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See detailLong-term outcome of Epilepsy surgery among 399 patients with non-lesional pathology including mesial temporal lobe sclerosis.
Scholsem, M.; Cohen-Gadol, A.; Martin, Didier ULg et al

Conference (2006, March)

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See detailLong-term outcome of Leigh syndrome caused by the NARP-T8993C mtDNA mutation.
DEBRAY, François-Guillaume ULg; Lambert, Marie; Lortie, Anne et al

in American Journal of Medical Genetics. Part A (2007), 143A(17), 2046-51

Mutations at mitochondrial DNA (mtDNA) nucleotide 8993 can cause neurogenic weakness, ataxia and retinitis pigmentosa (NARP syndrome), or maternally inherited Leigh syndrome (LS), with a correlation ... [more ▼]

Mutations at mitochondrial DNA (mtDNA) nucleotide 8993 can cause neurogenic weakness, ataxia and retinitis pigmentosa (NARP syndrome), or maternally inherited Leigh syndrome (LS), with a correlation between the amount of mutant mtDNA and the severity of the neurological disease. The T8993C mutation is generally considered to be clinically milder than the T8993G mutation but when the level of heteroplasmy exceeds 90%, progressive neurodegeneration has been found. We report on a long-term follow-up of a patient who presented at 4 years of age with typical LS but showed an unexpected resolution of his symptoms and a favorable outcome. At 18 years of age, his neurological examination was near normal, with neither peripheral neuropathy nor retinopathy. mtDNA analysis identified the presence of T8993C mutation at high level (>95%) in the patient's blood leukocytes. This case report and literature review emphasizes the variability of the phenotypic expression of the T8993C mutation and the need for caution in predictive counseling in such patients. (c) 2007 Wiley-Liss, Inc. [less ▲]

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See detailLong-term outcome of patients with acromegaly and congestive heart failure
Bihan, Hélène; Espinosa, Consuelo; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(11), 5308-5313

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac ... [more ▼]

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac abnormalities. However, the long-term cardiac effects of treatment for acromegaly have not been studied in patients who have already developed chronic congestive heart failure (CHF). We reviewed the charts of 330 consecutive patients with acromegaly treated in two French and Belgian centers since 1985. Ten patients with both acromegaly and CHF (eight men, two women, mean age 49.7 yr) were studied retrospectively. One of them was excluded because CHF was due to severe aortic stenosis. CHF ( New York Heart Association stages III-IV and echocardiography showing dilated hypokinetic cardiomyopathy with left ventricular systolic dysfunction and a left ventricular ejection fraction less than 45%) was diagnosed before, concomitantly, or after acromegaly in, respectively, two, five, and two patients. Three patients were referred with terminal heart failure requiring transplantation. One patient had transient CHF associated with a hypertensive crisis. The other eight patients had symptomatic chronic CHF. Control of GH hypersecretion failed, totally or partially, in three patients: one had a long-term survival, and the two others died at 1 and 5 yr. Good GH control was achieved in five patients: four of these are still alive 2-16 yr after diagnosis of CHF, their clinical status is stable or improved, and their quality of life is good. Overall, the 1- and 5-yr mortality ( or transplantation) rates for patients with chronic symptomatic CHF were 25% ( 2 of 8 patients) and 37.5% ( 3 of 8 patients), respectively. In conclusion, less than 3% of acromegalic patients developed CHF in this study. Although effective treatment of acromegaly improved short-term cardiovascular status, its impact on long-term survival is questionable. [less ▲]

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See detailLong-term outcome of patients with heart failure and dynamic functional mitral regurgitation
Lancellotti, Patrizio ULg; Gerard, P. G.; Ancion, A. et al

in European Heart Journal (2005, September), 26(Suppl. 1), 539

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See detailLong-term outcome of patients with heart failure and dynamic functional mitral regurgitation.
LANCELLOTTI, Patrizio ULg; Gérard, Paul ULg; Pierard, Luc ULg

in European Heart Journal (2005), 26(15), 1528-32

AIMS: In patients with heart failure and chronic ischaemic mitral regurgitation (MR), the mortality risk is related to the quantified severity of MR at rest and its dynamic changes during exercise. The ... [more ▼]

AIMS: In patients with heart failure and chronic ischaemic mitral regurgitation (MR), the mortality risk is related to the quantified severity of MR at rest and its dynamic changes during exercise. The impact of dynamic MR on long-term mortality, hospital admission for heart failure, and major adverse cardiac events has never been investigated. METHODS AND RESULTS: We prospectively studied 161 patients with chronic ischaemic left ventricular (LV) dysfunction and at least mild MR who underwent quantitative measurement of the effective regurgitant orifice (ERO) of MR at rest and during semi-supine exercise test and who were followed up for 35+/-11 months. The 20 patients who underwent surgery were censored at the time of operation. Of the 141 patients who were treated medically, 23 died, 22 required hospitalization for heart failure, 4 had nonfatal myocardial infarction, and 11 developed unstable angina. By multivariate analysis, an exercise-induced increase in ERO by > or =13 mm(2) and a greater increase in transtricuspid pressure gradient during exercise emerged as predictors of mortality and of hospital admission for heart failure. MR severity under basal conditions (ERO> or =20 mm(2)) was an independent predictor of only cardiac death. Greater LV volumes at rest and lack of contractile reserve during exercise were additional independent markers of poor outcome. CONCLUSION: In patients with ischaemic heart disease and LV dysfunction, large exercise-induced increases in MR identify patients at high risk of morbidity and of death. [less ▲]

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See detailLong-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy.
Hovels-Gurich, Hedwig H; Bauer, Sebastian B; Schnitker, Ralph et al

in European Journal of Paediatric Neurology : Official Journal of the European Paediatric Neurology Society (2008), 12(5), 378-386

The purpose of this prospective study was to assess whether outcome of speech and language in children 5-10 years after corrective surgery for tetralogy of Fallot (TOF) or ventricular septal defect (VSD ... [more ▼]

The purpose of this prospective study was to assess whether outcome of speech and language in children 5-10 years after corrective surgery for tetralogy of Fallot (TOF) or ventricular septal defect (VSD) in infancy was influenced by the preoperative condition of hypoxemia or cardiac insufficiency and whether it was associated with perioperative risk factors and neurodevelopmental outcome. A total of 35 unselected children, 19 with TOF and hypoxemia and 16 with VSD and cardiac insufficiency, operated with combined deep hypothermic circulatory arrest and low-flow cardiopulmonary bypass at mean age 0.7+/-0.3 (mean+/-standard deviation) years, underwent, at mean age 7.4+/-1.6 years, standardized evaluation of speech and language functions. Results were compared between subgroups and related to perioperative factors, sociodemographic and neurodevelopmental status. Age at testing, socioeconomic status and history of speech and language development were not different between the subgroups. In contrast, total scores on oral and speech motor control functions (TFS) as well as on oral and speech apraxia (Mayo Test) were significantly reduced (p<0.02 to <0.05), and scores on anatomical oral structures tended to be lower (p<0.09) in the TOF group as compared to the VSD group. No differences were found for auditory word recognition and phonological awareness as assessed by the Auditory Closure subtest of the Illinois Test of Psycholinguistic Abilities and the test of auditory analysis skills, respectively. In all children, higher age at testing and better socioeconomic status were associated with better results in all domains of assessment (p<0.001 to <0.04). Consistent impairments of all oral and speech motor control functions (TFS and Mayo Test) were present in 29% of all children with a mean age of 6.5 years in contrast to 43% with normal performance and a mean age of 8.3 years. On the receptive speech tasks, only 6% scored below the normal range of their age group. TFS subscores were significantly correlated with age, bypass duration and motor function, but not correlated with socioeconomic status, duration of cardiac arrest, intelligence and academic achievement. Children with preoperative hypoxemia due to cyanotic cardiac defects in infancy are at higher risk for dysfunction in speech and language than those with cardiac insufficiency due to acyanotic heart defects. Age at testing, socioeconomic status, and duration of cardiopulmonary bypass influenced test results. Long-term outcome in speech and language functions can be considered as a sensitive indicator of overall child development after cardiac surgery. [less ▲]

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See detailLong-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort
Schnitzler, F.; Fidder, H.; Ferrante, M. et al

in Gut (2009), 58(4), 492-500

BACKGROUND AND AIMS: This observational study assessed the long-term clinical benefit of infliximab (IFX) in 614 consecutive patients with Crohn's disease (CD) from a single centre during a median follow ... [more ▼]

BACKGROUND AND AIMS: This observational study assessed the long-term clinical benefit of infliximab (IFX) in 614 consecutive patients with Crohn's disease (CD) from a single centre during a median follow-up of 55 months (interquartile range (IQR) 27-83). METHODS: The primary analysis looked at the proportion of patients with initial response to IFX who had sustained clinical benefit at the end of follow-up. The long-term effects of IFX on the course of CD as reflected by the rate of surgery and hospitalisations and need for corticosteroids were also analysed. RESULTS: 10.9% of patients were primary non-responders to IFX. Sustained benefit was observed in 347 of the 547 patients (63.4%) receiving long-term treatment. In 68.3% of these, treatment with IFX was ongoing and in 31.7% IFX was stopped, with the patient being in remission. Seventy patients (12.8%) had to stop IFX due to side effects and 118 (21.6%) due to loss of response. Although the yearly drop-out rates of IFX in patients with episodic (10.7%) and scheduled treatment (7.1%) were similar, the need for hospitalisations and surgery decreased less in the episodic than in the scheduled group. Steroid discontinuation also occurred in a higher proportion of patients in the scheduled group than in the episodic group. CONCLUSIONS: In this large real-life cohort of patients with CD, long-term treatment with IFX was very efficacious to maintain improvement during a median follow-up of almost 5 years and changed disease outcome by decreasing the rate of hospitalisations and surgery. [less ▲]

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See detailLong-term outcomes in dogs with sinonasal aspergillosis treated with intranasal infusions of enilconazole
Schuller, S.; Clercx, Cécile ULg

in Journal of the American Animal Hospital Association (2007), 43(1, Jan-Feb), 33-38

Long-term outcomes ( mean 38 +/- 17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole ( 1%, n= 15; 2%, n ... [more ▼]

Long-term outcomes ( mean 38 +/- 17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole ( 1%, n= 15; 2%, n= 12). Long-term outcomes with both treatment protocols were good, with half of the dogs being asymptomatic throughout the follow-up period. The remaining dogs showed mild clinical signs compatible with chronic rhinitis/sinusitis. These clinical signs were interpreted as chronic lymphoplasmacytic rhinitis/sinusitis and episodes of bacterial rather than fungal infection. Three dogs had confirmed reinfection or relapse 2 to 36 months after clinical resolution. [less ▲]

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See detailLong-Term Performance in Vitro and in Vivo of Dual-Energy X-Ray Absorptiometry
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Zegels, Brigitte ULg et al

in Clinical Rheumatology (1995), 14(2), 180-6

Dual-energy X-ray absorptiometry (DXA) is actually considered as one of the most appropriate techniques for measuring bone mineral content (BMC) and bone mineral density (BMD). An anthropomorphic phantom ... [more ▼]

Dual-energy X-ray absorptiometry (DXA) is actually considered as one of the most appropriate techniques for measuring bone mineral content (BMC) and bone mineral density (BMD). An anthropomorphic phantom and a 25-year-old girl were repeatedly measured, 160 times and 50 times respectively, over an 18-month period to investigate performance in vitro and in vivo of a commercial DXA equipment (HOLOGIC QDR 1000). DXA is a highly accurate technique, the BMC and BMD determinations only overestimated the exact value of the phantom by 0.20% and 0.51% respectively. In vivo long-term (18 months) reproducibility of BMD of the spine is characterized by an interassay coefficient of variation (CVt) of 0.8% while, for the different regions of interest of the hip, BMD CVt varies from 1.1% (total zone) to 5.3% (Ward's triangle). In the subject tested, BMD sensitivity for changes of 2.2% at the lumbar spine and 3% at the hip were recorded. [less ▲]

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See detailLong-Term Photometric and Spectroscopic Monitoring of Slowly Pulsating B Stars
Aerts, C.; De Cat, P.; De Ridder, J. et al

in The Impact of Large-Scale Surveys on Pulsating Star Research, ASP Conference Series, Vol. 203; also IAU Colloquium #176. Edited by L. Szabados and D. Kurtz, p.437 (2000)

We review the current status of our long-term monitoring project on slowly pulsating B stars that we started in the course of 1996 and that was recently completed as far as the first part of our plan is ... [more ▼]

We review the current status of our long-term monitoring project on slowly pulsating B stars that we started in the course of 1996 and that was recently completed as far as the first part of our plan is concerned. In total, we have selected 17 southern and 8 northern stars. The idea is to fully exploit our current data in the near future and to select the most interesting targets for further very-long-term follow-up monitoring. A first conclusion is that half of the southern targets turn out to be spectroscopic binaries. Some of these have circular orbits and periods of the same order of magnitude as the intrinsic pulsation period(s) of the primary. The eccentric binaries have periods ranging from 12 to 460 d. For most stars the photometric behaviour is dominated by the same frequency as the intrinsic spectroscopic variability. Multiperiodicity in the expected frequency range is found for almost all stars. Two objects, however, turn out to have only one dominant pulsation mode. [less ▲]

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See detailLong-term photometric campaign at ESO and the new eclipsing P Cygni star R 81 in the LMC
Wolf, B.; Sterken, C.; Stahl, O. et al

in The Messenger (1987), 47

The Long-term Photometry of Variables project is described. All measurements were carried out in the Stromgren uvby system and preference was given to differential measurements with two comparison stars ... [more ▼]

The Long-term Photometry of Variables project is described. All measurements were carried out in the Stromgren uvby system and preference was given to differential measurements with two comparison stars. Included in this photometry program was the study of R 81, the counterpart of P Cyg in the LMC. A variation period of 74.59 + or - 0.01 days was obtained for this eclipsing binary. [less ▲]

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See detailLong-term photometry of variables at ESO. I - The first data catalogue (1982-1986)
Manfroid, Jean ULg; Sterken, C.; Bruch, A. et al

in Astronomy and Astrophysics. Supplement Series (1991), 87

This paper presents the catalog of photometric data in the Stromgren system obtained during the first four years (October 1982 - September 1986) of the Long-Term Photometry of Variables (LTPV) program at ... [more ▼]

This paper presents the catalog of photometric data in the Stromgren system obtained during the first four years (October 1982 - September 1986) of the Long-Term Photometry of Variables (LTPV) program at ESO. The data are available in computer-readable form. [less ▲]

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See detailLong-Term Photometry of Variables at ESO. I.
Manfroid, Jean ULg; Sterken, C.; Bruch, A. et al

Report (1991)

Not Available

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See detailLong-Term Photometry of Variables at ESO. II. The Second Data Catalogue (1986-1990).
Sterken, C.; Manfroid, Jean ULg; Anton, K. et al

in European Southern Observatory Scientific Report (1993), 12

Not Available

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See detailLong-term photometry of variables at ESO. III. The third data catalogue (1990-1992).
Manfroid, Jean ULg; Sterken, C.; Cunow, B. et al

in Astronomy and Astrophysics. Supplement Series (1995), 109

In this paper we present the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables ... [more ▼]

In this paper we present the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. The catalogue is available in computer readable form at the Centre de Donnees de Strasbourg. [less ▲]

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See detailLong-term photometry of variables at ESO. IV. The fourth data catalogue (1992-1994).
Sterken, C.; Manfroid, Jean ULg; Beele, D. et al

in Astronomy and Astrophysics. Supplement Series (1995), 113

In this paper we present the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992-August 23, 1994 in the framework of the Long-Term Photometry of ... [more ▼]

In this paper we present the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992-August 23, 1994 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. The catalogue is available in computer readable form at the Centre de Donnees de Strasbourg via anonymous ftp 130.79.128.5. [less ▲]

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See detailLong-term photometry of Variables I. (Manfroid+ 1991)
Manfroid, Jean ULg; Sterken, C.; Bruch, A. et al

Report (1995)

This is the first catalogue of photometric data in the Stroemgren system obtained during the period October 1982 - September 1986. Full description can be found in ESO report SP 8. Since our goal is not ... [more ▼]

This is the first catalogue of photometric data in the Stroemgren system obtained during the period October 1982 - September 1986. Full description can be found in ESO report SP 8. Since our goal is not absolute (all-sky) photometry, the observations should be used for differential photometry only. The mean values of the r.m.s. deviations of the differential measurements of comparison stars are around (from Table 5 of paper) ------------------------------------ System y b-y m1 c1 ------------------------------------ 1 0.0109 0.0088 0.0133 0.0136 4 0.0068 0.0057 0.0079 0.0118 5 0.0087 0.0070 0.0114 0.0114 6 0.0090 0.0078 0.0126 0.0132 7 0.0071 0.0033 0.0041 0.0065 ------------------------------------ (2 data files). [less ▲]

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See detailLong-term photometry of Variables III (Manfroid+, 1995)
Manfroid, Jean ULg; Sterken, C.; Cunow, B. et al

Report (1995)

This is the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables (LTPV) program at ... [more ▼]

This is the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. All data have been obtained with the Danish 50-cm telescope. The mean values of the r.m.s. deviations of the differential measurements of comparison stars are around (from Table 4 of paper) ------------------------------ y b-y m1 c1 ------------------------------ 0.005 0.002 0.004 0.006 ------------------------------ (2 data files). [less ▲]

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See detailLong-term photometry of Variables IV (Sterken+, 1995)
Sterken, C.; Manfroid, Jean ULg; Beele, D. et al

Report (1996)

This is the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992 - August 23, 1994 in the framework of the Long-Term Photometry of Variables (LTPV ... [more ▼]

This is the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992 - August 23, 1994 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. Since our goal is not absolute (all-sky) photometry, the observations should be used for differential photometry only. The mean values of the r.m.s. deviations of the differential measurements of comparison stars are around (from Table 3 of paper) ------------------------------ y b-y m1 c1 ------------------------------ 0.005 0.002 0.004 0.007 ------------------------------ (2 data files). [less ▲]

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Peer Reviewed
See detailLong-term precision of quantitative digital radiology
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Albert, Adelin ULg et al

in Revue du Rhumatisme et des Maladies Osteo-Articulaires (1992), 59

Detailed reference viewed: 3 (2 ULg)