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See detailLes matrices inverses généralisées et leur utilisation dans le modèle linéaire
Iemma, A. F.; Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1992), (1), 25

In this note, we first present three different types of generalized inverse matrices (conditional, least squares and MOORE-PENROSE inverse matrices), as well as some of their properties. Applications of ... [more ▼]

In this note, we first present three different types of generalized inverse matrices (conditional, least squares and MOORE-PENROSE inverse matrices), as well as some of their properties. Applications of these inverse matrices in the linear model are then examined (normal equations solutions, orthogonal projections, sums of squares and their sampling distributions, estimations of parametric functions and sums of squares related to hypotheses testing). [less ▲]

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See detailLes matrices métalliques et céramiques : de nouveaux matériaux composites
Montrieux, Henri-Michel ULg; Lecomte-Beckers, Jacqueline ULg; Mertens, Anne ULg

in Plus Composites (2013), article n°3

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une ... [more ▼]

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une matrice métallique ou céramique. Certains de ces matériaux nouveaux sont toujours au stade du développement. Il s’agit par exemple des composites pour applications structurales avec une matrice légère en aluminium ou en magnésium pour lesquels les rapports rigidité-poids et résistance-poids sont élevés. La résilience est aussi améliorée par rapport aux matrices classiques simplement renforcées. D’autres composites à matrice métallique tels que les cermets sont industrialisés comme outils de coupe. Des composites à matrice céramique comme le carbone-carbone ou le carbone-SiC peuvent être industrialisés et présentent une durabilité et une température d’utilisation maximale exceptionnelle. Pour terminer, l’article fournit quelques informations sur les techniques nouvelles de mise à forme des matériaux composites telles que le friction stir processing et l’additive manufacturing. [less ▲]

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See detailMatrimonial property and Succession under EU Private International Law : a Happy Marriage?
Wautelet, Patrick ULg

Conference (2014, March)

In this presentation, I attempt to examine the relationship between the Succession Regulation (650/2012) and matrimonial property. I do so by looking at the difficulties which could arise both from a ... [more ▼]

In this presentation, I attempt to examine the relationship between the Succession Regulation (650/2012) and matrimonial property. I do so by looking at the difficulties which could arise both from a practical perspective as well as from a more fundamental angle. Attention is given to the future Matrimonial Property Regulation and the need to coordinate it with the Succession Regulation. [less ▲]

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See detailMatrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid
Devy, L.; Hollender, P.; Munaut, Carine ULg et al

in Biochemical Pharmacology (2002), 63(2), 179-189

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and ... [more ▼]

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and NB4 cell lines, representative of acute myelogenous leukemia, their ability to express matrix metalloproteases (MMPs), tissue inhibitors of metalloproteases (TIMPs) and urokinase plasminogen activator (uPA) in response to differentiating agents. Granulocytic differentiation by all-trans-retinoic acid (ATRA) and aclacinomycin (ACLA) strongly increased HL-60 and NB4 cell migration and invasion. At mRNA and protein levels, these cell lines produced significant amounts of MMP-9 (HL-60 < NB4). Granulocytic differentiation by ACLA increased both pro and active forms of MMP-9 whereas ATRA decreased them and stimulated uPA mRNAs. TIMP-1, the physiological MMP inhibitor, increased during granulocytic differentiation whereas TIMP-2 did not significantly vary. Use of Batimastat and aprotinin suggests that ATRA was active by modulating the uPA system while ACLA interfered with MMP expression. In conclusion, our data demonstrate that HL-60 and NB4 cells express MMPs and uPA which are differentially regulated by the differentiating agents ATRA and ACLA and suggest the clinical usefulness of MMPs and serine protease inhibitors in the prophylaxis and treatment of the ATRA syndrome. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailMatrix Effect on Laser Induced Breakdown Spectroscopy of Fine Coal
Xie, Chengli; Lu, Jidong; Li, Jie ULg et al

in Journal of Engineering Thermophysics (2008), 29(2), 331-334

The feasibility of laser—induced breakdown spectroscopy as a diagnostic tool for elementary analysis was documented widely,as well as the matrix effect of target material was proved to be remarkable ... [more ▼]

The feasibility of laser—induced breakdown spectroscopy as a diagnostic tool for elementary analysis was documented widely,as well as the matrix effect of target material was proved to be remarkable impact on the spectral analysis. The influence of physical characteristics of fine coal,including particle size and area density,on the emission spectrum was surveyed,such as spectral intensity,standard deviation of characteristic spectrum and the detection threshold.An intense laser radiation with a wavelength of 1064 nm was used to ablate fine coal to form plasma plume,and the emission spectrum emitted as the plasma cooling of was analyzed by high—resolution echelle grating spectrometer coupled to intensified CCD camera.The results suggest that moderate particle size and material density are more advantageous to quantitative analysis of coal by laser—induced breakdown spectroscopy than the smallest or biggest size,which can be interpretable by heat—transfer mechanism in target after a shot of laser pulse. [less ▲]

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See detailMatrix elements of SU(6) generators for baryons at arbitrary N-c
Matagne, Nicolas; Stancu, Floarea ULg

in Physical Review D (2006), 73(11),

We present explicit formulas for the matrix elements of the SU(6) generators for totally symmetric spin-flavor states, relevant for baryon spectroscopy in large N-c QCD. We rely on the interplay between ... [more ▼]

We present explicit formulas for the matrix elements of the SU(6) generators for totally symmetric spin-flavor states, relevant for baryon spectroscopy in large N-c QCD. We rely on the interplay between two different methods to calculate these matrix elements. As an outcome, general analytic formulas of the corresponding SU(6) isoscalar factors are derived for arbitrary N-c. These results can be used to study excited states of nonstrange and strange baryons. [less ▲]

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See detailMatrix elements of SU(6) generators for baryons with arbitrary $N_c$ quarks in mixed symmetric states $[N_c- 1,1]$
Matagne, Nicolas; Stancu, Floarea ULg

in Nucl. Phys. (2009), A826

We derive general analytic formulae for the matrix elements of the SU(6) generators for mixed symmetric $[N_c-1,1]$ spin-flavor states with an arbitrary number $N_c$ of quarks. They are relevant for ... [more ▼]

We derive general analytic formulae for the matrix elements of the SU(6) generators for mixed symmetric $[N_c-1,1]$ spin-flavor states with an arbitrary number $N_c$ of quarks. They are relevant for baryon spectroscopy in the $1/N_c$ expansion method applied to light baryons and can be used to study excited states. In this way previous work on non-strange baryons can be extended to both non-strange and strange baryons. [less ▲]

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See detailMatrix for analysing reading literacy curricula and official guidelines
Schillings, Patricia ULg

in Teaching Reading in Europe : Context, policies and practices (2011)

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See detailMatrix metalloprotease in bronchoalveolar lavage from healthy and RAO horses in crisis and in remission.
Art, Tatiana ULg; Kirschvink, Nathalie; de Moffaerts, Brieuc et al

in 3rd World Equine Airways Symposium (WEAS) (2005)

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See detailMatrix Metalloproteases and Epithelia-to-mesenchymal transition: implications for carcinoma metastasis.
Gilles, Christine ULg; Newgreen, Don; Sato, H. et al

in Savagner, P. (Ed.) Rise and Fall of Epithelial Phenotype: concepts of Epithelial-Mesenchymal Transition. (2005)

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See detailMatrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?
Garbacki, Nancy ULg; Di Valentin, Emmanuel ULg; Piette, Jacques ULg et al

in Pulmonary Pharmacology & Therapeutics (2009), 22(4), 267-278

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue ... [more ▼]

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed. [less ▲]

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See detailMatrix Metalloproteinase Family
Baramova, E.; Foidart, Jean-Michel ULg

in Cell Biology International (1995), 19(3), 239-42

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See detailMatrix metalloproteinase inhibition impairs adipose tissue development in mice
Lijnen, Roger; Maquoi, Erik ULg; Hansen, L. B. et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2002), 22(3), 374-379

The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type mice were fed the HFD (42% fat) for up to ... [more ▼]

The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type mice were fed the HFD (42% fat) for up to 12 weeks and were daily injected intraperitoneally with the inhibitor (100 mg/kg) or with vehicle. After 12 weeks of the HFD, the body weights of both groups were comparable, but the weight of the isolated subcutaneous (SC) or gonadal (GON) fat deposits was significantly lower in the inhibitor-treated group than in the control group (88 +/- 11 versus 251 +/- 66 mg, respectively, for SC fat [P<0.05]; 90 +/- 24 versus 217 +/- 30 mg, respectively, for GON fat [P<0.02]). The number of adipocytes was somewhat higher and the diameter was somewhat smaller (but not significantly) in adipose tissues of the inhibitor-treated group. Adipose tissue of the inhibitor-treated mice contained more collagen than did that of the vehicle-treated mice (Sirius red-stained area of 42 +/- 2.6% versus 22 +/- 4.4%, respectively, for SC fat [P<0.05]; 21 +/- 5.1% versus 4.7 +/- 0.92%, respectively, for GON fat [P<0.01]); a distinct collagen-rich cap was formed around the inhibitor-treated tissue. In situ zymography with casein- or gelatin-containing gels confirmed a reduced MMP activity in SC and GON adipose tissues of inhibitor-treated mice. Thus, in this model, growth and development of adipose tissue appears to be limited by the formation of a collagen-rich matrix cap around the inhibitor-treated tissue. These data suggest a functional role for MMPs in the development of adipose tissue. [less ▲]

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See detailMatrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice
Bracke, K.; Cataldo, Didier ULg; Maes, T. et al

in International Archives of Allergy & Immunology (2005), 138(2), 169-179

An imbalance between proteinases and their inhibitors is believed to play an essential role in the development of chronic obstructive pulmonary disease ( COPD) and pulmonary emphysema. COPD is mainly ... [more ▼]

An imbalance between proteinases and their inhibitors is believed to play an essential role in the development of chronic obstructive pulmonary disease ( COPD) and pulmonary emphysema. COPD is mainly caused by cigarette smoking, and is characterized by an increase in inflammatory cells in small airways and lung parenchyma. We examined the mRNA expression of several proteinases in lungs of mice exposed to cigarette smoke or control air. After 1, 3 and 6 months' smoke exposure there was a significant increase of matrix metalloproteinase (MMP)-12 and Cathepsin D mRNA, compared to air-exposed mice. To determine the cellular origin of MMP-12 and Cathepsin D, we isolated dendritic cells (DCs) and macrophages from the lungs of mice. There was an increase in MMP-12 mRNA after smoke exposure in both macrophage and DC populations, whereas Cathepsin D was predominantly expressed in macrophages. Immunohistochemistry clearly revealed the expression of Cathepsin D protein in alveolar macrophages of cigarette smoke-exposed mice, in contrast to air-exposed littermates. Western blots on lung tissue demonstrated an increase of MMP-12 protein in cigarette smoke- exposed animals. These results indicate that cigarette smoke increases the expression of MMP-12 and Cathepsin D in the lungs of mice, and that not only macrophages but also DCs produce MMP-12. Copyright (C) 2005 S. Karger AG, Basel. [less ▲]

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See detailMatrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
Detry, Benoît ULg; Erpicum, Charlotte ULg; Paupert, Jenny ULg et al

in Blood (2012), 119(21), 5048-56

Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to ... [more ▼]

Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how matrix metalloproteinase (MMP)–2 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and in 3D-culture systems, and through MMP2 inhibition. In all models used in vivo (3 murine models and thoracic duct development in zebrafish) and in vitro (lymphatic ring and spheroid assays), MMP2 blockage or down-regulation leads to reduced lymphangiogenesis or altered vessel branching. Our data show that lymphatic endothelial cell (LEC) migration through collagen fibers is affected by physical matrix constraints (matrix composition, density and cross-linking). Transmission electron microscopy (TEM) and confocal reflection microscopy using DQ-collagen highlight the contribution of MMP2 to mesenchymal-like migration of LEC associated with collagen fiber remodeling. Our findings provide new mechanistic insight into how LEC negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis. [less ▲]

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See detailMatrix metalloproteinase-3 is a highly mechanosensitive gene in human subchondral osteoblasts
Sanchez, Christelle ULg; Pesesse, Laurence ULg; Delcour, Jean-Pierre et al

in Osteoarthritis and Cartilage (2010), 17(suppl 2), 217

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See detailMatrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis
Ribbens, Clio ULg; Andre, Béatrice ULg; Jaspar, J. M. et al

in Journal of Rheumatology (2000), 120(1), 888-893

OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). METHODS: Serum MMP-3 ... [more ▼]

OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). METHODS: Serum MMP-3 levels were measured and compared to biological and clinical disease activity variables in 20 patients with active RA assessed serially during a one year prospective open label trial with methotrexate or tenidap. RESULTS: MMP-3 levels were significantly correlated with C-reactive protein (CRP) and interleukin 6 serum levels as well as with the disease activity score (DAS), not only at start in untreated patients but also during the 12 month followup period in both treated groups. Early changes (after 0.5, 1, 2, or 3 months) in MMP-3 levels were significantly associated with change in DAS observed 4 to 6 months later. CONCLUSION: In addition to CRP, a systemic marker of inflammation, serum MMP-3 may serve as a consistent synovial derived marker of RA disease activity, early changes of which predict disease outcome. [less ▲]

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See detailMatrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation
Guéders, Maud ULg; Balbin, M.; Rocks, Natacha ULg et al

in Journal of Immunology (2005), 175(4), 2589-2597

Matrix metalloproteinases (MMPs) are involved in inflammatory reaction, including asthma-related airway inflammation. MMP-8, mainly produced by neutrophils, has recently been reported to be increased in ... [more ▼]

Matrix metalloproteinases (MMPs) are involved in inflammatory reaction, including asthma-related airway inflammation. MMP-8, mainly produced by neutrophils, has recently been reported to be increased in the bronchoalveolar lavage fluid (BALF) from asthmatic patients. To evaluate the role of MMP-8 in asthma, we measured MMP-8 expression in lung tissue in an OVAsensitized mouse model of asthma and addressed the effect of MMP-8 deletion on allergen-induced bronchial inflammation. MMP-8 production was increased in lungs from C57BL/6 mice exposed to allergens. After allergen exposure, MMP-8-1-mice developed an airway inflammation characterized by an increased neutrophilic inflammation in BALF and an increased neutrophilic and eosinophilic infiltration in the airway walls. MMP-8 deficiency was associated with increased levels of IL-4 and antiOVA IgE and IgG1 in BALF and serum, respectively. Although allergen exposure induced an enhancement of LPS-induced CXC chemokine, KC, and MIP-2 levels in BALF and lung parenchyma, no difference was observed between the two genotypes. Inflammatory cell apoptosis was reduced in the lungs from MMP-8(-/-) mice. For the first time, our study evidences an important role of MMP-8 in the control of neutrophilic and eosinophilic infiltration during allergen-induced lung inflammation, and demonstrates that the anti-inflammatory effect of MMP-8 is partly due to a regulation of inflammatory cell apoptosis. [less ▲]

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See detailMatrix metalloproteinase-9 contributes to choroidal neovascularization
Lambert, Vincent ULg; Munaut, Carine ULg; Jost, M. et al

in American Journal of Pathology (2002), 161(4), 1247-1253

Age-related macular degeneration (AMD) is the primary cause of irreversible photoreceptors loss in adult patients and current therapies are limited. Increased levels of matrix metalloproteinases (MMPs ... [more ▼]

Age-related macular degeneration (AMD) is the primary cause of irreversible photoreceptors loss in adult patients and current therapies are limited. Increased levels of matrix metalloproteinases (MMPs) have been documented in neovascularization of severe ocular pathologies such as AMD and proliferative diabetic retinopathy. We report here that MMP-9 (gelatinase B) expression is induced and temporally regulated in the course of experimental choroidal neovascularization. We used transgenic mice expressing beta-galactosidase reporter gene under the dependence of MMP-9 promoter and RT-PCR analysis on choroidal neovascular structures microdissected from serial sections by laser pressure catapulting to show that MMP-9 expression is up-regulated concomitantly with the appearance of inflammatory cells in the subretinal lesion. In mice deficient in MMP-9 expression the development of choroidal neovascularization induced by laser photocoagulation still occurred, but at a reduced level. [less ▲]

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See detailMatrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
Cataldo, Didier ULg; Tournoy, K. G.; Vermaelen, K. et al

in American Journal of Pathology (2002), 161(2), 491-498

We investigated the specific role of matrix metalloproteinase (MMP)-9 in allergic asthma using a murine model of allergen-induced airway inflammation and airway hyperresponsiveness in MMP-9(-/-) mice and ... [more ▼]

We investigated the specific role of matrix metalloproteinase (MMP)-9 in allergic asthma using a murine model of allergen-induced airway inflammation and airway hyperresponsiveness in MMP-9(-/-) mice and their corresponding wild-type (WT) littermates. After a single intraperitoneal sensitization to ovalbumin, the mice were exposed daily either to ovalbumin (1%) or phosphate-buffered saline aerosols from days 14 to 21. Significantly less peribronchial mononuclear cell infiltration of the airways and less lymphocytes in the bronchoalveolar lavage fluid were detected in challenged MMP-9(-/-) as compared to WT mice. In contrast, comparable numbers of bronchoalveolar lavage fluid eosinophils; were observed in both genotypes. After allergen exposure, the WT mice developed a significant airway hyperresponsiveness to carbachol whereas the MMP-9(-/-) mice failed to do so. Allergen exposure induced an increase of MMP-9-related gelatinolytic activity in WT lung extracts. Quantitative reverse transcriptase-polymerase chain reaction showed increased mRNA levels of MMP-12, MMP-14, and urokinase-type plasminogen activator after allergen exposure in the lung extracts of WT mice but not in MMP-9-deficient mice. in contrast, the expression of tissue inhibitor of metalloproteinases-1 was enhanced after allergen exposure in both groups. We conclude that MMP-9 plays a key role in the development of airway inflammation after allergenexposure. [less ▲]

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