selected candidates for the HSCT. [less ▲]

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See detailLes leucémies - Chronique interuniversitaire
Fillet, Georges ULg

in Revue Médicale de Liège (1984), 39

Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood ... [more ▼]

Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood lymphoblastic leukemia. Some long-term survivors may be considered as cured. The chemotherapy of chronic leukemias is disappointing. Because of our limited conventional therapeutic means the allogenic bone marrow transplantation is now indicated in the following instances : the acute myeloid leukemia in first remission, the acute lymphoblastic leukemia (ALL) in second remission or in first remission of poor-risk ALL, and the chronic myeloid leukemia during the chronic phase. [less ▲]

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See detailLes leucémies - Chronique interuniversitaire
Fillet, Georges ULg

in Louvain Medical (1984), 103

Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood ... [more ▼]

Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood lymphoblastic leukemia. Some long-term survivors may be considered as cured. The chemotherapy of chronic leukemias is disappointing. Because of our limited conventional therapeutic means the allogenic bone marrow transplantation is now indicated in the following instances : the acute myeloid leukemia in first remission, the acute lymphoblastic leukemia (ALL) in second remission or in first remission of poor-risk ALL, and the chronic myeloid leukemia during the chronic phase. [less ▲]

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See detailLes leucémies chroniques. Aspects cliniques et thérapeutiques.
Fillet, Georges ULg

in Actualité Médicale Belge (1982), 9

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See detailLeucocyte subsets in the respiratory tract of dogs without respiratory disease : preliminary results.
Peeters, Dominique ULg; Day, M. J.; Laurent, A. et al

in Proceedings of the 12th Annual Congress of the ECVIM-CA (2002)

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See detailLeucoencephalite aigue hemorragique de Hurst: imagerie IRM.
Tshibanda, L.; NCHIMI LONGANG, Alain ULg; Otte, Manuel et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2007), 90(4), 290-3

A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing ... [more ▼]

A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing the cortex ribbon. Fulminant disease culminated in coma and death within twenty-four hours. A comprehensive correlation between pathological findings of acute haemorrhagic leukoencephalitis and both classical and advanced neuroimaging findings is provided. [less ▲]

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See detailLeukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3.
Slaets, Helena; Dumont, Debora; Vanderlocht, Joris et al

in Proteomics (2008), 8(6), 1237-47

Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures ... [more ▼]

Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures selectively against the combined insult of the proinflammatory cytokines interferon-gamma and tumor necrosis factor-alpha, but it does not protect against oxidative stress nor against staurosporine induced apoptosis. We further demonstrate that LIF activates the janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) and the phosphatidylinositol 3 kinase/Akt pathway in mature OLG. We show that LIF protection is independent of suppressors of cytokine signaling and Bcl-2 mRNA expression levels. To gain further insight into the protective mechanism, a quantitative proteomic approach (DIGE) was applied to identify differentially expressed proteins in LIF-treated OLG. Our results indicate that LIF induces a shift in the cellular machinery toward a prosurvival execution program, illustrated by an enhanced expression of isoforms of the antiapoptotic molecule 14-3-3. These data provide further insight into the mechanisms of LIF-mediated protection of mature OLGs. [less ▲]

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See detailLeukemia Viruses
Burny, A.; Bex, F.; Dequiedt, Franck ULg et al

in Encyclopedia of Immunology (1998)

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See detailLeukemia Viruses
Burny, A.; Willems, Luc ULg

in Encyclopedia of Immunology (1991)

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See detailLeukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ULg; Jacquel, Arnaud; Droin, Nathalie et al

in Haematologica (2011), 96(4), 612-6

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]

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See detailLeukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.
Baron, Frédéric ULg; Turhan, Ali G; Giron-Michel, Julien et al

in Blood (2002), 99(6), 2107-13

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces ... [more ▼]

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces growth factor independence. However, the influence of BCR-ABL expression on cell-mediated cytotoxicity is poorly understood. In the present study, we asked whether BCR-ABL expression interferes with leukemic target sensitivity to natural killer (NK) cell cytolysis. Our approach was based on the use of 2 BCR-ABL transfectants of the pluripotent hematopoietic cell line UT-7 expressing low (UT-7/E8, UT-7/G6) and high (UT-7/9) levels of BCR-ABL. As effector cells, we used CD56(bright), CD16-, CD2- NK cells differentiated in vitro from CD34 cord blood progenitors. We demonstrated that BCR-ABL transfectants UT-7/9 were lysed by NK cells with a higher efficiency than parental and low UT-7/E8.1 and UT-7/G6 transfectants. This enhanced susceptibility to lysis correlated with an increase in expression of intercellular adhesion molecule 1 (ICAM-1) by target cells. Treatment of UT-7/9 cells by STI571 (a specific inhibitor of the abl kinase) resulted in a decrease in NK susceptibility to lysis and ICAM-1 down-regulation in target cells. Furthermore, the constitutive activation of nuclear factor-kappaB (NF-kappaB) detected in BCR-ABL transfectant UT-7/9, was significantly attenuated when cells were treated by STI571. Interestingly, inhibition of NF-kappaB activation by BAY11-67082 (a specific NF-kappaB inhibitor) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants. Our results show that oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1 as a consequence of NF-kappaB activation. [less ▲]

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See detailLeukemogenesis by bovine leukemia virus (BLV)
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Viruses and human cancer, Liss Press, New York (1987)

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See detailLeukemogenesis by bovine leukemia virus (BLV) and human T-cell lymphotropic viruses : facts and hypotheses
Burny, A.; Cleuter, Y.; Kettmann, Richard ULg et al

in Cancer letters (suppl.) (1986)

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See detailLeukemogenesis by transactivating retroviruses : bovine leukemia virus as a model system
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Concepts and theories in carcinogenesis (1987)

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See detailLeukemogenesis by transactivating retroviruses: bovine leukemia virus as a model system
Burny, A.; Kettmann, Richard ULg; Mammerickx, M. et al

in Springer-Verlag Press (Berlin, Heidelberg) (1988)

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See detailLeukotriene B4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD.
Corhay, Jean-Louis ULg; Henket, Monique ULg; Nguyen Dang, Delphine ULg et al

in CHEST (2009), 136(4), 1047-1054

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from ... [more ▼]

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from patients with COPD. Objectives The aims of this study were to compare EBC and IS supernatant neutrophil chemotactic activity from ex-smoking COPD and healthy ex-smokers, and to assess the contribution of LTB(4) to this activity. Methods 34 COPD were compared to 24 controls. EBC and IS chemotactic activity for neutrophils were assessed by using Boyden microchambers. Chemotactic index (CI) was used to evaluate cell migration. LTB(4) was measured by a specific enzyme immunoassay. Contribution of LTB4 to EBC and sputum neutrophil chemotaxis was assessed by an LTB(4) receptor antagonist (U-75302: Cayman Chemical Company, Ann Arbor, MI, USA). Results EBC and IS from both COPD and healthy subjects displayed significant neutrophil chemotactic activity but this activity was raised in COPD compared to healthy subjects. Chemotactic activity contained in sputum, however, failed to correlate with that in EBC. In COPD there was a significant correlation between EBC neutrophil chemotactic activity and sputum neutrophil counts. LTB(4) levels were raised in EBC, but not in sputum, from COPD as compared to healthy subjects. LTB(4) receptor antagonist (2.5 10(-4) M) reduced by 44.6% and by 44.4% chemotactic activity contained in EBC and sputum respectively. Conclusions EBC and IS from COPD patients have a raised neutrophil chemotactic activity to which LTB4 contributes. [less ▲]

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