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See detailAndrew Pettigrew: le cadre d’analyse contextualiste
Pichault, François ULiege

in Allouche, José (Ed.) Encyclopédie des ressources humaines (2012)

Une présentation synthétique du cadre d'analyse contextualiste et de ses possibilités d'utilisation en GRH

Detailed reference viewed: 773 (59 ULiège)
See detailAndrew Pettigrew: le cadre d’analyse contextualiste
Pichault, François ULiege

in Allouche, José (Ed.) Encyclopédie des ressources humaines (2003)

Presentation of the contextualist analytical framework and its potential applications to the field of human resources

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See detailAndrien Jean-Jacques
Tomasovic, Dick ULiege

in Aubenas, Jacqueline (Ed.) Dic Doc: Dictionnaire des Documentaristes belges (1999)

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See detailAndrogen and Estrogen Action in the Preoptic Area and Activation of Copulatory Behavior in Quail
Balthazart, Jacques ULiege; Surlemont, C.

in Physiology & Behavior (1990), 48(5), 599-609

The sites of androgen and estrogen action on sexual behavior were studied in the preoptic area of castrated male Japanese quail by stereotaxic implantation of hormones, antihormones and metabolism ... [more ▼]

The sites of androgen and estrogen action on sexual behavior were studied in the preoptic area of castrated male Japanese quail by stereotaxic implantation of hormones, antihormones and metabolism inhibitors. The first experiment demonstrated that bilateral implantation of the aromatase inhibitor, androstatrienedione (ATD), in the sexually dimorphic nucleus (POM) of the preoptic area can completely suppress the behavioral activation produced by a systemic treatment with testosterone. The effects of ATD were only observed if the implants were located in the POM. In the second experiment, implants in the POM of the synthetic estrogen, diethylstilbestrol, restored copulatory behavior in castrated males while implants of the synthetic nonaromatizable androgen, methyltrienolone, were almost ineffective. During the third experiment, the activating effects of a systemic treatment with testosterone were blocked by stereotaxic implants in the POM of the antiestrogen, tamoxifen, or the antiandrogen, flutamide. The effects of tamoxifen were more pronounced than those of flutamide. In addition, tamoxifen was active in all parts of the POM while a behavioral inhibition was observed only for flutamide implants which were located in the caudal part of the nucleus. Taken together, these results demonstrate that the sexually dimorphic POM is the area where the behaviorally active estrogenic metabolites of T have to be produced. The estradiol derived from T aromatization presumably acts within the POM to activate copulation as demonstrated by the effectiveness of DES implanted in this region. Androgens also have a direct action on sexual behavior as suggested by the partial inhibition observed in flutamide-treated birds. It is, however, suggested that androgens and estrogens do not act in the same brain area to activate behavior. [less ▲]

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See detailAndrogen mediation of conditioned rhythmic cloacal sphincter movements in Japanese quail (Coturnix Japonica)
Holloway, Kevin S.; Balthazart, Jacques ULiege; Cornil, Charlotte ULiege

in Journal of Comparative Psychology (2005), 119(1), 49-57

Demonstrations of increased reproductive success due to sexual conditioning in Japanese quail (Coturnix japonica) have been reported, although the mechanisms that underlie these effects have remained ... [more ▼]

Demonstrations of increased reproductive success due to sexual conditioning in Japanese quail (Coturnix japonica) have been reported, although the mechanisms that underlie these effects have remained elusive. One possible mechanism is conditioned rhythmic cloacal sphincter movements (RCSM). Two experiments were conducted with male quail to determine whether associations between a conditioned stimulus (CS) and a hen would result in the ability of the CS to elicit RCSM, and to explore the androgen mediation of conditioned RCSM. The results suggest that a focal CS paired with visual access to a female will elicit RCSM via a representation of the hen activated by the CS. Further, the available evidence indicates that conditioned RCSM is androgen mediated and that this learning may transfer across breeding seasons. [less ▲]

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See detailAndrogen metabolism and the activation of male sexual behavior: It's more complicated than you think!
Ball, G. F.; Balthazart, Jacques ULiege

in Hormones & Behavior (2006), 49(1), 1-3

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See detailAndrogen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines.
Pignon, Jean-Christophe ULiege; Koopmansch, Benjamin ULiege; Nolens, Grégory ULiege et al

in Cancer Research (2009), 69(7), 2941-2949

EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR ... [more ▼]

EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR and ERBB2 expression in PCa cells. In steroid-depleted medium (SDM), EGFR protein was less abundant in androgen-sensitive LNCaP than in androgen ablation-resistant 22Rv1 cells, whereas transcript levels were similar. Dihydrotestosterone (DHT) treatment increased both EGFR mRNA and protein levels and stimulated RNA polymerase II recruitment to the EGFR gene promoter, whereas it decreased ERBB2 transcript and protein levels in LNCaP cells. DHT altered neither EGFR or ERBB2 levels nor the abundance of prostate-specific antigen (PSA), TMEPA1, or TMPRSS2 mRNAs in 22Rv1 cells, which express the full-length and a shorter AR isoform deleted from the COOH-terminal domain (ARDeltaCTD). The contribution of both AR isoforms to the expression of these genes was assessed by small interfering RNAs targeting only the full-length or both AR isoforms. Silencing of both isoforms strongly reduced PSA, TMEPA1, and TMPRSS2 transcript levels. Inhibition of both AR isoforms did not affect EGFR and ERBB2 transcript levels but decreased EGFR and increased ERBB2 protein levels. Proliferation of 22Rv1 cells in SDM was inhibited in the absence of AR and ARDeltaCTD. A further decrease was obtained with PKI166, an EGFR/ERBB2 kinase inhibitor. Overall, we showed that ARDeltaCTD is responsible for constitutive EGFR expression and ERBB2 repression in 22Rv1 cells and that ARDeltaCTD and tyrosine kinase receptors are necessary for sustained 22Rv1 cell growth. [less ▲]

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See detailAndrogen-dependent vasopressinergic neurons are involved in social recognition in rats.
Bluthe, R. M.; Schoenen, Jean ULiege; Dantzer, R.

in Brain Research (1990), 519(1-2), 150-7

Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen ... [more ▼]

Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen-dependent, the present experiments were undertaken to assess possible interactions between androgens and vasopressin in social recognition. Castrated male rats displayed a temporary disruption of social recognition when they were tested 1 week after surgery. There was no impairment, however, when they were tested every other day following surgery. The peripheral injection of a vasopressor antagonist of vasopressin, dPTyr(Me)AVP (30 micrograms/kg) impaired social recognition in normal male rats but was ineffective in castrated ones. This was not due to an effect of castration on the basic pharmacological properties of dPTyr(Me)AVP since the antagonist peptide was still able to block the facilitating effects of vasopressin on social recognition in castrated male rats. Implantation of a testosterone-filled capsule in castrated male rats restored sensitivity of social recognition to the action of the vasopressin antagonist. These results suggest that androgen-dependent vasopressinergic neurons are physiologically involved in the modulation of social recognition in male rats. [less ▲]

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See detailAndrogen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27.
Waltregny, David ULiege; Leav, Irwin; Signoretti, Sabina et al

in Molecular Endocrinology (2001), 15(5), 765-82

Androgens control both growth and differentiation of the normal prostate gland. However, the mechanisms by which androgens act upon the cell cycle machinery to regulate these two fundamental processes are ... [more ▼]

Androgens control both growth and differentiation of the normal prostate gland. However, the mechanisms by which androgens act upon the cell cycle machinery to regulate these two fundamental processes are largely unknown. The cyclin-dependent kinase (cdk) inhibitor p27 is a negative cell cycle regulator involved in differentiation-associated growth arrest. Here, we investigate the role and regulation of p27 in the testosterone proprionate (TP)-stimulated regeneration of the ventral prostate (VP) of castrated rats. Continuous TP administration to castrated rats triggered epithelial cell proliferation, which peaked at 72 h, and then declined despite further treatment. Castration-induced atrophy of the VP was associated with a significant increase in p27 expression as compared with the VP of intact animals. Twelve hours after the initiation of androgen treatment, total p27 levels as well as its fraction bound to cdk2, its main target, significantly dropped in the VP of castrated rats. Thereafter, concomitantly to the induction of epithelial cell proliferation, the glandular morphology of VP was progressively restored at 48-96 h of TP treatment. During this period of the regenerative process, whereas both proliferating basal and secretory epithelial cells did not express p27, the protein was selectively up-regulated in the nonproliferating secretory epithelial compartment. This up-regulation of p27 expression was coincident with an increase in its association with, and presumably inhibition of, cdk2. At each time point of TP treatment, p27 abundance in the VP was inversely correlated with the level of its proteasome-dependent degradation activity measured in vitro in VP lysates, whereas only slight changes in the amount of p27 transcripts were detected. In addition, the antiandrogen flutamide blocked maximal TP-induced p27 degradation completely. Finally, the expression of skp2, the ubiquitin ligase that targets p27 for degradation, was seen to increase with androgen administration, preceding maximal proliferation and concomitantly to augmented p27 degradation activity. Taken together, our data indicate that androgens mediate both proliferation and differentiation signals in normal prostate epithelial cells in vivo, through regulation of p27. [less ▲]

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See detailAndrogenic alopecia and stress-induced premature senescence by cumulative ultraviolet light exposure.
Franchimont, Claudine ULiege; Uhoda, I.; Saint Léger, Didier et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair ... [more ▼]

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair shedding and androgenic alopecia (AGA) is largely unknown. Objective : To compare the severity of AGA with the extent in solar elastosis. Method : The present study combining immunohistochemistry and computerized image analysis was undertaken in 140 men with AGA and 50 non-alopecic men. Solar elastosis was identified using the antibody to lyzozyme, and collagen was revealed by sirius red staining. The number and diameter of hair shafts were also assessed. Results : The scalp dermis was significantly thicker in AGA than in unaffected subjects. The difference was mainly due to a more severe elastosis in baldness. The earliest signs of solar elastosis preceded hair thinning. When elastosis was thicker than 0.2 mm, a negative exponential correlation was found between hair diameter and severity in solar elastosis. Conclusion : Chronic UVR exposure of the scalp may affect the hair cycle and be one exogenous factors influencing negatively the progression of AGA. The induction of stress-induced premature senescence (SIPS) through reactive oxygen species and microinflammation might be operative at the level of the follicular stem cells. [less ▲]

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See detailAndrogenic potential and anther in vitro culture of Lagenaria siceraria (Molina) Standl and edible-seed cucurbit
Kouakou, Kouakou L.; Doubi, Tra Serge; Koffi, Kouame Kevin et al

in International Journal of Biological and Chemical Sciences (2015), 9(4), 1779-1789

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See detailAndrogens and estrogens synergistically regulate the expression of doublecortin and enhance neuronal recruitment in the song system of adult female canaries.
Yamamura, Takashi; Barker, Jennifer ULiege; Balthazart, Jacques ULiege et al

in Journal of Neuroscience (2011)

Vocal control nuclei in songbirds display seasonal changes in volume that are regulated by testosterone (T) and its androgenic (5α-dihydrotestosterone; DHT) or estrogenic metabolites (17β-estradiol; E2 ... [more ▼]

Vocal control nuclei in songbirds display seasonal changes in volume that are regulated by testosterone (T) and its androgenic (5α-dihydrotestosterone; DHT) or estrogenic metabolites (17β-estradiol; E2). In male canaries, T regulates expression of the microtubule-associated protein doublecortin (DCX), a marker of neurogenesis. We examined the effect of T and its two metabolites alone or in combination on DCX expression in adult female canaries. Treatment with T or with DHT+E2 increased HVC volume and neuron numbers as well as the total numbers of fusiform (migrating) and round (differentiating) DCX neurons in the nucleus but generally not in adjacent areas. DHT or E2 alone did not increase these measures but increased the density of fusiform DCX cells per section. Similar results were observed in Area X although some effects did not reach significance presumably because plasticity in X is mediated transynaptically and follows HVC changes with some delay. There was no effect of any treatment on the total number of neurons in Area X and no change in DCX cell densities was detected in other parts of the nidopallium nor in LMAN. DHT and E2 by themselves thus increase density of DCX cells migrating through HVC but are not sufficient in isolation to induce the recruitment of these newborn neurons in the nucleus. These effects are generally not observed in the rest of the nidopallium implying that steroids only act on the attraction and recruitment of new neurons in HVC without having any major effects on their production at the ventricle wall. [less ▲]

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See detailAndrogens regulation of the ERBB1 and ERBB2 oncogene expression in human prostate cancer cells
Pignon, Jean-Christophe; Delacroix, Laurence; Nolens, Grégory et al

Poster (2006)

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See detailAndrogens regulation of the ERBB1 and ERBB2 oncogene expression in human prostate cancer cells
Pignon, Jean-Christophe ULiege; Delacroix, Laurence; Waltregny, David ULiege et al

in Acta Clinica Belgica (2006), 61(2, MAR-APR), 95-95

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See detailAndropause and psychopathology: minor symptoms rather than pathological ones.
Delhez, Marie; Hansenne, Michel ULiege; Legros, Jean-Jacques ULiege

in Psychoneuroendocrinology (2003), 28(7), 863-74

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects ... [more ▼]

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects were 153 men, aged 50-70 years, who participated in a screening of andropause. Total testosterone, FSH, LH and SHBG levels were measured. Depressed mood was assessed with the Carroll Rating Scale, anxiety with the "anxiety-insomnia" dimension of the General Health Questionnaire, and quality of life with the World Health Organisation Quality of Life questionnaire. The results showed that levels of free T decreased with age, whereas FSH and LH increased. Carroll Rating Scale scores were higher among hypogonadal subjects, but the mean score was low and not pathological. A negative correlation was observed between severity of depression as assessed by the Carroll Rating Scale and free T levels. However, subjects with a significant score on this scale did not exhibit different free T levels compared to subjects with a non-significant depressive score. Anxiety and quality of life did not differ between hypogonadal and eugonadal subjects. The present study therefore suggests that andropause is not characterised by specific psychological symptoms, but may be associated with "depressive symptoms" that are not considered as pathological. [less ▲]

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See detailAndy Warhol had spirituele kant (over Warhol-tentoonstelling in Mons)
Mus, Francis ULiege

Article for general public (2013)

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See detailL’anéantissement des donations : questions de droit international privé
Wautelet, Patrick ULiege; Fongaro, Eric

in Revue de planification patrimoniale belge et internationale (2015), 2(1), 39-64

Avec le développement d'une véritable pratique transfrontière de la planification successorale, les questions de droit international privé entourant les donations ont beaucoup retenu l'attention ces ... [more ▼]

Avec le développement d'une véritable pratique transfrontière de la planification successorale, les questions de droit international privé entourant les donations ont beaucoup retenu l'attention ces dernières années. Cet intérêt renouvelé pour un sujet classique a permis d'élucider le statut pour le moins complexe de la donation qui présente une dimension internationale. On a toutefois peu évoqué les difficultés que peuvent susciter la fragilité des donations : institution de droit civil aux contours pour le moins polymorphes, la donation est entourée de nombreuses limitations et obstacles qui ont pour objectif de conjurer les risques que peut faire naître, tant pour le donateur, sa famille que pour ses créanciers, cet acte particulier d'appauvrissement sans contrepartie. Le régime contemporain des donations est fondé sur une série de règles et mécanismes qui permettent de remettre en question la libéralité. Tantôt c'est la capacité d'une des parties (à donner ou à recevoir) qui fait l'objet de dispositions dérogatoires au droit commun, tantôt c'est le consentement du donateur qui suscite l'application d'une règle spéciale, tantôt encore des exigences particulières sont posées à propos des formes que doit revêtir une donation. Ces règles complexes, qui nourrissent un contentieux fourni, sont autant d'obstacles qui peuvent être posés au plein accomplissement des donations. Elles conduisent parfois à la révocation de la donation, qui peut produire ses effets ex nunc ou dans certains cas de façon rétroactive. Dans d'autres situations, la donation est annulée et dès lors considérée comme n'ayant jamais existé. Une donation peut également faire l'objet d'une déclaration ou encore être frappée de caducité ou de déchéance. Ces questions sont abordées dans la présente contribution sous l'angle du droit international privé belge et français, en mettant l'accent tant sur les différences que sur les simillitudes entre ces droits. [less ▲]

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See detailL'anéantissement des donations entre vifs
Moreau, Pierre ULiege

in Moreau, Pierre (Ed.) Libéralités et successions (2012)

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See detailAneignung Herrenloser Sachen
Gerkens, Jean-François ULiege

Scientific conference (2014, June 19)

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See detailAnemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza, Francis; Beguin, Yves ULiege; Bergmann, Pierre et al

in Blood (1998), 92(5), 1793-8

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect ... [more ▼]

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). These results were compared with those obtained from appropriate control groups. In all patients, we found a highly significant correlation between the logarithm of EPO (log[EPO]) and the hemoglobin (Hb) level. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. Thus, in children with cancer, anemia is associated with a decreased total bone marrow erythropoietic activity which, in contrast to what has been reported in anemic cancer adults, is not related to defective EPO production. [less ▲]

Detailed reference viewed: 57 (1 ULiège)