Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
See detailHIGHER MALE THAN FEMALE RECOMBINATION RATE LARGELY CONTROLLED BY MISSENSE VARIANTS IN RNF212, MLH3, HFM1, MSH5 AND MSH4 IN CATTLE
Kadri, Naveen Kumar ULg; Harland, Chad ULg; Faux, Pierre ULg et al

Poster (2016, May 11)

We herein study genetic recombination in three dairy cattle populations from France, New-Zealand and the Netherlands. We identify 2,395,177 crossover (CO) events in sperm cells transmitted by 2,940 sires ... [more ▼]

We herein study genetic recombination in three dairy cattle populations from France, New-Zealand and the Netherlands. We identify 2,395,177 crossover (CO) events in sperm cells transmitted by 2,940 sires to 94,516 offspring, and 579,996 CO events in oocytes transmitted by 11,461 cows to 25,332 offspring. When measured in identical family structures, the average number of CO in males (23.3) was found to be larger than in females (21.4). The heritability of global recombination rate (GRR) was estimated at 0.13 in males and 0.08 in females. The genetic correlation was equal to 0.66, indicating that shared variants are influencing GRR in both genders. Haplotype-based genome-wide association studies revealed seven genome-wide significant QTL. Variants identified by next-generating sequencing in 5 Mb windows encompassing the QTL peaks were imputed in order to perform a sequence-based association analysis. For four QTLs, we identified missense mutations in genes known to be involved in meiotic recombination among the most significantly associated variants. The P259S variant identified in RNF212 had already been reported, whereas missense mutations in MLH3 (N408S), HFM1 (S1189L), MSH5 (R631Q), MSH4 (C342Y) and a second in RNF212 (A77T) are new. Surprisingly, variants previously identified in REC8 were not associated with a QTL detected on BTA10 whereas variants in RNF212B, a paralog of RNF212, showed much stronger association with the phenotype in this region. This suggests that RNF212B might be involved in the recombination process. Most of the identified mutations had significant effects in both genders with three of them accounting each for approximately 10% of the genetic variance in males (the allelic substitution effect being approximately equal to one additional CO per genome). Thus, a large fraction of the genetic variance is associated with missense mutations in genes known to be involved in meiotic recombination. Our results are very different from reports of recombination in other species. For instance, in human, recombination rate is higher in females, distinct variants affect recombination rate in males and females, and the genetic correlation is close to 0, whereas in cattle, we observed a higher recombination rate in males controlled by shared variants effective in both sexes. [less ▲]

Detailed reference viewed: 37 (2 ULg)
See detailHigher Needs for Enacted Knowledge. The case of Belgian Prison Governors
Dubois, Christophe ULg

Scientific conference (2017, April 27)

Considering that Belgian prison policy has been characterized by an increase of managerial and legal regulations in the last fifteen years, this rise of “inscribed knowledge” (Freeman & Sturdy, 2015 ... [more ▼]

Considering that Belgian prison policy has been characterized by an increase of managerial and legal regulations in the last fifteen years, this rise of “inscribed knowledge” (Freeman & Sturdy, 2015) leads to a sharper need of prison managers for “practical wisdom” (Chia and Holt, 2009). Two statements enlighten this paradoxical irony. Firstly, law and policy don't apply automatically, but must always be interpreted by human actors in relation to the situation. Secondly, the increase in legal and managerial demands reinforces prison governors’ more general inclinations to “satisficing” decisions (Simon, 1956). Drawing on two years of qualitative research with 30 Belgian prison governors, Christophe aims at analysing how prison governors are “enacting” prison policy and organisations (Weick, 1988), rather than being simply determined by it. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailHigher Octonions
Kreusch, Marie ULg

Conference (2015, June 11)

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailHigher order noise-shaping filters for high-performance micromachined accelerometers
Dong, Yufeng; Kraft, Michaël ULg; Redman-White, William

in IEEE Transactions on Instrumentation and Measurement (2007), 56(5), 1666-1674

Micromachined inertial sensors that have been incorporated in sigma-delta force-feedback loops have been proven to improve linearity, dynamic range, and bandwidth, and also provide a direct digital output ... [more ▼]

Micromachined inertial sensors that have been incorporated in sigma-delta force-feedback loops have been proven to improve linearity, dynamic range, and bandwidth, and also provide a direct digital output. Previous work mainly focused on using the sensing element only to form a second-order single-loop sigma-delta modulator (SigmaDeltaM); however, the advantages of higher order single-loop electromechanical SigmaDeltaM have not been fully explored. High-performance inertial sensors require higher signal-to-quantization noise ratio (SQNR). This paper presents topologies for higher order single-loop electromechanical SigmaDeltaM with optimal stable coefficients that lead to a better SQNR. The topologies have good immunity to fabrication tolerances, which was verified by Monte Carlo analysis. The topologies are applicable not only to accelerometers but also to other inertial sensors such as gyroscopes. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Peer Reviewed
See detailHigher order sigma-delta modulators interfaces for capacitive sensors (Invited)
Kraft, Michael ULg

in The IEE Seminar and Exhibition on MEMS Sensor Technologies (2005)

Detailed reference viewed: 19 (0 ULg)
Peer Reviewed
See detailHigher order sigma-delta modulators interfaces for capapcitive sensors
Kraft, Michaël ULg; Dong, Yufeng

in 2005 NSTI Nanotechnology Conference and Trade Show : NSTI Nanotech 2005 (2005, May)

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailHigher plant-like subunit composition of mitochondrial complex I from Chlamydomonas reinhardtii: 31 conserved components among eukaryotes
Cardol, Pierre ULg; Vanrobaeys, F.; Devreese, B. et al

in Biochimica et Biophysica Acta-Bioenergetics (2004), 1658(3), 212-224

The rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) is the most intricate membrane-bound enzyme of the mitochondrial respiratory chain. Notably the bovine enzyme comprises up to 46 subunits ... [more ▼]

The rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) is the most intricate membrane-bound enzyme of the mitochondrial respiratory chain. Notably the bovine enzyme comprises up to 46 subunits, while 27 subunits could be considered as widely conserved among eukaryotic complex I. By combining proteomic and genomic approaches, we characterized the complex I composition from the unicellular green alga Chlamydomonas reinhardtii. After purification by blue-native polyacrylamide gel electrophoresis (BN-PAGE), constitutive subunits were analyzed by SDS-PAGE coupled to tandem mass spectrometry (MS) that allowed the identification of 30 proteins. We compared the known complex I components from higher plants, mammals, nematodes and fungi with this MS data set and the translated sequences from the algal genome project. This revealed that the Chlamydomonas complex I is likely composed of 42 proteins, for a total molecular mass of about 970 kDa. In addition to the 27 typical components, we have identified four new complex I subunit families (bovine ESSS, PFFD, B16.6, B12 homologues), extending the number of widely conserved eukaryote complex I components to 31. In parallel, our analysis showed that a variable number of subunits appears to be specific to each eukaryotic kingdom (animals, fungi or plants). Protein sequence divergence in these kingdom-specific sets is significant and currently we cannot exclude the possibility that homology between them exists, but has not yet been detected. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 35 (3 ULg)
Full Text
Peer Reviewed
See detailHigher prevalence of clinically relevant pituitary adenomas confirmed.
Beckers, Albert ULg

in Clinical Endocrinology (2010), 72(3), 290-291

Detailed reference viewed: 16 (8 ULg)
Full Text
Peer Reviewed
See detailHigher risk of death among MEN1 patients with mutations in the JunD interacting domain. A Groupe d'étude des Tumeurs Endocrines (GTE) cohort study
Thevenon, Julien; Bourredjem, Abderrahmane; Faivre, Laurence et al

in Human Molecular Genetics (2013)

BackgroundMultiple Endocrine Neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors ... [more ▼]

BackgroundMultiple Endocrine Neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Although genotype-phenotype studies have so far failed to identify any statistical correlations, some families harbor recurrent tumor patterns. The function of MENIN is unclear but has been described through the discovery of its interacting partners. Mutations in the interacting domains of MENIN functional partners have been shown to directly alter its regulation abilities.MethodsWe report on a cohort of MEN1 patients from the Groupe d'etude des Tumeurs Endocrines. Patients with a molecular diagnosis and a clinical follow-up, totalling 262 families and 806 patients were included. Associations between mutation type, location or interacting factors of the MENIN protein and death as well as the occurrence of MEN1-related tumors were tested using a frailty Cox model to adjust for potential heterogeneity across families.ResultsAccounting for the heterogeneity across families, the overall risk of death was significantly higher when mutations affected the JunD interacting domain (adjusted HR=1.88: 95%-CI=1.15- 3.07). Patients had a higher risk of death from cancers of the MEN1 spectrum (HR=2.34; 95%-CI=1.23- 4.43).ConclusionThis genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor and should thus be considered for surgical indications, genetic counseling and follow-up. [less ▲]

Detailed reference viewed: 49 (14 ULg)
Full Text
Peer Reviewed
See detailHigher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.
El Hour, Mehdi ULg; Moncada-Pazos, A.; Blacher, Silvia ULg et al

in Oncogene (2010), 29(20), 3025-32

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in ... [more ▼]

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12−/−) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12−/− mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression. [less ▲]

Detailed reference viewed: 160 (40 ULg)
Full Text
See detailHigher Symmetries of the conformal Laplacian
Radoux, Fabian ULg

Conference (2014, July 14)

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailHigher symmetries of the conformal Laplacian
Radoux, Fabian ULg

Conference (2013, May 29)

Detailed reference viewed: 8 (1 ULg)
Full Text
See detailHigher symmetries of the conformal Laplacian
Radoux, Fabian ULg

Scientific conference (2013, December 10)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailHigher symmetries of the conformal Laplacian
Radoux, Fabian ULg

Scientific conference (2013, July 30)

Detailed reference viewed: 4 (1 ULg)
Full Text
See detailHigher Symmetries of the conformal Laplacian
Radoux, Fabian ULg

Conference (2014, June 09)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailHigher Symmetries of the Laplacian via Quantization
Michel, Jean-Philippe ULg

in Annales de l'Institut Fourier (2014), 64

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally ... [more ▼]

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally at manifold and recover results of Eastwood, Leistner, Gover and ilhan. In particular, conformally equivariant quantization establishes a correspondence between the algebra of Hamiltonian symmetries of the null geodesic ow and the algebra of higher symmetries of the conformal Laplacian. Combined with a symplectic reduction, this leads to a quantization of the minimal nilpotent coadjoint orbit of the conformal group. The star-deformation of its algebra of regular functions is isomorphic to the algebra of higher symmetries of the conformal Laplacian. Both identify with the quotient of the universal envelopping algebra by the Joseph ideal. [less ▲]

Detailed reference viewed: 23 (5 ULg)
See detailHigher-Moment Equity Risk Premiums in Hedge Funds
Lambert, Marie ULg

Doctoral thesis (2010)

Detailed reference viewed: 149 (14 ULg)
Full Text
Peer Reviewed
See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Conference (2012, April)

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model ... [more ▼]

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model with location, trading and higher-moment factors in order to describe the dynamics of the Equity Hedge (Market Neutral, Short Selling and Long/Short strategies), Event Driven, Relative Value, and Funds of Hedge Funds styles. The volatility, skewness and kurtosis implied in the US options markets are used by Hedge Fund managers as instruments to anticipate market movements. Managers should adjust their market exposure in response to variations in the implied higher moments. We show that higher-moment premia improve a conditional asset pricing model both in terms of explanatory power (R-squares and Schwarz criterion) and specification errors across all Hedge Fund styles. [less ▲]

Detailed reference viewed: 29 (4 ULg)
Full Text
Peer Reviewed
See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Conference (2012, January)

Detailed reference viewed: 14 (2 ULg)
See detailHigher-moment risk exposures in hedge funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Scientific conference (2013, January 16)

Detailed reference viewed: 28 (6 ULg)