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See detailLess vasoocclusive disease after intravenous ersus oral busulfan for autologous hematopoietic cell transplantation : the Belgian pediatric experience
Huybrechts, S.; BEGUIN, Yves ULg; Ferster, A. et al

in Belgian Journal of Hematology (2012), 3(2), 34-40

Busulfan is commonly used in preparative conditioning regimens prior to hematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years ... [more ▼]

Busulfan is commonly used in preparative conditioning regimens prior to hematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years Busulfan was only available in an oral form, resulting in large inter- and intra-patients variability in plasma exposure, associated with higher graft failure rate as well as higher toxicity such as venoocclusive disease. With the development of an intravenous formulation of Busulfan, a more accurate control of both the inter- and intra-patient variability has been provided. The goal of this study was to evaluate the use and efficacy of intravenous Busulfan in comparison with the oral formulation in children undergoing an autologous transplantation after conditioning with Busulfan. Despite the small number of patients, this study confirmed the apparent benefit of intravenous Busulfan in children undergoing an autologous HSCT. The use of a 5-level dose schedule defined by body weight resulted in an efficient engraftment with marked reduction in the incidence of veno-occlusive disease compared with oral Bu. In terms of diseasefree outcome, survival and event-free survival, similar results have been obtained in both groups. The choice of this formulation of Busulfan should therefore be considered. [less ▲]

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See detailLessons from Ontarget
Berlaimont, V.; Billiouw, J.-M.; Brohet, C. et al

in Acta Clinica Belgica (2008), 63(3), 142-151

The recently published results of the ONTARGET trial shed a new light on the cardiovascular protection of patients at high risk of a cardiovascular event. Despite a number of trials looking at the ... [more ▼]

The recently published results of the ONTARGET trial shed a new light on the cardiovascular protection of patients at high risk of a cardiovascular event. Despite a number of trials looking at the efficacy of Angiotensin Converting Enzyme inhibitors (ACEis) or Angiotensin Receptor Blockers (ARBs) in the prevention of cardiovascvular events in patients with specific high risk profiles, the question of the equivalence of ACEis and ARBs remained unanswered. The ONTARGET trial has shown that telmisartan 80 mg administered for a median duration of 4.5 years to patients at high risk of developing a major cardiovascular event, is equally effective to ramipril 10 mg. In addition, telmisartan was slightly better tolerated. The comparator ramipril has been chosen as it is currently the gold standard ACEi since the results of the HOPE study, in terms of the composite outcome of cardiovascular death, myocardial infarction and stroke. Moreover, ONTARGET is the first trial to test the hypothesis of superiority of adding an ARB (telmisartan 80 mg) to an ACEI (ramipril 10 mg) over the ACEi ramipril monotherapy in cardiovascular protection of the same broad range of high-risk patients. Surprisingly, despite a more pronounced blood pressure lowering, the combination of the two agents did not lead to an additional decrease in the number of events, but had significantly more side-effects compared to ramipril monotherapy. ONTARGET is a landmark study, performed according to the highest statistical and clinial standards, providing compelling evidence and clear answers to two important clinical questions. [less ▲]

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See detailLessons from Principal-Agent Theory for Public Expenditure Management in Pacific Island Countries
Paul, Elisabeth ULg

in Pacific Economic Bulletin (2006), 21(2),

The paper discusses how the principal-agent theory of economics may provide a suitable analytical framework and interesting lessons for the targeting of public expenditure management reforms in Pacific ... [more ▼]

The paper discusses how the principal-agent theory of economics may provide a suitable analytical framework and interesting lessons for the targeting of public expenditure management reforms in Pacific island economies [less ▲]

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See detailLessons from the discovery of leptin: is obesity an endocrine disease?
Scheen, André ULg

in Acta Clinica Belgica (1996), 51(6), 371-6

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See detailLessons from the field: Negotiating Transnational Gender, Class and Race Positions as a Researcher Working on Andean Domestic Workers in Brussels
Vivas Romero, Maria ULg

Scientific conference (2015, January 30)

This paper shows the links between migrant transnationalism and the methodological debates concerning the researcher’s positionality and self-reflexivity, which have not been systematically considered in ... [more ▼]

This paper shows the links between migrant transnationalism and the methodological debates concerning the researcher’s positionality and self-reflexivity, which have not been systematically considered in transnational studies. Drawing from my experiences as a transnational female migrant conducting fieldwork among Andean domestic workers in the city of Brussels; I intent to contribute to the conceptualization of positionality by reflecting on the effect of the researcher’s transnational gender, class and race positions in qualitative migration research. Firstly, I address the conflicts that arose from my positioning as an “insider” that initially granted me a social proximity with my participants but later raised awareness on the existent social boundaries between us and temporarily blocked my access to the field. Secondly, I will highlight the methodological strategies through, which I worked around the existent boundaries of power relations and eventually gained access to the field, meaning: A- Constantly, engaging in self-reflexivity and questioning my “insider/outsider positioning, B- Consciously and unconsciously negotiating my class, gender and race positioning’s in order to re-draw the boundaries in the relationship between the participants and the researcher, C- Relying on my experiences as a transnational migrant in order to grasp the meaning of their practices, which guided me to avoid my spontaneous interpretations and reconsider those that my participants gave me . Finally, I will argue that both mobilizing one’s personal background and negotiating our intersecting transnational positionalities during fieldwork constitute valuable methodological resources that might lead us to do research that is produced through more symmetrical power relations. [less ▲]

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See detailLessons from the Liege Acromegaly Survey (LAS)
PETROSSIANS, Patrick ULg; Zacharieva, Sabina; Chanson, Philippe et al

in Endocrine Abstracts - 15 the European Congress of Endocrinology (2013, May)

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See detailLessons from the past for a better future: Ethnoecology, a promising link between tradition and science regarding biodiversity management
Malaisse, François ULg

Conference (2001, April 06)

After reviewing biological diversity data concerning tropical countries, main biodiversity issues and challenges are listed. The evolution of the “ethnoecology” concept and its present meaning are ... [more ▼]

After reviewing biological diversity data concerning tropical countries, main biodiversity issues and challenges are listed. The evolution of the “ethnoecology” concept and its present meaning are examined. Starting from two or four roots, including ethnoagronomy, ethnoecology is taking progressively a dominant position regarding local knowledge as well as in modern ecosystems’ management. The various levels of environmental knowledge are pinpointed from examples taken in Tibet, pre-Saharan Morocco, Guinea-Bisseau, Upper Katanga and Zambia, and finally Bolivia. Lessons from the past are highlighted through present ecological studies and interaction outputs are stressed and discussed. Finally, a success story of validation of non-woody forest product is presented, with the establishment of a business subject regarding wild edible mushrooms from the wetter miombo area of South Central Africa. [less ▲]

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See detailLessons from the year 2001 Mycosphaerella graminicola epidemic on winter wheat in Belgium
Calay, F.; Coquillart, L.; Lucas, C. et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002, May 07), 67(2), 197-204

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See detailLessons learned from efforts to improve the quality of care in children with end-stage renal disease in the Netherlands and Belgium.
Tromp, Wilma F.; van der Lee, Johanna H.; Offringa, Martin et al

in Archives of Disease in Childhood (2011), 96(12), 1093-6

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See detailLessons learnt from carotid artery trials
Van Damme, Hendrik ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (2006), 106(5), 489-499

The objective of the authors is to assess the natural history of carotid artery disease and the role of carotid intervention in preventing ipsilateral stroke. The development of endovascular techniques ... [more ▼]

The objective of the authors is to assess the natural history of carotid artery disease and the role of carotid intervention in preventing ipsilateral stroke. The development of endovascular techniques for correction of carotid artery stenoses made this less invasive technique very popular, with an inherent risk of unregulated overuse by a variety of medical specialists, who are not always well informed on the natural history of carotid artery disease. It re-opened the discussion on the value of carotid endarterectomy for stroke prophylaxis. This ongoing debate offers the opportunity to distil evidence-based guidelines for the management of extracranial carotid artery stenoses. In recent papers, some authors expressed doubts on the validity and general applicability of the results of the pivotal randomised trials of carotid endarterectomy. The excellent results in terms of operative outcome and long term stroke prevention would, according to certain comments, not be attainable in routine practice. Another criticism of carotid endarterectomy is its higher operative morbidity in terms of cranial nerve lesions and myocardial infarctions, compared to endovascular procedures. This consideration is, for some authors, the main reason to espouse carotid artery stenting as a better alternative to carotid endarterectomy. Any evidence supporting this point of view is missing. The supposed equivalence or non-inferiority of carotid artery stenting is purely speculative. The aim of this review paper is to summarize the crude data of carotid surgery trials. The authors aim to answer four questions. For which lesions is carotid endarterectomy most beneficial ? Are the results of randomised carotid surgery trials biased by the selection of patients ? Is operative morbidity, other than stroke, under-estimated ? Is carotid artery stenting safe and efficacious ? An in-depth review with a critical analysis is made of recently published and on-going trials, comparing carotid surgery with percutaneous carotid angioplasty. [less ▲]

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See detailLessons learnt from Co-Financed Action with NGOs
Aguilar, Luisa; Pirotte, Gautier ULg

Report (2005)

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See detailLessons to be learned from varicella-zoster virus
Rentier, Bernard ULg; Piette, Jacques ULg; Baudoux, Laurence et al

in Veterinary Microbiology (1996), 53(1-2), 55-66

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the ... [more ▼]

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the skin where it causes typical lesions. There, it penetrates the peripheral nervous system and it remains latent in dorsal root ganglia. It is still debatable whether VZV persists in neurons or in satellite cells. During latency, VZV expresses a limited set of transcripts of its immediate early (IE) and early (E) genes but no protein has been detected. Mechanisms of reactivation from ganglia have not been identified. However, dysfunction of the cellular immune system appears to be involved in this process. The cell-associated nature of VZV has made it difficult to identify a temporal order of gene expression, but there appears to be a cascade mechanism as for HSV-1. The lack of high titre cell-free virions or recombination mutants has hindered so far the understanding of VZV gene functions. Five genes, ORFs 4, 10, 61, 62, and 63 that encode regulatory proteins could be involved in VZV latency. ORF4p activates gene promoters with basal activities. ORF10p seems to activate the ORF 62 promoter. ORF61p has trans-activating and trans-repressing activities. The major IE protein ORF62p, a virion component, has DNA-binding and regulatory functions, transactivates many VZV promoters and even regulates its own expression. ORF63p is a nuclear IE protein of yet unclear regulatory functions, abundantly expressed very early in infection. We have established an animal model of VZV latency in the rat nervous system, enabling us to study the expression of viral mRNA and protein expression during latency, and yielding results similar to those found in humans. This model is beginning to shed light on the molecular events in VZV persistent infection and on the regulatory mechanisms that maintain the virus in a latent stage in nerve cells. [less ▲]

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See detailLet the Country Grow
Maiorano, Diego ULg

in Economic and Political Weekly (2013), XLVIII(22),

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See detailLet's Talk Ambiguity: Citizen science in new and emerging technologies
Van Oudheusden, Michiel ULg

Conference (2014, July 04)

Citizen science (CS) is a fairly new concept that is rapidly gaining traction in the industrialized democratic world. Although it is often likened to public participation in science, CS takes on many ... [more ▼]

Citizen science (CS) is a fairly new concept that is rapidly gaining traction in the industrialized democratic world. Although it is often likened to public participation in science, CS takes on many forms and orientations. In this presentation, I link CS developments and practices to the advent of new and emerging technologies (NEST), such as bio- and nanotechnologies. I draw on three Flemish cases of CS linked to NEST to illustrate how CS co-evolves with Flemish and European policy shifts towards responsible innovation governance. The cases serve to highlight how various conceptions of CS enact divergent rationales for public involvement in science and promote competing visions of the volatile relationship between science and society. The clash of CS perspectives within and through NEST produces a highly ambiguous innovation context that is simultaneously characterized by excitement and (pre)caution; public and formal expertise; policy dictates and public dialogue; and deterministic and constructionist views of innovation. How implicated actors (policymakers, scientists, citizens, and other stakeholders) make sense of, and deal with, these ambiguities is one of the key challenges CS faces today. [less ▲]

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See detailLethal white foal syndrome – Revue de la littérature à partir de 2 cas cliniques
Sandersen, Charlotte ULg; Delguste, Catherine ULg; Cassart, Dominique ULg et al

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2002)

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See detailLets get our city clean
Gosset, Christiane ULg; Trinon, J.

in Case Studies Pack, Volume II, Healthy Cities Symposium (1989)

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See detailLetter To The Editor
Groß-Hardt, E; Henschke, M; Pfennig, Andreas ULg

in AIChE Journal (2003), 49(6), 1610-1611

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See detailLetter to the Editor.
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Seminars in arthritis and rheumatism (2015), 44(5), 15

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