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See detailLong-term care insurance and optimal taxation for altruistic children
Jousten, Alain ULg; Lipszyc, B.; Marchand, Maurice et al

in Finanzarchiv (2005), 61(1), 1-18

We model long-term care insurance in an optimal taxation framework. Every adult decides upon the amount and type of care he purchases for his dependent parent. We consider two alternatives: nursing-home ... [more ▼]

We model long-term care insurance in an optimal taxation framework. Every adult decides upon the amount and type of care he purchases for his dependent parent. We consider two alternatives: nursing-home care provided by the government, and home care paid by the child with some lump-sum subsidy by the government. The only source of information asymmetry is the government's inability to observe the degree of altruism of the adult child for his/her parent. Further tax collection entails some social costs. In such a second-best setting, we show that the quality of institutional care has to be kept relatively low and that compared to altruistic children, nonaltruistic ones enjoy a high level of consumption. [less ▲]

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See detailLong-Term Care: the State, the Market and the Family
Motohiro, Sato; Pestieau, Pierre ULg

in Economica (2008), (75), 435-454

In this paper we study the optimal design of a long term care policy in a setting that includes three types of care to dependent parents: public nursing, private nursing and assistance in time by children ... [more ▼]

In this paper we study the optimal design of a long term care policy in a setting that includes three types of care to dependent parents: public nursing, private nursing and assistance in time by children. Private nursing can be financed either by financial aid from children or by private insurance. The social planner can use a number of instruments: public nursing, subsidy to aiding children, subsidy to private insurance premiums, all financed by a flat tax on earnings. [less ▲]

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See detailLong-term climate commitments projected with climate-carbon cycle models
Plattner, G. K.; Knutti, R.; Joos, F. et al

in Journal of Climate (2008), 21(12), 2721-2751

Eight earth system models of intermediate complexity (EMICs) are used to project climate change commitments for the recent Intergovernmental Panel on Climate Change's (IPCC's) Fourth Assessment Report ... [more ▼]

Eight earth system models of intermediate complexity (EMICs) are used to project climate change commitments for the recent Intergovernmental Panel on Climate Change's (IPCC's) Fourth Assessment Report (AR4). Simulations are run until the year 3000 A. D. and extend substantially farther into the future than conceptually similar simulations with atmosphere-ocean general circulation models (AOGCMs) coupled to carbon cycle models. In this paper the following are investigated: 1) the climate change commitment in response to stabilized greenhouse gases and stabilized total radiative forcing, 2) the climate change commitment in response to earlier CO2 emissions, and 3) emission trajectories for profiles leading to the stabilization of atmospheric CO2 and their uncertainties due to carbon cycle processes. Results over the twenty-first century compare reasonably well with results from AOGCMs, and the suite of EMICs proves well suited to complement more complex models. Substantial climate change commitments for sea level rise and global mean surface temperature increase after a stabilization of atmospheric greenhouse gases and radiative forcing in the year 2100 are identified. The additional warming by the year 3000 is 0.6-1.6 K for the low-CO2 IPCC Special Report on Emissions Scenarios (SRES) B1 scenario and 1.3-2.2 K for the high-CO2 SRES A2 scenario. Correspondingly, the post-2100 thermal expansion commitment is 0.3-1.1 m for SRES B1 and 0.5-2.2 m for SRES A2. Sea level continues to rise due to thermal expansion for several centuries after CO2 stabilization. In contrast, surface temperature changes slow down after a century. The meridional overturning circulation is weakened in all EMICs, but recovers to nearly initial values in all but one of the models after centuries for the scenarios considered. Emissions during the twenty-first century continue to impact atmospheric CO2 and climate even at year 3000. All models find that most of the anthropogenic carbon emissions are eventually taken up by the ocean (49%-62%) in year 3000, and that a substantial fraction (15%-28%) is still airborne even 900 yr after carbon emissions have ceased. Future stabilization of atmospheric CO2 and climate change requires a substantial reduction of CO2 emissions below present levels in all EMICs. This reduction needs to be substantially larger if carbon cycle-climate feedbacks are accounted for or if terrestrial CO2 fertilization is not operating. Large differences among EMICs are identified in both the response to increasing atmospheric CO2 and the response to climate change. This highlights the need for improved representations of carbon cycle processes in these models apart from the sensitivity to climate change. Sensitivity simulations with one single EMIC indicate that both carbon cycle and climate sensitivity related uncertainties on projected allowable emissions are substantial. [less ▲]

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See detailLong-term cold therapy to treat knee osteoarthritis: proof-of-concept.
Henrotin, Yves ULg

in Hospital Health Care (2009)

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See detailThe long-term cytoskeletal rearrangement induced by rabbit enteropathogenic Escherichia coli is Esp-dependent but intimin-independent
Nougayrède, J. P.; Marchès, O.; Boury, M. et al

in Molecular Microbiology (1999), 31

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See detailLong-term denosuamab treatment in postmenopausal women with osteoporosis : results from the first two years of the FREEDOM trial extension
Bone, H.; Chapurlat, R.; Brandi, M. et al

in Osteoporosis International (2011), 22(S4), 527-528

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See detailLong-term denosumab treatment of postmenopausal women with osteoporosis: results from the first year extension study of the FREEDOM trial
Chapurlat, R.; Papapoulos, Socrates; Bone, Henry G et al

in Arthritis and Rheumatism (2010, October), 62(10), 903

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See detailLong-term depression of trigeminal nociceptive evoked potentials by supraorbital 1Hz electrical stimulations is deficient in migraineurs but not in tension-type headache patients
Magis, Delphine ULg; Bolla, M.; De Pasqua, Victor ULg et al

in Cephalalgia : An International Journal of Headache (2006, November), 26(11), 1386

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See detailLong-term dietary segregation of common dolphins Delphinus delphis in the Bay of Biscay, determined using cadmium as an ecological tracer
Lahaye, Virginie; Bustamante, Paco; Spitz, Jérome et al

in Marine Ecology. Progress Series (2005), 305

Dietary studies in marine mammals are traditionally performed by stomach contents analyses, which may be insufficient to determine long-term dietary preferences of these upper level predators. Our primary ... [more ▼]

Dietary studies in marine mammals are traditionally performed by stomach contents analyses, which may be insufficient to determine long-term dietary preferences of these upper level predators. Our primary objective was to test the efficiency of trace metal measurements as complementary tools in dietary studies. Variations in cadmium (Cd) exposure through the diet and its effective renal levels in the short-beaked common dolphin Delphinus delphis were investigated to study the long-term feeding ecology of this predator in the neritic and oceanic waters of the Bay of Biscay. Based upon previous stomach contents analyses, the main prey occurring in the diet of common dolphins were analysed for their Cd contents. Results showed that cephalopods, and especially oceanic Cranchids and Histioteuthids, constituted a major source of Cd for common dolphins. Estimated Cd intake would therefore be 12 times higher in oceanic common dolphins (1400 ± 65 μg d–1) compared to neritic ones (120 ± 30 μg d–1). Accumulation of renal Cd concentrations with age was 5 times higher in by-caught oceanic dolphins than neritic ones (p < 0.0001). Within the neritic area, renal Cd accumulation rate was 2 times higher in by-caught individuals compared to stranded ones (p = 0.002). Thus, the use of Cd concentrations in by-caught dolphins proved efficient for assessing the existence of dietary segregation between neritic and oceanic common dolphins from the Bay of Biscay. However, using Cd data to make inferences about the feeding ecology of stranded animals should be considered cautiously. [less ▲]

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See detailLong-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.
Schetelig, Johannes; Fetscher, Sebastian; Reichle, Albrecht et al

in Haematologica (2003), 88(11), 1272-8

BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the impact of high-dose chemotherapy (HDCT) and autologous hematopoietic stem cell transplantation in patients with AIL. Data on 29 patients, who were transplanted between 1992 and 1998 in 16 transplant centers, were collected on standardized documentation forms. RESULTS: The median age at transplantation was 53 years. HDCT was given as part of 1st-line therapy (N=14; 48%) or 2nd/3rd-line therapy (N=15; 52%). Regimens for the mobilization of peripheral blood stem cells (PBSC) included VIPE (N=7; 26%), DexaBEAM (N=6; 22%), CHOP-like regimens (N=6; 22%), other regimens (N=5; 19%) or alternatively growth factor alone (N=3; 11%). The median yield of PBSC was 3.8x106 CD34+cells/kg. Two patients received autologous bone marrow. The HDCT consisted of BEAM-type regimens in 16 patients, ICE-type regimens in 7, and other regimens in 6 patients. There was one treatment-related death. The rate of complete remissions increased from 45% before HDCT to 76% after HDCT. As of January 2003, after a median observation time of living patients of 5 years (range 2.5 to 10 years), 14 patients have died (13 from progressive disease), and 15 patients are alive. The probability of 5-year overall and event-free survival was 44% (95% CI, 22% to 66%) and 37% (95% CI, 17% to 57%), respectively. Long-term disease-free survival was observed in patients transplanted during 1st-line treatment as well as in the context of 2nd/3rd-line therapy. INTERPRETATION AND CONCLUSIONS: There is evidence that AIL is susceptible to high-dose chemotherapy. HDCT and autologous stem cell transplantation should be considered in selected patients with AIL. [less ▲]

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See detailLong-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study.
Van Gaal, Luc F; Scheen, André ULg; Rissanen, Aila M et al

in European Heart Journal (2008), 29(14), 1761-71

AIMS: Rimonabant, the first selective cannabinoid type 1 receptor blocker, has been shown to produce weight loss and improvements in several cardiometabolic risk factors over 1 year. We report the 2 year ... [more ▼]

AIMS: Rimonabant, the first selective cannabinoid type 1 receptor blocker, has been shown to produce weight loss and improvements in several cardiometabolic risk factors over 1 year. We report the 2 year efficacy and tolerability data of rimonabant. METHODS AND RESULTS: Patients with a body mass index > or =30 or >27 kg/m(2) with treated/untreated hypertension, dyslipidaemia, or both, were randomized to double-blind treatment with placebo, rimonabant 5 or 20 mg once daily plus a calorie-restricted diet for 2 years. Weight loss from baseline to 2 years in the intention-to-treat population was significantly greater with rimonabant 20 mg (mean +/- SD: -5.5 +/- 7.7 kg; P < 0.001) and 5 mg (-2.9 +/- 6.5 kg; P = 0.002) than placebo (-1.2 +/- 6.8 kg). Rimonabant 20 mg produced significantly greater improvements than placebo in waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose and insulin levels, insulin resistance, and metabolic syndrome prevalence. Rimonabant 20 mg produced clinically meaningful improvements in all Impact of Weight on Quality of Life-Lite questionnaire domain scores at 2 years. Rimonabant was generally well tolerated and rates of adverse events, including depressed mood disorders and disturbances were similar to placebo during year 2. Proportions of patients with clinically significant depression (Hospital Anxiety and Depression Scale score >11) were similar in all treatment groups. CONCLUSION: Rimonabant 20 mg over 2 years promoted clinically relevant and durable weight loss and improvements in cardiometabolic risk factors. [less ▲]

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See detailLong-term effect on plasma, meat and milk selenium and blood glutathion peroxydase of feeding selenium-enriched barley and haylage to Belgian Blue cows, calves and fattened bulls
de Behr, V.; Marche, C.; Coenen, M. et al

in Proceedings of 7th Conference of the European Society of Veterinary and Comparative Nutrition (2003)

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See detailLong-term effects of androgen treatment on fear reactions in ewes.
Bouissou, Marie-France; Vandenheede, Marc ULg

in Hormones & Behavior (1996), 30

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See detailLong-term Effects of Avocado/Soybean Unsaponifiable on Human Chondrocytes Metabolism
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Osteoarthritis and Cartilage (2001), 9(supplB), 25

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See detailLong-term Effects of Avocado/Soybean Unsaponifiable on Human Chondrocytes Metabolism
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Clinical Rheumatology (2001), 20(5), 45

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See detailLong-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial.
Kahan, Andre; Uebelhart, Daniel; De Vathaire, Florent et al

in Arthritis and Rheumatism (2009), 60(2), 524-33

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an ... [more ▼]

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an international, randomized, double-blind, placebo-controlled trial in which 622 patients with knee OA were randomly assigned to receive either 800 mg CS (n = 309 patients) or placebo (n = 313 patients) once daily for 2 years. Radiographs of the target knee, using the Lyon schuss view, were obtained at the time of enrollment and at 12, 18, and 24 months. The minimum joint space width (JSW) of the medial compartment of the tibiofemoral joint was assessed by digital image analysis. The primary outcome was the loss in minimum JSW over 2 years. RESULTS: The intent-to-treat analysis demonstrated a significant reduction (P < 0.0001) in minimum JSW loss in the CS group (mean +/- SEM -0.07 +/- 0.03 mm) as compared with the placebo group (-0.31 +/- 0.04 mm). The percentage of patients with radiographic progression > or =0.25 mm was significantly reduced in the CS group compared with the placebo group (28% versus 41% [P < 0.0005]; relative risk reduction 33% [95% confidence interval 16-46%]). The number of patients needed to treat was 8 (95% confidence interval 5-17). Pain improved significantly faster in the CS group than in the placebo group (P < 0.01). There were no differences in safety between groups. CONCLUSION: The long-term combined structure-modifying and symptom-modifying effects of CS suggest that it could be a disease-modifying agent in patients with knee OA. [less ▲]

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