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See detailHepatobiliary disease : primary and metastatic liver tumours
Hustinx, Roland ULg; Detry, Olivier ULg

in Cook, Gary JR; Maisey, Michael M; Britton, Keith (Eds.) et al Clinical Nuclear Medicine (2007)

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion ... [more ▼]

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, this heavily-illustrated text offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques. [less ▲]

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See detailHépatocarcinome: Place de la chirurgie
DETRY, Olivier ULg

Conference given outside the academic context (2016)

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See detailHepatocholecystitis due to Salmonella Dublin in a crossbred calf
Ronzoni, Anna; Bayrou, Calixte ULg; Evrard, Laurence ULg et al

Scientific conference (2014, October 17)

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See detailHepatocholecystitis due to Salmonella Dublin in a crossbred calf
Ronzoni, Anna ULg; Bayrou, Calixte ULg; Evrard, Laurence ULg et al

Conference (2013, August 30)

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See detailHepatocyte iron release in rats.
Beguin, Yves ULg; Huebers, H. A.; Weber, Géraldine ULg et al

in Journal of Laboratory & Clinical Medicine (1989), 113(3), 346-54

Hepatocyte iron release was studied in vivo in rats. After the injection of iron 59-labeled ferritin, hemoglobin, or human asialotransferrin, the proportions of the radioactive iron returned to the plasma ... [more ▼]

Hepatocyte iron release was studied in vivo in rats. After the injection of iron 59-labeled ferritin, hemoglobin, or human asialotransferrin, the proportions of the radioactive iron returned to the plasma and incorporated into stores were determined under various conditions. Iron 55-labeled rat transferrin was injected at the same time as the 59Fe-labeled compound, and storage iron release was calculated from the cumulative incorporation of the two isotopes in the red cell mass over 2 weeks. The various 59Fe-labeled compounds were processed differently by the hepatocyte, but the radioactive iron was incorporated in the same iron stores. About 6% of the hepatocyte storage iron was released daily in normal rats, but a pool of iron that is not mobilized spontaneously was clearly identified in iron overload. Iron turnover in the hepatocyte was regulated by the rate of erythropoiesis and iron status of the animal, and inflammation blocked hepatocyte iron release. A strong correlation between hepatocyte iron release and plasma transferrin receptor levels was observed (p less than 0.001), suggesting that plasma transferrin receptors could mediate the regulation of hepatocyte iron mobilization in rats. [less ▲]

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See detailHepatocyte transplantation in anhepatic rats: effect on survival, blood chemistry and growth factor profile
Khalili, T.; Arkadopoulos, N.; Detry, Olivier ULg et al

in Surgical Forum (1997), 44

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See detailHepatocyte transplantation prolongs survival and prevent development of brain edema in pigs with ischemic liver failure
Arkadopoulos, N.; Chen, S.; Khalili, T. et al

in Surgical Forum (1997), 44

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See detailHepatocyte transplantation using the domino concept in a child with Tetrabiopterin non-responsive phenylketonuria.
Stephenne, X.; DEBRAY, François-Guillaume ULg; Smets, F. et al

in Cell Transplantation (2012), 21(12), 2765-70

Phenylketonuria is a metabolic disease caused by phenylalanine hydroxylase deficiency. Treatment is based on a strict natural protein-restricted diet that is associated with the risk of malnutrition and ... [more ▼]

Phenylketonuria is a metabolic disease caused by phenylalanine hydroxylase deficiency. Treatment is based on a strict natural protein-restricted diet that is associated with the risk of malnutrition and severe psychosocial burden. Oral administration of tetrahydrobiopterin can increase residual enzyme activity, but most patients with severe clinical phenotypes are non-responders. We performed liver cell transplantation in 6 years-old boy with severe tetrahydrobiopterin non-responsive phenylketonuria, who failed to comply with diet prescriptions. The transplanted hepatocytes were obtained in part from an explanted glycogen storage type 1b liver. Following two infusions, blood phenylalanine levels returned within the therapeutic target while the phenylalanine half-life assessed by loading tests decreased from 43 h to 19 h. However, three months later, blood phenylalanine concentrations increased and the phenylalanine intake had to be reduced. Cell based therapy is a promising therapeutic option in phenylketonuria and the domino concept may solve the issue of cell sources for hepatocyte transplantation. [less ▲]

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See detailHepatoprotective and anti-diabetic activities of Fraxinus angustifolia Vahl extracts in animal models: Characterization by HPLC analysis
Medjahed, Zineb; Atmani-Kilani, Dina; Fauconnier, Marie-Laure ULg et al

in Turkish Journal of Medical Sciences (2016), 46(3), 910-920

Background and aim: The present study was designed to explore anti-diabetic and hepato-protective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo.

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See detailHepatoprotective effects of crude rhubarbe extract extend to the modulation of gut microbiota in a murine acute alcohol-induced steato-hepatitis model
Taminiau, Bernard ULg; Neyrinck, A.M.; Nezer, Carine et al

Conference (2014, October 17)

Binge drinking is emerging and alarming social and health problem, leading to alcoholic liver disease (ALD). It is characterized by hepatic steatosis coupled with inflammation. A way to limit the ... [more ▼]

Binge drinking is emerging and alarming social and health problem, leading to alcoholic liver disease (ALD). It is characterized by hepatic steatosis coupled with inflammation. A way to limit the evolution of ALD would be the use of bioactive compounds to reduce fat accumulation and inflammation. A specific crude rhubarb extract has been tested in a murine model of acute alcohol-induced steato-hepatitis. 18 male C57BL/6J mice has been fed with a standard diet, enriched with (OH-EV1 group) or without the rhubarb extract (CT and OH groups) for 17 days. Groups OH and OH-EV1 were then submitted to binge drinking and euthanazed. Physiological parameters have been measured. Moreover, bacterial ceacal contents were analyzed by pyrosequencing and 16S rDNA v1-V3 targeted metagenomic analysis. Inflammatory markers levels in liver and total hepatic cholesterol level show that the standardized extract limits inflammation and lipid accumulation. Moreover, metagenomic analysis revealed the composition of major bacterial populations in caecum. Several populations were statistically influenced by the rhubarb enriched diet compared normal diet as shown after binge drinking. Among these populations, few were strongly correlated with the levels of inflammatory markers in the liver. We targeted 3 populations for further analysis : two Alistipes populations and Parabacteroides goldsteinii. The Alistipes belong to yet undescribed species. Based upon the only nucleic trace from pyrosequecing, 3 quantitative RT-PCR tests were created to target these populations in gut samples. Quantitative determination of these populations confirmed the statistical correlation with inflammatory markers and results from metagenomic study. [less ▲]

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See detailHepatotoxicity with thiazolidinediones: is it a class effect?
Scheen, André ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2001), 24(12), 873-88

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications ... [more ▼]

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications. Thiazolidinediones, more commonly termed glitazones, are the first drugs to specifically target muscular insulin resistance. They have proven efficacy for reducing plasma glucose levels in patients with type 2 diabetes mellitus treated with diet alone, sulphonylureas, metformin or insulin. In addition, they are associated with some improvement of the cardiovascular risk profile. However, troglitazone, the first compound approved by the Food and Drug Administration in the US, proved to be hepatotoxic and was withdrawn from the market after the report of several dozen deaths or cases of severe hepatic failure requiring liver transplantation. It remains unclear whether or not hepatotoxicity is a class effect or is related to unique properties of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy with regard to blood glucose control in patients with type 2 diabetes mellitus as compared with troglitazone. In controlled clinical trials, the incidence of significant (> or =3 x upper limit of normal) increases in liver enzyme levels (ALT in particular) was similar with rosiglitazone or pioglitazone as compared with placebo, whereas troglitazone was associated with a 3-fold greater incidence. In contrast to the numerous case reports of acute liver failure in patients receiving troglitzone, only a few case reports of hepatotoxicity have been reported in patients treated with rosiglitazone until now, with a causal relationship remaining uncertain. Furthermore, no single case of severe hepatotoxicity has been reported yet with pioglitazone. It should be mentioned that troglitazone, unlike pioglitazone and rosiglitazone, induces the cytochrome P450 isoform 3A4, which is partly responsible for its metabolism, and may be prone to drug interactions. Importantly enough, obesity, insulin resistance and type 2 diabetes mellitus are associated with liver abnormalities, especially non-alcoholic steatohepatitis, independent of any pharmacological treatment. This association obviously complicates the selection of patients who are good candidates for a treatment with glitazones as well as the monitoring of liver tests after initiation of therapy with any thiazolidinedione compound. While regular monitoring of liver enzymes is still recommended and more long term data are desirable, current evidence from clinical trials and postmarketing experience in the US supports the conclusion that rosiglitazone and pioglitazone do not share the hepatotoxic profile of troglitazone. [less ▲]

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See detailHepatozoonosis in cats : ABCD guidelines on prevention and management
Lloret, A.; Addie, D.D.; Boucraut-Baralon, C. et al

in Journal of Feline Medicine and Surgery (2015), 17

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See detailThe HepCar registry: report on a one-year registration program of hepatocellular carcinoma (HCC) in Belgium. What is daily practice in HCC?
Van Vlierberghe, H.; Colle, I.; Henrion, J. et al

in Acta Gastro-Enterologica Belgica (2005), 68(4), 403-411

INTRODUCTION: Due to a rise in HCV induced liver cirrhosis, hepatocellular carcinoma becomes more prevalent in Western European countries. The HepCar registry is an initiative in which patients with ... [more ▼]

INTRODUCTION: Due to a rise in HCV induced liver cirrhosis, hepatocellular carcinoma becomes more prevalent in Western European countries. The HepCar registry is an initiative in which patients with hepatocellular carcinoma, their treatment and follow up are registered. MATERIALS AND METHODS: Belgian physicians were asked to report all new cases of hepatocellular carcinoma which were seen between January 2003 and December 2003. Reporting was done on a voluntary basis. Data reported were: demographic figures, the nature of the underlying liver disease, presentation characteristics of the tumour, laboratory findings and choice of therapy. Every six months, a reminder was sent to determine survival. RESULTS: 131 patients (94 male/37 female) were reported. Mean age was 63 years +/- 13. Underlying liver disease was HCV (n = 54, 41%), HBV (n = 22, 17%), alcoholic liver disease (n = 39, 30%) and miscellaneous (n =16, 12%). Diagnosis of hepatocellular carcinoma was made by surveillance in 47 (36%) patients. After logistic regression, survival was 5 times better for patients inside the Milan criteria (one lesion less than 5 cm in diameter or less than 3 nodules each less than 3 cm in the absence of vascular invasion and metastasis). DISCUSSION: Tumours inside the Milan criteria have a better survival. The majority of the patients have an underlying cirrhosis as background for the development of a HCC. [less ▲]

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See detailHepcidin determination in dried blood by microfluidic LC-MS/MS: comparison of DBS and volumetric absorptive microsampling for matrix effect and recovery.
Houbart, Virginie ULg; COBRAIVILLE, Gaël ULg; Servais, Anne-Catherine ULg et al

in Bioanalysis (2015), 7(21), 2789-99

BACKGROUND: Dried blood analysis experiences a growing interest due to practical, ethical and financial advantages compared with classical wet plasma or serum analysis. Besides classical DBS, new ... [more ▼]

BACKGROUND: Dried blood analysis experiences a growing interest due to practical, ethical and financial advantages compared with classical wet plasma or serum analysis. Besides classical DBS, new alternatives are commercialized as volumetric absorptive microsampling (VAMS) that are expected to overcome hematocrit influence. RESULTS: The feasibility of hepcidin (a peptide hormone) extraction and determination from DBS and VAMS blood sampling was investigated. Experimental design was used to determine the optimal extraction conditions. Matrix effect and extraction recovery were studied and a special attention was paid to phospholipid removal. CONCLUSION: The data suggest that the combination of VAMS and phospholipid removal plates provides low matrix effect and high sensitivity, and constitutes an easy and promising protocol for hepcidin analysis. [less ▲]

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See detailL'Héra de Zeus. Ennemie intime, épouse définitive
Pirenne-Delforge, Vinciane ULg; Pironti, Gabriella

Book published by Les Belles Lettres (2016)

Dans les dictionnaires de mythologie, la déesse Héra est une épouse irascible et une mère imparfaite face à un Zeus frivole, peuplant le monde grec de ses « bâtards ». Et, de fait, depuis l’Iliade ... [more ▼]

Dans les dictionnaires de mythologie, la déesse Héra est une épouse irascible et une mère imparfaite face à un Zeus frivole, peuplant le monde grec de ses « bâtards ». Et, de fait, depuis l’Iliade, l’Olympe retentit des colères d’Héra : bien des traditions narratives mettent en scène la fureur de la déesse, les infidélités de son royal époux et les persécutions auxquelles elle soumet ses rejetons illégitimes comme Héraclès ou Dionysos. Mais comment rapporter cette image à la dimension cultuelle de la déesse souveraine en ses sanctuaires d’Argos, de Samos ou d’ailleurs ? Faut-il y voir la preuve que les mythes et les cultes grecs forment deux ensembles hétérogènes et inconciliables, respectivement la fantaisie de l’imagination et le sérieux des actes de la vie religieuse ? En affrontant ces questions, l’enquête sur l’Héra de Zeus ouvre de nouvelles perspectives pour comprendre la société des dieux, le destin des héros et la vie des hommes. Épouse et reine, elle partage le trône et le lit du roi. Ennemie intime de Zeus, elle est aussi la farouche gardienne de la légitimité et de l’intégrité de la famille olympienne. En s’abstenant de projeter sur le monde des dieux grecs des lectures moralisantes et des catégories d’interprétation anachroniques, on voit se dessiner l’Héra de Zeus en des traits plus subtils et plus complexes qui donnent à repenser la configuration du pouvoir en Grèce ancienne, avec les tensions qui l’habitent, et par là-même le fonctionnement du polythéisme. [less ▲]

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See detailHéra et les enfants de Zeus : la 'fabrique' de l'Olympe entre textes et images
Pironti, Gabriella; Pirenne-Delforge, Vinciane ULg

in Belayche, Nicole; Pirenne-Delforge, Vinciane (Eds.) Fabriquer du divin. Constructions et ajustements de la représentation des dieux dans l'Antiquité (2015)

Quelles relations la déesse Héra entretient-elle avec les enfants de Zeus ? La question pourrait paraître banale à première vue : le conflit semble bien être la tonalité dominante des récits mythiques qui ... [more ▼]

Quelles relations la déesse Héra entretient-elle avec les enfants de Zeus ? La question pourrait paraître banale à première vue : le conflit semble bien être la tonalité dominante des récits mythiques qui mettent la déesse en présence des bâtards de son divin époux. Toutefois, quand on aborde ce sujet en faisant « réagir » les textes et les images, les traditions narratives et les représentations figurées, le tableau s’enrichit et devient d’autant plus intéressant qu’il est plus complexe. Certes, les relations d’Héra aux enfants de Zeus sont conflictuelles et prennent part au vaste thème des oppositions entre la déesse et son époux. Mais la confrontation entre deux corpus de nature différente – fût-elle partielle et ciblée sur des cas significatifs – permet de questionner avec davantage de pertinence la dynamique des représentations divines qui est au cœur du présent volume. Il ne s’agira pas de réconcilier à tout prix des ensembles documentaires qui offrent bien des différences dans les choix opérés et le développement de la thématique en jeu, mais de comprendre le sens de ces représentations qui, tout en étant différentes, comme le sont les langages qui les construisent, ne cessent pas pour autant d’être comparables. [less ▲]

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See detailHéra et Zeus à Lesbos : entre poésie lyrique et décret civique
Pirenne-Delforge, Vinciane ULg; Pironti, Gabriella

in Zeitschrift für Papyrologie und Epigraphik (2014), 191

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See detailHéra, Apollon et l'Héraion de Délos à la période archaïque
Pirenne-Delforge, Vinciane ULg

in Mazarakis Ainian, Alexandre (Ed.) Les sanctuaires archaïques des Cyclades (2017)

L’Héraion de Délos fut identifié en 1911, quand les archéologues de l’École française d’Athènes mirent au jour un dépôt archaïque dans un édifice surmonté du temple dorique toujours visible au flanc du ... [more ▼]

L’Héraion de Délos fut identifié en 1911, quand les archéologues de l’École française d’Athènes mirent au jour un dépôt archaïque dans un édifice surmonté du temple dorique toujours visible au flanc du mont Cynthe. Des inscriptions archaïques sur les objets dédiés attestèrent qu’Héra était la déesse honorée en ce lieu. Les interprétations de son culte dans l’île ont alors oscillé entre deux pôles : c’était soit une manière pour les Déliens d’apaiser sa colère contre Léto qui avait donné naissance à Apollon, ainsi que le raconte l’Hymne homérique au dieu, soit une tentative de maintenir sur l’île des fidèles tentés d’aller honorer la déesse dans le grand sanctuaire de Samos. Ces deux points de vue sont infondés : le premier, parce que les traditions narratives ont leur propre langage qui ne peut être projeté comme tel sur les cultes ; le second, parce que le désir d’honorer Héra à Délos peut être expliqué en soi, sans faire référence à une prétendue compétition avec le fameux sanctuaire de la déesse samienne. Afin de fonder l’analyse du dossier sur des prémisses plus valides, trois questions sont ici posées. 1) Qui furent les fidèles de la déesse pendant la période archaïque, des femmes, des hommes, des Délien(ne)s, des étrangers ? 2) Quelle place l’Héraion occupait-il parmi les autres sanctuaires déliens et quel était le rôle d’Héra parmi les autres dieux de Délos ? 3) Pouvons-nous utiliser l’Hymne homérique à Apollon pour comprendre le culte d’Héra et la situation de son temple sur l’île ? Ces trois questions sont abordées l’une après l’autre : la première par une analyse des types d’offrandes faites à Héra et de l’identité des dédicants qui ont inscrit leur démarche ; la deuxième en prenant en considération l’ensemble du panthéon délien archaïque ; la troisième en évaluant attentivement ce qu’implique, sur un plan narratif, la colère d’Héra contre Léto. [less ▲]

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