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See detailLIGAND-INDEPENDENT IDENTIFICATION OF ORPHAN GPCR ARRESTIN BINDING
Dupuis, Nadine ULg; Gilissen, Julie ULg; Derj, Anouar ULg et al

Poster (2014, June 05)

Detailed reference viewed: 29 (9 ULg)
See detailLigand-independent Identification of orphan GPCR Signaling pathways
Dupuis, Nadine ULg

Conference (2014, July 16)

Detailed reference viewed: 16 (1 ULg)
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See detailLigands and tracers for PET studies of the 5-HT system--current status.
Crouzel, C.; Guillaume, Marcel ULg; Barre, L. et al

in International Journal of Radiation Applications and Instrumentation. Part B : Nuclear Medicine and Biology (1992), 19(8), 857-70

The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and ... [more ▼]

The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and those with future potential. Practical recommendations are given for the preparation of two useful radioligands for PET studies of central 5-HT2 receptors, namely [18F]setoperone and [18F]altanserin. Though, it has not proved possible to recommend tracers or radioligands for the study of other aspects of serotonergic system, prospects for future radiochemical development are indicated, especially for developing radioligands for the 5-HT re-uptake site, and for the 5-HT1 and 5-HT3 receptors. [less ▲]

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See detailLigands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders
Monchaud, David; Allain, C.; Bertrand, Hélène et al

in Biochimie (2008), 90(8), 1207-1223

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity ... [more ▼]

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity of putative ligands. This assay is based on the loss of fluorescence upon displacement of thiazole orange from quadruplex and duplex-DNA matrices. The original protocol was tested using various quadruplex and duplex-DNA targets, and with a wide panel of G-quadruplex ligands belonging to different families (i.e. from quinacridines to metalloorganic ligands) likely to display various binding modes. The reliability of the assay is further supported by comparisons with FRET-melting and ESI-MS assays. [less ▲]

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See detailLigated anionic block copolymerization of methyl methacrylate with n-butyl acrylate and n-nonyl acrylate as promoted by lithium 2-(2-methoxyethoxy) ethoxide/diphenylmethyllithium
Nugay, Nihan; Nugay, Turgut; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(8), 1543-1548

Poly(methyl methacrylate-b-n-butyl acrylate) (PMMA-b-Pn-BuA) and poly(methyl methacrylate-b-n-nonyl acrylate) (PMMA-b-Pn-NonA) diblock copolymers have been successfully synthesized by the sequential ... [more ▼]

Poly(methyl methacrylate-b-n-butyl acrylate) (PMMA-b-Pn-BuA) and poly(methyl methacrylate-b-n-nonyl acrylate) (PMMA-b-Pn-NonA) diblock copolymers have been successfully synthesized by the sequential anionic polymerization of methyl methacrylate (MMA) and the n-alkyl acrylate (n-BuA or n-NonA), in a 90/10 toluene/ tetrahydrofuran (THF) mixture at -78°C. When diphenylmethyllithium (DPMLi) ligated with lithium 2-(2-methoxyethoxy) ethoxide (LiOEEM) is used as the initiator, the polymerization of each block appears to be living. Molecular weight and composition of block copolymers can be predicted from the monomer over initator molar ratio and the molecular weight distribution is narrow. Size exclusion chromatography (SEC) supports that no homo-PMMA contaminates the final copolymer. Although the reverse polymerization sequence Pn-NonA-b-PMMA always results in some contamination by homo-Pn-NonA, it has no really significant effect on the final product characteristics. [less ▲]

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See detailLight absorption in conical silicon particles
Bogdanowicz, J; Gilbert, M; Innocenti, N et al

in Optics Express (2013), 21(3), 3891

The problem of the absorption of light by a nanoscale dielectric cone is discussed. A simplified solution based on the analytical Mie theory of scattering and absorption by cylindrical objects is proposed ... [more ▼]

The problem of the absorption of light by a nanoscale dielectric cone is discussed. A simplified solution based on the analytical Mie theory of scattering and absorption by cylindrical objects is proposed and supported by the experimental observation of sharply localized holes in conical silicon tips after high-fluence irradiation. This study reveals that light couples with tapered objects dominantly at specific locations, where the local radius corresponds to one of the resonant radii of a cylindrical object, as predicted by Mie theory. [less ▲]

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See detailLight and Electron microscopic immunolocalization of Bovine pregnancy-associated glycoprotein in the Bovine Placentome
Demez, Pierre ULg; Zolli, A. P.; Beckers, Jean-François ULg et al

in 1st Joint meeting of the Royal Microscopical society and the Belgian Societies for Cell biology, clinical cytology, Electron Microscopy and pathology-Abstract book (1993)

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See detailLight and electron microscopic immunolocalization of bovine pregnancy-associated glycoprotein in the bovine placentome.
Zoli, A.; Demez, Pierre ULg; Beckers, Jean-François ULg et al

in Biology of Reproduction (1992), 46(4), 623-9

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that ... [more ▼]

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that protein in the placentomes and possibly the cells responsible for its production. Highly specific antisera raised against pure bPAG were used to demonstrate the cellular localization of the protein in bovine placentomes by light and electron microscopic techniques. Strong immunostaining was observed exclusively in the cytoplasm of large binucleate cells present predominantly in fetal cotyledonary tissue (villi). Some smaller weakly immunostained cells were also present in caruncular epithelium. By ultrastructural immunogold procedures, the protein was detected only within amorphous cytoplasmic granules. Granules of identical size, but weakly labeled, were found on the maternal side. All cells containing labeled granules were binucleate. These results suggest that bPAG is probably synthesized by trophoblast binucleate cells and stored in granules prior to delivery into the maternal circulation after cell migration. [less ▲]

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See detailLight and electron microscopical localization of structural lipids with Sudan Black B and osmium tetroxide
Compère, Philippe ULg; Lhoas, Marie-Laure; Goffinet, Gerhard ULg

in Micron and Microscopica Acta (1989), 20(2), 119-120

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See detailLight as a modulator of cognitive brain function
Vandewalle, Gilles ULg; Maquet, Pierre ULg; Dijk, D. J.

in Trends in Cognitive Sciences (2009), 13(10), 429-38

Humans are a diurnal species usually exposed to light while engaged in cognitive tasks. Light not only guides performance on these tasks through vision but also exerts non-visual effects that are mediated ... [more ▼]

Humans are a diurnal species usually exposed to light while engaged in cognitive tasks. Light not only guides performance on these tasks through vision but also exerts non-visual effects that are mediated in part by recently discovered retinal ganglion cells maximally sensitive to blue light. We review recent neuroimaging studies which demonstrate that the wavelength, duration and intensity of light exposure modulate brain responses to (non-visual) cognitive tasks. These responses to light are initially observed in alertness-related subcortical structures (hypothalamus, brainstem, thalamus) and limbic areas (amygdala and hippocampus), followed by modulations of activity in cortical areas, which can ultimately affect behaviour. Light emerges as an important modulator of brain function and cognition. [less ▲]

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See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2013, May 24)

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See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2012, September)

Detailed reference viewed: 14 (2 ULg)
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See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2012, December)

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See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2012, April)

Detailed reference viewed: 19 (1 ULg)
See detailLight as a modulator of executive and emotional brain functions
Vandewalle, Gilles ULg

Scientific conference (2014)

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See detailLight as a modulator of executive and emotional brain functions
Vandewalle, Gilles ULg

Conference (2012, June)

Detailed reference viewed: 9 (2 ULg)
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See detailLight curve of the Ap star TW Columbae
Renson, Pierre ULg; Manfroid, Jean ULg

in Astronomy and Astrophysics (1992), 256

The uvby light curves of the Ap star TW Col are analyzed. The presence of a small-scale dip in the curves appears to be in conflict with a simple spotted-rotator model. TW Col is the second star, after 46 ... [more ▼]

The uvby light curves of the Ap star TW Col are analyzed. The presence of a small-scale dip in the curves appears to be in conflict with a simple spotted-rotator model. TW Col is the second star, after 46 Eri, for which such a phenomenon seems to be confirmed. [less ▲]

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See detailThe light curves of periodic Be stars in NGC 3766
Balona, L. A.; Sterken, C.; Manfroid, Jean ULg

in Monthly Notices of the Royal Astronomical Society (1991), 252

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of ... [more ▼]

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of dramatic changes in the shapes and amplitudes of the light curves, phase locking is maintained and the period is unchanged over the five-year interval. It is concluded that within observational limits there is no evidence for coherent multiperiodicity in any of the four stars. No obvious correlation is found between the amplitudes or shapes of the light curves and the H-alpha line profiles. These findings are discussed in the light of the nonradial pulsation and starspot hypotheses, and they are shown to be observationally indistinguishable. A model in which matter is trapped in a magnetic field and forced into corotation with the star is discussed. [less ▲]

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See detailLight Guiding Plate With Internal Micro-Prisms
Habraken, Serge ULg

Patent (2003)

A guiding plate is used to split light in several beams, called fan out. In a different embodiment, the light splitting is used to produce an extraction as a uniform lighting

Detailed reference viewed: 20 (3 ULg)