Les leucémies - Chronique interuniversitaire
in Revue Médicale de Liège (1984), 39
Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood ... [more ▼]
Owing to the polychemotherapy treatments the proportion of long-term survivors in adult acute leukemia achieving a complete remission id of about 15 to 30%. this percentage attains 50% in childhood lymphoblastic leukemia. Some long-term survivors may be considered as cured. The chemotherapy of chronic leukemias is disappointing. Because of our limited conventional therapeutic means the allogenic bone marrow transplantation is now indicated in the following instances : the acute myeloid leukemia in first remission, the acute lymphoblastic leukemia (ALL) in second remission or in first remission of poor-risk ALL, and the chronic myeloid leukemia during the chronic phase. [less ▲]Detailed reference viewed: 49 (2 ULg)
Les leucémies chroniques. Aspects cliniques et thérapeutiques.
in Actualité Médicale Belge (1982), 9Detailed reference viewed: 15 (0 ULg)
Leucocyte subsets in the respiratory tract of dogs without respiratory disease : preliminary results.
Peeters, Dominique ; ; et al
in Proceedings of the 12th Annual Congress of the ECVIM-CA (2002)Detailed reference viewed: 3 (0 ULg)
Leucoencephalite aigue hemorragique de Hurst: imagerie IRM.
; NCHIMI LONGANG, Alain ; et al
in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2007), 90(4), 290-3
A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing ... [more ▼]
A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing the cortex ribbon. Fulminant disease culminated in coma and death within twenty-four hours. A comprehensive correlation between pathological findings of acute haemorrhagic leukoencephalitis and both classical and advanced neuroimaging findings is provided. [less ▲]Detailed reference viewed: 40 (1 ULg)
Leucose bovine enzootique et virus de la leucémie bovine : Mise en place d'une stratégie de lutte efficace.
Post doctoral thesis (1990)Detailed reference viewed: 41 (7 ULg)
Leukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3.
; ; et al
in Proteomics (2008), 8(6), 1237-47
Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures ... [more ▼]
Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures selectively against the combined insult of the proinflammatory cytokines interferon-gamma and tumor necrosis factor-alpha, but it does not protect against oxidative stress nor against staurosporine induced apoptosis. We further demonstrate that LIF activates the janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) and the phosphatidylinositol 3 kinase/Akt pathway in mature OLG. We show that LIF protection is independent of suppressors of cytokine signaling and Bcl-2 mRNA expression levels. To gain further insight into the protective mechanism, a quantitative proteomic approach (DIGE) was applied to identify differentially expressed proteins in LIF-treated OLG. Our results indicate that LIF induces a shift in the cellular machinery toward a prosurvival execution program, illustrated by an enhanced expression of isoforms of the antiapoptotic molecule 14-3-3. These data provide further insight into the mechanisms of LIF-mediated protection of mature OLGs. [less ▲]Detailed reference viewed: 80 (9 ULg)
Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ; ; et al
in Haematologica (2011), 96(4), 612-6
Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]
Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]Detailed reference viewed: 34 (4 ULg)
Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.
Baron, Frédéric ; ; et al
in Blood (2002), 99(6), 2107-13
Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces ... [more ▼]
Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces growth factor independence. However, the influence of BCR-ABL expression on cell-mediated cytotoxicity is poorly understood. In the present study, we asked whether BCR-ABL expression interferes with leukemic target sensitivity to natural killer (NK) cell cytolysis. Our approach was based on the use of 2 BCR-ABL transfectants of the pluripotent hematopoietic cell line UT-7 expressing low (UT-7/E8, UT-7/G6) and high (UT-7/9) levels of BCR-ABL. As effector cells, we used CD56(bright), CD16-, CD2- NK cells differentiated in vitro from CD34 cord blood progenitors. We demonstrated that BCR-ABL transfectants UT-7/9 were lysed by NK cells with a higher efficiency than parental and low UT-7/E8.1 and UT-7/G6 transfectants. This enhanced susceptibility to lysis correlated with an increase in expression of intercellular adhesion molecule 1 (ICAM-1) by target cells. Treatment of UT-7/9 cells by STI571 (a specific inhibitor of the abl kinase) resulted in a decrease in NK susceptibility to lysis and ICAM-1 down-regulation in target cells. Furthermore, the constitutive activation of nuclear factor-kappaB (NF-kappaB) detected in BCR-ABL transfectant UT-7/9, was significantly attenuated when cells were treated by STI571. Interestingly, inhibition of NF-kappaB activation by BAY11-67082 (a specific NF-kappaB inhibitor) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants. Our results show that oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1 as a consequence of NF-kappaB activation. [less ▲]Detailed reference viewed: 12 (0 ULg)
Leukemie bij runderen: model voor leukemie veroorzaakt door een retrovirus
Willems, Luc ; ; Kettmann, Richard
in Kanker (1991)Detailed reference viewed: 19 (1 ULg)
Leukemogenesis by bovine leukemia virus (BLV)
; ; et al
in Viruses and human cancer, Liss Press, New York (1987)Detailed reference viewed: 7 (0 ULg)
Leukemogenesis by bovine leukemia virus (BLV) and human T-cell lymphotropic viruses : facts and hypotheses
; ; Kettmann, Richard et al
in Cancer letters (suppl.) (1986)Detailed reference viewed: 7 (1 ULg)
Leukemogenesis by transactivating retroviruses : bovine leukemia virus as a model system
; ; et al
in Concepts and theories in carcinogenesis (1987)Detailed reference viewed: 9 (1 ULg)
Leukemogenesis by transactivating retroviruses: bovine leukemia virus as a model system
; Kettmann, Richard ; et al
in Springer-Verlag Press (Berlin, Heidelberg) (1988)Detailed reference viewed: 12 (3 ULg)
Leukotriene B4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD.
Corhay, Jean-Louis ; Henket, Monique ; Nguyen Dang, Delphine et al
in CHEST (2009), 136(4), 1047-1054
Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from ... [more ▼]
Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from patients with COPD. Objectives The aims of this study were to compare EBC and IS supernatant neutrophil chemotactic activity from ex-smoking COPD and healthy ex-smokers, and to assess the contribution of LTB(4) to this activity. Methods 34 COPD were compared to 24 controls. EBC and IS chemotactic activity for neutrophils were assessed by using Boyden microchambers. Chemotactic index (CI) was used to evaluate cell migration. LTB(4) was measured by a specific enzyme immunoassay. Contribution of LTB4 to EBC and sputum neutrophil chemotaxis was assessed by an LTB(4) receptor antagonist (U-75302: Cayman Chemical Company, Ann Arbor, MI, USA). Results EBC and IS from both COPD and healthy subjects displayed significant neutrophil chemotactic activity but this activity was raised in COPD compared to healthy subjects. Chemotactic activity contained in sputum, however, failed to correlate with that in EBC. In COPD there was a significant correlation between EBC neutrophil chemotactic activity and sputum neutrophil counts. LTB(4) levels were raised in EBC, but not in sputum, from COPD as compared to healthy subjects. LTB(4) receptor antagonist (2.5 10(-4) M) reduced by 44.6% and by 44.4% chemotactic activity contained in EBC and sputum respectively. Conclusions EBC and IS from COPD patients have a raised neutrophil chemotactic activity to which LTB4 contributes. [less ▲]Detailed reference viewed: 51 (6 ULg)
Leur première pièce. L'émergence des auteurs dramatiques dans le théâtre belge francophone
Scientific conference (2011, April 27)Detailed reference viewed: 9 (0 ULg)
Leurres de la qualité dans l'enseignement supérieur ? Variations internationales sur un thème ambigu
Fallon, Catherine ; Leclercq, Bruno
Book published by Academia-L'Harmattan (2014)
Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le ... [more ▼]
Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le plus souvent des principes inspirés du New Public Management qui s'enracinent dans une critique néo-libérale de l’Etat providence. D’un endroit à l’autre, ce sont toutefois des méthodes, des critères et surtout des usages très différents de l’évaluation des formations qui se rangent sous cette appellation. Les textes rassemblés dans ce volume font état de cette diversité des pratiques internationales ainsi que de l’irréductible multiplicité des projets que cherche à servir simultanément la démarche « Qualité » dans l’enseignement supérieur. En soulignant les ambiguïtés d’un dispositif tout à la fois discursif et technique, ils cherchent à en déjouer les éventuels « leurres ». [less ▲]Detailed reference viewed: 120 (10 ULg)
Leuven English Old to New (LEON): Some ideas on a new corpus for longitudinal diachronic studies.
Conference (2009, July 09)
Despite the explosion of diachronic corpora of English in the last few decades, still not a single corpus exists that covers the entire documented history of English. Although its compilation is generally ... [more ▼]
Despite the explosion of diachronic corpora of English in the last few decades, still not a single corpus exists that covers the entire documented history of English. Although its compilation is generally perceived as most attractive (Rissanen 2000: 13), corpus compilers do not seem to believe in its creation in the near future. This is regrettable, as many linguists dealing with longitudinal developments such as grammaticalization need to cover very long time spans, and are forced to combine several, not necessarily compatible, corpora (e.g. Hilpert 2008, van Linden 2009). Clearly, their results are less reliable than they might be if a single corpus existed (for example, Gries and Hilpert’s data (2008) show a major shift in the collocational profile of shall about 1710; however, this is precisely where one corpus they use ends and a second – rather different one – begins). So I tentatively started compiling a corpus myself, provisionally called LEON (Leuven English Old to New). The basic architecture of LEON comprises a 400,000 word corpus for each HC-period, and after 1710 for the periods 1710-1780, 1780-1850, 1850-1920, 1920-1990 and post-1990. Data available from 1250-1350, a less well represented period, serve as a template on which other subperiods are to be based to acquire best comparability of genre and region. To make up for the lack of some genres (letters, diaries) and social stratification, for each period after 1350 an additional, selfsufficient 600,000 words corpus is envisaged. While LEON is primarily conceived as a ‘meta-corpus’, mining existing corpora, some additions are envisaged too (e.g. the unedited Statutes Rwl. B.520, dated a1325). LEON does not aim at full comparability (which would be presumptuous), but wants to optimize the usefulness of concepts like ‘equal size of subperiods’ or ‘diachronic text prototype’ (HC). LEON might be, as compared to the present ‘big evil’, a ‘lesser evil’. References Gries, Stefan Th. and Martin Hilpert. The identification of stages in diachronic data: variability-based neighbour clustering. Corpora Vol. 3 (1): 59–81. Hilpert, Martin. 2008. Germanic future constructions A usage-based approach to language change. Amsterdam & Philadelphia: John Benjamins. Los, Bettelou. 2005. The rise of the to-infinitive. Oxford: Oxford University Press. Rissanen, Matti & Merja Kytö. 1993. General introduction. In Rissanen, Matti, Merja Kytö & Minna Palander-Collin, eds. 1993. Early English in the computer age: Explorations through the Helsinki Corpus. Berlin: Mouton de Gruyter. 1-17. Rissanen, Matti. 2000. The world of English historical corpora: From Cædmon to computer age. Journal of English Linguistics 28: 7-20. van Linden, An. 2009. Dynamic, deontic and evaluative adjectives and their clausal complement patterns: A synchronic-diachronic account. PhD dissertation, University of Leuven. [less ▲]Detailed reference viewed: 46 (1 ULg)
Levallois et Gravettien
Otte, Marcel ; Noiret, Pierre
in Praehistoria (in press)
Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]
Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]Detailed reference viewed: 48 (6 ULg)